GREMLIN Database
CHEZ - Protein phosphatase CheZ
UniProt: P0A9H9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10151
Length: 214 (204)
Sequences: 500 (314)
Seq/√Len: 22.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_R113_D5.9161.00
71_N74_E4.8391.00
68_R140_D4.3481.00
50_D54_R3.1941.00
37_L41_I2.9550.99
80_Q128_T2.9130.99
144_L148_V2.8470.99
63_A150_K2.8400.99
82_Q86_S2.7110.99
57_Y141_F2.6940.99
79_H124_H2.4930.98
97_W107_A2.3920.97
29_R152_M2.3710.97
101_P107_A2.2190.96
76_S148_V2.2110.96
29_R153_M2.1420.95
61_M64_Q2.0440.94
95_D99_A2.0310.93
77_Q129_N2.0190.93
104_L108_R1.9930.93
78_P94_W1.9320.91
58_V203_D1.9110.91
63_A142_Q1.8200.89
75_A131_Q1.7770.87
96_D101_P1.7590.87
44_A47_A1.7540.87
102_I107_A1.7000.85
63_A72_S1.6600.84
144_L199_V1.6530.83
199_V204_Q1.6500.83
94_W107_A1.6450.83
45_A49_P1.6420.83
165_M169_E1.6410.83
59_V153_M1.6360.83
32_L49_P1.6000.81
57_Y148_V1.5920.81
106_D116_Q1.5900.81
96_D102_I1.5860.81
116_Q123_A1.5830.80
39_Q42_A1.5550.79
74_E135_I1.5370.78
85_K174_Q1.4740.75
30_D183_Q1.4350.73
96_D106_D1.4300.73
103_D111_V1.3990.71
83_M117_F1.3700.70
98_F133_L1.3640.69
48_I53_D1.3630.69
45_A81_D1.3380.68
45_A166_V1.3360.68
40_A151_R1.3210.67
97_W111_V1.2950.65
96_D165_M1.2780.64
182_N191_V1.2640.63
35_L153_M1.2520.63
67_E136_M1.2430.62
24_L159_I1.2360.62
192_D198_V1.2250.61
104_L167_L1.2230.61
100_D117_F1.2130.60
94_W145_T1.2060.60
60_Q71_N1.1630.57
114_T128_T1.1530.56
97_W101_P1.1290.55
104_L107_A1.1270.54
85_K168_L1.1220.54
29_R107_A1.1190.54
35_L59_V1.1110.53
61_M121_V1.1030.53
63_A67_E1.1020.53
17_I67_E1.1000.53
103_D107_A1.0980.52
37_L111_V1.0960.52
193_T197_G1.0940.52
14_A34_E1.0880.52
29_R97_W1.0850.52
205_V212_L1.0830.51
136_M156_I1.0770.51
102_I105_A1.0760.51
53_D192_D1.0760.51
27_M162_Q1.0720.51
32_L41_I1.0710.51
29_R170_N1.0700.51
47_A164_L1.0650.50
98_F111_V1.0650.50
86_S125_T1.0540.49
69_A73_V1.0420.49
47_A115_R1.0390.48
25_T211_S1.0370.48
74_E163_L1.0300.48
107_A110_L1.0280.48
159_I186_L1.0260.48
114_T118_L1.0200.47
36_G70_L1.0190.47
72_S197_G1.0180.47
61_M157_Q1.0160.47
70_L195_K1.0130.47
74_E88_K1.0120.47
140_D149_I0.9940.45
108_R167_L0.9940.45
79_H197_G0.9890.45
21_I24_L0.9870.45
41_I49_P0.9860.45
76_S204_Q0.9850.45
20_R23_S0.9850.45
62_T155_V0.9830.45
98_F115_R0.9800.44
59_V148_V0.9800.44
70_L187_N0.9790.44
119_A130_A0.9790.44
75_A198_V0.9710.44
135_I141_F0.9700.44
66_A207_D0.9700.44
41_I171_I0.9700.44
173_E201_S0.9640.43
56_Y157_Q0.9610.43
22_G136_M0.9550.43
190_Q200_A0.9510.43
146_G163_L0.9440.42
45_A52_R0.9410.42
30_D33_R0.9370.42
85_K123_A0.9360.42
159_I164_L0.9340.41
28_L139_Q0.9310.41
180_R183_Q0.9210.41
83_M121_V0.9200.40
25_T212_L0.9200.40
207_D211_S0.9160.40
95_D164_L0.9090.40
189_P207_D0.9070.40
76_S197_G0.9060.40
110_L115_R0.9020.39
91_T122_P0.8940.39
16_D159_I0.8880.38
94_W118_L0.8840.38
25_T69_A0.8810.38
25_T152_M0.8790.38
38_D142_Q0.8770.38
82_Q124_H0.8720.37
75_A127_F0.8690.37
31_S190_Q0.8690.37
122_P125_T0.8670.37
68_R109_E0.8580.36
86_S174_Q0.8470.36
105_A200_A0.8460.36
98_F107_A0.8440.36
100_D107_A0.8440.36
49_P52_R0.8390.35
50_D150_K0.8350.35
84_E121_V0.8330.35
58_V210_D0.8330.35
27_M31_S0.8310.35
200_A210_D0.8170.34
69_A156_I0.8160.34
107_A156_I0.8150.34
136_M149_I0.8130.34
125_T200_A0.8110.34
27_M44_A0.8080.33
140_D148_V0.8050.33
187_N204_Q0.8030.33
52_R64_Q0.8000.33
120_D123_A0.7990.33
40_A111_V0.7960.33
14_A27_M0.7900.32
62_T145_T0.7830.32
39_Q151_R0.7790.32
102_I131_Q0.7770.32
60_Q64_Q0.7740.31
158_E166_V0.7720.31
46_E151_R0.7710.31
58_V149_I0.7700.31
18_I153_M0.7690.31
177_R180_R0.7660.31
22_G73_V0.7620.31
135_I162_Q0.7610.31
76_S136_M0.7570.30
20_R169_E0.7550.30
151_R159_I0.7480.30
29_R41_I0.7410.29
171_I176_S0.7400.29
24_L69_A0.7380.29
148_V191_V0.7180.28
192_D195_K0.7150.28
102_I106_D0.7140.28
73_V136_M0.7140.28
78_P118_L0.7120.28
42_A151_R0.7110.28
22_G26_R0.7110.28
79_H128_T0.7100.28
49_P167_L0.7050.27
23_S79_H0.6990.27
72_S78_P0.6960.27
20_R63_A0.6930.27
148_V204_Q0.6900.27
78_P110_L0.6890.27
81_D134_E0.6870.27
86_S120_D0.6870.27
129_N150_K0.6860.26
23_S96_D0.6840.26
87_A94_W0.6840.26
123_A130_A0.6810.26
17_I166_V0.6810.26
27_M40_A0.6770.26
82_Q130_A0.6710.26
109_E177_R0.6660.25
59_V204_Q0.6650.25
179_K193_T0.6650.25
126_S175_E0.6610.25
185_L204_Q0.6600.25
39_Q43_E0.6530.25
175_E179_K0.6510.25
72_S94_W0.6500.25
194_S197_G0.6490.25
91_T95_D0.6470.24
82_Q91_T0.6460.24
20_R35_L0.6460.24
172_P179_K0.6460.24
79_H127_F0.6400.24
74_E77_Q0.6400.24
69_A211_S0.6340.24
118_L144_L0.6340.24
140_D145_T0.6310.24
86_S119_A0.6300.24
151_R211_S0.6290.24
14_A154_D0.6290.24
49_P137_M0.6260.23
169_E172_P0.6260.23
16_D164_L0.6240.23
33_R157_Q0.6240.23
71_N187_N0.6210.23
13_S32_L0.6200.23
92_Q111_V0.6170.23
89_A182_N0.6110.23
100_D152_M0.6100.23
130_A161_R0.6090.23
88_K123_A0.6060.22
96_D179_K0.6040.22
97_W108_R0.6020.22
34_E37_L0.5970.22
79_H100_D0.5950.22
136_M162_Q0.5950.22
187_N210_D0.5940.22
40_A47_A0.5930.22
78_P142_Q0.5920.22
187_N190_Q0.5890.22
12_H86_S0.5870.22
60_Q151_R0.5870.22
179_K183_Q0.5860.22
174_Q181_E0.5860.22
64_Q183_Q0.5840.21
66_A144_L0.5830.21
192_D197_G0.5820.21
32_L52_R0.5820.21
67_E73_V0.5810.21
82_Q120_D0.5740.21
58_V67_E0.5740.21
52_R61_M0.5740.21
48_I104_L0.5740.21
25_T164_L0.5730.21
80_Q114_T0.5720.21
152_M155_V0.5720.21
138_A167_L0.5710.21
74_E90_L0.5710.21
92_Q112_T0.5700.21
74_E93_R0.5690.21
87_A117_F0.5690.21
38_D63_A0.5650.21
122_P152_M0.5630.20
94_W137_M0.5620.20
168_L171_I0.5610.20
74_E176_S0.5600.20
166_V171_I0.5600.20
108_R190_Q0.5590.20
54_R212_L0.5580.20
24_L183_Q0.5570.20
81_D86_S0.5570.20
73_V176_S0.5570.20
72_S157_Q0.5560.20
86_S117_F0.5550.20
85_K127_F0.5540.20
97_W104_L0.5530.20
32_L211_S0.5500.20
70_L190_Q0.5470.20
92_Q108_R0.5450.20
132_L164_L0.5430.20
21_I31_S0.5420.20
58_V200_A0.5390.19
73_V133_L0.5380.19
77_Q81_D0.5350.19
90_L166_V0.5340.19
33_R87_A0.5330.19
102_I117_F0.5330.19
135_I140_D0.5250.19
169_E204_Q0.5230.19
108_R195_K0.5220.19
116_Q176_S0.5190.19
123_A179_K0.5180.19
172_P185_L0.5150.18
64_Q162_Q0.5150.18
15_G135_I0.5150.18
38_D51_A0.5090.18
87_A92_Q0.5080.18
127_F174_Q0.5060.18
119_A123_A0.5060.18
119_A126_S0.5010.18
96_D162_Q0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kmiZ 2 0.8271 100 0.187 Contact Map
3j9tb 1 0.757 47.2 0.954 Contact Map
1ka2A 2 0.8832 46.6 0.954 Contact Map
3fx7A 2 0.3178 34 0.957 Contact Map
1tr2A 1 0.9112 16.8 0.963 Contact Map
1nfnA 1 0.4299 14.6 0.964 Contact Map
2d3dA 1 0.1168 14.4 0.964 Contact Map
4iggA 2 0.7804 14 0.964 Contact Map
2hc5A 1 0.5234 13.4 0.965 Contact Map
2l7bA 1 0.757 13.2 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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