GREMLIN Database
CFA - Cyclopropane-fatty-acyl-phospholipid synthase
UniProt: P0A9H7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11531
Length: 382 (343)
Sequences: 3524 (2304)
Seq/√Len: 124.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_K224_D4.3701.00
329_L348_T3.8591.00
43_N66_W3.7241.00
169_M231_R3.5161.00
203_Q207_Q3.5161.00
331_A334_E3.5051.00
182_A193_V3.3621.00
42_K68_E3.3611.00
157_K184_Y3.2591.00
170_R192_S3.2091.00
147_N150_S3.1291.00
211_E214_D2.9971.00
64_D342_R2.9541.00
252_V255_R2.9291.00
196_V225_L2.8811.00
203_Q217_I2.8701.00
142_W323_A2.8511.00
133_P149_E2.8471.00
332_W344_K2.6341.00
253_V263_F2.5431.00
194_V218_L2.3751.00
157_K161_E2.3711.00
181_L235_V2.3681.00
159_I235_V2.3611.00
159_I264_L2.3541.00
254_D372_R2.3391.00
146_D154_A2.3221.00
194_V229_F2.2901.00
210_C217_I2.2791.00
171_V181_L2.2711.00
200_A204_K2.2271.00
59_G280_W2.1981.00
71_R74_M2.1891.00
323_A326_E2.1831.00
205_M209_R2.0151.00
262_I371_S2.0141.00
195_G217_I2.0061.00
336_A344_K1.9621.00
136_Q156_L1.9501.00
319_T323_A1.9291.00
63_M346_M1.9241.00
136_Q180_G1.8941.00
238_F267_T1.8851.00
49_R66_W1.8761.00
252_V256_N1.8701.00
332_W336_A1.8311.00
325_Y329_L1.8291.00
129_R334_E1.8271.00
336_A341_E1.8041.00
157_K189_Y1.8021.00
232_I256_N1.8011.00
174_I253_V1.7941.00
156_L180_G1.7621.00
206_A217_I1.7571.00
160_C185_M1.7551.00
325_Y348_T1.7171.00
176_C195_G1.7041.00
210_C215_V1.6721.00
143_K146_D1.6331.00
146_D150_S1.6261.00
171_V185_M1.5991.00
208_E211_E1.5951.00
40_R70_D1.5911.00
300_S370_F1.5861.00
162_K311_H1.5601.00
201_E204_K1.5551.00
184_Y188_N1.5401.00
143_K154_A1.5361.00
125_D128_S1.5351.00
194_V216_T1.5331.00
157_K188_N1.5321.00
161_E189_Y1.5171.00
129_R335_I1.4971.00
334_E337_D1.4911.00
77_S360_A1.4791.00
160_C189_Y1.4781.00
251_A255_R1.4681.00
186_A213_L1.4651.00
225_L229_F1.4421.00
257_L263_F1.4401.00
322_M355_A1.4321.00
150_S154_A1.4221.00
124_N201_E1.4201.00
192_S216_T1.4171.00
164_Q262_I1.4161.00
76_F356_G1.4071.00
128_S135_M1.3871.00
134_F153_Q1.3801.00
204_K208_E1.3781.00
325_Y355_A1.3701.00
197_T203_Q1.3591.00
230_D258_K1.3581.00
170_R194_V1.3511.00
183_H209_R1.3411.00
169_M191_V1.3361.00
149_E327_R1.3281.00
149_E153_Q1.3141.00
313_F365_L1.3101.00
183_H210_C1.3091.00
160_C184_Y1.2991.00
210_C213_L1.2861.00
312_N364_Q1.2791.00
291_L363_I1.2761.00
46_F61_S1.2721.00
281_I354_C1.2681.00
232_I257_L1.2541.00
186_A215_V1.2501.00
126_L339_Y1.2501.00
294_V310_W1.2410.99
45_D66_W1.2380.99
263_F370_F1.2320.99
162_K369_V1.2200.99
176_C206_A1.2190.99
284_Y346_M1.2120.99
165_L191_V1.2090.99
259_P372_R1.2050.99
172_L232_I1.2030.99
38_D70_D1.1960.99
77_S359_R1.1950.99
141_Y158_M1.1940.99
322_M359_R1.1870.99
166_K169_M1.1750.99
264_L369_V1.1470.99
318_D322_M1.1460.99
181_L233_V1.1340.99
357_A363_I1.1310.99
165_L171_V1.1280.99
181_L185_M1.1280.99
319_T322_M1.1230.99
60_E63_M1.1230.99
308_E371_S1.1230.99
325_Y352_N1.1200.99
298_A310_W1.1190.99
182_A217_I1.1190.99
125_D338_N1.1150.99
61_S66_W1.1140.99
140_A151_A1.1130.99
162_K309_D1.1120.99
170_R258_K1.1100.99
236_G266_H1.1100.99
205_M208_E1.1090.99
218_L227_D1.1010.99
168_G191_V1.1010.99
183_H187_S1.0990.99
41_V46_F1.0960.99
311_H316_D1.0920.99
46_F50_V1.0880.99
53_E57_G1.0840.99
245_N248_T1.0830.99
134_F156_L1.0780.99
197_T219_L1.0770.99
307_M370_F1.0760.99
113_W200_A1.0730.99
133_P153_Q1.0700.98
285_I346_M1.0620.98
139_C316_D1.0550.98
163_L264_L1.0530.98
228_Q259_P1.0470.98
321_L354_C1.0440.98
269_G366_W1.0430.98
173_D195_G1.0400.98
356_G360_A1.0380.98
318_D359_R1.0290.98
129_R331_A1.0250.98
107_Q112_A1.0200.98
123_G339_Y1.0140.98
48_K52_Q1.0120.98
247_D251_A1.0090.98
163_L191_V1.0010.98
307_M368_V0.9970.98
253_V265_L0.9960.98
200_A219_L0.9950.98
160_C165_L0.9870.97
326_E330_A0.9870.97
262_I369_V0.9840.97
323_A327_R0.9830.97
63_M342_R0.9790.97
115_V288_N0.9770.97
234_S249_Y0.9680.97
254_D304_H0.9670.97
160_C188_N0.9670.97
139_C236_G0.9660.97
342_R346_M0.9620.97
249_Y253_V0.9570.97
150_S153_Q0.9570.97
355_A359_R0.9560.97
182_A215_V0.9490.97
122_L127_F0.9380.97
158_M311_H0.9340.96
297_I368_V0.9300.96
295_R299_Q0.9260.96
144_D150_S0.9250.96
108_S245_N0.9240.96
232_I253_V0.9170.96
247_D302_E0.9040.96
333_P336_A0.9040.96
216_T220_Q0.9030.96
184_Y189_Y0.9010.96
185_M190_D0.8960.96
231_R262_I0.8940.95
116_G198_I0.8930.95
35_A81_R0.8900.95
268_I289_G0.8890.95
318_D355_A0.8870.95
41_V47_F0.8840.95
111_R114_I0.8840.95
310_W366_W0.8800.95
117_K200_A0.8800.95
335_I344_K0.8730.95
60_E283_K0.8730.95
203_Q219_L0.8730.95
218_L229_F0.8720.95
126_L130_M0.8660.95
228_Q258_K0.8650.95
310_W368_V0.8640.95
207_Q217_I0.8620.94
141_Y313_F0.8610.94
210_C214_D0.8600.94
55_S278_D0.8600.94
73_D355_A0.8590.94
194_V220_Q0.8530.94
156_L181_L0.8520.94
153_Q184_Y0.8520.94
227_D256_N0.8520.94
162_K264_L0.8520.94
207_Q211_E0.8510.94
73_D352_N0.8450.94
124_N135_M0.8430.94
307_M310_W0.8420.94
153_Q188_N0.8410.94
70_D74_M0.8410.94
157_K160_C0.8390.94
56_L59_G0.8390.94
250_F300_S0.8380.94
333_P337_D0.8320.93
171_V233_V0.8320.93
72_L76_F0.8290.93
156_L184_Y0.8290.93
248_T252_V0.8290.93
42_K65_G0.8280.93
328_F344_K0.8260.93
246_Y290_C0.8170.93
353_A357_A0.8140.93
218_L225_L0.8120.93
357_A362_D0.8100.92
204_K207_Q0.8080.92
332_W348_T0.8050.92
184_Y187_S0.8050.92
220_Q224_D0.8040.92
73_D325_Y0.8020.92
133_P327_R0.8010.92
249_Y263_F0.7970.92
58_L75_F0.7930.92
248_T251_A0.7930.92
78_K82_A0.7920.92
343_F347_F0.7910.92
331_A335_I0.7910.92
81_R360_A0.7890.91
159_I233_V0.7880.91
95_T98_I0.7870.91
125_D334_E0.7840.91
37_A69_C0.7810.91
176_C217_I0.7800.91
106_L244_K0.7800.91
124_N205_M0.7790.91
344_K348_T0.7770.91
40_R68_E0.7750.91
63_M284_Y0.7740.91
237_M241_V0.7730.91
97_R100_G0.7730.91
298_A307_M0.7700.90
153_Q157_K0.7680.90
156_L160_C0.7670.90
165_L189_Y0.7620.90
61_S67_W0.7590.90
297_I300_S0.7580.90
139_C266_H0.7570.90
313_F316_D0.7560.90
92_F97_R0.7540.89
60_E284_Y0.7530.89
134_F149_E0.7460.89
167_P190_D0.7440.89
69_C72_L0.7430.89
156_L235_V0.7430.89
238_F297_I0.7380.88
272_K293_S0.7370.88
236_G240_H0.7370.88
254_D303_P0.7350.88
267_T297_I0.7310.88
263_F305_F0.7300.88
121_D200_A0.7280.88
134_F209_R0.7270.88
142_W319_T0.7230.87
186_A193_V0.7220.87
196_V218_L0.7210.87
165_L169_M0.7210.87
62_Y348_T0.7180.87
170_R227_D0.7180.87
117_K201_E0.7140.87
165_L231_R0.7140.87
107_Q115_V0.7130.87
39_I58_L0.7050.86
163_L233_V0.7030.86
300_S305_F0.7010.86
268_I286_F0.7010.86
79_V83_G0.7000.86
329_L344_K0.6990.86
138_S238_F0.6960.85
61_S64_D0.6960.85
319_T359_R0.6920.85
329_L332_W0.6900.85
140_A148_L0.6880.85
249_Y265_L0.6820.84
87_Q91_H0.6820.84
312_N366_W0.6800.84
136_Q181_L0.6790.84
57_G61_S0.6770.84
243_P290_C0.6770.84
75_F79_V0.6760.84
91_H94_D0.6760.84
275_L279_P0.6760.84
128_S133_P0.6670.83
134_F187_S0.6670.83
37_A78_K0.6640.83
294_V368_V0.6640.83
73_D359_R0.6640.83
253_V257_L0.6630.82
206_A209_R0.6630.82
74_M77_S0.6630.82
132_D180_G0.6620.82
327_R330_A0.6620.82
126_L335_I0.6620.82
341_E345_R0.6590.82
33_G36_P0.6580.82
114_I117_K0.6560.82
130_M351_L0.6560.82
182_A195_G0.6560.82
257_L261_G0.6560.82
160_C171_V0.6530.82
278_D282_N0.6520.81
286_F289_G0.6520.81
337_D340_S0.6500.81
107_Q223_R0.6480.81
253_V305_F0.6460.81
279_P282_N0.6460.81
164_Q167_P0.6440.81
200_A207_Q0.6420.80
73_D356_G0.6410.80
191_V231_R0.6400.80
132_D149_E0.6320.79
254_D373_G0.6320.79
129_R344_K0.6310.79
96_L99_A0.6310.79
203_Q206_A0.6300.79
270_S353_A0.6290.79
141_Y154_A0.6270.79
168_G192_S0.6250.79
198_I219_L0.6240.79
69_C75_F0.6220.78
267_T364_Q0.6220.78
315_A359_R0.6210.78
238_F265_L0.6190.78
290_C296_Q0.6180.78
119_H137_Y0.6160.78
173_D240_H0.6160.78
107_Q245_N0.6150.78
165_L185_M0.6140.77
247_D303_P0.6140.77
46_F66_W0.6100.77
89_P94_D0.6090.77
129_R133_P0.6070.77
300_S303_P0.6060.76
173_D279_P0.6060.76
112_A223_R0.6040.76
183_H215_V0.6030.76
116_G197_T0.6020.76
125_D129_R0.6010.76
220_Q225_L0.5990.76
332_W335_I0.5990.76
268_I358_F0.5980.76
255_R258_K0.5970.75
335_I339_Y0.5950.75
294_V366_W0.5930.75
296_Q299_Q0.5930.75
94_D98_I0.5880.74
222_Y241_V0.5880.74
41_V50_V0.5880.74
346_M351_L0.5880.74
128_S209_R0.5870.74
67_W349_Y0.5870.74
121_D199_S0.5850.74
49_R64_D0.5830.74
49_R57_G0.5830.74
169_M230_D0.5810.73
170_R228_Q0.5810.73
227_D347_F0.5810.73
140_A320_T0.5800.73
297_I370_F0.5800.73
116_G121_D0.5770.73
228_Q256_N0.5760.73
158_M162_K0.5740.73
278_D283_K0.5730.72
131_L137_Y0.5720.72
173_D185_M0.5720.72
113_W117_K0.5720.72
164_Q169_M0.5710.72
107_Q288_N0.5690.72
187_S209_R0.5670.72
49_R53_E0.5670.72
350_Y358_F0.5660.72
37_A74_M0.5640.71
291_L354_C0.5620.71
113_W198_I0.5620.71
166_K231_R0.5600.71
108_S223_R0.5600.71
120_Y175_G0.5600.71
246_Y267_T0.5580.70
182_A206_A0.5570.70
89_P92_F0.5560.70
137_Y178_W0.5550.70
145_A154_A0.5550.70
56_L279_P0.5540.70
80_L83_G0.5530.70
141_Y311_H0.5510.70
171_V193_V0.5510.70
49_R60_E0.5510.70
325_Y351_L0.5500.69
160_C364_Q0.5500.69
92_F98_I0.5500.69
289_G354_C0.5500.69
322_M326_E0.5500.69
160_C231_R0.5490.69
45_D48_K0.5490.69
311_H369_V0.5470.69
286_F354_C0.5470.69
41_V44_P0.5460.69
93_K100_G0.5450.69
163_L369_V0.5450.69
169_M189_Y0.5450.69
207_Q216_T0.5440.69
300_S368_V0.5440.69
118_E346_M0.5440.69
74_M78_K0.5440.69
276_N282_N0.5430.68
160_C181_L0.5430.68
353_A363_I0.5420.68
294_V298_A0.5410.68
174_I252_V0.5410.68
350_Y354_C0.5400.68
328_F343_F0.5390.68
176_C196_V0.5370.68
126_L129_R0.5370.68
286_F350_Y0.5340.67
107_Q116_G0.5330.67
200_A249_Y0.5310.67
232_I263_F0.5300.67
95_T100_G0.5300.67
129_R338_N0.5290.66
254_D305_F0.5280.66
76_F352_N0.5280.66
54_G57_G0.5280.66
137_Y317_Y0.5270.66
161_E184_Y0.5260.66
320_T324_W0.5260.66
115_V245_N0.5260.66
88_L91_H0.5250.66
167_P188_N0.5250.66
80_L356_G0.5250.66
111_R115_V0.5250.66
113_W219_L0.5230.66
117_K283_K0.5230.66
92_F96_L0.5230.66
37_A70_D0.5230.66
149_E323_A0.5220.65
243_P296_Q0.5220.65
119_H286_F0.5210.65
158_M313_F0.5210.65
196_V256_N0.5200.65
268_I350_Y0.5200.65
139_C313_F0.5190.65
297_I312_N0.5180.65
101_A104_F0.5160.65
113_W116_G0.5160.65
186_A189_Y0.5160.65
63_M285_I0.5150.64
187_S214_D0.5140.64
205_M210_C0.5140.64
273_T295_R0.5130.64
119_H288_N0.5130.64
73_D322_M0.5120.64
43_N46_F0.5120.64
163_L231_R0.5110.64
339_Y343_F0.5110.64
238_F250_F0.5110.64
187_S213_L0.5100.64
168_G230_D0.5090.63
272_K295_R0.5090.63
207_Q219_L0.5090.63
172_L235_V0.5090.63
50_V277_V0.5080.63
270_S290_C0.5080.63
219_L249_Y0.5070.63
207_Q215_V0.5060.63
179_G206_A0.5060.63
59_G63_M0.5050.63
120_Y137_Y0.5050.63
173_D233_V0.5050.63
137_Y155_K0.5050.63
119_H268_I0.5040.63
251_A337_D0.5040.63
356_G359_R0.5030.63
340_S347_F0.5030.63
119_H358_F0.5000.62
180_G184_Y0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fk8A 1 0.6859 100 0.568 Contact Map
1kpgA 1 0.6963 100 0.574 Contact Map
3hemA 2 0.6937 100 0.594 Contact Map
3busA 1 0.6178 100 0.688 Contact Map
4ckbA 1 0.8796 100 0.708 Contact Map
4iv0A 1 0.6466 100 0.713 Contact Map
4ineA 2 0.9476 100 0.72 Contact Map
2o57A 2 0.6754 100 0.725 Contact Map
4pneA 2 0.6728 100 0.731 Contact Map
3ujcA 1 0.6335 100 0.736 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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