GREMLIN Database
BTUR - Cob(I)yrinic acid a,c-diamide adenosyltransferase
UniProt: P0A9H5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10130
Length: 196 (171)
Sequences: 2206 (1206)
Seq/√Len: 92.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_L158_I3.6691.00
179_P185_D3.6041.00
165_R169_E3.0401.00
173_T183_A2.9761.00
49_A125_L2.9101.00
148_N170_L2.9001.00
147_L156_V2.6311.00
140_L166_D2.6291.00
60_G115_M2.5991.00
106_R142_E2.3631.00
113_K142_E2.3111.00
85_Q111_H2.2551.00
155_T191_Q2.2221.00
42_T46_F2.1951.00
48_T157_I2.1791.00
45_A125_L2.1191.00
55_H72_G2.0511.00
129_L143_V2.0241.00
50_T76_L1.9731.00
53_V82_V1.9491.00
140_L164_H1.8911.00
35_T163_C1.8841.00
33_V167_I1.7901.00
111_H114_R1.7601.00
30_I183_A1.7161.00
145_Q149_E1.6951.00
49_A61_V1.6631.00
176_E180_V1.6601.00
52_A57_K1.6351.00
46_F50_T1.6241.00
31_I158_I1.6221.00
34_F44_A1.5791.00
140_L144_V1.5741.00
112_A126_L1.5671.00
45_A159_T1.5621.00
32_I155_T1.5561.00
168_L174_V1.5531.00
31_I150_R1.5451.00
83_E121_L1.5291.00
146_A156_V1.5271.00
61_V125_L1.5221.00
31_I147_L1.4971.00
133_V164_H1.4751.00
61_V82_V1.4671.00
77_L82_V1.4641.00
46_F61_V1.4180.99
50_T77_L1.4010.99
103_A107_E1.3960.99
32_I173_T1.3940.99
106_R110_Q1.3920.99
37_N179_P1.3770.99
121_L124_V1.3770.99
99_E103_A1.3740.99
49_A82_V1.3700.99
134_A162_G1.3690.99
49_A59_V1.3640.99
174_V181_K1.3260.99
74_R78_E1.3230.99
83_E115_M1.3160.99
144_V170_L1.2800.99
32_I191_Q1.2770.99
144_V148_N1.2750.99
163_C168_L1.2670.99
124_V154_Q1.2450.98
116_L146_A1.2380.98
110_Q113_K1.2180.98
87_M108_V1.2090.98
70_P75_N1.1930.98
141_E166_D1.1890.98
130_T163_C1.1850.98
30_I188_V1.1660.98
151_P154_Q1.1620.98
60_G121_L1.1360.97
57_K122_D1.0970.97
62_V112_A1.0830.96
118_D121_L1.0830.96
32_I183_A1.0760.96
53_V76_L1.0650.96
65_I131_Y1.0560.96
97_N100_S1.0490.96
62_V111_H1.0380.95
139_P142_E1.0380.95
107_E110_Q1.0250.95
117_A149_E1.0240.95
133_V138_L1.0190.95
29_G150_R0.9960.94
58_K120_S0.9950.94
102_T106_R0.9920.94
145_Q148_N0.9880.94
168_L180_V0.9710.93
31_I170_L0.9640.93
133_V143_V0.9580.93
172_D186_A0.9560.93
116_L154_Q0.9550.93
95_T98_R0.9500.93
88_A108_V0.9490.93
141_E145_Q0.9490.93
115_M121_L0.9460.92
113_K146_A0.9390.92
114_R118_D0.9350.92
33_V130_T0.9350.92
34_F48_T0.9350.92
60_G85_Q0.9230.92
122_D153_Q0.9150.91
119_S153_Q0.9140.91
110_Q114_R0.9130.91
89_T104_A0.9120.91
62_V85_Q0.9120.91
52_A122_D0.8640.89
133_V140_L0.8520.88
113_K145_Q0.8510.88
37_N162_G0.8450.87
89_T100_S0.8360.87
74_R84_F0.8320.87
87_M111_H0.8280.86
35_T161_R0.8260.86
31_I129_L0.8240.86
38_G41_K0.8220.86
155_T173_T0.8190.86
48_T195_D0.8170.86
150_R154_Q0.8130.85
123_M157_I0.8070.85
183_A188_V0.8020.85
116_L124_V0.7990.84
88_A105_C0.7980.84
43_T63_Q0.7960.84
43_T48_T0.7930.84
113_K149_E0.7910.84
163_C167_I0.7850.83
62_V108_V0.7820.83
64_F112_A0.7720.82
92_T97_N0.7630.82
36_G47_G0.7610.81
150_R156_V0.7560.81
109_W146_A0.7530.81
34_F183_A0.7450.80
62_V87_M0.7430.80
83_E114_R0.7410.80
34_F177_L0.7350.79
67_G86_V0.7350.79
58_K122_D0.7320.79
109_W113_K0.7310.79
106_R139_P0.7290.79
89_T101_D0.7150.77
38_G47_G0.7130.77
27_E189_K0.7110.77
48_T123_M0.7060.76
41_K47_G0.7050.76
111_H115_M0.7000.76
136_D164_H0.6980.75
44_A177_L0.6970.75
76_L79_P0.6940.75
36_G41_K0.6930.75
57_K155_T0.6870.74
46_F77_L0.6830.74
192_I196_Y0.6730.73
92_T137_Y0.6660.72
57_K192_I0.6660.72
113_K117_A0.6640.72
28_R152_H0.6610.71
144_V166_D0.6600.71
34_F43_T0.6580.71
115_M124_V0.6570.71
132_M138_L0.6560.71
47_G73_E0.6550.71
55_H192_I0.6550.71
138_L143_V0.6510.70
75_N78_E0.6510.70
48_T194_I0.6500.70
142_E146_A0.6500.70
34_F179_P0.6430.69
190_A196_Y0.6410.69
58_K83_E0.6400.69
109_W112_A0.6360.69
34_F191_Q0.6340.68
74_R86_V0.6310.68
95_T100_S0.6310.68
129_L133_V0.6290.68
53_V59_V0.6290.68
112_A124_V0.6260.67
121_L154_Q0.6180.66
116_L156_V0.6180.66
104_A107_E0.6150.66
61_V84_F0.6130.66
28_R188_V0.6120.66
136_D139_P0.6080.65
119_S154_Q0.6080.65
130_T195_D0.6040.65
65_I104_A0.5990.64
149_E186_A0.5980.64
83_E120_S0.5950.63
63_Q74_R0.5940.63
94_D195_D0.5920.63
171_A174_V0.5910.63
183_A191_Q0.5900.63
33_V171_A0.5890.63
52_A123_M0.5860.62
101_D105_C0.5850.62
95_T101_D0.5840.62
65_I92_T0.5810.62
32_I194_I0.5750.61
40_G47_G0.5750.61
68_T71_N0.5740.61
109_W116_L0.5740.61
130_T167_I0.5730.61
101_D104_A0.5720.60
44_A48_T0.5690.60
74_R195_D0.5650.59
29_G151_P0.5630.59
131_Y135_Y0.5630.59
97_N101_D0.5620.59
93_W97_N0.5580.59
51_R54_G0.5560.58
36_G42_T0.5550.58
51_R175_S0.5540.58
39_K155_T0.5540.58
39_K43_T0.5540.58
35_T180_V0.5520.58
36_G40_G0.5480.57
55_H195_D0.5450.57
191_Q194_I0.5430.56
163_C174_V0.5420.56
93_W96_Q0.5410.56
166_D170_L0.5390.56
101_D131_Y0.5380.56
88_A101_D0.5370.56
60_G111_H0.5360.55
139_P144_V0.5350.55
30_I150_R0.5340.55
34_F173_T0.5330.55
190_A195_D0.5310.55
99_E102_T0.5300.55
68_T192_I0.5300.55
120_S149_E0.5300.55
98_R101_D0.5290.55
168_L181_K0.5290.55
174_V180_V0.5260.54
146_A149_E0.5230.54
85_Q108_V0.5220.54
37_N178_R0.5220.54
32_I48_T0.5200.53
68_T86_V0.5200.53
90_G97_N0.5200.53
66_K128_E0.5190.53
98_R102_T0.5160.53
67_G135_Y0.5140.52
189_K196_Y0.5140.52
59_V82_V0.5130.52
90_G93_W0.5130.52
86_V108_V0.5090.52
36_G73_E0.5080.52
53_V81_G0.5040.51
151_P170_L0.5020.51
112_A115_M0.5010.51
170_L174_V0.5000.51
69_W86_V0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g5tA 2 0.801 100 0.412 Contact Map
2orvA 3 0.6531 99.9 0.631 Contact Map
2j9rA 3 0.6888 99.8 0.724 Contact Map
1w4rA 3 0.7143 99.7 0.742 Contact Map
1xx6A 4 0.7143 99.7 0.755 Contact Map
3e2iA 3 0.6786 99.7 0.756 Contact Map
2b8tA 3 0.75 99.5 0.789 Contact Map
4uxhA 3 0.699 98.9 0.834 Contact Map
2orwA 3 0.7041 98.8 0.841 Contact Map
4blqA 3 0.8214 97.1 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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