GREMLIN Database
MUG - G/U mismatch-specific DNA glycosylase
UniProt: P0A9H1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12717
Length: 168 (161)
Sequences: 894 (575)
Seq/√Len: 45.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_C104_L4.7491.00
49_R55_E4.6231.00
6_L13_V4.4161.00
28_F56_A3.5861.00
91_K95_K3.5371.00
72_R84_E3.2751.00
118_Q128_L3.0181.00
125_K134_Q2.9571.00
47_T50_Q2.9471.00
13_V96_I2.4831.00
157_R161_Q2.4341.00
96_I104_L2.4221.00
58_H61_D2.3791.00
42_Y47_T2.3551.00
43_Q150_E2.2891.00
12_V46_F2.2351.00
42_Y50_Q2.2181.00
51_L62_Y2.0540.99
148_S151_K1.9230.99
109_K123_W1.9220.99
12_V64_C1.9160.99
95_K99_Y1.8460.99
155_A158_E1.7620.98
6_L99_Y1.7580.98
71_D91_K1.7290.98
105_A138_L1.6800.98
113_E121_A1.6300.97
43_Q149_L1.6120.97
107_L138_L1.5910.97
43_Q153_V1.5120.96
76_Q79_E1.5040.95
75_V79_E1.4750.95
104_L133_T1.4650.95
22_S32_H1.4550.95
44_A156_Y1.4470.94
2_V24_A1.3980.93
47_T53_P1.3940.93
40_V152_L1.3690.93
154_E158_E1.3640.92
87_A90_R1.3360.92
38_W159_L1.3160.91
40_V153_V1.2670.89
48_D62_Y1.2610.89
50_Q53_P1.2600.89
22_S26_T1.2390.88
94_E117_S1.2330.88
93_I97_E1.2240.88
92_L104_L1.2190.87
109_K113_E1.2110.87
43_Q50_Q1.2040.87
12_V159_L1.1950.86
49_R58_H1.1800.86
55_E58_H1.1680.85
11_R102_Q1.1610.85
103_A162_A1.1430.84
76_Q144_L1.1190.82
22_S25_G1.1190.82
36_R152_L1.1100.82
17_I77_A1.1080.82
30_F140_N1.1030.81
97_E131_G1.0960.81
105_A136_W1.0740.80
36_R40_V1.0690.79
38_W51_L1.0670.79
147_V151_K1.0620.79
23_S156_Y1.0370.77
46_F64_C1.0370.77
156_Y160_D1.0340.77
57_Q60_L1.0270.77
94_E97_E1.0110.75
34_A141_P1.0100.75
30_F152_L0.9950.74
20_G24_A0.9920.74
149_L153_V0.9910.74
94_E98_D0.9900.74
109_K122_Q0.9880.74
69_L91_K0.9870.74
85_L92_L0.9760.73
73_P99_Y0.9740.73
46_F51_L0.9600.72
125_K158_E0.9570.71
30_F66_V0.9540.71
33_P48_D0.9530.71
118_Q158_E0.9520.71
4_D95_K0.9420.70
36_R143_G0.9070.67
84_E108_G0.8970.66
102_Q134_Q0.8910.66
77_A144_L0.8870.65
46_F160_D0.8810.65
87_A91_K0.8680.64
130_I133_T0.8680.64
18_N84_E0.8650.63
51_L59_L0.8560.63
18_N108_G0.8500.62
140_N145_S0.8440.62
9_G60_L0.8390.61
10_L28_F0.8360.61
23_S31_A0.8330.61
88_G92_L0.8230.60
26_T31_A0.8210.59
9_G95_K0.8170.59
102_Q161_Q0.8130.59
90_R93_I0.8110.58
28_F159_L0.8050.58
41_I44_A0.8030.58
20_G84_E0.8010.57
81_S84_E0.8000.57
91_K98_D0.7990.57
151_K154_E0.7990.57
68_K107_L0.7970.57
36_R141_P0.7860.56
20_G55_E0.7860.56
136_W162_A0.7820.56
27_G32_H0.7820.56
30_F107_L0.7670.54
56_A66_V0.7640.54
82_K86_H0.7630.54
40_V149_L0.7580.53
107_L145_S0.7540.53
15_C160_D0.7520.53
106_I115_G0.7490.52
44_A158_E0.7470.52
59_L66_V0.7410.52
89_G135_I0.7400.52
20_G23_S0.7370.51
24_A73_P0.7350.51
18_N74_T0.7350.51
139_P145_S0.7310.51
2_V68_K0.7250.50
69_L90_R0.7250.50
14_F64_C0.7240.50
2_V103_A0.7240.50
97_E132_S0.7230.50
25_G73_P0.7140.49
48_D58_H0.7090.49
47_T55_E0.7060.48
14_F105_A0.7030.48
32_H144_L0.7030.48
41_I47_T0.7030.48
26_T29_P0.6970.47
4_D9_G0.6970.47
107_L144_L0.6960.47
19_P74_T0.6930.47
93_I131_G0.6890.47
15_C96_I0.6890.47
109_K137_V0.6890.47
85_L106_I0.6820.46
6_L95_K0.6820.46
29_P68_K0.6810.46
74_T123_W0.6800.46
63_R139_P0.6780.46
69_L85_L0.6770.45
6_L9_G0.6750.45
8_P98_D0.6670.44
84_E144_L0.6670.44
21_L105_A0.6670.44
107_L140_N0.6640.44
119_R122_Q0.6610.44
56_A60_L0.6590.44
147_V152_L0.6590.44
31_A59_L0.6570.44
83_Q90_R0.6460.42
66_V106_I0.6460.42
10_L99_Y0.6420.42
7_A61_D0.6420.42
19_P72_R0.6420.42
23_S29_P0.6410.42
14_F140_N0.6400.42
74_T84_E0.6330.41
122_Q127_T0.6320.41
17_I148_S0.6310.41
68_K71_D0.6310.41
107_L141_P0.6300.41
73_P105_A0.6260.41
127_T130_I0.6250.40
17_I30_F0.6250.40
123_W155_A0.6220.40
40_V141_P0.6200.40
38_W156_Y0.6180.40
11_R122_Q0.6180.40
2_V66_V0.6170.40
68_K144_L0.6140.39
9_G99_Y0.6100.39
15_C138_L0.6070.39
28_F38_W0.6070.39
89_G115_G0.6050.39
69_L114_Q0.6040.39
125_K162_A0.6030.38
9_G53_P0.6010.38
141_P145_S0.5960.38
136_W152_L0.5960.38
12_V103_A0.5950.38
150_E157_R0.5950.38
18_N73_P0.5890.37
141_P152_L0.5870.37
23_S160_D0.5860.37
96_I133_T0.5860.37
47_T138_L0.5850.37
73_P108_G0.5830.37
77_A108_G0.5820.37
93_I130_I0.5790.36
17_I111_A0.5730.36
30_F39_K0.5690.35
20_G71_D0.5670.35
2_V150_E0.5640.35
82_K102_Q0.5620.35
154_E157_R0.5560.34
36_R145_S0.5550.34
83_Q87_A0.5530.34
8_P99_Y0.5500.34
46_F103_A0.5470.33
68_K88_G0.5450.33
112_Y121_A0.5420.33
51_L56_A0.5400.33
67_T139_P0.5390.33
102_Q125_K0.5380.33
61_D120_G0.5380.33
146_R153_V0.5370.33
126_Q137_V0.5340.32
25_G112_Y0.5340.32
54_Q94_E0.5310.32
76_Q145_S0.5260.32
27_G156_Y0.5260.32
14_F37_F0.5250.32
68_K84_E0.5250.32
23_S88_G0.5220.31
103_A134_Q0.5210.31
131_G158_E0.5160.31
6_L86_H0.5150.31
83_Q117_S0.5140.31
9_G100_Q0.5130.31
38_W103_A0.5120.30
106_I135_I0.5110.30
30_F141_P0.5100.30
106_I140_N0.5100.30
94_E99_Y0.5090.30
158_E161_Q0.5070.30
91_K127_T0.5050.30
36_R146_R0.5050.30
117_S154_E0.5010.30
24_A106_I0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l3fA 1 0.9107 100 0.397 Contact Map
2c2qA 1 0.9762 100 0.438 Contact Map
1wywA 1 1 100 0.478 Contact Map
1mugA 1 0.9821 100 0.48 Contact Map
2d3yA 1 0.9702 99.9 0.667 Contact Map
1vk2A 1 0.9226 99.8 0.689 Contact Map
1ui0A 1 0.9167 99.8 0.698 Contact Map
1oe4A 2 0.9286 98.1 0.863 Contact Map
3ikbA 1 0.9048 98.1 0.865 Contact Map
4wlpB 2 0.4405 39.5 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.007 seconds.