GREMLIN Database
MODE - Transcriptional regulator ModE
UniProt: P0A9G8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13227
Length: 262 (245)
Sequences: 388 (251)
Seq/√Len: 16.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_K90_D5.3541.00
221_M247_V4.4771.00
149_V180_I4.1631.00
145_Q167_G3.5791.00
29_A83_Q3.5150.99
125_T181_L2.7280.97
189_I247_V2.6510.96
133_G149_V2.5120.95
14_K82_G2.3930.93
90_D93_A2.3510.93
131_W182_L2.3220.92
149_V178_V2.3160.92
215_E234_P2.2670.91
96_Q99_A2.2620.91
158_L251_F2.2390.91
205_G221_M2.1960.90
162_I258_I2.1700.89
135_I162_I2.1650.89
180_I256_V2.1450.89
221_M249_A2.1070.88
135_I174_E2.0770.87
251_F256_V2.0670.87
86_I240_S2.0370.86
21_R51_A2.0330.86
213_G217_C2.0140.85
53_N66_R2.0090.85
207_I219_V1.9770.84
203_L223_L1.9760.84
125_T166_S1.9680.84
154_G203_L1.9570.84
63_L66_R1.9540.84
133_G253_A1.8750.81
27_H72_G1.8570.80
66_R186_W1.8560.80
78_L86_I1.8300.79
234_P250_Y1.7500.76
138_R174_E1.7230.75
188_G198_N1.6970.74
28_I63_L1.6410.71
198_N234_P1.6410.71
141_D247_V1.6190.70
47_S51_A1.6060.69
205_G249_A1.5910.69
151_L154_G1.5780.68
70_G73_G1.5770.68
134_T150_L1.5660.67
70_G74_G1.5560.67
138_R167_G1.5550.67
233_V239_T1.5510.67
16_F55_M1.5430.66
143_V213_G1.5400.66
50_D71_K1.5330.66
24_L127_A1.4940.64
50_D127_A1.4890.63
118_I158_L1.4830.63
139_D247_V1.4620.62
148_D157_R1.4580.62
85_L112_N1.4450.61
143_V257_I1.4440.61
210_I219_V1.4440.61
191_Q245_Q1.4320.60
57_Q254_D1.4170.59
37_G76_A1.4120.59
138_R145_Q1.3930.58
28_I223_L1.3930.58
143_V232_T1.3920.58
20_R86_I1.3910.58
71_K183_K1.3800.57
146_H200_D1.3780.57
19_P96_Q1.3740.57
216_Q239_T1.3350.55
86_I89_Y1.3270.54
18_D86_I1.3200.54
160_V180_I1.3150.54
156_T249_A1.3080.53
154_G219_V1.3080.53
131_W229_L1.2970.52
92_L111_L1.2810.52
29_A78_L1.2770.51
174_E258_I1.2720.51
51_A59_S1.2420.49
24_L89_Y1.2260.48
43_I258_I1.2160.48
160_V256_V1.2150.48
198_N215_E1.2120.48
215_E239_T1.1860.46
42_G76_A1.1810.46
131_W151_L1.1740.45
204_P248_T1.1650.45
229_L249_A1.1600.45
46_K257_I1.1570.44
188_G252_N1.1550.44
146_H215_E1.1520.44
18_D88_L1.1400.43
19_P89_Y1.1300.43
47_S125_T1.1240.42
153_D156_T1.1220.42
140_H164_A1.1210.42
49_W184_A1.1120.42
158_L173_D1.1120.42
192_D197_Q1.1060.41
91_L122_S1.1020.41
159_K212_R1.0610.39
28_I76_A1.0510.38
215_E252_N1.0500.38
141_D215_E1.0440.38
134_T177_E1.0380.38
61_H81_Y1.0370.38
214_A235_V1.0330.37
164_A167_G1.0320.37
88_L130_Q1.0250.37
189_I221_M1.0250.37
171_G178_V1.0210.37
189_I258_I1.0160.37
114_L122_S1.0150.36
157_R245_Q1.0140.36
26_K31_S1.0130.36
30_L166_S1.0090.36
194_A240_S1.0060.36
200_D252_N1.0030.36
35_S125_T0.9920.35
31_S52_I0.9900.35
142_D198_N0.9860.35
51_A64_V0.9850.35
35_S39_K0.9810.35
32_G73_G0.9810.35
209_H255_S0.9800.35
52_I164_A0.9780.34
27_H120_R0.9770.34
59_S63_L0.9740.34
39_K133_G0.9730.34
125_T229_L0.9670.34
35_S103_L0.9650.34
170_L179_L0.9620.34
26_K87_Q0.9610.34
89_Y127_A0.9610.34
97_Q153_D0.9560.33
20_R42_G0.9560.33
51_A135_I0.9530.33
241_L247_V0.9520.33
28_I43_I0.9450.33
151_L256_V0.9450.33
177_E184_A0.9410.33
174_E197_Q0.9400.33
26_K98_K0.9380.32
30_L86_I0.9360.32
54_E88_L0.9360.32
135_I164_A0.9330.32
102_V115_L0.9230.32
23_S27_H0.9210.32
123_L188_G0.9160.31
198_N213_G0.9160.31
246_N250_Y0.9020.31
96_Q130_Q0.8960.30
185_P257_I0.8940.30
28_I44_S0.8860.30
138_R182_L0.8810.30
182_L186_W0.8730.29
35_S76_A0.8680.29
39_K71_K0.8670.29
234_P254_D0.8660.29
196_A253_A0.8630.29
117_A167_G0.8550.28
139_D146_H0.8470.28
220_L230_C0.8430.28
202_Q250_Y0.8410.28
35_S259_A0.8370.27
199_A228_T0.8330.27
36_Q39_K0.8320.27
189_I207_I0.8310.27
48_A79_T0.8310.27
142_D215_E0.8280.27
127_A231_A0.8230.27
214_A243_Q0.8210.27
56_N127_A0.8060.26
89_Y169_R0.8020.26
76_A99_A0.7960.26
27_H249_A0.7900.25
18_D89_Y0.7870.25
72_G76_A0.7870.25
137_A159_K0.7870.25
120_R130_Q0.7870.25
214_A224_P0.7850.25
51_A58_L0.7850.25
43_I120_R0.7820.25
161_A187_V0.7790.25
171_G242_Q0.7770.25
67_A248_T0.7750.25
35_S114_L0.7730.25
29_A235_V0.7710.25
131_W225_D0.7680.24
60_E63_L0.7670.24
154_G158_L0.7640.24
100_F186_W0.7610.24
35_S51_A0.7600.24
115_L251_F0.7580.24
99_A103_L0.7550.24
37_G251_F0.7520.24
120_R210_I0.7490.24
55_M81_Y0.7480.24
23_S42_G0.7470.24
33_S75_G0.7450.23
163_T183_K0.7430.23
55_M66_R0.7400.23
128_R166_S0.7370.23
128_R163_T0.7350.23
76_A259_A0.7330.23
192_D248_T0.7330.23
24_L50_D0.7310.23
36_Q139_D0.7280.23
96_Q186_W0.7280.23
43_I212_R0.7260.23
62_I162_I0.7250.23
146_H260_T0.7250.23
55_M79_T0.7240.23
41_A113_S0.7230.23
75_G130_Q0.7230.23
151_L203_L0.7190.22
20_R90_D0.7120.22
37_G49_W0.7110.22
29_A191_Q0.7100.22
239_T258_I0.7020.22
109_L158_L0.7000.22
91_L176_K0.6980.22
39_K257_I0.6960.21
156_T253_A0.6940.21
77_V139_D0.6900.21
111_L170_L0.6890.21
24_L56_N0.6890.21
28_I59_S0.6870.21
188_G199_A0.6870.21
91_L97_Q0.6860.21
28_I90_D0.6850.21
71_K127_A0.6840.21
52_I125_T0.6830.21
189_I231_A0.6800.21
241_L250_Y0.6790.21
97_Q101_D0.6780.21
55_M121_F0.6760.21
32_G70_G0.6750.21
122_S135_I0.6680.20
41_A123_L0.6670.20
103_L259_A0.6640.20
53_N168_A0.6640.20
42_G226_G0.6620.20
136_T245_Q0.6570.20
62_I221_M0.6540.20
41_A96_Q0.6530.20
33_S45_Y0.6520.20
228_T238_A0.6510.20
135_I229_L0.6510.20
19_P169_R0.6480.20
89_Y96_Q0.6480.20
141_D144_Q0.6470.20
61_H231_A0.6440.20
83_Q242_Q0.6440.20
50_D166_S0.6430.19
59_S149_V0.6410.19
17_A76_A0.6400.19
163_T166_S0.6390.19
123_L252_N0.6380.19
171_G192_D0.6370.19
63_L147_V0.6370.19
224_P246_N0.6350.19
161_A185_P0.6310.19
76_A125_T0.6270.19
17_A96_Q0.6230.19
143_V146_H0.6230.19
198_N233_V0.6200.19
158_L260_T0.6170.19
139_D168_A0.6160.19
28_I82_G0.6160.19
153_D189_I0.6120.18
29_A158_L0.6110.18
202_Q225_D0.6110.18
143_V253_A0.6110.18
96_Q185_P0.6080.18
44_S122_S0.6080.18
207_I221_M0.6070.18
232_T244_G0.6060.18
64_V213_G0.6060.18
147_V256_V0.6050.18
224_P258_I0.6050.18
127_A133_G0.6040.18
245_Q248_T0.6030.18
76_A81_Y0.6030.18
171_G244_G0.6010.18
135_I192_D0.6000.18
28_I134_T0.6000.18
205_G256_V0.5990.18
68_T118_I0.5990.18
158_L210_I0.5980.18
103_L152_A0.5980.18
52_I228_T0.5970.18
168_A193_E0.5970.18
148_D198_N0.5970.18
141_D198_N0.5960.18
150_L171_G0.5930.18
72_G125_T0.5900.18
205_G233_V0.5880.18
190_T250_Y0.5880.18
93_A233_V0.5870.18
68_T213_G0.5850.17
199_A234_P0.5830.17
19_P232_T0.5830.17
137_A202_Q0.5830.17
169_R230_C0.5830.17
164_A254_D0.5820.17
147_V228_T0.5780.17
93_A212_R0.5780.17
188_G197_Q0.5770.17
215_E250_Y0.5760.17
17_A152_A0.5750.17
120_R259_A0.5750.17
77_V168_A0.5730.17
53_N57_Q0.5720.17
199_A244_G0.5720.17
18_D149_V0.5700.17
138_R147_V0.5700.17
124_Q169_R0.5660.17
131_W245_Q0.5660.17
69_G128_R0.5640.17
59_S130_Q0.5630.17
85_L247_V0.5610.17
41_A230_C0.5610.17
159_K194_A0.5590.17
60_E150_L0.5590.17
116_A170_L0.5570.17
182_L251_F0.5570.17
212_R235_V0.5560.16
78_L216_Q0.5560.16
206_I214_A0.5550.16
160_V181_L0.5550.16
71_K105_D0.5550.16
42_G259_A0.5530.16
127_A185_P0.5500.16
66_R104_S0.5480.16
27_H217_C0.5470.16
87_Q196_A0.5470.16
187_V257_I0.5460.16
17_A41_A0.5430.16
217_C235_V0.5420.16
200_D215_E0.5410.16
99_A259_A0.5390.16
120_R151_L0.5390.16
37_G118_I0.5370.16
96_Q100_F0.5370.16
31_S82_G0.5360.16
63_L133_G0.5350.16
121_F179_L0.5350.16
126_S172_L0.5290.16
90_D95_I0.5230.15
142_D187_V0.5200.15
92_L160_V0.5190.15
35_S82_G0.5180.15
60_E85_L0.5170.15
80_R250_Y0.5140.15
135_I138_R0.5110.15
253_A257_I0.5100.15
35_S91_L0.5090.15
78_L201_N0.5080.15
104_S205_G0.5070.15
174_E224_P0.5050.15
234_P252_N0.5040.15
145_Q164_A0.5030.15
83_Q158_L0.5010.15
97_Q112_N0.5010.15
147_V189_I0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b9mA 2 0.9771 100 0.619 Contact Map
2ijlA 2 0.4198 99.6 0.823 Contact Map
1fr3A 5 0.2557 99.6 0.823 Contact Map
1gutA 5 0.2557 99.6 0.827 Contact Map
1h9mA 3 0.5267 99.3 0.858 Contact Map
4x6gA 4 0.9084 98.7 0.886 Contact Map
1uthA 2 0.6298 98.6 0.89 Contact Map
3szpA 3 0.874 98.6 0.89 Contact Map
2h98A 2 0.5534 98.6 0.891 Contact Map
3fzvA 4 0.8626 98.5 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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