GREMLIN Database
ACEA - Isocitrate lyase
UniProt: P0A9G6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10022
Length: 434 (415)
Sequences: 725 (168)
Seq/√Len: 8.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
329_D332_T5.7511.00
52_K149_D5.7361.00
373_E380_E5.1611.00
60_E86_E4.9160.99
81_A152_L4.8020.99
306_H311_G4.4230.99
276_G305_I4.0590.98
26_P214_V3.7850.97
78_L127_T3.7660.96
129_R151_F3.7100.96
272_A288_C3.3830.93
208_E212_K3.3290.93
357_S361_N3.0010.88
192_V212_K2.9820.88
138_A401_Q2.9180.87
192_V208_E2.9150.87
55_R59_G2.6750.81
117_V175_M2.6530.81
14_E17_Q2.6140.80
135_Q148_V2.6140.80
101_L115_N2.5590.78
101_L114_A2.4370.75
395_T402_E2.3930.73
373_E376_K2.3690.73
306_H312_K2.3630.72
90_L120_V2.3470.72
214_V414_I2.2630.69
277_L305_I2.2570.69
48_L149_D2.2450.68
329_D343_M2.2440.68
82_K402_E2.2410.68
192_V211_Q2.2040.67
22_G312_K2.1920.66
376_K379_V2.1830.66
405_T431_E2.1770.66
258_T264_R2.1740.66
58_H313_L2.1600.65
168_A204_V2.1290.64
198_M431_E2.0980.63
209_A212_K2.0940.63
236_D272_A2.0550.61
394_Y397_V2.0490.61
332_T343_M2.0490.61
56_L152_L2.0050.59
265_T271_Q1.9780.58
158_A172_M1.9740.58
208_E211_Q1.9650.57
165_V211_Q1.9450.57
165_V192_V1.9420.56
292_T327_N1.9150.55
350_I379_V1.9110.55
267_A271_Q1.9060.55
169_F411_V1.9000.55
47_Q51_A1.8980.55
117_V120_V1.8960.55
236_D297_L1.8870.54
15_W20_W1.8630.53
367_N371_Q1.8520.53
420_S423_T1.8490.53
426_T431_E1.8490.53
370_A379_V1.8300.52
204_V212_K1.8300.52
169_F173_K1.7940.50
42_E47_Q1.7870.50
355_I396_F1.7590.49
378_Y394_Y1.7380.48
270_E300_R1.7370.48
78_L105_M1.7330.48
12_Q16_T1.7320.48
379_V384_Q1.7160.47
367_N392_D1.7100.47
135_Q146_R1.6760.45
296_E300_R1.6680.45
165_V208_E1.6680.45
68_S362_M1.6520.44
69_L362_M1.6520.44
338_Q342_D1.6510.44
237_A265_T1.6470.44
210_I248_Y1.6390.44
325_Q330_D1.6180.43
339_Q342_D1.5850.42
335_S339_Q1.5740.41
192_V402_E1.5610.41
22_G311_G1.5520.40
169_F223_T1.5500.40
82_K395_T1.5260.39
209_A271_Q1.5260.39
236_D288_C1.5090.39
209_A214_V1.5040.39
373_E385_P1.4840.38
82_K150_Y1.4830.38
57_L313_L1.4680.37
214_V415_I1.4470.36
117_V171_L1.4370.36
101_L119_A1.4290.36
172_M183_V1.4270.36
165_V212_K1.4250.35
237_A267_A1.4220.35
52_K150_Y1.4050.35
72_L99_A1.3890.34
99_A120_V1.3880.34
39_V151_F1.3830.34
168_A212_K1.3730.33
332_T335_S1.3680.33
56_L60_E1.3630.33
173_K223_T1.3360.32
177_E417_G1.3220.32
209_A288_C1.3130.31
360_F402_E1.3030.31
165_V412_T1.3000.31
23_I309_Y1.3000.31
23_I311_G1.2770.30
122_E177_E1.2710.30
149_D152_L1.2670.30
248_Y274_S1.2600.29
126_N168_A1.2550.29
38_S129_R1.2530.29
135_Q147_Y1.2470.29
22_G306_H1.2450.29
80_Q120_V1.2450.29
192_V412_T1.2210.28
198_M405_T1.2200.28
43_C223_T1.2190.28
406_G425_L1.2170.28
31_D414_I1.2140.28
239_D265_T1.2140.28
80_Q105_M1.2060.28
133_Q177_E1.2050.28
241_I265_T1.2040.28
299_R303_Q1.1960.27
209_A272_A1.1960.27
172_M185_F1.1950.27
364_D385_P1.1950.27
65_Y374_G1.1920.27
46_A227_T1.1900.27
50_A299_R1.1860.27
9_E12_Q1.1840.27
247_P250_S1.1840.27
177_E413_T1.1750.27
11_L33_V1.1700.26
29_A33_V1.1640.26
223_T228_L1.1620.26
368_A373_E1.1580.26
17_Q20_W1.1580.26
410_K413_T1.1570.26
82_K148_V1.1420.26
136_W270_E1.1350.25
121_V180_A1.1290.25
308_K311_G1.1270.25
23_I269_I1.1270.25
135_Q150_Y1.1260.25
15_W18_P1.1220.25
412_T420_S1.1180.25
395_T401_Q1.1160.25
412_T416_Q1.1160.25
169_F222_V1.1150.25
256_E264_R1.1130.25
367_N370_A1.1110.25
65_Y304_A1.1070.24
50_A227_T1.1000.24
105_M127_T1.0980.24
101_L120_V1.0950.24
248_Y288_C1.0840.24
253_I257_R1.0750.23
288_C350_I1.0710.23
398_S401_Q1.0690.23
405_T422_V1.0670.23
117_V121_V1.0670.23
41_P418_G1.0660.23
212_K402_E1.0650.23
204_V208_E1.0630.23
150_Y397_V1.0630.23
204_V209_A1.0610.23
121_V175_M1.0590.23
413_T416_Q1.0570.23
212_K422_V1.0570.23
330_D341_S1.0560.23
206_T279_Y1.0550.23
359_W396_F1.0550.23
208_E402_E1.0500.23
115_N119_A1.0500.23
360_F385_P1.0370.22
236_D432_S1.0350.22
168_A327_N1.0340.22
425_L431_E1.0240.22
212_K412_T1.0190.22
208_E416_Q1.0150.22
209_A297_L1.0130.22
8_I12_Q1.0090.22
105_M223_T1.0060.21
82_K192_V1.0040.21
385_P397_V1.0040.21
278_A366_A1.0020.21
427_G432_S0.9990.21
26_P414_I0.9960.21
102_A174_A0.9960.21
285_L313_L0.9960.21
239_D264_R0.9950.21
288_C297_L0.9940.21
192_V204_V0.9920.21
418_G421_S0.9880.21
7_Q36_R0.9880.21
47_Q226_P0.9790.21
427_G431_E0.9750.21
263_F335_S0.9750.21
150_Y248_Y0.9730.21
12_Q30_E0.9730.21
52_K152_L0.9690.20
276_G350_I0.9680.20
38_S291_S0.9680.20
355_I361_N0.9680.20
55_R308_K0.9670.20
46_A50_A0.9630.20
210_I247_P0.9620.20
133_Q222_V0.9610.20
182_A395_T0.9600.20
360_F377_H0.9570.20
239_D267_A0.9530.20
229_L423_T0.9500.20
364_D392_D0.9480.20
40_N224_G0.9380.20
272_A297_L0.9370.20
90_L114_A0.9320.19
41_P417_G0.9320.19
42_E427_G0.9250.19
80_Q230_V0.9250.19
23_I306_H0.9250.19
211_Q422_V0.9230.19
68_S358_M0.9230.19
308_K342_D0.9190.19
413_T417_G0.9160.19
208_E398_S0.9150.19
307_A342_D0.9120.19
253_I258_T0.9120.19
209_A417_G0.9100.19
236_D291_S0.9060.19
300_R303_Q0.9050.19
236_D379_V0.9040.19
350_I360_F0.9040.19
36_R136_W0.9040.19
295_L329_D0.9010.19
303_Q343_M0.8970.19
412_T422_V0.8970.19
327_N361_N0.8950.19
122_E245_C0.8940.18
126_N129_R0.8940.18
117_V158_A0.8890.18
347_F359_W0.8880.18
34_K137_S0.8860.18
117_V180_A0.8820.18
177_E223_T0.8820.18
168_A215_A0.8780.18
77_A83_A0.8690.18
292_T398_S0.8690.18
11_L15_W0.8660.18
28_S31_D0.8540.17
414_I417_G0.8530.17
82_K401_Q0.8530.17
177_E291_S0.8510.17
120_V210_I0.8510.17
39_V48_L0.8410.17
228_L342_D0.8370.17
237_A271_Q0.8360.17
20_W212_K0.8330.17
355_I403_V0.8320.17
41_P185_F0.8310.17
120_V330_D0.8310.17
39_V47_Q0.8280.17
211_Q402_E0.8250.17
99_A169_F0.8240.17
211_Q412_T0.8240.17
115_N204_V0.8190.17
223_T417_G0.8190.17
286_V304_A0.8190.17
355_I359_W0.8180.17
172_M175_M0.8150.17
99_A114_A0.8150.17
57_L374_G0.8140.17
64_G342_D0.8120.17
129_R204_V0.8100.16
81_A149_D0.8080.16
413_T418_G0.8070.16
39_V45_L0.8050.16
126_N212_K0.8030.16
181_A343_M0.7980.16
52_K81_A0.7950.16
273_I304_A0.7890.16
325_Q384_Q0.7860.16
128_F286_V0.7860.16
40_N43_C0.7850.16
224_G371_Q0.7840.16
158_A168_A0.7810.16
334_A338_Q0.7810.16
17_Q350_I0.7790.16
41_P379_V0.7780.16
52_K147_Y0.7770.16
376_K432_S0.7730.16
423_T426_T0.7730.16
277_L304_A0.7730.16
14_E228_L0.7730.16
360_F395_T0.7710.16
82_K208_E0.7700.16
236_D271_Q0.7650.15
39_V129_R0.7630.15
128_F151_F0.7610.15
75_G361_N0.7610.15
181_A198_M0.7600.15
241_I325_Q0.7590.15
67_N341_S0.7530.15
192_V401_Q0.7500.15
206_T271_Q0.7480.15
168_A410_K0.7470.15
236_D413_T0.7460.15
80_Q337_Q0.7460.15
265_T427_G0.7420.15
296_E303_Q0.7410.15
120_V135_Q0.7380.15
122_E126_N0.7370.15
73_T120_V0.7360.15
328_L333_I0.7310.15
250_S263_F0.7300.15
97_A294_D0.7300.15
206_T265_T0.7270.15
198_M426_T0.7260.15
412_T423_T0.7250.15
210_I250_S0.7250.15
210_I398_S0.7240.15
105_M135_Q0.7240.15
209_A305_I0.7230.15
357_S362_M0.7230.15
37_G355_I0.7220.15
109_Q262_F0.7190.14
15_W33_V0.7180.14
267_A270_E0.7170.14
367_N385_P0.7160.14
75_G103_A0.7150.14
173_K384_Q0.7140.14
18_P21_E0.7130.14
237_A296_E0.7130.14
51_A190_A0.7110.14
212_K379_V0.7100.14
6_Q11_L0.7090.14
254_T257_R0.7080.14
241_I414_I0.7060.14
169_F403_V0.7050.14
236_D305_I0.7040.14
38_S56_L0.7020.14
7_Q10_E0.7010.14
29_A152_L0.7000.14
126_N204_V0.6980.14
152_L385_P0.6970.14
211_Q368_A0.6940.14
208_E412_T0.6930.14
120_V172_M0.6910.14
64_G341_S0.6910.14
117_V283_A0.6900.14
126_N236_D0.6890.14
150_Y241_I0.6870.14
45_L49_G0.6870.14
192_V398_S0.6860.14
105_M417_G0.6840.14
17_Q33_V0.6820.14
207_Q265_T0.6810.14
339_Q343_M0.6810.14
185_F209_A0.6800.14
192_V422_V0.6790.14
231_A340_L0.6790.14
251_E304_A0.6790.14
121_V168_A0.6790.14
303_Q307_A0.6770.14
31_D364_D0.6770.14
25_R221_D0.6760.14
198_M291_S0.6750.14
51_A226_P0.6740.14
177_E416_Q0.6740.14
380_E388_A0.6720.14
17_Q29_A0.6710.14
359_W401_Q0.6710.14
67_N338_Q0.6690.13
296_E342_D0.6680.13
18_P29_A0.6680.13
90_L230_V0.6680.13
98_D403_V0.6660.13
52_K122_E0.6660.13
198_M259_S0.6650.13
224_G432_S0.6650.13
68_S406_G0.6640.13
115_N198_M0.6640.13
325_Q333_I0.6640.13
129_R350_I0.6640.13
41_P209_A0.6620.13
69_L355_I0.6610.13
253_I264_R0.6600.13
308_K371_Q0.6590.13
416_Q423_T0.6590.13
18_P294_D0.6580.13
129_R230_V0.6580.13
160_A176_I0.6570.13
224_G380_E0.6560.13
226_P286_V0.6560.13
360_F364_D0.6520.13
361_N394_Y0.6520.13
23_I312_K0.6520.13
75_G355_I0.6520.13
135_Q286_V0.6510.13
247_P361_N0.6500.13
21_E229_L0.6500.13
270_E304_A0.6500.13
351_T409_D0.6500.13
171_L175_M0.6490.13
402_E412_T0.6480.13
26_P413_T0.6480.13
236_D345_Y0.6470.13
65_Y341_S0.6460.13
209_A276_G0.6450.13
80_Q377_H0.6450.13
133_Q347_F0.6450.13
288_C417_G0.6440.13
120_V175_M0.6430.13
67_N368_A0.6420.13
236_D263_F0.6420.13
331_K342_D0.6410.13
303_Q339_Q0.6410.13
313_L423_T0.6400.13
376_K385_P0.6400.13
335_S341_S0.6400.13
291_S297_L0.6390.13
267_A272_A0.6380.13
114_A172_M0.6350.13
33_V136_W0.6330.13
152_L182_A0.6320.13
20_W126_N0.6310.13
241_I253_I0.6300.13
26_P416_Q0.6290.13
248_Y286_V0.6270.13
39_V263_F0.6260.13
251_E278_A0.6260.13
117_V265_T0.6250.13
410_K414_I0.6230.13
115_N192_V0.6230.13
229_L266_H0.6230.13
126_N177_E0.6220.13
50_A117_V0.6210.13
68_S377_H0.6200.13
36_R394_Y0.6170.13
378_Y397_V0.6170.13
127_T359_W0.6160.12
236_D266_H0.6150.12
341_S350_I0.6150.12
10_E13_K0.6140.12
68_S340_L0.6140.12
185_F288_C0.6130.12
380_E385_P0.6120.12
333_I337_Q0.6120.12
207_Q285_L0.6110.12
237_A350_I0.6100.12
137_S410_K0.6080.12
177_E418_G0.6080.12
358_M396_F0.6080.12
208_E214_V0.6070.12
32_V218_L0.6060.12
104_S208_E0.6060.12
209_A380_E0.6050.12
253_I263_F0.6050.12
100_N105_M0.6050.12
135_Q151_F0.6040.12
169_F219_A0.6030.12
40_N210_I0.6020.12
305_I309_Y0.6010.12
64_G380_E0.6000.12
297_L374_G0.5990.12
114_A119_A0.5980.12
237_A427_G0.5980.12
235_A276_G0.5970.12
272_A306_H0.5960.12
296_E427_G0.5960.12
182_A285_L0.5960.12
80_Q367_N0.5950.12
57_L285_L0.5920.12
236_D267_A0.5920.12
333_I368_A0.5910.12
52_K274_S0.5910.12
368_A377_H0.5890.12
192_V416_Q0.5890.12
374_G379_V0.5880.12
69_L361_N0.5870.12
43_C313_L0.5860.12
209_A236_D0.5860.12
222_V230_V0.5860.12
204_V211_Q0.5850.12
347_F351_T0.5850.12
350_I374_G0.5850.12
207_Q267_A0.5840.12
271_Q274_S0.5840.12
41_P367_N0.5830.12
90_L357_S0.5830.12
364_D373_E0.5820.12
13_K16_T0.5820.12
165_V431_E0.5820.12
151_F420_S0.5820.12
350_I376_K0.5810.12
190_A402_E0.5810.12
337_Q377_H0.5780.12
80_Q376_K0.5770.12
75_G401_Q0.5760.12
36_R370_A0.5740.12
81_A88_V0.5740.12
11_L29_A0.5740.12
361_N416_Q0.5710.12
31_D241_I0.5700.12
294_D350_I0.5700.12
237_A379_V0.5690.12
114_A174_A0.5680.12
385_P394_Y0.5680.12
106_Y110_S0.5660.12
266_H278_A0.5660.12
303_Q342_D0.5650.12
56_L86_E0.5650.12
212_K401_Q0.5650.12
352_L399_H0.5630.12
28_S40_N0.5630.12
208_E413_T0.5610.12
72_L120_V0.5600.12
16_T26_P0.5580.11
333_I377_H0.5580.11
15_W29_A0.5580.11
208_E360_F0.5580.11
26_P212_K0.5560.11
214_V413_T0.5550.11
115_N155_V0.5540.11
321_S324_W0.5540.11
329_D339_Q0.5540.11
75_G359_W0.5530.11
355_I358_M0.5520.11
55_R335_S0.5520.11
68_S357_S0.5520.11
138_A208_E0.5520.11
23_I228_L0.5520.11
288_C415_I0.5510.11
15_W21_E0.5510.11
65_Y230_V0.5490.11
80_Q271_Q0.5490.11
71_A115_N0.5490.11
64_G229_L0.5490.11
264_R338_Q0.5480.11
36_R190_A0.5480.11
248_Y265_T0.5470.11
329_D335_S0.5460.11
335_S338_Q0.5460.11
47_Q350_I0.5450.11
291_S432_S0.5450.11
31_D361_N0.5450.11
136_W355_I0.5430.11
67_N374_G0.5430.11
259_S297_L0.5430.11
40_N145_P0.5410.11
59_G367_N0.5390.11
237_A251_E0.5370.11
20_W379_V0.5360.11
11_L18_P0.5360.11
129_R341_S0.5360.11
110_S176_I0.5350.11
31_D325_Q0.5340.11
364_D368_A0.5340.11
316_Y320_P0.5340.11
119_A122_E0.5320.11
376_K380_E0.5320.11
286_V350_I0.5310.11
151_F423_T0.5300.11
316_Y321_S0.5290.11
90_L109_Q0.5290.11
297_L416_Q0.5280.11
271_Q288_C0.5280.11
296_E331_K0.5270.11
371_Q392_D0.5270.11
150_Y178_A0.5270.11
173_K405_T0.5270.11
251_E274_S0.5260.11
215_A325_Q0.5260.11
26_P209_A0.5260.11
185_F272_A0.5250.11
41_P416_Q0.5250.11
360_F423_T0.5250.11
230_V367_N0.5250.11
37_G136_W0.5240.11
396_F403_V0.5240.11
7_Q136_W0.5240.11
55_R342_D0.5240.11
85_I359_W0.5230.11
411_V427_G0.5230.11
303_Q338_Q0.5220.11
224_G299_R0.5210.11
240_L369_Y0.5200.11
96_A110_S0.5190.11
168_A185_F0.5170.11
69_L75_G0.5170.11
175_M332_T0.5170.11
385_P417_G0.5170.11
135_Q237_A0.5160.11
23_I46_A0.5150.11
396_F401_Q0.5130.11
119_A175_M0.5120.11
40_N367_N0.5110.11
12_Q29_A0.5110.11
371_Q412_T0.5100.11
105_M414_I0.5100.11
64_G373_E0.5090.11
104_S137_S0.5080.11
117_V229_L0.5080.11
210_I364_D0.5070.11
41_P177_E0.5070.11
211_Q360_F0.5070.11
185_F227_T0.5070.11
82_K297_L0.5060.11
64_G300_R0.5060.11
215_A357_S0.5050.11
295_L371_Q0.5030.11
208_E368_A0.5030.11
292_T395_T0.5030.11
247_P286_V0.5030.11
64_G228_L0.5020.11
236_D423_T0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dquA 4 0.9355 100 0.274 Contact Map
3lg3A 4 0.9631 100 0.346 Contact Map
3i4eA 4 0.947 100 0.352 Contact Map
3eolA 4 0.8341 100 0.362 Contact Map
1f8mA 4 0.977 100 0.366 Contact Map
3lyeA 4 0.6429 100 0.783 Contact Map
1xg4A 4 0.6567 100 0.789 Contact Map
1zlpA 4 0.6429 100 0.79 Contact Map
3eooA 4 0.6659 100 0.79 Contact Map
3fa4A 5 0.6728 100 0.796 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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