GREMLIN Database
CUER - HTH-type transcriptional regulator CueR
UniProt: P0A9G4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13256
Length: 135 (114)
Sequences: 12741 (8869)
Seq/√Len: 830.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_E102_R3.7281.00
40_T43_H3.3711.00
88_V106_L2.9521.00
95_I99_Q2.7971.00
19_F23_K2.7491.00
85_L109_A2.6561.00
15_K22_E2.4631.00
87_K90_E1.9441.00
32_S38_T1.9141.00
14_S18_R1.8281.00
6_V44_L1.8221.00
4_S8_K1.7771.00
2_N38_T1.7541.00
23_K64_G1.7131.00
88_V92_E1.6901.00
81_K85_L1.6871.00
54_R60_L1.6861.00
102_R106_L1.6761.00
59_N62_E1.6181.00
6_V47_L1.6041.00
88_V102_R1.6031.00
51_R54_R1.5801.00
46_E71_N1.5761.00
94_H97_E1.5611.00
92_E106_L1.5511.00
93_R97_E1.5271.00
99_Q102_R1.5071.00
46_E67_V1.4531.00
81_K113_P1.4501.00
90_E94_H1.4481.00
85_L113_P1.4361.00
95_I98_L1.4011.00
84_T109_A1.3871.00
25_L50_L1.3361.00
2_N5_D1.2961.00
88_V109_A1.2701.00
5_D8_K1.2701.00
92_E95_I1.2691.00
9_I44_L1.2501.00
3_I18_R1.2461.00
62_E87_K1.2191.00
30_M40_T1.2111.00
96_E99_Q1.1971.00
79_D82_R1.1731.00
91_I95_I1.1601.00
13_T16_A1.1541.00
96_E100_S1.1451.00
10_T47_L1.1371.00
6_V43_H1.1231.00
94_H98_L1.1121.00
20_Y47_L1.1111.00
51_R55_Q1.0911.00
95_I102_R1.0781.00
64_G68_N1.0471.00
98_L102_R1.0411.00
50_L63_S1.0291.00
5_D9_I1.0211.00
107_A111_A1.0171.00
7_A14_S1.0081.00
92_E96_E0.9951.00
62_E65_E0.9771.00
21_E27_T0.9731.00
21_E39_Y0.9651.00
57_G94_H0.9421.00
41_Q45_N0.9351.00
4_S14_S0.9301.00
55_Q97_E0.9271.00
17_I47_L0.9261.00
23_K61_E0.9251.00
89_A93_R0.9141.00
93_R96_E0.9031.00
85_L89_A0.9011.00
2_N36_Y0.9001.00
17_I39_Y0.9001.00
61_E64_G0.8921.00
19_F60_L0.8741.00
82_R86_E0.8681.00
89_A92_E0.8441.00
10_T44_L0.8431.00
29_P39_Y0.8421.00
12_L51_R0.8301.00
26_V43_H0.8191.00
87_K94_H0.8181.00
44_L48_T0.8181.00
30_M38_T0.8171.00
26_V50_L0.8161.00
97_E100_S0.8021.00
9_I48_T0.7891.00
9_I41_Q0.7851.00
16_A19_F0.7851.00
10_T17_I0.7791.00
91_I98_L0.7771.00
90_E93_R0.7701.00
86_E89_A0.7531.00
32_S36_Y0.7511.00
58_F66_L0.7441.00
99_Q103_D0.7421.00
12_L47_L0.7401.00
7_A17_I0.7361.00
111_A114_G0.7311.00
31_R37_R0.7271.00
72_D75_R0.7251.00
30_M43_H0.7251.00
34_N38_T0.7231.00
85_L88_V0.7211.00
100_S103_D0.7161.00
29_P43_H0.7111.00
83_R86_E0.7071.00
56_V101_M0.7031.00
49_L53_A0.7011.00
21_E26_V0.6971.00
42_Q45_N0.6901.00
82_R85_L0.6841.00
47_L54_R0.6811.00
13_T19_F0.6781.00
3_I7_A0.6751.00
111_A115_D0.6751.00
76_H79_D0.6691.00
81_K109_A0.6671.00
78_A82_R0.6671.00
62_E86_E0.6551.00
21_E29_P0.6511.00
19_F22_E0.6461.00
31_R34_N0.6421.00
107_A110_N0.6391.00
101_M104_Q0.6341.00
48_T51_R0.6261.00
12_L16_A0.6241.00
94_H101_M0.6171.00
10_T20_Y0.6111.00
43_H46_E0.6101.00
83_R87_K0.6061.00
45_N48_T0.6041.00
110_N113_P0.6041.00
91_I101_M0.6021.00
80_V83_R0.6001.00
86_E90_E0.6001.00
65_E68_N0.5991.00
24_G27_T0.5921.00
91_I105_L0.5901.00
97_E101_M0.5871.00
54_R63_S0.5861.00
91_I102_R0.5861.00
84_T105_L0.5861.00
76_H80_V0.5811.00
100_S104_Q0.5801.00
4_S36_Y0.5801.00
46_E68_N0.5781.00
103_D107_A0.5741.00
52_Q97_E0.5721.00
10_T51_R0.5721.00
32_S35_G0.5681.00
53_A58_F0.5621.00
33_E38_T0.5601.00
10_T14_S0.5591.00
109_A113_P0.5591.00
17_I21_E0.5491.00
70_F73_P0.5421.00
2_N14_S0.5381.00
48_T52_Q0.5341.00
6_V10_T0.5311.00
92_E99_Q0.5281.00
6_V26_V0.5261.00
78_A81_K0.5151.00
88_V91_I0.5121.00
69_L73_P0.5101.00
60_L63_S0.5101.00
21_E31_R0.5091.00
42_Q46_E0.5061.00
88_V95_I0.5031.00
110_N114_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q06A 2 0.9407 100 0.165 Contact Map
2dg6A 2 0.9333 100 0.214 Contact Map
3gp4A 4 0.9704 100 0.22 Contact Map
3gpvA 2 0.8519 100 0.223 Contact Map
3hh0A 4 0.9704 100 0.227 Contact Map
2zhgA 2 0.8815 100 0.236 Contact Map
4ua1A 2 0.9185 99.9 0.241 Contact Map
3qaoA 2 0.9556 99.9 0.27 Contact Map
1r8dA 2 0.7926 99.9 0.295 Contact Map
2vz4A 2 0.7333 99.9 0.298 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0066 seconds.