NHAR - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

NHAR - Transcriptional activator protein NhaR

UniProt:	P0A9G2	Sequences: MSMSHINYNHLYYFWHVYKEGSVVGAAEALYLTPQTITGQIRALEERLQGKLFKRKGRGLEPSELGELVYRYADKMFTLSQEMLDIVNYRKESNLLFDVGVADALSKRLVSSVLNAAVVEGEPIHLRCFESTHEMLLEQLSQHKLDMIISDCPIDSTQQEGLFSVRIGECGVSFWCTNPPPEKPFPACLEERRLLIPGRRSMLGRKLLNWFNSQGLNVEILGEFDDAALMKAFGAMHNAIFVAPTLYAYDFYADKTVVEIGRVENVMEEYHAIFAERMIQHPAVQRICNTDYSALFSPAVR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11078
Length:	301 (282)
Sequences:	79167 (57396)
Seq/√Len:	3417.9

ECOLI - NHAR LYSR LEUO OXYR ABGR NAC YBDO YFER TTDR YFIE YDCI DSDC PGRR TDCA YEIE CYNR YNEJ YGFI CYSB YBHD HCAR GCVA YAFC YBEF YIAU DMLR YIDZ CBL YNFL XAPR YHAJ YEEY AAER YCAN ILVY YAHB ICIA YDHB PERR METR ALLS YHJC YJIE LRHA HDFR
BACSU - CYSL GLTR YCGK YWQM YWBI YUST GLTC YYBE YVBU YOFA ALSR YXJO CITR BSDA YTLI CZCR YKUM YRAN YOAU

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
75_K	79_L	3.592	1.00
20_E	29_A	3.391	1.00
165_V	292_Y	2.692	1.00
100_G	145_L	2.565	1.00
72_Y	86_I	2.443	1.00
16_H	29_A	2.280	1.00
234_G	241_F	2.279	1.00
96_L	127_R	2.198	1.00
169_E	269_E	2.197	1.00
166_R	169_E	2.179	1.00
171_G	245_T	2.170	1.00
96_L	125_H	2.113	1.00
166_R	269_E	2.093	1.00
25_G	28_E	2.085	1.00
19_K	74_D	2.068	1.00
50_G	65_L	2.056	1.00
13_Y	40_Q	2.045	1.00
169_E	267_M	2.022	1.00
185_F	188_C	2.019	1.00
116_A	290_T	1.992	1.00
72_Y	79_L	1.984	1.00
180_P	192_R	1.970	1.00
15_W	70_Y	1.969	1.00
231_K	251_F	1.957	1.00
15_W	74_D	1.957	1.00
98_D	127_R	1.956	1.00
235_A	256_T	1.942	1.00
15_W	19_K	1.922	1.00
195_L	239_A	1.912	1.00
16_H	19_K	1.912	1.00
13_Y	37_I	1.899	1.00
16_H	20_E	1.894	1.00
176_C	260_I	1.893	1.00
173_S	245_T	1.889	1.00
18_Y	62_P	1.882	1.00
76_M	80_S	1.876	1.00
235_A	251_F	1.856	1.00
70_Y	74_D	1.823	1.00
23_V	41_I	1.797	1.00
180_P	183_K	1.734	1.00
193_R	221_L	1.733	1.00
54_K	61_E	1.726	1.00
69_V	83_M	1.717	1.00
173_S	259_E	1.683	1.00
68_L	86_I	1.681	1.00
164_S	271_H	1.673	1.00
139_Q	144_K	1.636	1.00
18_Y	70_Y	1.621	1.00
19_K	29_A	1.596	1.00
117_A	287_I	1.590	1.00
20_E	25_G	1.583	1.00
15_W	73_A	1.565	1.00
14_F	70_Y	1.554	1.00
163_F	276_E	1.546	1.00
13_Y	32_L	1.518	1.00
10_H	40_Q	1.515	1.00
138_E	142_Q	1.500	1.00
117_A	124_I	1.484	1.00
24_V	34_P	1.482	1.00
10_H	47_R	1.478	1.00
165_V	274_F	1.464	1.00
64_E	67_E	1.464	1.00
22_S	25_G	1.457	1.00
72_Y	75_K	1.454	1.00
33_T	36_T	1.453	1.00
7_N	10_H	1.434	1.00
51_K	54_K	1.433	1.00
10_H	43_A	1.432	1.00
16_H	30_L	1.420	1.00
204_G	208_L	1.417	1.00
150_S	273_I	1.407	1.00
15_W	77_F	1.402	1.00
288_C	292_Y	1.402	1.00
280_Q	284_V	1.386	1.00
72_Y	82_E	1.380	1.00
107_K	228_A	1.379	1.00
76_M	83_M	1.374	1.00
163_F	274_F	1.373	1.00
152_C	271_H	1.371	1.00
274_F	288_C	1.352	1.00
178_N	256_T	1.348	1.00
272_A	288_C	1.338	1.00
140_L	148_I	1.338	1.00
98_D	129_F	1.338	1.00
8_Y	80_S	1.321	1.00
286_R	289_N	1.309	1.00
116_A	120_E	1.308	1.00
56_K	61_E	1.305	1.00
94_N	123_P	1.298	1.00
139_Q	145_L	1.297	1.00
69_V	84_L	1.288	1.00
192_R	240_I	1.287	1.00
141_S	161_G	1.286	1.00
147_M	284_V	1.283	1.00
79_L	82_E	1.282	1.00
170_C	246_L	1.282	1.00
147_M	272_A	1.270	1.00
118_V	221_L	1.269	1.00
120_E	290_T	1.264	1.00
47_R	84_L	1.260	1.00
176_C	240_I	1.258	1.00
230_M	241_F	1.254	1.00
71_R	75_K	1.237	1.00
251_F	256_T	1.230	1.00
232_A	235_A	1.221	1.00
72_Y	83_M	1.211	1.00
14_F	53_F	1.205	1.00
249_Y	253_A	1.202	1.00
245_T	259_E	1.194	1.00
68_L	71_R	1.193	1.00
178_N	258_V	1.189	1.00
245_T	249_Y	1.189	1.00
166_R	271_H	1.183	1.00
115_N	119_V	1.181	1.00
118_V	193_R	1.176	1.00
67_E	71_R	1.175	1.00
42_R	46_E	1.173	1.00
211_F	216_L	1.161	1.00
32_L	36_T	1.160	1.00
164_S	273_I	1.136	1.00
39_G	43_A	1.133	1.00
115_N	236_M	1.129	1.00
14_F	18_Y	1.129	1.00
39_G	42_R	1.128	1.00
195_L	230_M	1.126	1.00
127_R	223_E	1.115	1.00
116_A	119_V	1.114	1.00
14_F	52_L	1.106	1.00
181_P	192_R	1.106	1.00
131_S	139_Q	1.101	1.00
97_F	287_I	1.097	1.00
121_G	286_R	1.095	1.00
38_T	42_R	1.087	1.00
75_K	82_E	1.085	1.00
11_L	73_A	1.084	1.00
289_N	292_Y	1.084	1.00
117_A	290_T	1.081	1.00
106_S	130_E	1.075	1.00
275_A	278_M	1.073	1.00
23_V	60_L	1.073	1.00
184_P	188_C	1.071	1.00
193_R	219_E	1.070	1.00
17_V	26_A	1.065	1.00
68_L	72_Y	1.065	1.00
259_E	262_R	1.061	1.00
224_F	230_M	1.060	1.00
16_H	26_A	1.060	1.00
40_Q	43_A	1.057	1.00
231_K	235_A	1.057	1.00
175_W	259_E	1.055	1.00
12_Y	81_Q	1.054	1.00
9_N	12_Y	1.054	1.00
76_M	79_L	1.053	1.00
285_Q	289_N	1.050	1.00
112_S	236_M	1.043	1.00
177_T	237_H	1.033	1.00
232_A	236_M	1.032	1.00
250_D	254_D	1.029	1.00
113_V	291_D	1.023	1.00
62_P	66_G	1.021	1.00
165_V	288_C	1.020	1.00
84_L	88_N	0.996	1.00
171_G	267_M	0.992	1.00
175_W	248_A	0.979	1.00
32_L	37_I	0.979	1.00
18_Y	53_F	0.978	1.00
174_F	240_I	0.978	1.00
13_Y	30_L	0.973	1.00
78_T	82_E	0.971	1.00
176_C	180_P	0.970	1.00
81_Q	84_L	0.970	1.00
69_V	73_A	0.968	1.00
120_E	293_S	0.965	1.00
156_S	161_G	0.962	1.00
117_A	121_G	0.961	1.00
81_Q	85_D	0.960	1.00
205_R	208_L	0.956	1.00
196_I	220_I	0.950	1.00
129_F	139_Q	0.950	1.00
290_T	293_S	0.949	1.00
17_V	23_V	0.944	1.00
14_F	62_P	0.941	1.00
224_F	233_F	0.935	1.00
139_Q	142_Q	0.926	1.00
43_A	46_E	0.919	1.00
26_A	37_I	0.916	1.00
161_G	276_E	0.915	1.00
68_L	90_R	0.911	1.00
14_F	44_L	0.908	1.00
100_G	148_I	0.908	1.00
281_H	284_V	0.906	1.00
113_V	290_T	0.906	1.00
50_G	87_V	0.901	1.00
53_F	60_L	0.893	1.00
125_H	219_E	0.888	1.00
25_G	29_A	0.887	1.00
18_Y	66_G	0.879	1.00
145_L	148_I	0.871	1.00
103_D	226_D	0.871	1.00
71_R	74_D	0.863	1.00
75_K	78_T	0.858	1.00
21_G	61_E	0.857	1.00
100_G	150_S	0.857	1.00
124_I	283_A	0.855	1.00
152_C	269_E	0.853	1.00
193_R	220_I	0.849	1.00
194_L	218_V	0.848	1.00
24_V	28_E	0.848	1.00
9_N	40_Q	0.844	1.00
162_L	273_I	0.844	1.00
30_L	37_I	0.842	1.00
99_V	147_M	0.842	1.00
65_L	90_R	0.840	1.00
163_F	166_R	0.838	1.00
175_W	241_F	0.838	1.00
205_R	209_N	0.837	1.00
182_E	192_R	0.831	1.00
176_C	182_E	0.828	1.00
8_Y	77_F	0.827	1.00
95_L	124_I	0.826	1.00
95_L	283_A	0.824	1.00
129_F	145_L	0.822	1.00
207_L	211_F	0.819	1.00
56_K	59_G	0.819	1.00
171_G	265_N	0.816	1.00
210_W	214_Q	0.815	1.00
115_N	238_N	0.808	1.00
187_A	190_E	0.807	1.00
252_Y	255_K	0.806	1.00
289_N	293_S	0.805	1.00
185_F	263_V	0.803	1.00
21_G	67_E	0.803	1.00
280_Q	285_Q	0.800	1.00
65_L	87_V	0.798	1.00
18_Y	21_G	0.797	1.00
14_F	69_V	0.795	1.00
248_A	251_F	0.794	1.00
17_V	41_I	0.793	1.00
251_F	254_D	0.792	1.00
42_R	51_K	0.792	1.00
19_K	70_Y	0.787	1.00
34_P	38_T	0.783	1.00
82_E	86_I	0.780	1.00
80_S	83_M	0.779	1.00
118_V	238_N	0.777	1.00
177_T	238_N	0.775	1.00
17_V	53_F	0.774	1.00
80_S	84_L	0.772	1.00
188_C	191_E	0.771	1.00
20_E	26_A	0.770	1.00
282_P	286_R	0.769	1.00
171_G	261_G	0.766	1.00
141_S	156_S	0.763	1.00
65_L	68_L	0.761	1.00
79_L	83_M	0.757	1.00
10_H	13_Y	0.753	1.00
141_S	162_L	0.752	1.00
137_L	141_S	0.752	1.00
21_G	59_G	0.752	1.00
147_M	287_I	0.746	1.00
233_F	238_N	0.740	1.00
175_W	243_A	0.739	1.00
176_C	258_V	0.738	1.00
117_A	286_R	0.730	1.00
12_Y	16_H	0.728	1.00
73_A	76_M	0.725	1.00
209_N	213_S	0.723	1.00
88_N	91_K	0.722	1.00
83_M	87_V	0.720	1.00
54_K	63_S	0.716	1.00
156_S	160_E	0.714	1.00
210_W	213_S	0.712	1.00
23_V	37_I	0.712	1.00
93_S	121_G	0.712	1.00
17_V	37_I	0.711	1.00
61_E	67_E	0.711	1.00
190_E	216_L	0.710	1.00
62_P	67_E	0.706	1.00
120_E	286_R	0.702	1.00
101_V	106_S	0.701	1.00
204_G	223_E	0.699	1.00
98_D	145_L	0.698	1.00
74_D	78_T	0.697	1.00
143_H	275_A	0.695	1.00
286_R	290_T	0.692	1.00
244_P	247_Y	0.692	1.00
36_T	40_Q	0.689	1.00
278_M	281_H	0.689	1.00
226_D	229_L	0.688	1.00
209_N	212_N	0.688	1.00
67_E	70_Y	0.685	1.00
65_L	69_V	0.681	1.00
175_W	252_Y	0.679	1.00
54_K	59_G	0.679	1.00
208_L	212_N	0.676	1.00
146_D	284_V	0.676	1.00
64_E	68_L	0.673	1.00
45_E	50_G	0.673	1.00
198_G	223_E	0.668	1.00
98_D	146_D	0.665	1.00
183_K	258_V	0.664	1.00
116_A	293_S	0.664	1.00
69_V	87_V	0.662	1.00
205_R	210_W	0.661	1.00
206_K	210_W	0.660	1.00
149_I	291_D	0.658	1.00
222_G	233_F	0.658	1.00
248_A	252_Y	0.657	1.00
125_H	223_E	0.653	1.00
191_E	219_E	0.653	1.00
207_L	210_W	0.652	1.00
9_N	43_A	0.650	1.00
82_E	85_D	0.649	1.00
197_P	230_M	0.648	1.00
12_Y	15_W	0.647	1.00
101_V	110_V	0.646	1.00
72_Y	76_M	0.644	1.00
97_F	283_A	0.643	1.00
179_P	237_H	0.643	1.00
179_P	182_E	0.643	1.00
78_T	81_Q	0.641	1.00
45_E	55_R	0.640	1.00
250_D	253_A	0.640	1.00
180_P	193_R	0.639	1.00
73_A	77_F	0.638	1.00
179_P	183_K	0.638	1.00
179_P	258_V	0.638	1.00
41_I	45_E	0.637	1.00
107_K	232_A	0.636	1.00
28_E	31_Y	0.633	1.00
23_V	59_G	0.631	1.00
252_Y	259_E	0.631	1.00
211_F	218_V	0.629	1.00
178_N	255_K	0.629	1.00
176_C	181_P	0.624	1.00
17_V	22_S	0.620	1.00
194_L	240_I	0.619	1.00
26_A	30_L	0.615	1.00
174_F	242_V	0.615	1.00
103_D	132_T	0.613	1.00
187_A	214_Q	0.612	1.00
130_E	225_D	0.612	1.00
140_L	273_I	0.611	1.00
174_F	189_L	0.607	1.00
287_I	291_D	0.606	1.00
198_G	225_D	0.595	1.00
282_P	285_Q	0.594	1.00
174_F	194_L	0.585	1.00
151_D	268_E	0.585	1.00
147_M	288_C	0.585	1.00
230_M	234_G	0.583	1.00
208_L	211_F	0.583	1.00
97_F	147_M	0.582	1.00
110_V	113_V	0.581	1.00
152_C	156_S	0.581	1.00
85_D	89_Y	0.580	1.00
36_T	39_G	0.580	1.00
140_L	162_L	0.578	1.00
68_L	87_V	0.578	1.00
168_G	270_Y	0.578	1.00
12_Y	77_F	0.577	1.00
163_F	277_R	0.577	1.00
177_T	180_P	0.576	1.00
9_N	13_Y	0.574	1.00
62_P	70_Y	0.574	1.00
130_E	226_D	0.574	1.00
112_S	115_N	0.571	1.00
170_C	268_E	0.568	1.00
53_F	62_P	0.568	1.00
206_K	209_N	0.567	1.00
48_L	69_V	0.566	1.00
35_Q	39_G	0.565	1.00
48_L	87_V	0.565	1.00
94_N	125_H	0.565	1.00
95_L	123_P	0.563	1.00
100_G	131_S	0.562	1.00
50_G	54_K	0.561	1.00
233_F	239_A	0.561	1.00
121_G	124_I	0.560	1.00
274_F	285_Q	0.560	1.00
7_N	47_R	0.560	1.00
172_V	242_V	0.559	1.00
112_S	116_A	0.557	1.00
204_G	210_W	0.557	1.00
89_Y	93_S	0.555	1.00
33_T	39_G	0.555	1.00
224_F	229_L	0.553	1.00
100_G	129_F	0.553	1.00
14_F	66_G	0.552	1.00
114_L	126_L	0.545	1.00
95_L	121_G	0.544	1.00
77_F	81_Q	0.543	1.00
176_C	183_K	0.543	1.00
13_Y	41_I	0.539	1.00
105_L	109_L	0.538	1.00
199_R	223_E	0.535	1.00
48_L	51_K	0.534	1.00
256_T	259_E	0.533	1.00
167_I	272_A	0.532	1.00
71_R	86_I	0.531	1.00
243_A	248_A	0.528	1.00
107_K	226_D	0.526	1.00
23_V	34_P	0.524	1.00
227_A	244_P	0.524	1.00
51_K	65_L	0.522	1.00
77_F	80_S	0.520	1.00
109_L	113_V	0.519	1.00
13_Y	26_A	0.518	1.00
41_I	53_F	0.518	1.00
23_V	55_R	0.517	1.00
284_V	288_C	0.517	1.00
85_D	88_N	0.514	1.00
187_A	216_L	0.512	1.00
72_Y	87_V	0.512	1.00
203_L	207_L	0.511	1.00
152_C	164_S	0.509	1.00
21_G	60_L	0.509	1.00
76_M	84_L	0.509	1.00
18_Y	67_E	0.508	1.00
32_L	40_Q	0.506	1.00
11_L	69_V	0.502	1.00
73_A	80_S	0.501	1.00
138_E	144_K	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1uthA	2	0.7375	100	0.101	Contact Map
2esnA	3	0.9801	100	0.102	Contact Map
3fzvA	4	0.9402	100	0.13	Contact Map
2h98A	2	0.6711	100	0.131	Contact Map
3fxqA	3	0.9668	100	0.133	Contact Map
2h9bA	2	0.6711	100	0.136	Contact Map
1ixcA	4	0.9502	100	0.138	Contact Map
1al3A	1	0.691	100	0.139	Contact Map
4x6gA	4	0.9834	100	0.144	Contact Map
3szpA	3	0.9435	100	0.157	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0107 seconds.