GREMLIN Database
NHAR - Transcriptional activator protein NhaR
UniProt: P0A9G2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11078
Length: 301 (282)
Sequences: 79167 (57396)
Seq/√Len: 3417.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_K79_L3.5921.00
20_E29_A3.3911.00
165_V292_Y2.6921.00
100_G145_L2.5651.00
72_Y86_I2.4431.00
16_H29_A2.2801.00
234_G241_F2.2791.00
96_L127_R2.1981.00
169_E269_E2.1971.00
166_R169_E2.1791.00
171_G245_T2.1701.00
96_L125_H2.1131.00
166_R269_E2.0931.00
25_G28_E2.0851.00
19_K74_D2.0681.00
50_G65_L2.0561.00
13_Y40_Q2.0451.00
169_E267_M2.0221.00
185_F188_C2.0191.00
116_A290_T1.9921.00
72_Y79_L1.9841.00
180_P192_R1.9701.00
15_W70_Y1.9691.00
231_K251_F1.9571.00
15_W74_D1.9571.00
98_D127_R1.9561.00
235_A256_T1.9421.00
15_W19_K1.9221.00
195_L239_A1.9121.00
16_H19_K1.9121.00
13_Y37_I1.8991.00
16_H20_E1.8941.00
176_C260_I1.8931.00
173_S245_T1.8891.00
18_Y62_P1.8821.00
76_M80_S1.8761.00
235_A251_F1.8561.00
70_Y74_D1.8231.00
23_V41_I1.7971.00
180_P183_K1.7341.00
193_R221_L1.7331.00
54_K61_E1.7261.00
69_V83_M1.7171.00
173_S259_E1.6831.00
68_L86_I1.6811.00
164_S271_H1.6731.00
139_Q144_K1.6361.00
18_Y70_Y1.6211.00
19_K29_A1.5961.00
117_A287_I1.5901.00
20_E25_G1.5831.00
15_W73_A1.5651.00
14_F70_Y1.5541.00
163_F276_E1.5461.00
13_Y32_L1.5181.00
10_H40_Q1.5151.00
138_E142_Q1.5001.00
117_A124_I1.4841.00
24_V34_P1.4821.00
10_H47_R1.4781.00
165_V274_F1.4641.00
64_E67_E1.4641.00
22_S25_G1.4571.00
72_Y75_K1.4541.00
33_T36_T1.4531.00
7_N10_H1.4341.00
51_K54_K1.4331.00
10_H43_A1.4321.00
16_H30_L1.4201.00
204_G208_L1.4171.00
150_S273_I1.4071.00
15_W77_F1.4021.00
288_C292_Y1.4021.00
280_Q284_V1.3861.00
72_Y82_E1.3801.00
107_K228_A1.3791.00
76_M83_M1.3741.00
163_F274_F1.3731.00
152_C271_H1.3711.00
274_F288_C1.3521.00
178_N256_T1.3481.00
272_A288_C1.3381.00
140_L148_I1.3381.00
98_D129_F1.3381.00
8_Y80_S1.3211.00
286_R289_N1.3091.00
116_A120_E1.3081.00
56_K61_E1.3051.00
94_N123_P1.2981.00
139_Q145_L1.2971.00
69_V84_L1.2881.00
192_R240_I1.2871.00
141_S161_G1.2861.00
147_M284_V1.2831.00
79_L82_E1.2821.00
170_C246_L1.2821.00
147_M272_A1.2701.00
118_V221_L1.2691.00
120_E290_T1.2641.00
47_R84_L1.2601.00
176_C240_I1.2581.00
230_M241_F1.2541.00
71_R75_K1.2371.00
251_F256_T1.2301.00
232_A235_A1.2211.00
72_Y83_M1.2111.00
14_F53_F1.2051.00
249_Y253_A1.2021.00
245_T259_E1.1941.00
68_L71_R1.1931.00
178_N258_V1.1891.00
245_T249_Y1.1891.00
166_R271_H1.1831.00
115_N119_V1.1811.00
118_V193_R1.1761.00
67_E71_R1.1751.00
42_R46_E1.1731.00
211_F216_L1.1611.00
32_L36_T1.1601.00
164_S273_I1.1361.00
39_G43_A1.1331.00
115_N236_M1.1291.00
14_F18_Y1.1291.00
39_G42_R1.1281.00
195_L230_M1.1261.00
127_R223_E1.1151.00
116_A119_V1.1141.00
14_F52_L1.1061.00
181_P192_R1.1061.00
131_S139_Q1.1011.00
97_F287_I1.0971.00
121_G286_R1.0951.00
38_T42_R1.0871.00
75_K82_E1.0851.00
11_L73_A1.0841.00
289_N292_Y1.0841.00
117_A290_T1.0811.00
106_S130_E1.0751.00
275_A278_M1.0731.00
23_V60_L1.0731.00
184_P188_C1.0711.00
193_R219_E1.0701.00
17_V26_A1.0651.00
68_L72_Y1.0651.00
259_E262_R1.0611.00
224_F230_M1.0601.00
16_H26_A1.0601.00
40_Q43_A1.0571.00
231_K235_A1.0571.00
175_W259_E1.0551.00
12_Y81_Q1.0541.00
9_N12_Y1.0541.00
76_M79_L1.0531.00
285_Q289_N1.0501.00
112_S236_M1.0431.00
177_T237_H1.0331.00
232_A236_M1.0321.00
250_D254_D1.0291.00
113_V291_D1.0231.00
62_P66_G1.0211.00
165_V288_C1.0201.00
84_L88_N0.9961.00
171_G267_M0.9921.00
175_W248_A0.9791.00
32_L37_I0.9791.00
18_Y53_F0.9781.00
174_F240_I0.9781.00
13_Y30_L0.9731.00
78_T82_E0.9711.00
176_C180_P0.9701.00
81_Q84_L0.9701.00
69_V73_A0.9681.00
120_E293_S0.9651.00
156_S161_G0.9621.00
117_A121_G0.9611.00
81_Q85_D0.9601.00
205_R208_L0.9561.00
196_I220_I0.9501.00
129_F139_Q0.9501.00
290_T293_S0.9491.00
17_V23_V0.9441.00
14_F62_P0.9411.00
224_F233_F0.9351.00
139_Q142_Q0.9261.00
43_A46_E0.9191.00
26_A37_I0.9161.00
161_G276_E0.9151.00
68_L90_R0.9111.00
14_F44_L0.9081.00
100_G148_I0.9081.00
281_H284_V0.9061.00
113_V290_T0.9061.00
50_G87_V0.9011.00
53_F60_L0.8931.00
125_H219_E0.8881.00
25_G29_A0.8871.00
18_Y66_G0.8791.00
145_L148_I0.8711.00
103_D226_D0.8711.00
71_R74_D0.8631.00
75_K78_T0.8581.00
21_G61_E0.8571.00
100_G150_S0.8571.00
124_I283_A0.8551.00
152_C269_E0.8531.00
193_R220_I0.8491.00
194_L218_V0.8481.00
24_V28_E0.8481.00
9_N40_Q0.8441.00
162_L273_I0.8441.00
30_L37_I0.8421.00
99_V147_M0.8421.00
65_L90_R0.8401.00
163_F166_R0.8381.00
175_W241_F0.8381.00
205_R209_N0.8371.00
182_E192_R0.8311.00
176_C182_E0.8281.00
8_Y77_F0.8271.00
95_L124_I0.8261.00
95_L283_A0.8241.00
129_F145_L0.8221.00
207_L211_F0.8191.00
56_K59_G0.8191.00
171_G265_N0.8161.00
210_W214_Q0.8151.00
115_N238_N0.8081.00
187_A190_E0.8071.00
252_Y255_K0.8061.00
289_N293_S0.8051.00
185_F263_V0.8031.00
21_G67_E0.8031.00
280_Q285_Q0.8001.00
65_L87_V0.7981.00
18_Y21_G0.7971.00
14_F69_V0.7951.00
248_A251_F0.7941.00
17_V41_I0.7931.00
251_F254_D0.7921.00
42_R51_K0.7921.00
19_K70_Y0.7871.00
34_P38_T0.7831.00
82_E86_I0.7801.00
80_S83_M0.7791.00
118_V238_N0.7771.00
177_T238_N0.7751.00
17_V53_F0.7741.00
80_S84_L0.7721.00
188_C191_E0.7711.00
20_E26_A0.7701.00
282_P286_R0.7691.00
171_G261_G0.7661.00
141_S156_S0.7631.00
65_L68_L0.7611.00
79_L83_M0.7571.00
10_H13_Y0.7531.00
141_S162_L0.7521.00
137_L141_S0.7521.00
21_G59_G0.7521.00
147_M287_I0.7461.00
233_F238_N0.7401.00
175_W243_A0.7391.00
176_C258_V0.7381.00
117_A286_R0.7301.00
12_Y16_H0.7281.00
73_A76_M0.7251.00
209_N213_S0.7231.00
88_N91_K0.7221.00
83_M87_V0.7201.00
54_K63_S0.7161.00
156_S160_E0.7141.00
210_W213_S0.7121.00
23_V37_I0.7121.00
93_S121_G0.7121.00
17_V37_I0.7111.00
61_E67_E0.7111.00
190_E216_L0.7101.00
62_P67_E0.7061.00
120_E286_R0.7021.00
101_V106_S0.7011.00
204_G223_E0.6991.00
98_D145_L0.6981.00
74_D78_T0.6971.00
143_H275_A0.6951.00
286_R290_T0.6921.00
244_P247_Y0.6921.00
36_T40_Q0.6891.00
278_M281_H0.6891.00
226_D229_L0.6881.00
209_N212_N0.6881.00
67_E70_Y0.6851.00
65_L69_V0.6811.00
175_W252_Y0.6791.00
54_K59_G0.6791.00
208_L212_N0.6761.00
146_D284_V0.6761.00
64_E68_L0.6731.00
45_E50_G0.6731.00
198_G223_E0.6681.00
98_D146_D0.6651.00
183_K258_V0.6641.00
116_A293_S0.6641.00
69_V87_V0.6621.00
205_R210_W0.6611.00
206_K210_W0.6601.00
149_I291_D0.6581.00
222_G233_F0.6581.00
248_A252_Y0.6571.00
125_H223_E0.6531.00
191_E219_E0.6531.00
207_L210_W0.6521.00
9_N43_A0.6501.00
82_E85_D0.6491.00
197_P230_M0.6481.00
12_Y15_W0.6471.00
101_V110_V0.6461.00
72_Y76_M0.6441.00
97_F283_A0.6431.00
179_P237_H0.6431.00
179_P182_E0.6431.00
78_T81_Q0.6411.00
45_E55_R0.6401.00
250_D253_A0.6401.00
180_P193_R0.6391.00
73_A77_F0.6381.00
179_P183_K0.6381.00
179_P258_V0.6381.00
41_I45_E0.6371.00
107_K232_A0.6361.00
28_E31_Y0.6331.00
23_V59_G0.6311.00
252_Y259_E0.6311.00
211_F218_V0.6291.00
178_N255_K0.6291.00
176_C181_P0.6241.00
17_V22_S0.6201.00
194_L240_I0.6191.00
26_A30_L0.6151.00
174_F242_V0.6151.00
103_D132_T0.6131.00
187_A214_Q0.6121.00
130_E225_D0.6121.00
140_L273_I0.6111.00
174_F189_L0.6071.00
287_I291_D0.6061.00
198_G225_D0.5951.00
282_P285_Q0.5941.00
174_F194_L0.5851.00
151_D268_E0.5851.00
147_M288_C0.5851.00
230_M234_G0.5831.00
208_L211_F0.5831.00
97_F147_M0.5821.00
110_V113_V0.5811.00
152_C156_S0.5811.00
85_D89_Y0.5801.00
36_T39_G0.5801.00
140_L162_L0.5781.00
68_L87_V0.5781.00
168_G270_Y0.5781.00
12_Y77_F0.5771.00
163_F277_R0.5771.00
177_T180_P0.5761.00
9_N13_Y0.5741.00
62_P70_Y0.5741.00
130_E226_D0.5741.00
112_S115_N0.5711.00
170_C268_E0.5681.00
53_F62_P0.5681.00
206_K209_N0.5671.00
48_L69_V0.5661.00
35_Q39_G0.5651.00
48_L87_V0.5651.00
94_N125_H0.5651.00
95_L123_P0.5631.00
100_G131_S0.5621.00
50_G54_K0.5611.00
233_F239_A0.5611.00
121_G124_I0.5601.00
274_F285_Q0.5601.00
7_N47_R0.5601.00
172_V242_V0.5591.00
112_S116_A0.5571.00
204_G210_W0.5571.00
89_Y93_S0.5551.00
33_T39_G0.5551.00
224_F229_L0.5531.00
100_G129_F0.5531.00
14_F66_G0.5521.00
114_L126_L0.5451.00
95_L121_G0.5441.00
77_F81_Q0.5431.00
176_C183_K0.5431.00
13_Y41_I0.5391.00
105_L109_L0.5381.00
199_R223_E0.5351.00
48_L51_K0.5341.00
256_T259_E0.5331.00
167_I272_A0.5321.00
71_R86_I0.5311.00
243_A248_A0.5281.00
107_K226_D0.5261.00
23_V34_P0.5241.00
227_A244_P0.5241.00
51_K65_L0.5221.00
77_F80_S0.5201.00
109_L113_V0.5191.00
13_Y26_A0.5181.00
41_I53_F0.5181.00
23_V55_R0.5171.00
284_V288_C0.5171.00
85_D88_N0.5141.00
187_A216_L0.5121.00
72_Y87_V0.5121.00
203_L207_L0.5111.00
152_C164_S0.5091.00
21_G60_L0.5091.00
76_M84_L0.5091.00
18_Y67_E0.5081.00
32_L40_Q0.5061.00
11_L69_V0.5021.00
73_A80_S0.5011.00
138_E144_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uthA 2 0.7375 100 0.101 Contact Map
2esnA 3 0.9801 100 0.102 Contact Map
3fzvA 4 0.9402 100 0.13 Contact Map
2h98A 2 0.6711 100 0.131 Contact Map
3fxqA 3 0.9668 100 0.133 Contact Map
2h9bA 2 0.6711 100 0.136 Contact Map
1ixcA 4 0.9502 100 0.138 Contact Map
1al3A 1 0.691 100 0.139 Contact Map
4x6gA 4 0.9834 100 0.144 Contact Map
3szpA 3 0.9435 100 0.157 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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