GREMLIN Database
METR - HTH-type transcriptional regulator MetR
UniProt: P0A9F9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10591
Length: 317 (284)
Sequences: 79387 (57596)
Seq/√Len: 3417.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_Q75_Q3.5781.00
16_C25_T3.3551.00
156_S286_R2.6461.00
68_L82_A2.4521.00
94_A139_L2.4461.00
12_A25_T2.3831.00
228_V235_A2.1931.00
160_D263_R2.1921.00
90_R121_D2.1891.00
157_P263_R2.1811.00
157_P160_D2.1771.00
171_H187_E2.1701.00
110_N288_H2.1581.00
46_F61_Q2.1301.00
162_E239_H2.0891.00
9_T36_Q2.0591.00
90_R119_E2.0511.00
11_Q70_N2.0301.00
68_L75_Q1.9961.00
11_Q15_N1.9941.00
21_A24_A1.9931.00
160_D261_W1.9871.00
229_A250_L1.9671.00
164_R239_H1.9591.00
180_T183_D1.9501.00
110_N284_S1.9401.00
12_A16_C1.9381.00
92_R121_D1.9361.00
225_I245_F1.9351.00
15_N70_N1.9341.00
14_R58_F1.8991.00
11_Q66_L1.8941.00
12_A15_N1.8931.00
190_L233_G1.8921.00
9_T33_L1.8581.00
72_V76_I1.8491.00
167_L254_K1.8111.00
66_L70_N1.8051.00
164_R253_T1.7661.00
229_A245_F1.7631.00
188_T215_L1.7531.00
155_Y265_Y1.7031.00
50_V57_R1.6811.00
176_K183_D1.6761.00
19_L37_F1.6751.00
14_R66_L1.6641.00
65_L79_A1.6631.00
64_I82_A1.6521.00
130_P142_V1.6461.00
133_A138_E1.6301.00
16_C21_A1.5961.00
11_Q69_A1.5621.00
154_H270_D1.5521.00
15_N25_T1.5451.00
68_L71_Q1.5191.00
111_F281_F1.5191.00
6_H36_Q1.5081.00
156_S268_V1.4981.00
6_H43_R1.4911.00
18_S21_A1.4881.00
132_P136_Q1.4811.00
10_L66_L1.4631.00
9_T28_Q1.4571.00
29_T32_A1.4431.00
6_H39_D1.4371.00
111_F118_V1.4351.00
20_A30_Q1.4271.00
282_I286_R1.4101.00
47_R50_V1.4081.00
144_T267_A1.4081.00
268_V282_I1.4021.00
12_A26_L1.3971.00
154_H268_V1.3961.00
101_I222_L1.3951.00
68_L78_Q1.3791.00
146_D265_Y1.3751.00
86_P117_Q1.3711.00
60_P63_E1.3621.00
52_K57_R1.3581.00
11_Q73_L1.3561.00
72_V79_A1.3541.00
199_L203_R1.3451.00
133_A139_L1.3361.00
92_R123_K1.3301.00
75_Q78_Q1.3281.00
114_N284_S1.3201.00
280_A283_R1.3181.00
266_A282_I1.3141.00
4_V76_I1.3101.00
65_L80_L1.3101.00
134_L142_V1.3041.00
88_Q117_Q1.2961.00
135_Q152_G1.2951.00
110_N114_N1.2951.00
3_E6_H1.2931.00
141_L266_A1.2801.00
161_Y240_W1.2751.00
67_Q71_Q1.2701.00
224_L235_A1.2661.00
169_P250_L1.2661.00
274_R278_T1.2571.00
68_L79_A1.2511.00
141_L278_T1.2501.00
167_L234_I1.2491.00
187_E234_I1.2461.00
245_F250_L1.2321.00
226_Q229_A1.2251.00
157_P265_Y1.2211.00
43_R80_L1.2211.00
112_H215_L1.2191.00
239_H253_T1.2141.00
28_Q32_A1.2091.00
169_P252_V1.2071.00
64_I67_Q1.1931.00
10_L49_F1.1891.00
35_H39_D1.1841.00
112_H188_T1.1811.00
109_E113_K1.1791.00
239_H243_E1.1771.00
10_L14_R1.1521.00
109_E230_A1.1511.00
155_Y267_A1.1451.00
63_E67_Q1.1281.00
38_S42_Q1.1251.00
178_R257_G1.1221.00
172_P187_E1.1211.00
35_H38_S1.1201.00
64_I68_L1.1161.00
121_D217_S1.1061.00
177_T252_V1.1041.00
284_S288_H1.0871.00
71_Q78_Q1.0871.00
188_T214_S1.0851.00
115_W280_A1.0831.00
106_P230_A1.0801.00
7_L69_A1.0751.00
100_C124_S1.0721.00
206_L211_V1.0721.00
110_N113_K1.0721.00
243_E247_R1.0711.00
166_V253_T1.0681.00
156_S282_I1.0671.00
19_L56_L1.0671.00
10_L48_L1.0661.00
12_A22_A1.0641.00
5_K8_K1.0591.00
72_V75_Q1.0531.00
190_L224_L1.0531.00
36_Q39_D1.0531.00
253_T256_L1.0451.00
179_I183_D1.0441.00
283_R286_R1.0411.00
135_Q150_R1.0411.00
226_Q230_A1.0411.00
34_S38_S1.0411.00
13_L22_A1.0371.00
225_I229_A1.0331.00
279_E283_R1.0241.00
111_F284_S1.0231.00
107_A285_A1.0191.00
80_L84_N1.0161.00
269_R272_E1.0151.00
91_L281_F1.0141.00
162_E261_W1.0091.00
218_V224_L1.0061.00
168_A231_R0.9981.00
123_K133_A0.9911.00
244_S248_Q0.9901.00
8_K77_S0.9901.00
74_P78_Q0.9811.00
13_L19_L0.9731.00
284_S287_N0.9731.00
58_F62_G0.9711.00
165_L234_I0.9521.00
111_F115_W0.9521.00
28_Q33_L0.9511.00
65_L69_A0.9511.00
166_V242_V0.9491.00
14_R49_F0.9461.00
9_T26_L0.9431.00
77_S80_L0.9361.00
39_D42_Q0.9341.00
114_N287_N0.9331.00
22_A33_L0.9321.00
10_L40_L0.9271.00
218_V227_M0.9241.00
10_L58_F0.9241.00
167_L171_H0.9121.00
133_A136_Q0.9071.00
200_D203_R0.9051.00
77_S81_Q0.9001.00
21_A25_T0.8931.00
71_Q74_P0.8921.00
97_C220_N0.8911.00
107_A284_S0.8891.00
46_F83_C0.8871.00
5_K36_Q0.8861.00
171_H174_A0.8841.00
49_F56_L0.8811.00
275_Q278_T0.8791.00
17_G57_R0.8651.00
200_D204_H0.8611.00
94_A130_P0.8581.00
139_L142_V0.8561.00
67_Q70_N0.8551.00
89_T277_V0.8471.00
61_Q83_C0.8441.00
20_A24_A0.8421.00
14_R62_G0.8411.00
146_D263_R0.8381.00
94_A144_T0.8351.00
76_I80_L0.8321.00
131_Q135_Q0.8301.00
154_H157_P0.8291.00
109_E232_M0.8281.00
118_V277_V0.8191.00
171_H175_A0.8171.00
242_V245_F0.8171.00
26_L33_L0.8171.00
93_I141_L0.8141.00
94_A142_V0.8111.00
205_F209_A0.8101.00
52_K55_P0.8101.00
153_L267_A0.8071.00
107_A288_H0.8071.00
183_D186_S0.8051.00
75_Q79_A0.8031.00
76_I79_A0.8021.00
172_P177_T0.8021.00
78_Q82_A0.8001.00
245_F248_Q0.8001.00
123_K139_L0.7991.00
171_H188_T0.7961.00
167_L172_P0.7941.00
30_Q34_S0.7911.00
166_V235_A0.7911.00
61_Q64_I0.7901.00
14_R17_G0.7901.00
173_L187_E0.7891.00
17_G55_P0.7881.00
89_T118_V0.7871.00
15_N66_L0.7871.00
10_L65_L0.7861.00
112_H232_M0.7851.00
229_A248_Q0.7841.00
119_E214_S0.7841.00
276_P280_A0.7831.00
13_L49_F0.7801.00
4_V73_L0.7781.00
38_S47_R0.7761.00
17_G63_E0.7761.00
16_C22_A0.7751.00
162_E259_G0.7741.00
168_A232_M0.7741.00
180_T257_G0.7701.00
175_A188_T0.7701.00
13_L37_F0.7701.00
8_K12_A0.7691.00
283_R287_N0.7661.00
189_L213_P0.7581.00
182_E185_A0.7571.00
202_W206_L0.7561.00
6_H9_T0.7541.00
79_A83_C0.7511.00
162_E255_T0.7471.00
227_M232_M0.7441.00
69_A72_V0.7371.00
19_L33_L0.7371.00
246_E249_G0.7361.00
152_G270_D0.7311.00
95_I100_C0.7311.00
13_L33_L0.7301.00
87_Q115_W0.7301.00
70_N74_P0.7301.00
129_D132_P0.7291.00
166_V237_L0.7281.00
141_L281_F0.7261.00
50_V59_T0.7221.00
63_E66_L0.7221.00
114_N280_A0.7201.00
135_Q153_L0.7201.00
220_N223_L0.7191.00
272_E275_Q0.7161.00
168_A171_H0.7101.00
167_L252_V0.7101.00
185_A211_V0.7021.00
111_F280_A0.7021.00
140_D278_T0.7001.00
174_A252_V0.7001.00
280_A284_S0.6981.00
110_N287_N0.6971.00
8_K11_Q0.6961.00
193_P217_S0.6941.00
137_G269_R0.6921.00
61_Q65_L0.6901.00
170_D231_R0.6851.00
238_P241_V0.6851.00
166_V246_E0.6821.00
170_D174_A0.6821.00
204_H208_P0.6801.00
32_A36_Q0.6801.00
205_F208_P0.6791.00
58_F63_E0.6761.00
101_I226_Q0.6761.00
60_P64_I0.6741.00
57_R63_E0.6721.00
50_V55_P0.6691.00
274_R279_E0.6681.00
167_L173_L0.6621.00
92_R139_L0.6621.00
199_L217_S0.6581.00
178_R255_T0.6571.00
65_L83_C0.6561.00
92_R140_D0.6561.00
78_Q81_Q0.6551.00
189_L234_I0.6541.00
246_E253_T0.6541.00
216_K227_M0.6481.00
68_L72_V0.6461.00
41_E51_R0.6461.00
119_E217_S0.6441.00
5_K39_D0.6431.00
204_H207_Q0.6421.00
192_Y224_L0.6401.00
124_S219_D0.6381.00
165_L236_A0.6361.00
41_E46_F0.6361.00
24_A27_H0.6321.00
201_V205_F0.6271.00
145_S262_S0.6251.00
74_P77_S0.6241.00
182_E209_A0.6231.00
242_V246_E0.6231.00
129_D133_A0.6141.00
203_R207_Q0.6141.00
37_F41_E0.6131.00
244_S247_R0.6121.00
104_L107_A0.6121.00
13_L18_S0.6111.00
165_L184_L0.6101.00
276_P279_E0.6101.00
95_I104_L0.6071.00
106_P109_E0.6051.00
202_W205_F0.6041.00
172_P175_A0.6031.00
206_L213_P0.6031.00
173_L176_K0.6011.00
170_D173_L0.6011.00
8_K73_L0.5991.00
91_L277_V0.5971.00
64_I83_C0.5961.00
170_D252_V0.5931.00
10_L62_G0.5931.00
106_P110_N0.5921.00
69_A73_L0.5901.00
172_P176_K0.5891.00
22_A26_L0.5881.00
200_D205_F0.5861.00
81_Q85_E0.5861.00
201_V204_H0.5851.00
141_L282_I0.5851.00
193_P219_D0.5841.00
88_Q119_E0.5821.00
46_F50_V0.5811.00
281_F285_A0.5811.00
224_L228_V0.5801.00
44_L65_L0.5781.00
73_L77_S0.5751.00
134_L153_L0.5741.00
32_A35_H0.5701.00
169_P249_G0.5691.00
44_L83_C0.5681.00
5_K9_T0.5671.00
3_E39_D0.5671.00
91_L141_L0.5671.00
199_L205_F0.5651.00
218_V223_L0.5651.00
19_L55_P0.5641.00
143_M285_A0.5611.00
163_V236_A0.5601.00
134_L267_A0.5591.00
49_F58_F0.5551.00
31_S35_H0.5541.00
124_S220_N0.5531.00
268_V279_E0.5531.00
161_Y262_S0.5521.00
14_R63_E0.5511.00
165_L189_L0.5501.00
158_M266_A0.5481.00
173_L179_I0.5451.00
227_M233_G0.5451.00
29_T35_H0.5441.00
115_W118_V0.5431.00
89_T117_Q0.5361.00
44_L47_R0.5361.00
58_F66_L0.5361.00
203_R206_L0.5341.00
159_F264_L0.5341.00
237_L242_V0.5331.00
94_A123_K0.5321.00
186_S214_S0.5291.00
221_T238_P0.5291.00
101_I220_N0.5281.00
67_Q82_A0.5241.00
19_L30_Q0.5231.00
99_S103_W0.5231.00
9_T37_F0.5231.00
28_Q36_Q0.5221.00
171_H234_I0.5201.00
47_R61_Q0.5201.00
82_A85_E0.5191.00
108_L120_M0.5181.00
146_D155_Y0.5171.00
130_P137_G0.5171.00
194_V217_S0.5151.00
278_T282_I0.5131.00
182_E211_V0.5121.00
154_H271_G0.5111.00
17_G56_L0.5081.00
96_E99_S0.5081.00
103_W107_A0.5071.00
106_P226_Q0.5051.00
68_L83_C0.5031.00
166_V251_V0.5031.00
135_Q138_E0.5001.00
19_L51_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fxqA 3 0.9085 100 0.157 Contact Map
2esnA 3 0.9117 100 0.157 Contact Map
1uthA 2 0.7003 100 0.164 Contact Map
3fzvA 4 0.8927 100 0.167 Contact Map
1ixcA 4 0.9054 100 0.169 Contact Map
1al3A 1 0.7035 100 0.176 Contact Map
2h98A 2 0.6625 100 0.179 Contact Map
2h9bA 2 0.6656 100 0.181 Contact Map
4x6gA 4 0.9401 100 0.181 Contact Map
3hhgA 3 0.9085 100 0.185 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.