GREMLIN Database
GCVA - Glycine cleavage system transcriptional activator
UniProt: P0A9F6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11795
Length: 305 (286)
Sequences: 79739 (57752)
Seq/√Len: 3414.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_E79_Q3.6351.00
20_H29_E3.3411.00
158_E289_L2.6041.00
16_A29_E2.5271.00
72_D86_K2.5221.00
99_S141_V2.4021.00
159_K266_A2.3261.00
50_L65_E2.2241.00
159_K162_A2.2081.00
162_A266_A2.1951.00
95_A126_R2.1861.00
15_D74_K2.1461.00
115_S291_K2.1311.00
173_L189_H2.1151.00
13_V40_Q2.0981.00
230_A237_A2.0961.00
15_D19_R2.0821.00
166_L241_N2.0761.00
72_D79_Q2.0621.00
95_A124_D2.0331.00
16_A20_H1.9981.00
115_S287_W1.9951.00
162_A264_K1.9851.00
164_Y241_N1.9831.00
231_I252_R1.9691.00
182_T185_D1.9541.00
97_T126_R1.9091.00
25_R28_E1.8961.00
16_A19_R1.8921.00
18_A62_L1.8781.00
227_L247_E1.8401.00
15_D70_F1.8401.00
166_L255_C1.8361.00
70_F74_K1.8251.00
192_L235_G1.8221.00
231_I247_E1.8201.00
76_I80_L1.8161.00
13_V37_V1.8071.00
19_R74_K1.7931.00
169_C256_P1.7491.00
190_T217_G1.7271.00
18_A70_F1.7241.00
157_V268_Y1.7181.00
54_R61_L1.6751.00
68_S86_K1.6731.00
135_D140_D1.6351.00
20_H25_R1.6301.00
72_D75_E1.6281.00
69_Y83_A1.5981.00
156_R273_D1.5611.00
22_S25_R1.5501.00
158_E271_C1.5381.00
10_A47_F1.5311.00
15_D73_I1.5281.00
201_Q205_R1.5011.00
10_A40_Q1.4901.00
23_F41_I1.4781.00
19_R29_E1.4711.00
10_A43_S1.4671.00
271_C285_R1.4611.00
285_R289_L1.4601.00
134_E138_A1.4521.00
106_I224_A1.4491.00
56_R61_L1.4401.00
72_D82_E1.4351.00
33_T36_A1.4311.00
119_A287_W1.4301.00
146_F270_V1.4281.00
16_A30_L1.4281.00
79_Q82_E1.4151.00
51_K54_R1.4101.00
178_K185_D1.4071.00
156_R271_C1.4051.00
116_F284_F1.4011.00
135_D141_V1.3971.00
148_G268_Y1.3871.00
14_F70_F1.3751.00
202_T205_R1.3691.00
7_P10_A1.3631.00
283_A286_Q1.3531.00
24_T34_Q1.3521.00
136_K144_A1.3491.00
13_V32_V1.3461.00
76_I83_A1.3421.00
97_T128_Q1.3401.00
91_S122_G1.3261.00
71_L75_E1.3261.00
93_K122_G1.3201.00
277_E281_I1.3191.00
269_L285_R1.3161.00
116_F123_I1.3121.00
69_Y84_T1.3061.00
115_S119_A1.2931.00
15_D77_F1.2931.00
143_V269_L1.2911.00
72_D83_A1.2891.00
163_E242_V1.2871.00
8_L80_L1.2831.00
247_E252_R1.2801.00
228_Q231_I1.2791.00
64_E67_Q1.2711.00
226_V237_A1.2691.00
137_L154_G1.2681.00
159_K268_Y1.2631.00
32_V36_A1.2611.00
171_P252_R1.2551.00
171_P254_V1.2551.00
169_C236_V1.2361.00
189_H236_V1.2331.00
39_H43_S1.2311.00
117_N217_G1.2181.00
68_S71_L1.2171.00
114_S232_H1.2101.00
117_N190_T1.2041.00
68_S72_D1.2031.00
114_S118_S1.2011.00
241_N255_C1.1971.00
14_F53_F1.1801.00
143_V281_I1.1801.00
180_L259_D1.1721.00
157_V270_V1.1611.00
14_F18_A1.1531.00
241_N245_Q1.1451.00
111_P232_H1.1421.00
174_L189_H1.1361.00
75_E82_E1.1261.00
130_V135_D1.1161.00
255_C258_N1.1131.00
120_Y283_A1.1111.00
39_H42_K1.1101.00
67_Q71_L1.1061.00
228_Q232_H1.1031.00
11_L73_I1.1021.00
287_W291_K1.0991.00
181_K185_D1.0981.00
158_E285_R1.0981.00
190_T215_Q1.0951.00
179_P254_V1.0941.00
245_Q249_E1.0831.00
126_R219_I1.0801.00
227_L231_I1.0731.00
16_A26_A1.0651.00
42_K46_D1.0551.00
40_Q43_S1.0531.00
84_T88_Q1.0531.00
47_F84_T1.0501.00
76_I79_Q1.0501.00
137_L152_W1.0441.00
164_Y264_K1.0441.00
23_F60_L1.0391.00
246_S250_A1.0391.00
128_Q135_D1.0381.00
168_V255_C1.0381.00
287_W290_A1.0311.00
286_Q289_L1.0271.00
112_R288_I1.0261.00
282_A286_Q1.0221.00
115_S118_S1.0191.00
9_N12_R1.0171.00
105_A129_A1.0151.00
38_S42_K1.0141.00
200_W204_T1.0111.00
78_S82_E1.0111.00
272_H275_Q1.0081.00
170_S233_G0.9991.00
193_H216_Q0.9951.00
14_F52_L0.9941.00
116_F287_W0.9751.00
17_A26_A0.9731.00
96_L284_F0.9671.00
220_F226_V0.9661.00
192_L226_V0.9651.00
69_Y73_I0.9651.00
43_S46_D0.9611.00
17_A23_F0.9541.00
75_E78_S0.9521.00
80_L84_T0.9501.00
26_A37_V0.9441.00
62_L66_G0.9381.00
18_A53_F0.9341.00
25_R29_E0.9331.00
116_F120_Y0.9301.00
168_V244_A0.9281.00
32_V37_V0.9281.00
135_D138_A0.9281.00
207_L212_I0.9241.00
81_T84_T0.9211.00
183_P260_V0.9191.00
167_P236_V0.9141.00
220_F229_A0.9131.00
169_C173_L0.9121.00
102_P222_H0.9091.00
12_R81_T0.9071.00
13_V30_L0.9011.00
14_F44_L0.9011.00
14_F62_L0.9001.00
9_N40_Q0.8951.00
21_L61_L0.8891.00
50_L87_L0.8811.00
119_A290_A0.8781.00
112_R287_W0.8771.00
81_T85_R0.8761.00
156_R159_K0.8751.00
278_L281_I0.8741.00
114_S234_Q0.8731.00
65_E68_S0.8721.00
99_S144_A0.8711.00
112_R291_K0.8691.00
173_L176_G0.8581.00
247_E250_A0.8581.00
148_G266_A0.8571.00
82_E86_K0.8571.00
71_L74_K0.8561.00
65_E87_L0.8561.00
80_L83_A0.8501.00
24_T28_E0.8491.00
53_F60_L0.8481.00
94_G280_K0.8451.00
117_N234_Q0.8381.00
56_R59_S0.8351.00
279_G283_A0.8281.00
12_R16_A0.8281.00
20_H26_A0.8251.00
202_T206_Q0.8241.00
6_P47_F0.8241.00
18_A21_L0.8221.00
79_Q83_A0.8201.00
30_L37_V0.8181.00
141_V144_A0.8181.00
19_R70_F0.8161.00
21_L59_S0.8121.00
175_T189_H0.8121.00
99_S146_F0.8121.00
34_Q38_S0.8101.00
177_E190_T0.8091.00
124_D215_Q0.8051.00
74_K78_S0.8001.00
277_E282_A0.8001.00
98_V143_V0.8001.00
190_T216_Q0.7971.00
123_I280_K0.7921.00
17_A53_F0.7911.00
67_Q70_F0.7881.00
174_L179_P0.7871.00
14_F69_Y0.7861.00
164_Y262_V0.7841.00
128_Q141_V0.7831.00
184_E187_A0.7801.00
182_T259_D0.7781.00
83_A87_L0.7771.00
18_A66_G0.7751.00
185_D188_K0.7731.00
187_A212_I0.7731.00
170_S234_Q0.7691.00
10_A13_V0.7661.00
42_K51_K0.7661.00
155_L270_V0.7641.00
21_L67_Q0.7641.00
229_A234_Q0.7641.00
100_L105_A0.7621.00
169_C174_L0.7611.00
12_R15_D0.7591.00
8_L77_F0.7591.00
17_A37_V0.7581.00
139_D272_H0.7551.00
73_I76_I0.7521.00
23_F37_V0.7521.00
244_A247_E0.7491.00
168_V237_A0.7491.00
54_R63_T0.7471.00
172_L233_G0.7461.00
164_Y257_F0.7421.00
283_A287_W0.7401.00
170_S173_L0.7381.00
275_Q278_L0.7351.00
176_G254_V0.7351.00
222_H225_M0.7341.00
286_Q290_A0.7321.00
119_A283_A0.7221.00
168_V239_A0.7211.00
116_F283_A0.7191.00
64_E68_S0.7171.00
191_L214_V0.7141.00
143_V284_F0.7131.00
142_D281_I0.7121.00
17_A41_I0.7081.00
173_L177_E0.7061.00
168_V248_I0.7061.00
200_W203_Y0.7061.00
65_E69_Y0.7061.00
106_I228_Q0.7041.00
137_L155_L0.6971.00
94_G123_I0.6971.00
195_A219_I0.6971.00
200_W206_Q0.6961.00
172_L176_G0.6941.00
69_Y87_L0.6931.00
173_L190_T0.6931.00
111_P114_S0.6921.00
97_T142_D0.6921.00
180_L257_F0.6881.00
12_R77_F0.6851.00
201_Q206_Q0.6811.00
72_D76_I0.6811.00
240_N243_M0.6801.00
92_A120_Y0.6781.00
9_N43_S0.6781.00
182_T260_V0.6781.00
169_C254_V0.6781.00
115_S290_A0.6761.00
154_G273_D0.6721.00
191_L236_V0.6721.00
14_F66_G0.6711.00
244_A248_I0.6701.00
62_L67_Q0.6681.00
54_R59_S0.6681.00
203_Y206_Q0.6661.00
167_P238_L0.6591.00
248_I255_C0.6581.00
36_A40_Q0.6561.00
124_D219_I0.6551.00
28_E31_F0.6551.00
194_D226_V0.6531.00
248_I251_G0.6531.00
172_L175_T0.6501.00
61_L67_Q0.6491.00
169_C175_T0.6481.00
195_A221_S0.6431.00
6_P84_T0.6421.00
97_T141_V0.6411.00
279_G282_A0.6371.00
82_E85_R0.6341.00
147_Y265_N0.6311.00
109_L112_R0.6301.00
218_P229_A0.6271.00
18_A67_Q0.6201.00
231_I250_A0.6191.00
45_E55_R0.6181.00
48_L69_Y0.6181.00
111_P115_S0.6181.00
129_A221_S0.6181.00
78_S81_T0.6171.00
77_F81_T0.6141.00
246_S249_E0.6111.00
206_Q209_L0.6061.00
184_E210_N0.6021.00
17_A22_S0.6021.00
143_V285_R0.6021.00
167_P186_L0.5971.00
9_N13_V0.5951.00
50_L54_R0.5921.00
41_I45_E0.5901.00
85_R89_A0.5871.00
220_F225_M0.5811.00
271_C282_A0.5811.00
68_S87_L0.5801.00
96_L143_V0.5791.00
102_P131_D0.5761.00
100_L109_L0.5761.00
48_L87_L0.5751.00
26_A30_L0.5751.00
171_P251_G0.5741.00
188_K215_Q0.5741.00
45_E50_L0.5721.00
200_W205_R0.5711.00
163_E265_N0.5671.00
23_F34_Q0.5671.00
7_P47_F0.5651.00
136_K155_L0.5641.00
120_Y123_I0.5641.00
160_L269_L0.5611.00
284_F288_I0.5611.00
110_V114_S0.5601.00
36_A39_H0.5581.00
239_A244_A0.5561.00
73_I77_F0.5531.00
53_F62_L0.5511.00
148_G157_V0.5511.00
48_L51_K0.5501.00
93_K124_D0.5491.00
226_V230_A0.5491.00
7_P43_S0.5471.00
165_L238_L0.5471.00
172_L254_V0.5471.00
173_L236_V0.5461.00
137_L140_D0.5461.00
111_P228_Q0.5451.00
174_L178_K0.5451.00
32_V40_Q0.5451.00
114_S117_N0.5441.00
35_A39_H0.5431.00
280_K283_A0.5421.00
86_K89_A0.5411.00
187_A213_N0.5401.00
167_P191_L0.5371.00
94_G122_G0.5361.00
89_A92_A0.5351.00
96_L280_K0.5351.00
207_L210_N0.5331.00
83_A86_K0.5331.00
21_L60_L0.5311.00
108_W112_R0.5301.00
99_S130_V0.5301.00
223_S240_N0.5301.00
252_R255_C0.5251.00
281_I285_R0.5241.00
85_R88_Q0.5221.00
175_T181_K0.5201.00
134_E140_D0.5191.00
62_L70_F0.5181.00
99_S128_Q0.5161.00
129_A222_H0.5161.00
136_K270_V0.5161.00
106_I222_H0.5151.00
33_T39_H0.5151.00
51_K65_E0.5151.00
224_A228_Q0.5141.00
35_A38_S0.5121.00
271_C277_E0.5121.00
204_T207_L0.5101.00
23_F59_S0.5101.00
205_R208_G0.5071.00
104_F108_W0.5061.00
13_V41_I0.5051.00
229_A235_G0.5051.00
288_I291_K0.5051.00
15_D81_T0.5021.00
101_L104_F0.5021.00
282_A285_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uthA 2 0.7246 100 0.136 Contact Map
3fzvA 4 0.9311 100 0.14 Contact Map
2esnA 3 0.9541 100 0.141 Contact Map
3szpA 3 0.941 100 0.143 Contact Map
3fxqA 3 0.941 100 0.149 Contact Map
1ixcA 4 0.9377 100 0.153 Contact Map
3hhgA 3 0.9541 100 0.162 Contact Map
4x6gA 4 0.9836 100 0.162 Contact Map
1al3A 1 0.7049 100 0.164 Contact Map
2h9bA 2 0.6852 100 0.171 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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