CYSB - ECOLI - GREMLIN Contacts

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CYSB - HTH-type transcriptional regulator CysB

UniProt:	P0A9F3	Sequences: MKLQQLRYIVEVVNHNLNVSSTAEGLYTSQPGISKQVRMLEDELGIQIFSRSGKHLTQVTPAGQEIIRIAREVLSKVDAIKSVAGEHTWPDKGSLYIATTHTQARYALPNVIKGFIERYPRVSLHMHQGSPTQIADAVSKGNADFAIATEALHLYEDLVMLPCYHWNRAIVVTPDHPLAGKKAITIEELAQYPLVTYTFGFTGRSELDTAFNRAGLTPRIVFTATDADVIKTYVRLGLGVGVIASMAVDPVADPDLVRVDAHDIFSHSTTKIGFRRSTFLRSYMYDFIQRFAPHLTRDVVDAAVALRSNEEIEVMFKDIKLPEK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10184
Length:	324 (289)
Sequences:	79346 (57793)
Seq/√Len:	3399.6

ECOLI - CYSB CBL OXYR YBHD LYSR CYNR AAER YFER NAC TDCA YDHB TTDR YAFC HCAR METR PGRR YAHB ABGR DMLR YEEY YNFL ILVY LEUO YHJC YDCI YCAN YEIE ALLS YBDO YIAU YFIE XAPR YBEF DSDC YNEJ NHAR GCVA ICIA YGFI YIDZ YHAJ YJIE LRHA PERR HDFR
BACSU - YWBI YCGK CYSL GLTC YYBE YTLI ALSR BSDA GLTR CITR YWQM YVBU YUST YOFA YXJO YKUM CZCR YOAU YRAN

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
72_E	76_K	3.571	1.00
15_H	25_G	3.408	1.00
161_L	292_A	2.702	1.00
98_A	143_A	2.544	1.00
69_I	83_V	2.417	1.00
234_V	241_G	2.312	1.00
114_G	294_H	2.244	1.00
176_H	192_Y	2.232	1.00
167_N	245_S	2.228	1.00
11_E	25_G	2.221	1.00
165_H	269_T	2.187	1.00
162_P	165_H	2.173	1.00
94_S	125_H	2.158	1.00
21_S	24_E	2.125	1.00
14_N	71_R	2.108	1.00
162_P	269_T	2.094	1.00
94_S	123_S	2.091	1.00
231_K	251_V	2.040	1.00
185_T	188_E	2.032	1.00
8_Y	36_Q	2.019	1.00
46_I	62_A	2.010	1.00
235_R	255_D	1.994	1.00
10_V	67_I	1.989	1.00
165_H	267_H	1.966	1.00
96_Y	125_H	1.953	1.00
114_G	290_R	1.950	1.00
69_I	76_K	1.950	1.00
10_V	71_R	1.916	1.00
11_E	14_N	1.903	1.00
195_V	239_G	1.888	1.00
8_Y	33_I	1.882	1.00
13_V	59_V	1.881	1.00
73_V	77_V	1.878	1.00
172_V	259_V	1.877	1.00
19_V	37_V	1.876	1.00
11_E	15_H	1.869	1.00
10_V	14_N	1.858	1.00
169_A	245_S	1.825	1.00
67_I	71_R	1.810	1.00
50_S	58_Q	1.723	1.00
66_I	80_I	1.718	1.00
193_P	221_V	1.710	1.00
169_A	258_R	1.694	1.00
235_R	251_V	1.685	1.00
134_I	146_A	1.677	1.00
137_A	142_N	1.668	1.00
160_M	271_K	1.666	1.00
65_E	83_V	1.660	1.00
115_F	287_F	1.640	1.00
14_N	25_G	1.607	1.00
181_K	188_E	1.592	1.00
13_V	67_I	1.585	1.00
9_I	67_I	1.568	1.00
15_H	21_S	1.566	1.00
10_V	70_A	1.563	1.00
159_V	276_R	1.542	1.00
90_P	121_R	1.541	1.00
136_D	140_K	1.535	1.00
8_Y	28_T	1.533	1.00
115_F	122_V	1.522	1.00
20_S	30_Q	1.514	1.00
61_P	64_Q	1.500	1.00
5_Q	36_Q	1.483	1.00
29_S	32_G	1.466	1.00
5_Q	43_E	1.448	1.00
161_L	274_F	1.448	1.00
5_Q	39_M	1.436	1.00
18_N	21_S	1.435	1.00
47_Q	50_S	1.433	1.00
204_R	208_D	1.417	1.00
10_V	74_L	1.416	1.00
11_E	26_L	1.416	1.00
69_I	72_E	1.412	1.00
288_I	292_A	1.406	1.00
174_P	255_D	1.383	1.00
150_E	271_K	1.381	1.00
148_A	273_G	1.380	1.00
69_I	79_A	1.374	1.00
159_V	274_F	1.370	1.00
73_V	80_I	1.366	1.00
105_R	228_D	1.359	1.00
114_G	118_R	1.336	1.00
92_K	121_R	1.335	1.00
274_F	288_I	1.335	1.00
145_F	284_M	1.332	1.00
286_D	289_Q	1.322	1.00
272_I	288_I	1.317	1.00
96_Y	127_H	1.308	1.00
280_L	284_M	1.293	1.00
66_I	81_K	1.291	1.00
43_E	81_K	1.279	1.00
129_G	133_Q	1.277	1.00
139_S	157_D	1.272	1.00
145_F	272_I	1.272	1.00
166_W	246_M	1.266	1.00
172_V	240_V	1.266	1.00
137_A	143_A	1.263	1.00
230_I	241_G	1.259	1.00
192_Y	240_V	1.256	1.00
3_L	77_V	1.255	1.00
116_I	221_V	1.254	1.00
118_R	290_R	1.235	1.00
76_K	79_A	1.230	1.00
245_S	249_D	1.228	1.00
64_Q	68_R	1.212	1.00
38_R	42_D	1.209	1.00
68_R	72_E	1.207	1.00
245_S	258_R	1.201	1.00
251_V	255_D	1.198	1.00
69_I	80_I	1.190	1.00
174_P	257_V	1.186	1.00
232_T	235_R	1.184	1.00
116_I	193_P	1.180	1.00
65_E	68_R	1.179	1.00
114_G	117_E	1.171	1.00
113_K	117_E	1.169	1.00
9_I	49_F	1.167	1.00
162_P	271_K	1.166	1.00
211_F	216_L	1.164	1.00
177_P	192_Y	1.161	1.00
182_K	257_V	1.157	1.00
160_M	273_G	1.156	1.00
195_V	230_I	1.154	1.00
28_T	32_G	1.131	1.00
95_L	287_F	1.129	1.00
9_I	48_I	1.124	1.00
249_D	252_A	1.115	1.00
35_K	39_M	1.113	1.00
35_K	38_R	1.112	1.00
125_H	223_T	1.111	1.00
9_I	13_V	1.103	1.00
34_S	38_R	1.098	1.00
113_K	236_L	1.098	1.00
52_S	58_Q	1.096	1.00
12_V	22_T	1.096	1.00
7_R	78_D	1.094	1.00
193_P	219_R	1.087	1.00
19_V	56_L	1.086	1.00
115_F	290_R	1.084	1.00
119_Y	286_D	1.077	1.00
289_Q	292_A	1.077	1.00
171_V	258_R	1.075	1.00
72_E	79_A	1.074	1.00
290_R	294_H	1.074	1.00
224_A	230_I	1.073	1.00
275_R	278_T	1.068	1.00
183_A	262_H	1.064	1.00
104_A	128_Q	1.056	1.00
11_E	22_T	1.056	1.00
73_V	76_K	1.053	1.00
6_L	70_A	1.050	1.00
285_Y	289_Q	1.049	1.00
129_G	137_A	1.047	1.00
138_V	146_A	1.043	1.00
111_V	291_F	1.034	1.00
173_T	237_G	1.030	1.00
59_V	63_G	1.029	1.00
161_L	288_I	1.022	1.00
65_E	69_I	1.021	1.00
4_Q	7_R	1.021	1.00
36_Q	39_M	1.016	1.00
258_R	261_A	1.016	1.00
110_N	236_L	1.012	1.00
232_T	236_L	1.010	1.00
139_S	155_Y	1.010	1.00
171_V	248_V	1.009	1.00
184_I	188_E	1.007	1.00
205_S	208_D	1.003	1.00
231_K	235_R	1.002	1.00
81_K	85_G	0.990	1.00
170_I	240_V	0.987	1.00
55_H	58_Q	0.986	1.00
78_D	82_S	0.983	1.00
8_Y	26_L	0.980	1.00
186_I	263_D	0.977	1.00
152_L	155_Y	0.976	1.00
13_V	49_F	0.974	1.00
250_P	253_D	0.971	1.00
167_N	267_H	0.966	1.00
115_F	119_Y	0.965	1.00
78_D	81_K	0.962	1.00
28_T	33_I	0.960	1.00
172_V	176_H	0.951	1.00
196_T	220_I	0.949	1.00
118_R	293_P	0.946	1.00
75_S	79_A	0.945	1.00
66_I	70_A	0.945	1.00
290_R	293_P	0.940	1.00
12_V	19_V	0.937	1.00
9_I	59_V	0.932	1.00
224_A	233_Y	0.927	1.00
49_F	56_L	0.924	1.00
157_D	276_R	0.917	1.00
13_V	63_G	0.916	1.00
176_H	193_P	0.915	1.00
111_V	290_R	0.915	1.00
281_R	284_M	0.911	1.00
127_H	137_A	0.909	1.00
9_I	40_L	0.909	1.00
22_T	33_I	0.907	1.00
176_H	179_A	0.901	1.00
137_A	140_K	0.899	1.00
46_I	84_A	0.898	1.00
123_S	219_R	0.895	1.00
133_Q	136_D	0.892	1.00
39_M	42_D	0.889	1.00
17_L	58_Q	0.880	1.00
98_A	148_A	0.880	1.00
143_A	146_A	0.874	1.00
65_E	87_H	0.874	1.00
248_V	251_V	0.872	1.00
68_R	71_R	0.872	1.00
21_S	25_G	0.867	1.00
122_V	283_Y	0.865	1.00
172_V	177_P	0.859	1.00
101_H	226_D	0.855	1.00
150_E	269_T	0.851	1.00
20_S	24_E	0.848	1.00
193_P	220_I	0.845	1.00
188_E	191_Q	0.845	1.00
171_V	241_G	0.843	1.00
97_I	145_F	0.839	1.00
289_Q	293_P	0.833	1.00
72_E	75_S	0.832	1.00
158_L	273_G	0.828	1.00
176_H	180_G	0.827	1.00
180_G	193_P	0.827	1.00
52_S	55_H	0.827	1.00
159_V	162_P	0.819	1.00
177_P	182_K	0.818	1.00
98_A	146_A	0.816	1.00
62_A	87_H	0.815	1.00
194_L	218_P	0.811	1.00
207_L	211_F	0.810	1.00
26_L	33_I	0.809	1.00
127_H	143_A	0.808	1.00
210_A	214_A	0.804	1.00
17_L	64_Q	0.793	1.00
12_V	37_V	0.791	1.00
9_I	66_I	0.789	1.00
62_A	84_A	0.789	1.00
93_G	283_Y	0.789	1.00
205_S	209_T	0.788	1.00
13_V	17_L	0.787	1.00
187_E	190_A	0.786	1.00
38_R	47_Q	0.782	1.00
98_A	134_I	0.780	1.00
91_D	119_Y	0.777	1.00
76_K	80_I	0.775	1.00
178_L	192_Y	0.773	1.00
113_K	238_L	0.773	1.00
12_V	49_F	0.772	1.00
93_G	122_V	0.763	1.00
14_N	67_I	0.762	1.00
30_Q	34_S	0.762	1.00
145_F	287_F	0.761	1.00
58_Q	64_Q	0.756	1.00
135_A	139_S	0.755	1.00
173_T	238_L	0.752	1.00
175_D	179_A	0.752	1.00
77_V	80_I	0.746	1.00
282_S	286_D	0.746	1.00
15_H	22_T	0.746	1.00
59_V	64_Q	0.745	1.00
4_Q	36_Q	0.744	1.00
233_Y	238_L	0.743	1.00
167_N	260_D	0.740	1.00
118_R	286_D	0.740	1.00
116_I	238_L	0.739	1.00
17_L	55_H	0.738	1.00
111_V	294_H	0.738	1.00
79_A	83_V	0.736	1.00
171_V	243_I	0.735	1.00
235_R	253_D	0.732	1.00
77_V	81_K	0.732	1.00
129_G	134_I	0.729	1.00
185_T	262_H	0.728	1.00
114_G	293_P	0.726	1.00
62_A	65_E	0.718	1.00
139_S	158_L	0.716	1.00
80_I	84_A	0.714	1.00
5_Q	8_Y	0.714	1.00
3_L	74_L	0.713	1.00
70_A	73_V	0.713	1.00
19_V	33_I	0.709	1.00
115_F	286_D	0.708	1.00
7_R	11_E	0.707	1.00
96_Y	143_A	0.707	1.00
209_T	213_R	0.707	1.00
190_A	216_L	0.706	1.00
85_G	88_T	0.706	1.00
204_R	223_T	0.703	1.00
32_G	36_Q	0.701	1.00
244_A	247_A	0.699	1.00
172_V	257_V	0.698	1.00
179_A	257_V	0.698	1.00
12_V	33_I	0.696	1.00
50_S	55_H	0.695	1.00
50_S	60_T	0.692	1.00
185_T	263_D	0.691	1.00
210_A	213_R	0.683	1.00
207_L	210_A	0.682	1.00
147_I	291_F	0.682	1.00
99_T	104_A	0.682	1.00
144_D	284_M	0.681	1.00
173_T	176_H	0.680	1.00
71_R	75_S	0.678	1.00
226_D	229_V	0.677	1.00
96_Y	144_D	0.676	1.00
172_V	178_L	0.673	1.00
205_S	210_A	0.670	1.00
62_A	66_I	0.667	1.00
278_T	281_R	0.666	1.00
280_L	285_Y	0.665	1.00
222_F	233_Y	0.665	1.00
191_Q	219_R	0.663	1.00
183_A	260_D	0.661	1.00
19_V	55_H	0.661	1.00
141_G	275_R	0.659	1.00
95_L	283_Y	0.657	1.00
99_T	108_L	0.656	1.00
75_S	78_D	0.656	1.00
198_T	223_T	0.652	1.00
41_E	46_I	0.649	1.00
70_A	74_L	0.648	1.00
209_T	212_N	0.646	1.00
197_Y	230_I	0.646	1.00
61_P	65_E	0.646	1.00
211_F	218_P	0.645	1.00
64_Q	67_I	0.645	1.00
208_D	212_N	0.643	1.00
286_D	290_R	0.642	1.00
174_P	254_P	0.642	1.00
206_E	210_A	0.637	1.00
178_L	181_K	0.635	1.00
79_A	82_S	0.634	1.00
123_S	223_T	0.632	1.00
167_N	264_I	0.632	1.00
66_I	84_A	0.632	1.00
22_T	26_L	0.627	1.00
175_D	237_G	0.625	1.00
170_I	189_L	0.624	1.00
12_V	18_N	0.623	1.00
133_Q	137_A	0.621	1.00
187_E	214_A	0.621	1.00
175_D	257_V	0.620	1.00
41_E	51_R	0.619	1.00
194_L	240_V	0.619	1.00
24_E	27_Y	0.618	1.00
105_R	232_T	0.618	1.00
92_K	123_S	0.618	1.00
208_D	211_F	0.617	1.00
7_R	10_V	0.616	1.00
37_V	41_E	0.614	1.00
164_Y	270_T	0.611	1.00
139_S	142_N	0.610	1.00
175_D	178_L	0.609	1.00
69_I	73_V	0.605	1.00
128_Q	225_T	0.604	1.00
65_E	84_A	0.598	1.00
282_S	285_Y	0.597	1.00
4_Q	39_M	0.595	1.00
198_T	225_T	0.594	1.00
178_L	184_I	0.594	1.00
145_F	288_I	0.593	1.00
136_D	139_S	0.589	1.00
108_L	111_V	0.585	1.00
95_L	145_F	0.585	1.00
170_I	242_V	0.585	1.00
170_I	194_L	0.585	1.00
159_V	277_S	0.581	1.00
82_S	86_E	0.580	1.00
287_F	291_F	0.579	1.00
59_V	67_I	0.577	1.00
230_I	234_V	0.576	1.00
149_T	268_S	0.575	1.00
233_Y	239_G	0.574	1.00
128_Q	226_D	0.571	1.00
136_D	142_N	0.570	1.00
110_N	114_G	0.568	1.00
31_P	35_K	0.567	1.00
224_A	229_V	0.562	1.00
112_I	124_L	0.561	1.00
32_G	35_K	0.559	1.00
261_A	264_I	0.557	1.00
44_L	66_I	0.556	1.00
203_G	207_L	0.553	1.00
168_R	242_V	0.553	1.00
46_I	50_S	0.553	1.00
44_L	84_A	0.552	1.00
103_Q	107_A	0.552	1.00
166_W	268_S	0.550	1.00
4_Q	8_Y	0.549	1.00
206_E	209_T	0.548	1.00
29_S	35_K	0.547	1.00
274_F	285_Y	0.545	1.00
177_P	181_K	0.544	1.00
49_F	59_V	0.541	1.00
110_N	113_K	0.540	1.00
243_I	248_V	0.537	1.00
138_V	158_L	0.536	1.00
199_F	223_T	0.534	1.00
44_L	47_Q	0.534	1.00
183_A	188_E	0.533	1.00
68_R	83_V	0.533	1.00
7_R	74_L	0.532	1.00
74_L	77_V	0.528	1.00
176_H	240_V	0.528	1.00
181_K	184_I	0.527	1.00
227_A	244_A	0.526	1.00
8_Y	37_V	0.525	1.00
138_V	273_G	0.523	1.00
37_V	49_F	0.522	1.00
98_A	127_H	0.522	1.00
177_P	180_G	0.521	1.00
147_I	272_I	0.520	1.00
204_R	207_L	0.516	1.00
163_C	272_I	0.516	1.00
119_Y	122_V	0.515	1.00
150_E	160_M	0.515	1.00
74_L	78_D	0.514	1.00
70_A	77_V	0.510	1.00
93_G	119_Y	0.509	1.00
93_G	121_R	0.508	1.00
204_R	210_A	0.507	1.00
8_Y	22_T	0.507	1.00
105_R	226_D	0.505	1.00
6_L	66_I	0.504	1.00
131_P	148_A	0.504	1.00
47_Q	62_A	0.501	1.00
284_M	288_I	0.501	1.00
19_V	51_R	0.500	1.00
17_L	56_L	0.500	1.00
28_T	36_Q	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1al3A	1	0.7315	100	0.096	Contact Map
1ixcA	4	0.9012	100	0.154	Contact Map
2esnA	3	0.9012	100	0.157	Contact Map
4x6gA	4	0.9321	100	0.158	Contact Map
1uthA	2	0.6975	100	0.159	Contact Map
3fzvA	4	0.8827	100	0.16	Contact Map
2h98A	2	0.6543	100	0.164	Contact Map
3fxqA	3	0.9012	100	0.166	Contact Map
2h9bA	2	0.6574	100	0.166	Contact Map
3szpA	3	0.892	100	0.183	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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