GREMLIN Database
CYSB - HTH-type transcriptional regulator CysB
UniProt: P0A9F3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10184
Length: 324 (289)
Sequences: 79346 (57793)
Seq/√Len: 3399.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_E76_K3.5711.00
15_H25_G3.4081.00
161_L292_A2.7021.00
98_A143_A2.5441.00
69_I83_V2.4171.00
234_V241_G2.3121.00
114_G294_H2.2441.00
176_H192_Y2.2321.00
167_N245_S2.2281.00
11_E25_G2.2211.00
165_H269_T2.1871.00
162_P165_H2.1731.00
94_S125_H2.1581.00
21_S24_E2.1251.00
14_N71_R2.1081.00
162_P269_T2.0941.00
94_S123_S2.0911.00
231_K251_V2.0401.00
185_T188_E2.0321.00
8_Y36_Q2.0191.00
46_I62_A2.0101.00
235_R255_D1.9941.00
10_V67_I1.9891.00
165_H267_H1.9661.00
96_Y125_H1.9531.00
114_G290_R1.9501.00
69_I76_K1.9501.00
10_V71_R1.9161.00
11_E14_N1.9031.00
195_V239_G1.8881.00
8_Y33_I1.8821.00
13_V59_V1.8811.00
73_V77_V1.8781.00
172_V259_V1.8771.00
19_V37_V1.8761.00
11_E15_H1.8691.00
10_V14_N1.8581.00
169_A245_S1.8251.00
67_I71_R1.8101.00
50_S58_Q1.7231.00
66_I80_I1.7181.00
193_P221_V1.7101.00
169_A258_R1.6941.00
235_R251_V1.6851.00
134_I146_A1.6771.00
137_A142_N1.6681.00
160_M271_K1.6661.00
65_E83_V1.6601.00
115_F287_F1.6401.00
14_N25_G1.6071.00
181_K188_E1.5921.00
13_V67_I1.5851.00
9_I67_I1.5681.00
15_H21_S1.5661.00
10_V70_A1.5631.00
159_V276_R1.5421.00
90_P121_R1.5411.00
136_D140_K1.5351.00
8_Y28_T1.5331.00
115_F122_V1.5221.00
20_S30_Q1.5141.00
61_P64_Q1.5001.00
5_Q36_Q1.4831.00
29_S32_G1.4661.00
5_Q43_E1.4481.00
161_L274_F1.4481.00
5_Q39_M1.4361.00
18_N21_S1.4351.00
47_Q50_S1.4331.00
204_R208_D1.4171.00
10_V74_L1.4161.00
11_E26_L1.4161.00
69_I72_E1.4121.00
288_I292_A1.4061.00
174_P255_D1.3831.00
150_E271_K1.3811.00
148_A273_G1.3801.00
69_I79_A1.3741.00
159_V274_F1.3701.00
73_V80_I1.3661.00
105_R228_D1.3591.00
114_G118_R1.3361.00
92_K121_R1.3351.00
274_F288_I1.3351.00
145_F284_M1.3321.00
286_D289_Q1.3221.00
272_I288_I1.3171.00
96_Y127_H1.3081.00
280_L284_M1.2931.00
66_I81_K1.2911.00
43_E81_K1.2791.00
129_G133_Q1.2771.00
139_S157_D1.2721.00
145_F272_I1.2721.00
166_W246_M1.2661.00
172_V240_V1.2661.00
137_A143_A1.2631.00
230_I241_G1.2591.00
192_Y240_V1.2561.00
3_L77_V1.2551.00
116_I221_V1.2541.00
118_R290_R1.2351.00
76_K79_A1.2301.00
245_S249_D1.2281.00
64_Q68_R1.2121.00
38_R42_D1.2091.00
68_R72_E1.2071.00
245_S258_R1.2011.00
251_V255_D1.1981.00
69_I80_I1.1901.00
174_P257_V1.1861.00
232_T235_R1.1841.00
116_I193_P1.1801.00
65_E68_R1.1791.00
114_G117_E1.1711.00
113_K117_E1.1691.00
9_I49_F1.1671.00
162_P271_K1.1661.00
211_F216_L1.1641.00
177_P192_Y1.1611.00
182_K257_V1.1571.00
160_M273_G1.1561.00
195_V230_I1.1541.00
28_T32_G1.1311.00
95_L287_F1.1291.00
9_I48_I1.1241.00
249_D252_A1.1151.00
35_K39_M1.1131.00
35_K38_R1.1121.00
125_H223_T1.1111.00
9_I13_V1.1031.00
34_S38_R1.0981.00
113_K236_L1.0981.00
52_S58_Q1.0961.00
12_V22_T1.0961.00
7_R78_D1.0941.00
193_P219_R1.0871.00
19_V56_L1.0861.00
115_F290_R1.0841.00
119_Y286_D1.0771.00
289_Q292_A1.0771.00
171_V258_R1.0751.00
72_E79_A1.0741.00
290_R294_H1.0741.00
224_A230_I1.0731.00
275_R278_T1.0681.00
183_A262_H1.0641.00
104_A128_Q1.0561.00
11_E22_T1.0561.00
73_V76_K1.0531.00
6_L70_A1.0501.00
285_Y289_Q1.0491.00
129_G137_A1.0471.00
138_V146_A1.0431.00
111_V291_F1.0341.00
173_T237_G1.0301.00
59_V63_G1.0291.00
161_L288_I1.0221.00
65_E69_I1.0211.00
4_Q7_R1.0211.00
36_Q39_M1.0161.00
258_R261_A1.0161.00
110_N236_L1.0121.00
232_T236_L1.0101.00
139_S155_Y1.0101.00
171_V248_V1.0091.00
184_I188_E1.0071.00
205_S208_D1.0031.00
231_K235_R1.0021.00
81_K85_G0.9901.00
170_I240_V0.9871.00
55_H58_Q0.9861.00
78_D82_S0.9831.00
8_Y26_L0.9801.00
186_I263_D0.9771.00
152_L155_Y0.9761.00
13_V49_F0.9741.00
250_P253_D0.9711.00
167_N267_H0.9661.00
115_F119_Y0.9651.00
78_D81_K0.9621.00
28_T33_I0.9601.00
172_V176_H0.9511.00
196_T220_I0.9491.00
118_R293_P0.9461.00
75_S79_A0.9451.00
66_I70_A0.9451.00
290_R293_P0.9401.00
12_V19_V0.9371.00
9_I59_V0.9321.00
224_A233_Y0.9271.00
49_F56_L0.9241.00
157_D276_R0.9171.00
13_V63_G0.9161.00
176_H193_P0.9151.00
111_V290_R0.9151.00
281_R284_M0.9111.00
127_H137_A0.9091.00
9_I40_L0.9091.00
22_T33_I0.9071.00
176_H179_A0.9011.00
137_A140_K0.8991.00
46_I84_A0.8981.00
123_S219_R0.8951.00
133_Q136_D0.8921.00
39_M42_D0.8891.00
17_L58_Q0.8801.00
98_A148_A0.8801.00
143_A146_A0.8741.00
65_E87_H0.8741.00
248_V251_V0.8721.00
68_R71_R0.8721.00
21_S25_G0.8671.00
122_V283_Y0.8651.00
172_V177_P0.8591.00
101_H226_D0.8551.00
150_E269_T0.8511.00
20_S24_E0.8481.00
193_P220_I0.8451.00
188_E191_Q0.8451.00
171_V241_G0.8431.00
97_I145_F0.8391.00
289_Q293_P0.8331.00
72_E75_S0.8321.00
158_L273_G0.8281.00
176_H180_G0.8271.00
180_G193_P0.8271.00
52_S55_H0.8271.00
159_V162_P0.8191.00
177_P182_K0.8181.00
98_A146_A0.8161.00
62_A87_H0.8151.00
194_L218_P0.8111.00
207_L211_F0.8101.00
26_L33_I0.8091.00
127_H143_A0.8081.00
210_A214_A0.8041.00
17_L64_Q0.7931.00
12_V37_V0.7911.00
9_I66_I0.7891.00
62_A84_A0.7891.00
93_G283_Y0.7891.00
205_S209_T0.7881.00
13_V17_L0.7871.00
187_E190_A0.7861.00
38_R47_Q0.7821.00
98_A134_I0.7801.00
91_D119_Y0.7771.00
76_K80_I0.7751.00
178_L192_Y0.7731.00
113_K238_L0.7731.00
12_V49_F0.7721.00
93_G122_V0.7631.00
14_N67_I0.7621.00
30_Q34_S0.7621.00
145_F287_F0.7611.00
58_Q64_Q0.7561.00
135_A139_S0.7551.00
173_T238_L0.7521.00
175_D179_A0.7521.00
77_V80_I0.7461.00
282_S286_D0.7461.00
15_H22_T0.7461.00
59_V64_Q0.7451.00
4_Q36_Q0.7441.00
233_Y238_L0.7431.00
167_N260_D0.7401.00
118_R286_D0.7401.00
116_I238_L0.7391.00
17_L55_H0.7381.00
111_V294_H0.7381.00
79_A83_V0.7361.00
171_V243_I0.7351.00
235_R253_D0.7321.00
77_V81_K0.7321.00
129_G134_I0.7291.00
185_T262_H0.7281.00
114_G293_P0.7261.00
62_A65_E0.7181.00
139_S158_L0.7161.00
80_I84_A0.7141.00
5_Q8_Y0.7141.00
3_L74_L0.7131.00
70_A73_V0.7131.00
19_V33_I0.7091.00
115_F286_D0.7081.00
7_R11_E0.7071.00
96_Y143_A0.7071.00
209_T213_R0.7071.00
190_A216_L0.7061.00
85_G88_T0.7061.00
204_R223_T0.7031.00
32_G36_Q0.7011.00
244_A247_A0.6991.00
172_V257_V0.6981.00
179_A257_V0.6981.00
12_V33_I0.6961.00
50_S55_H0.6951.00
50_S60_T0.6921.00
185_T263_D0.6911.00
210_A213_R0.6831.00
207_L210_A0.6821.00
147_I291_F0.6821.00
99_T104_A0.6821.00
144_D284_M0.6811.00
173_T176_H0.6801.00
71_R75_S0.6781.00
226_D229_V0.6771.00
96_Y144_D0.6761.00
172_V178_L0.6731.00
205_S210_A0.6701.00
62_A66_I0.6671.00
278_T281_R0.6661.00
280_L285_Y0.6651.00
222_F233_Y0.6651.00
191_Q219_R0.6631.00
183_A260_D0.6611.00
19_V55_H0.6611.00
141_G275_R0.6591.00
95_L283_Y0.6571.00
99_T108_L0.6561.00
75_S78_D0.6561.00
198_T223_T0.6521.00
41_E46_I0.6491.00
70_A74_L0.6481.00
209_T212_N0.6461.00
197_Y230_I0.6461.00
61_P65_E0.6461.00
211_F218_P0.6451.00
64_Q67_I0.6451.00
208_D212_N0.6431.00
286_D290_R0.6421.00
174_P254_P0.6421.00
206_E210_A0.6371.00
178_L181_K0.6351.00
79_A82_S0.6341.00
123_S223_T0.6321.00
167_N264_I0.6321.00
66_I84_A0.6321.00
22_T26_L0.6271.00
175_D237_G0.6251.00
170_I189_L0.6241.00
12_V18_N0.6231.00
133_Q137_A0.6211.00
187_E214_A0.6211.00
175_D257_V0.6201.00
41_E51_R0.6191.00
194_L240_V0.6191.00
24_E27_Y0.6181.00
105_R232_T0.6181.00
92_K123_S0.6181.00
208_D211_F0.6171.00
7_R10_V0.6161.00
37_V41_E0.6141.00
164_Y270_T0.6111.00
139_S142_N0.6101.00
175_D178_L0.6091.00
69_I73_V0.6051.00
128_Q225_T0.6041.00
65_E84_A0.5981.00
282_S285_Y0.5971.00
4_Q39_M0.5951.00
198_T225_T0.5941.00
178_L184_I0.5941.00
145_F288_I0.5931.00
136_D139_S0.5891.00
108_L111_V0.5851.00
95_L145_F0.5851.00
170_I242_V0.5851.00
170_I194_L0.5851.00
159_V277_S0.5811.00
82_S86_E0.5801.00
287_F291_F0.5791.00
59_V67_I0.5771.00
230_I234_V0.5761.00
149_T268_S0.5751.00
233_Y239_G0.5741.00
128_Q226_D0.5711.00
136_D142_N0.5701.00
110_N114_G0.5681.00
31_P35_K0.5671.00
224_A229_V0.5621.00
112_I124_L0.5611.00
32_G35_K0.5591.00
261_A264_I0.5571.00
44_L66_I0.5561.00
203_G207_L0.5531.00
168_R242_V0.5531.00
46_I50_S0.5531.00
44_L84_A0.5521.00
103_Q107_A0.5521.00
166_W268_S0.5501.00
4_Q8_Y0.5491.00
206_E209_T0.5481.00
29_S35_K0.5471.00
274_F285_Y0.5451.00
177_P181_K0.5441.00
49_F59_V0.5411.00
110_N113_K0.5401.00
243_I248_V0.5371.00
138_V158_L0.5361.00
199_F223_T0.5341.00
44_L47_Q0.5341.00
183_A188_E0.5331.00
68_R83_V0.5331.00
7_R74_L0.5321.00
74_L77_V0.5281.00
176_H240_V0.5281.00
181_K184_I0.5271.00
227_A244_A0.5261.00
8_Y37_V0.5251.00
138_V273_G0.5231.00
37_V49_F0.5221.00
98_A127_H0.5221.00
177_P180_G0.5211.00
147_I272_I0.5201.00
204_R207_L0.5161.00
163_C272_I0.5161.00
119_Y122_V0.5151.00
150_E160_M0.5151.00
74_L78_D0.5141.00
70_A77_V0.5101.00
93_G119_Y0.5091.00
93_G121_R0.5081.00
204_R210_A0.5071.00
8_Y22_T0.5071.00
105_R226_D0.5051.00
6_L66_I0.5041.00
131_P148_A0.5041.00
47_Q62_A0.5011.00
284_M288_I0.5011.00
19_V51_R0.5001.00
17_L56_L0.5001.00
28_T36_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1al3A 1 0.7315 100 0.096 Contact Map
1ixcA 4 0.9012 100 0.154 Contact Map
2esnA 3 0.9012 100 0.157 Contact Map
4x6gA 4 0.9321 100 0.158 Contact Map
1uthA 2 0.6975 100 0.159 Contact Map
3fzvA 4 0.8827 100 0.16 Contact Map
2h98A 2 0.6543 100 0.164 Contact Map
3fxqA 3 0.9012 100 0.166 Contact Map
2h9bA 2 0.6574 100 0.166 Contact Map
3szpA 3 0.892 100 0.183 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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