MNTR - ECOLI - GREMLIN Contacts

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MNTR - Transcriptional regulator MntR

UniProt:	P0A9F1	Sequences: MSRRAGTPTAKKVTQLVNVEEHVEGFRQVREAHRRELIDDYVELISDLIREVGEARQVDMAARLGVSQPTVAKMLKRLATMGLIEMIPWRGVFLTAEGEKLAQESRERHQIVENFLLVLGVSPEIARRDAEGMEHHVSEETLDAFRLFTQKHGAK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13322
Length:	155 (118)
Sequences:	1856 (1250)
Seq/√Len:	115.0

ECOLI - MNTR
BACSU - MNTR
HALSA - Q9HRU8 Q9HME7 Q9HR69 Q9HRV3
SULSO - Q7LXP0 Q97WF3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
116_L	133_M	3.088	1.00
37_L	70_T	2.940	1.00
113_E	127_R	2.838	1.00
85_E	93_F	2.684	1.00
99_E	103_Q	2.657	1.00
125_I	140_E	2.634	1.00
43_E	109_H	2.554	1.00
57_Q	71_V	2.547	1.00
107_E	146_R	2.483	1.00
45_I	84_I	2.380	1.00
122_S	125_I	2.356	1.00
129_D	138_S	2.073	1.00
75_L	84_I	2.059	1.00
38_I	81_M	1.965	1.00
144_A	147_L	1.962	1.00
83_L	97_E	1.920	1.00
117_L	123_P	1.799	1.00
49_I	99_E	1.711	1.00
73_K	77_R	1.674	1.00
97_E	100_K	1.655	1.00
79_A	86_M	1.650	1.00
137_V	142_L	1.636	1.00
104_E	139_E	1.632	1.00
118_V	148_F	1.528	1.00
66_V	71_V	1.519	1.00
44_L	63_R	1.505	1.00
70_T	74_M	1.459	1.00
86_M	89_W	1.437	1.00
115_F	119_L	1.437	1.00
122_S	140_E	1.434	1.00
51_E	63_R	1.411	1.00
45_I	55_A	1.405	1.00
132_G	136_H	1.359	1.00
49_I	55_A	1.357	1.00
96_A	99_E	1.309	1.00
43_E	131_E	1.270	0.99
44_L	64_L	1.264	0.99
68_Q	74_M	1.257	0.99
38_I	74_M	1.255	0.99
113_E	117_L	1.248	0.99
47_D	106_R	1.236	0.99
112_V	137_V	1.179	0.99
73_K	76_K	1.174	0.99
36_E	40_D	1.169	0.99
121_V	141_T	1.168	0.99
121_V	129_D	1.162	0.99
131_E	134_E	1.161	0.99
59_D	62_A	1.149	0.99
60_M	75_L	1.141	0.99
54_E	91_G	1.098	0.98
57_Q	75_L	1.095	0.98
45_I	71_V	1.091	0.98
60_M	92_V	1.087	0.98
84_I	92_V	1.078	0.98
44_L	60_M	1.077	0.98
72_A	86_M	1.042	0.98
109_H	134_E	1.028	0.97
100_K	104_E	1.021	0.97
48_L	55_A	1.008	0.97
139_E	143_D	1.008	0.97
75_L	92_V	1.002	0.97
49_I	53_G	0.993	0.97
50_R	110_Q	0.986	0.97
35_R	38_I	0.971	0.96
39_D	105_S	0.971	0.96
42_V	46_S	0.970	0.96
34_R	38_I	0.965	0.96
115_F	118_V	0.964	0.96
107_E	111_I	0.958	0.96
131_E	135_H	0.948	0.96
129_D	141_T	0.935	0.96
39_D	135_H	0.927	0.95
119_L	144_A	0.920	0.95
35_R	89_W	0.915	0.95
75_L	86_M	0.913	0.95
85_E	95_T	0.877	0.94
105_S	108_R	0.876	0.94
40_D	135_H	0.871	0.94
110_Q	113_E	0.865	0.93
38_I	76_K	0.864	0.93
115_F	145_F	0.852	0.93
44_L	47_D	0.831	0.92
109_H	131_E	0.824	0.92
87_I	93_F	0.823	0.91
48_L	59_D	0.822	0.91
57_Q	68_Q	0.815	0.91
76_K	80_T	0.811	0.91
64_L	74_M	0.810	0.91
47_D	63_R	0.810	0.91
55_A	60_M	0.805	0.91
40_D	109_H	0.793	0.90
46_S	103_Q	0.790	0.90
115_F	148_F	0.789	0.90
43_E	47_D	0.779	0.89
58_V	68_Q	0.778	0.89
50_R	99_E	0.760	0.88
108_R	139_E	0.759	0.88
112_V	145_F	0.757	0.88
38_I	43_E	0.752	0.87
111_I	123_P	0.746	0.87
129_D	136_H	0.738	0.86
39_D	134_E	0.735	0.86
46_S	106_R	0.728	0.86
41_Y	70_T	0.720	0.85
71_V	75_L	0.718	0.85
115_F	149_T	0.708	0.84
126_A	131_E	0.704	0.84
69_P	145_F	0.694	0.83
110_Q	114_N	0.686	0.82
54_E	93_F	0.685	0.82
111_I	118_V	0.685	0.82
108_R	142_L	0.685	0.82
72_A	76_K	0.681	0.82
117_L	126_A	0.679	0.81
64_L	68_Q	0.677	0.81
40_D	73_K	0.666	0.80
113_E	123_P	0.664	0.80
40_D	131_E	0.663	0.80
57_Q	72_A	0.663	0.80
124_E	147_L	0.658	0.79
123_P	127_R	0.655	0.79
104_E	108_R	0.639	0.77
57_Q	86_M	0.636	0.77
47_D	105_S	0.636	0.77
44_L	48_L	0.627	0.76
45_I	60_M	0.626	0.76
112_V	141_T	0.624	0.76
86_M	90_R	0.623	0.76
119_L	148_F	0.621	0.75
108_R	136_H	0.620	0.75
85_E	96_A	0.610	0.74
40_D	43_E	0.609	0.74
43_E	134_E	0.605	0.73
82_G	97_E	0.604	0.73
129_D	137_V	0.604	0.73
109_H	127_R	0.602	0.73
133_M	136_H	0.598	0.73
46_S	50_R	0.591	0.72
74_M	77_R	0.586	0.71
34_R	81_M	0.584	0.71
60_M	64_L	0.583	0.71
56_R	59_D	0.573	0.69
60_M	71_V	0.562	0.68
137_V	141_T	0.559	0.68
67_S	84_I	0.558	0.67
88_P	115_F	0.557	0.67
143_D	150_Q	0.555	0.67
40_D	134_E	0.551	0.66
130_A	136_H	0.546	0.66
126_A	141_T	0.545	0.66
140_E	144_A	0.544	0.65
59_D	63_R	0.544	0.65
126_A	130_A	0.542	0.65
46_S	102_A	0.542	0.65
46_S	58_V	0.541	0.65
66_V	73_K	0.541	0.65
83_L	101_L	0.538	0.65
77_R	81_M	0.537	0.64
34_R	101_L	0.537	0.64
66_V	70_T	0.536	0.64
35_R	83_L	0.535	0.64
39_D	109_H	0.531	0.64
34_R	42_V	0.529	0.63
111_I	149_T	0.524	0.63
109_H	135_H	0.522	0.62
66_V	74_M	0.518	0.62
42_V	101_L	0.518	0.62
112_V	115_F	0.514	0.61
143_D	147_L	0.514	0.61
56_R	91_G	0.513	0.61
81_M	97_E	0.511	0.61
120_G	144_A	0.510	0.60
34_R	74_M	0.507	0.60
97_E	101_L	0.505	0.60
113_E	126_A	0.502	0.59
112_V	131_E	0.500	0.59
38_I	77_R	0.500	0.59

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1fx7A	4	0.8065	99.9	0.543	Contact Map
4o5vA	2	0.7871	99.9	0.549	Contact Map
2qq9A	2	0.7935	99.9	0.549	Contact Map
3hrsA	2	0.7806	99.9	0.553	Contact Map
2h09A	2	0.8194	99.8	0.592	Contact Map
1on2A	2	0.7871	99.8	0.606	Contact Map
2p8tA	1	0.6774	99.7	0.63	Contact Map
2x4hA	3	0.7935	99.7	0.652	Contact Map
2fxaA	4	0.9355	99.1	0.749	Contact Map
2qvoA	2	0.5419	98.8	0.769	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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