GREMLIN Database
MNTR - Transcriptional regulator MntR
UniProt: P0A9F1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13322
Length: 155 (118)
Sequences: 1856 (1250)
Seq/√Len: 115.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_L133_M3.0881.00
37_L70_T2.9401.00
113_E127_R2.8381.00
85_E93_F2.6841.00
99_E103_Q2.6571.00
125_I140_E2.6341.00
43_E109_H2.5541.00
57_Q71_V2.5471.00
107_E146_R2.4831.00
45_I84_I2.3801.00
122_S125_I2.3561.00
129_D138_S2.0731.00
75_L84_I2.0591.00
38_I81_M1.9651.00
144_A147_L1.9621.00
83_L97_E1.9201.00
117_L123_P1.7991.00
49_I99_E1.7111.00
73_K77_R1.6741.00
97_E100_K1.6551.00
79_A86_M1.6501.00
137_V142_L1.6361.00
104_E139_E1.6321.00
118_V148_F1.5281.00
66_V71_V1.5191.00
44_L63_R1.5051.00
70_T74_M1.4591.00
86_M89_W1.4371.00
115_F119_L1.4371.00
122_S140_E1.4341.00
51_E63_R1.4111.00
45_I55_A1.4051.00
132_G136_H1.3591.00
49_I55_A1.3571.00
96_A99_E1.3091.00
43_E131_E1.2700.99
44_L64_L1.2640.99
68_Q74_M1.2570.99
38_I74_M1.2550.99
113_E117_L1.2480.99
47_D106_R1.2360.99
112_V137_V1.1790.99
73_K76_K1.1740.99
36_E40_D1.1690.99
121_V141_T1.1680.99
121_V129_D1.1620.99
131_E134_E1.1610.99
59_D62_A1.1490.99
60_M75_L1.1410.99
54_E91_G1.0980.98
57_Q75_L1.0950.98
45_I71_V1.0910.98
60_M92_V1.0870.98
84_I92_V1.0780.98
44_L60_M1.0770.98
72_A86_M1.0420.98
109_H134_E1.0280.97
100_K104_E1.0210.97
48_L55_A1.0080.97
139_E143_D1.0080.97
75_L92_V1.0020.97
49_I53_G0.9930.97
50_R110_Q0.9860.97
35_R38_I0.9710.96
39_D105_S0.9710.96
42_V46_S0.9700.96
34_R38_I0.9650.96
115_F118_V0.9640.96
107_E111_I0.9580.96
131_E135_H0.9480.96
129_D141_T0.9350.96
39_D135_H0.9270.95
119_L144_A0.9200.95
35_R89_W0.9150.95
75_L86_M0.9130.95
85_E95_T0.8770.94
105_S108_R0.8760.94
40_D135_H0.8710.94
110_Q113_E0.8650.93
38_I76_K0.8640.93
115_F145_F0.8520.93
44_L47_D0.8310.92
109_H131_E0.8240.92
87_I93_F0.8230.91
48_L59_D0.8220.91
57_Q68_Q0.8150.91
76_K80_T0.8110.91
64_L74_M0.8100.91
47_D63_R0.8100.91
55_A60_M0.8050.91
40_D109_H0.7930.90
46_S103_Q0.7900.90
115_F148_F0.7890.90
43_E47_D0.7790.89
58_V68_Q0.7780.89
50_R99_E0.7600.88
108_R139_E0.7590.88
112_V145_F0.7570.88
38_I43_E0.7520.87
111_I123_P0.7460.87
129_D136_H0.7380.86
39_D134_E0.7350.86
46_S106_R0.7280.86
41_Y70_T0.7200.85
71_V75_L0.7180.85
115_F149_T0.7080.84
126_A131_E0.7040.84
69_P145_F0.6940.83
110_Q114_N0.6860.82
54_E93_F0.6850.82
111_I118_V0.6850.82
108_R142_L0.6850.82
72_A76_K0.6810.82
117_L126_A0.6790.81
64_L68_Q0.6770.81
40_D73_K0.6660.80
113_E123_P0.6640.80
40_D131_E0.6630.80
57_Q72_A0.6630.80
124_E147_L0.6580.79
123_P127_R0.6550.79
104_E108_R0.6390.77
57_Q86_M0.6360.77
47_D105_S0.6360.77
44_L48_L0.6270.76
45_I60_M0.6260.76
112_V141_T0.6240.76
86_M90_R0.6230.76
119_L148_F0.6210.75
108_R136_H0.6200.75
85_E96_A0.6100.74
40_D43_E0.6090.74
43_E134_E0.6050.73
82_G97_E0.6040.73
129_D137_V0.6040.73
109_H127_R0.6020.73
133_M136_H0.5980.73
46_S50_R0.5910.72
74_M77_R0.5860.71
34_R81_M0.5840.71
60_M64_L0.5830.71
56_R59_D0.5730.69
60_M71_V0.5620.68
137_V141_T0.5590.68
67_S84_I0.5580.67
88_P115_F0.5570.67
143_D150_Q0.5550.67
40_D134_E0.5510.66
130_A136_H0.5460.66
126_A141_T0.5450.66
140_E144_A0.5440.65
59_D63_R0.5440.65
126_A130_A0.5420.65
46_S102_A0.5420.65
46_S58_V0.5410.65
66_V73_K0.5410.65
83_L101_L0.5380.65
77_R81_M0.5370.64
34_R101_L0.5370.64
66_V70_T0.5360.64
35_R83_L0.5350.64
39_D109_H0.5310.64
34_R42_V0.5290.63
111_I149_T0.5240.63
109_H135_H0.5220.62
66_V74_M0.5180.62
42_V101_L0.5180.62
112_V115_F0.5140.61
143_D147_L0.5140.61
56_R91_G0.5130.61
81_M97_E0.5110.61
120_G144_A0.5100.60
34_R74_M0.5070.60
97_E101_L0.5050.60
113_E126_A0.5020.59
112_V131_E0.5000.59
38_I77_R0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fx7A 4 0.8065 99.9 0.543 Contact Map
4o5vA 2 0.7871 99.9 0.549 Contact Map
2qq9A 2 0.7935 99.9 0.549 Contact Map
3hrsA 2 0.7806 99.9 0.553 Contact Map
2h09A 2 0.8194 99.8 0.592 Contact Map
1on2A 2 0.7871 99.8 0.606 Contact Map
2p8tA 1 0.6774 99.7 0.63 Contact Map
2x4hA 3 0.7935 99.7 0.652 Contact Map
2fxaA 4 0.9355 99.1 0.749 Contact Map
2qvoA 2 0.5419 98.8 0.769 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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