GREMLIN Database
YEIL - Regulatory protein YeiL
UniProt: P0A9E9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12031
Length: 219 (193)
Sequences: 8711 (6722)
Seq/√Len: 483.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_W95_A3.4511.00
50_Y86_Q2.6891.00
22_H92_W2.6831.00
24_L27_D2.6381.00
187_I196_K2.6231.00
187_I194_L2.4911.00
138_L168_V2.3721.00
87_A91_C2.3051.00
44_R92_W2.2561.00
185_L200_Q2.1811.00
49_L85_V2.1181.00
43_T94_L2.0821.00
179_Q183_D2.0191.00
32_E84_A1.9971.00
97_P100_H1.9621.00
46_R89_E1.9611.00
143_A180_F1.9501.00
48_R86_Q1.9311.00
32_E51_A1.9221.00
197_N200_Q1.9111.00
139_V179_Q1.9001.00
20_L92_W1.8951.00
47_A85_V1.8901.00
198_R202_S1.8801.00
103_P107_N1.8281.00
22_H90_E1.8131.00
24_L90_E1.8041.00
159_H174_L1.7961.00
138_L172_H1.7901.00
30_V85_V1.7561.00
137_P140_N1.7421.00
47_A91_C1.7311.00
21_F95_A1.7291.00
25_A89_E1.7251.00
154_L192_G1.7131.00
50_Y84_A1.7041.00
98_M102_R1.6891.00
28_Y31_Q1.6801.00
23_F93_C1.6381.00
181_I188_K1.6231.00
160_T164_E1.5821.00
31_Q34_Q1.5771.00
142_L176_V1.5341.00
36_P81_E1.5341.00
64_F68_C1.5091.00
48_R88_I1.5071.00
139_V183_D1.5071.00
28_Y86_Q1.5051.00
58_V164_E1.4981.00
106_L113_R1.4901.00
150_Q195_I1.4761.00
123_N126_N1.4541.00
178_A182_H1.4401.00
27_D87_A1.4361.00
181_I187_I1.4331.00
23_F29_I1.3961.00
43_T92_W1.3761.00
17_D100_H1.3741.00
77_D124_Y1.3731.00
178_A181_I1.3581.00
48_R60_L1.3471.00
25_A90_E1.3391.00
72_E122_K1.3211.00
100_H103_P1.3191.00
48_R58_V1.3091.00
28_Y84_A1.3021.00
139_V176_V1.2811.00
30_V81_E1.2641.00
176_V179_Q1.2601.00
180_F185_L1.2551.00
168_V173_L1.2271.00
171_R175_Y1.2211.00
13_D107_N1.2161.00
145_F166_L1.2031.00
132_Q144_A1.1591.00
126_N130_L1.1521.00
150_Q198_R1.1471.00
159_H170_Y1.1271.00
145_F162_A1.1231.00
51_A131_T1.1211.00
200_Q203_G1.1191.00
49_L64_F1.1131.00
42_L47_A1.1051.00
71_G81_E1.1011.00
116_C119_L1.0981.00
48_R63_F1.0881.00
64_F70_I1.0871.00
63_F88_I1.0751.00
42_L91_C1.0691.00
199_K202_S1.0591.00
143_A147_L1.0571.00
46_R88_I1.0561.00
176_V180_F1.0531.00
53_L57_R1.0441.00
105_L108_D1.0431.00
29_I47_A1.0411.00
40_F93_C1.0401.00
23_F27_D1.0351.00
188_K193_Y1.0311.00
106_L110_L1.0311.00
189_S194_L1.0271.00
160_T170_Y1.0231.00
46_R91_C1.0221.00
46_R65_A1.0191.00
30_V83_R1.0121.00
40_F95_A1.0001.00
159_H188_K0.9961.00
44_R66_A0.9951.00
31_Q84_A0.9921.00
170_Y174_L0.9851.00
20_L43_T0.9801.00
102_R106_L0.9771.00
13_D16_A0.9731.00
166_L173_L0.9731.00
112_L116_C0.9631.00
46_R63_F0.9551.00
49_L83_R0.9511.00
18_T94_L0.9441.00
99_K103_P0.9431.00
21_F93_C0.9401.00
58_V86_Q0.9331.00
104_L111_F0.9311.00
105_L112_L0.9161.00
189_S192_G0.9141.00
103_P106_L0.9131.00
145_F165_Y0.9081.00
52_T58_V0.9061.00
20_L94_L0.9051.00
12_T16_A0.9041.00
19_R95_A0.9041.00
42_L67_P0.8931.00
59_S129_S0.8861.00
23_F91_C0.8841.00
102_R113_R0.8691.00
26_R86_Q0.8691.00
32_E52_T0.8521.00
113_R117_V0.8461.00
39_L101_Y0.8431.00
23_F47_A0.8341.00
65_A68_C0.8331.00
12_T15_S0.8231.00
168_V172_H0.8211.00
184_G196_K0.8171.00
18_T96_L0.8141.00
41_Y69_F0.8061.00
139_V180_F0.8041.00
42_L64_F0.7991.00
136_F144_A0.7981.00
109_T112_L0.7971.00
110_L114_K0.7951.00
144_A148_L0.7941.00
132_Q148_L0.7901.00
143_A185_L0.7801.00
13_D17_D0.7791.00
48_R161_Q0.7771.00
145_F149_S0.7761.00
174_L178_A0.7731.00
47_A93_C0.7721.00
142_L166_L0.7721.00
114_K118_T0.7681.00
121_H125_R0.7661.00
199_K203_G0.7641.00
39_L96_L0.7641.00
170_Y173_L0.7621.00
177_L188_K0.7571.00
52_T84_A0.7431.00
32_E131_T0.7431.00
50_Y58_V0.7361.00
71_G74_E0.7321.00
29_I93_C0.7211.00
183_D200_Q0.7191.00
108_D112_L0.7171.00
40_F70_I0.7161.00
37_S97_P0.7151.00
35_Q80_H0.7121.00
106_L112_L0.7071.00
101_Y105_L0.7061.00
28_Y50_Y0.7051.00
140_N143_A0.7051.00
44_R89_E0.7041.00
143_A201_L0.7011.00
74_E83_R0.7011.00
29_I70_I0.7011.00
42_L93_C0.7001.00
169_S172_H0.6991.00
47_A87_A0.6981.00
128_V148_L0.6971.00
23_F87_A0.6971.00
24_L87_A0.6941.00
142_L162_A0.6941.00
87_A90_E0.6931.00
147_L185_L0.6901.00
75_L98_M0.6841.00
158_K161_Q0.6841.00
132_Q136_F0.6791.00
29_I87_A0.6781.00
151_E198_R0.6751.00
138_L166_L0.6651.00
127_I130_L0.6641.00
39_L69_F0.6631.00
149_S153_D0.6591.00
114_K117_V0.6581.00
147_L202_S0.6551.00
122_K125_R0.6541.00
15_S18_T0.6541.00
147_L151_E0.6531.00
81_E85_V0.6511.00
101_Y111_F0.6471.00
42_L66_A0.6461.00
147_L201_L0.6421.00
59_S134_Q0.6401.00
41_Y94_L0.6371.00
104_L107_N0.6371.00
179_Q182_H0.6371.00
38_W97_P0.6351.00
53_L135_S0.6271.00
77_D80_H0.6251.00
51_A128_V0.6241.00
148_L152_G0.6210.99
119_L123_N0.6210.99
111_F114_K0.6200.99
151_E202_S0.6190.99
136_F140_N0.6160.99
102_R117_V0.6080.99
44_R90_E0.6060.99
163_A173_L0.6050.99
162_A173_L0.6040.99
17_D103_P0.6030.99
142_L177_L0.6030.99
185_L196_K0.6020.99
172_H175_Y0.6020.99
171_R174_L0.6010.99
146_I180_F0.5960.99
64_F85_V0.5930.99
125_R129_S0.5910.99
65_A152_G0.5900.99
142_L173_L0.5890.99
131_T135_S0.5850.99
128_V132_Q0.5850.99
72_E81_E0.5840.99
77_D121_H0.5820.99
50_Y60_L0.5820.99
138_L141_R0.5820.99
17_D96_L0.5790.99
74_E82_P0.5790.99
100_H104_L0.5750.99
74_E81_E0.5750.99
149_S152_G0.5740.99
77_D117_V0.5720.99
52_T56_G0.5710.99
185_L201_L0.5700.99
59_S135_S0.5700.99
74_E77_D0.5680.99
163_A168_V0.5650.99
145_F157_E0.5640.99
157_E162_A0.5630.99
195_I198_R0.5620.99
123_N127_I0.5610.99
142_L180_F0.5600.99
190_K193_Y0.5590.99
159_H173_L0.5590.99
63_F165_Y0.5570.99
47_A70_I0.5550.99
104_L108_D0.5540.99
69_F118_T0.5540.99
49_L61_I0.5510.99
146_I195_I0.5480.99
155_Y193_Y0.5440.99
13_D104_L0.5430.99
146_I193_Y0.5410.99
154_L194_L0.5400.99
109_T113_R0.5380.99
13_D108_D0.5370.99
118_T122_K0.5270.98
34_Q81_E0.5260.98
99_K102_R0.5240.98
70_I85_V0.5230.98
149_S156_H0.5220.98
73_I123_N0.5210.98
79_D124_Y0.5200.98
79_D121_H0.5190.98
186_L196_K0.5170.98
82_P127_I0.5110.98
73_I77_D0.5100.98
62_D68_C0.5090.98
92_W95_A0.5080.98
63_F149_S0.5080.98
160_T190_K0.5040.98
116_C120_S0.5040.98
78_K98_M0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dkwA 2 0.9361 100 0.243 Contact Map
4cydA 2 0.9406 100 0.247 Contact Map
3i54A 2 0.9361 100 0.249 Contact Map
3dv8A 2 0.9452 100 0.251 Contact Map
4ev0A 2 0.9543 100 0.255 Contact Map
2gauA 2 0.9269 100 0.256 Contact Map
3e97A 2 0.9178 100 0.257 Contact Map
3fx3A 2 0.9726 100 0.258 Contact Map
3kccA 2 0.863 100 0.26 Contact Map
1o5lA 2 0.5799 100 0.266 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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