GREMLIN Database
FNR - Fumarate and nitrate reduction regulatory protein
UniProt: P0A9E5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10325
Length: 250 (208)
Sequences: 7685 (5989)
Seq/√Len: 415.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_S123_E3.2351.00
51_P120_M2.8861.00
225_A234_E2.7951.00
79_Y114_Q2.7441.00
53_Q56_Q2.6311.00
166_A206_L2.4431.00
115_A119_S2.4431.00
73_S120_M2.4321.00
225_A232_T2.3871.00
35_N38_E2.3321.00
78_S113_A2.3041.00
223_M238_A2.1981.00
75_T117_E2.0931.00
125_P128_T2.0661.00
171_A218_F2.0361.00
236_N240_A2.0141.00
166_A210_T2.0081.00
59_F113_A2.0071.00
235_N238_A1.9771.00
217_R221_S1.9081.00
49_K120_M1.9081.00
61_A112_F1.9021.00
77_K114_Q1.8981.00
53_Q118_T1.8641.00
72_R122_C1.8591.00
51_P118_T1.8531.00
76_I119_S1.8361.00
61_A80_T1.8281.00
76_I113_A1.8241.00
167_E217_R1.8011.00
197_R212_S1.7941.00
54_K117_E1.7631.00
170_L214_L1.7591.00
131_D135_K1.7441.00
192_R230_Y1.7371.00
65_L109_H1.7341.00
52_I121_V1.7141.00
165_N168_E1.6951.00
60_K63_D1.6901.00
79_Y112_F1.6771.00
50_K123_E1.6771.00
151_I154_D1.6551.00
126_F130_D1.6501.00
178_S233_I1.6281.00
219_Q225_A1.5531.00
56_Q115_A1.5371.00
57_T114_Q1.5251.00
216_G220_K1.5161.00
134_G141_Q1.5131.00
190_E230_Y1.4841.00
54_K118_T1.4811.00
41_Q135_K1.4661.00
52_I58_L1.4641.00
219_Q226_V1.4611.00
72_R120_M1.4571.00
198_G202_N1.4451.00
87_E202_N1.4371.00
167_E221_S1.4271.00
128_T131_D1.4211.00
216_G219_Q1.4051.00
57_T60_K1.4051.00
77_K89_I1.3961.00
190_E232_T1.3881.00
93_H97_D1.3641.00
92_F116_L1.3401.00
206_L211_I1.3131.00
77_K87_E1.3091.00
77_K116_L1.3051.00
45_I128_T1.3011.00
57_T112_F1.2961.00
160_L172_A1.2861.00
106_S152_K1.2751.00
38_E136_M1.2601.00
218_F223_M1.2451.00
167_E214_L1.2281.00
209_E213_R1.2231.00
237_D240_A1.2211.00
59_F109_H1.2111.00
75_T116_L1.1851.00
93_H99_V1.1761.00
173_F204_L1.1721.00
173_F200_I1.1611.00
100_G109_H1.1551.00
71_I119_S1.1551.00
101_F150_E1.1491.00
214_L217_R1.1321.00
144_M147_M1.1181.00
55_G114_Q1.1161.00
238_A241_Q1.1141.00
58_L76_I1.1071.00
71_I76_I1.1031.00
33_T142_Q1.1021.00
75_T94_L1.0971.00
178_S236_N1.0891.00
127_E131_D1.0851.00
49_K72_R1.0841.00
75_T92_F1.0821.00
75_T119_S1.0671.00
154_D158_I1.0661.00
71_I93_H1.0601.00
214_L218_F1.0551.00
69_Y121_V1.0521.00
171_A175_Y1.0431.00
134_G138_N1.0361.00
59_F111_S1.0341.00
133_S140_R1.0331.00
77_K92_F1.0321.00
49_K122_C1.0281.00
197_R208_V1.0171.00
80_T159_L1.0121.00
34_L38_E1.0081.00
41_Q44_N1.0061.00
130_D134_G1.0011.00
78_S111_S0.9921.00
38_E41_Q0.9901.00
52_I56_Q0.9871.00
227_K230_Y0.9771.00
160_L176_N0.9771.00
82_T86_D0.9741.00
46_I124_I0.9701.00
173_F203_Y0.9681.00
88_Q157_M0.9671.00
36_E40_D0.9601.00
198_G208_V0.9591.00
69_Y123_E0.9571.00
52_I119_S0.9541.00
73_S95_A0.9541.00
208_V212_S0.9491.00
137_P140_R0.9441.00
130_D141_Q0.9431.00
133_S136_M0.9381.00
81_I87_E0.9351.00
167_E218_F0.9311.00
132_L139_L0.9211.00
78_S93_H0.9161.00
46_I122_C0.9141.00
204_L211_I0.9101.00
69_Y99_V0.8791.00
170_L204_L0.8721.00
71_I96_G0.8711.00
50_K121_V0.8691.00
206_L210_T0.8661.00
140_R144_M0.8651.00
41_Q45_I0.8641.00
131_D134_G0.8601.00
66_K125_P0.8581.00
142_Q146_L0.8501.00
172_A176_N0.8351.00
40_D44_N0.8341.00
164_K172_A0.8331.00
141_Q145_R0.8321.00
68_L129_L0.8311.00
138_N142_Q0.8301.00
226_V231_I0.8271.00
60_K112_F0.8261.00
52_I76_I0.8131.00
237_D241_Q0.8101.00
47_E50_K0.8091.00
200_I211_I0.8081.00
71_I95_A0.8081.00
77_K199_D0.8021.00
171_A223_M0.8001.00
58_L121_V0.7901.00
227_K232_T0.7891.00
87_E114_Q0.7841.00
52_I115_A0.7841.00
142_Q145_R0.7821.00
221_S238_A0.7721.00
68_L98_L0.7641.00
45_I131_D0.7621.00
103_A111_S0.7521.00
168_E171_A0.7501.00
76_I115_A0.7491.00
64_E108_H0.7461.00
208_V211_I0.7431.00
61_A159_L0.7411.00
201_G211_I0.7401.00
149_G153_G0.7391.00
104_I126_F0.7381.00
76_I121_V0.7371.00
197_R226_V0.7361.00
175_Y179_R0.7341.00
156_D176_N0.7341.00
207_T210_T0.7331.00
222_G234_E0.7271.00
81_I112_F0.7251.00
57_T79_Y0.7251.00
40_D43_D0.7171.00
160_L164_K0.7171.00
166_A169_R0.7161.00
175_Y223_M0.7121.00
179_R236_N0.7111.00
109_H113_A0.7111.00
171_A239_L0.7101.00
193_L231_I0.7021.00
73_S117_E0.7011.00
101_F109_H0.6991.00
129_L139_L0.6981.00
173_F177_L0.6981.00
70_A98_L0.6971.00
45_I133_S0.6961.00
158_I161_L0.6961.00
179_R240_A0.6941.00
42_L132_L0.6931.00
38_E138_N0.6911.00
100_G103_A0.6891.00
136_M140_R0.6881.00
210_T213_R0.6821.00
170_L211_I0.6821.00
129_L133_S0.6761.00
68_L124_I0.6731.00
106_S149_G0.6700.99
94_L97_D0.6680.99
147_M151_I0.6680.99
115_A118_T0.6650.99
175_Y240_A0.6640.99
212_S216_G0.6540.99
61_A81_I0.6530.99
91_G97_D0.6510.99
67_S125_P0.6490.99
58_L99_V0.6460.99
159_L163_K0.6440.99
53_Q115_A0.6420.99
79_Y87_E0.6420.99
88_Q162_S0.6350.99
76_I99_V0.6320.99
68_L104_I0.6310.99
73_S118_T0.6300.99
43_D46_I0.6260.99
70_A122_C0.6250.99
103_A109_H0.6240.99
197_R211_I0.6230.99
182_A188_P0.6230.99
71_I121_V0.6210.99
166_A204_L0.6190.99
133_S143_M0.6160.99
146_L150_E0.6120.99
58_L115_A0.6110.99
177_L191_F0.6080.99
181_F191_F0.6060.99
209_E212_S0.6040.99
183_Q192_R0.6040.99
79_Y89_I0.6020.99
102_D151_I0.6010.99
128_T132_L0.6000.99
155_Q158_I0.5980.99
176_N180_R0.5950.99
31_P39_L0.5920.99
223_M234_E0.5920.99
144_M148_S0.5900.99
177_L180_R0.5900.99
156_D172_A0.5890.99
35_N136_M0.5880.99
183_Q188_P0.5870.99
189_R192_R0.5850.99
62_G108_H0.5830.99
46_I72_R0.5820.99
34_L39_L0.5800.99
71_I94_L0.5760.98
217_R220_K0.5740.98
99_V113_A0.5710.98
226_V229_K0.5710.98
178_S189_R0.5690.98
228_G231_I0.5680.98
215_L226_V0.5660.98
65_L103_A0.5630.98
201_G212_S0.5630.98
82_T163_K0.5620.98
195_M199_D0.5620.98
170_L218_F0.5610.98
153_G180_R0.5610.98
106_S145_R0.5600.98
170_L215_L0.5570.98
82_T85_G0.5570.98
47_E123_E0.5550.98
173_F211_I0.5550.98
64_E127_E0.5510.98
37_H41_Q0.5500.98
189_R236_N0.5500.98
80_T156_D0.5490.98
160_L163_K0.5480.98
110_P152_K0.5480.98
151_I155_Q0.5470.98
173_F176_N0.5450.98
174_I233_I0.5430.98
41_Q136_M0.5400.98
171_A233_I0.5390.98
103_A110_P0.5380.98
127_E130_D0.5380.98
224_L231_I0.5380.98
137_P141_Q0.5380.98
174_I231_I0.5360.98
139_L142_Q0.5350.98
175_Y236_N0.5320.97
81_I85_G0.5310.97
196_T199_D0.5290.97
161_L169_R0.5290.97
188_P232_T0.5250.97
78_S110_P0.5230.97
37_H40_D0.5220.97
88_Q163_K0.5210.97
78_S90_T0.5190.97
211_I215_L0.5180.97
102_D150_E0.5150.97
187_S190_E0.5130.97
43_D47_E0.5120.97
92_F195_M0.5100.97
64_E149_G0.5090.97
150_E153_G0.5040.96
146_L149_G0.5040.96
67_S126_F0.5000.96
61_A111_S0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i54A 2 0.916 100 0.293 Contact Map
4cydA 2 0.896 100 0.294 Contact Map
3fx3A 2 0.912 100 0.302 Contact Map
3dkwA 2 0.9 100 0.304 Contact Map
3e97A 2 0.88 100 0.309 Contact Map
2gauA 2 0.868 100 0.31 Contact Map
3dv8A 2 0.852 100 0.311 Contact Map
4ev0A 2 0.852 100 0.318 Contact Map
1zybA 2 0.904 100 0.324 Contact Map
3e6cC 2 0.9 100 0.325 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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