GREMLIN Database
SOXS - Regulatory protein SoxS
UniProt: P0A9E2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10958
Length: 107 (100)
Sequences: 33184 (25988)
Seq/√Len: 2598.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_A96_F3.0031.00
48_Q56_Q2.6291.00
71_R79_D2.3821.00
15_D57_R2.3021.00
25_D35_K2.1191.00
56_Q95_Q1.9751.00
62_A88_F1.9721.00
13_W17_H1.9571.00
10_L38_L1.9531.00
61_L64_V1.9491.00
92_F103_Y1.8781.00
65_E79_D1.8221.00
11_I46_T1.7501.00
59_L96_F1.7051.00
23_N26_V1.6291.00
85_Q89_S1.6291.00
65_E80_L1.6121.00
42_F53_Y1.5781.00
17_H20_Q1.5571.00
71_R75_D1.5451.00
13_W30_K1.4841.00
18_I57_R1.4711.00
91_V94_R1.4521.00
57_R61_L1.4071.00
36_W40_R1.3901.00
64_V68_T1.3791.00
27_V50_L1.3711.00
37_Y41_M1.3571.00
51_G55_R1.3461.00
14_I54_I1.3241.00
48_Q52_D1.3141.00
72_P75_D1.2961.00
35_K39_Q1.2961.00
65_E71_R1.2391.00
87_T91_V1.2361.00
57_R60_L1.2341.00
11_I15_D1.2321.00
55_R91_V1.2161.00
74_F85_Q1.2121.00
63_A103_Y1.1931.00
74_F78_M1.1511.00
33_Y37_Y1.1361.00
39_Q50_L1.1201.00
59_L95_Q1.1051.00
66_L73_I1.0961.00
75_D78_M1.0891.00
12_A16_E1.0731.00
26_V30_K1.0721.00
13_W22_L1.0681.00
41_M45_V1.0651.00
56_Q60_L1.0611.00
37_Y40_R1.0591.00
10_L31_S1.0341.00
61_L65_E1.0261.00
98_R102_D1.0151.00
75_D79_D1.0021.00
38_L50_L1.0021.00
18_I61_L0.9991.00
49_T52_D0.9831.00
101_S105_H0.9731.00
55_R94_R0.9651.00
69_T104_R0.9651.00
86_Q89_S0.9431.00
11_I42_F0.9401.00
6_I33_Y0.9361.00
24_I39_Q0.8981.00
7_I46_T0.8911.00
63_A67_R0.8811.00
61_L80_L0.8641.00
91_V95_Q0.8541.00
99_T102_D0.8471.00
34_S37_Y0.8461.00
71_R76_I0.8451.00
101_S104_R0.8441.00
33_Y38_L0.8391.00
82_Y91_V0.8381.00
19_D79_D0.8301.00
36_W39_Q0.8301.00
41_M44_T0.8251.00
11_I53_Y0.8211.00
14_I50_L0.8151.00
50_L54_I0.8021.00
42_F50_L0.8001.00
9_D31_S0.7911.00
6_I41_M0.7861.00
60_L63_A0.7801.00
25_D29_K0.7781.00
18_I54_I0.7771.00
52_D56_Q0.7741.00
58_R80_L0.7701.00
6_I31_S0.7601.00
14_I57_R0.7591.00
22_L27_V0.7571.00
21_P83_V0.7491.00
93_R99_T0.7471.00
52_D55_R0.7421.00
24_I50_L0.7351.00
55_R95_Q0.7351.00
69_T76_I0.7311.00
89_S101_S0.7291.00
86_Q90_R0.7231.00
89_S93_R0.7221.00
77_A85_Q0.7021.00
28_A35_K0.6981.00
102_D105_H0.6961.00
9_D12_A0.6961.00
26_V29_K0.6891.00
9_D30_K0.6871.00
52_D95_Q0.6871.00
13_W31_S0.6841.00
76_I80_L0.6791.00
66_L76_I0.6781.00
90_R94_R0.6711.00
15_D53_Y0.6661.00
51_G87_T0.6631.00
66_L104_R0.6591.00
7_I45_V0.6571.00
8_Q12_A0.6551.00
10_L27_V0.6551.00
20_Q26_V0.6511.00
62_A80_L0.6411.00
53_Y57_R0.6381.00
17_H30_K0.6351.00
73_I76_I0.6281.00
98_R103_Y0.6281.00
24_I35_K0.6251.00
43_R49_T0.6081.00
84_S87_T0.5921.00
33_Y41_M0.5921.00
31_S38_L0.5911.00
27_V30_K0.5841.00
89_S99_T0.5811.00
19_D61_L0.5751.00
84_S90_R0.5691.00
60_L96_F0.5651.00
24_I36_W0.5581.00
63_A92_F0.5581.00
78_M83_V0.5571.00
7_I41_M0.5551.00
10_L42_F0.5521.00
83_V87_T0.5411.00
48_Q53_Y0.5371.00
96_F103_Y0.5351.00
18_I22_L0.5241.00
42_F46_T0.5221.00
8_Q11_I0.5211.00
6_I9_D0.5211.00
29_K32_G0.5061.00
40_R44_T0.5021.00
87_T90_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.9907 100 0.086 Contact Map
4fe7A 2 1 100 0.139 Contact Map
3w6vA 1 0.972 100 0.144 Contact Map
3oioA 1 1 100 0.146 Contact Map
1bl0A 1 0.9813 100 0.147 Contact Map
3mn2A 1 0.972 100 0.15 Contact Map
3oouA 1 0.972 100 0.16 Contact Map
3lsgA 2 0.9533 99.9 0.164 Contact Map
2k9sA 1 0.9813 99.9 0.164 Contact Map
3mklA 1 0.9907 99.9 0.167 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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