GREMLIN Database
ARAC - Arabinose operon regulatory protein
UniProt: P0A9E0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10054
Length: 292 (241)
Sequences: 32935 (27857)
Seq/√Len: 1794.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
236_K269_T3.1921.00
221_I229_D3.1431.00
187_S230_Q3.0461.00
244_M252_N2.9901.00
232_I269_T2.9691.00
198_A208_P2.8881.00
234_Q237_L2.7501.00
185_Y189_H2.7051.00
229_D268_C2.5821.00
265_F276_F2.5321.00
235_A261_F2.3811.00
238_L252_N2.3681.00
182_A211_L2.2611.00
215_F226_W2.1331.00
238_L253_V2.1281.00
189_H192_D2.1171.00
196_D199_S2.0141.00
271_A279_G1.9661.00
244_M248_T1.9581.00
56_V63_E1.9521.00
190_L230_Q1.9361.00
56_V65_V1.8741.00
186_I227_R1.8711.00
238_L244_M1.8521.00
224_L228_E1.8381.00
182_A204_V1.8311.00
185_Y203_H1.8271.00
183_C219_L1.7971.00
232_I268_C1.7531.00
245_P248_T1.7431.00
258_Q262_S1.7281.00
51_I94_Q1.7141.00
179_V219_L1.7091.00
58_K63_E1.6841.00
67_R70_D1.6821.00
264_V267_K1.6641.00
236_K276_F1.6641.00
197_I212_S1.6611.00
200_V223_V1.6531.00
54_Q65_V1.6421.00
234_Q238_L1.6281.00
210_R214_L1.6211.00
52_R92_Y1.6121.00
184_Q188_D1.5861.00
155_L158_Q1.5621.00
208_P212_S1.5491.00
237_L241_T1.5461.00
247_A258_Q1.5451.00
239_L246_I1.5391.00
221_I225_S1.5331.00
185_Y195_F1.5311.00
230_Q234_Q1.5041.00
211_L223_V1.4971.00
271_A275_E1.4791.00
260_Y264_V1.4651.00
210_R213_H1.4621.00
190_L234_Q1.4561.00
187_S226_W1.4521.00
255_F264_V1.4491.00
247_A251_R1.4461.00
176_D218_Q1.4351.00
58_K81_H1.4321.00
223_V227_R1.4311.00
131_S135_G1.4291.00
248_T252_N1.4261.00
154_N158_Q1.4261.00
248_T251_R1.4261.00
235_A253_V1.4111.00
249_V253_V1.4021.00
191_A252_N1.3981.00
206_L210_R1.3961.00
56_V83_G1.3931.00
45_Y76_P1.3891.00
54_Q67_R1.3851.00
183_C187_S1.3751.00
154_N157_E1.3671.00
274_S278_A1.3591.00
186_I230_Q1.3421.00
212_S223_V1.3411.00
234_Q253_V1.3321.00
199_S203_H1.3141.00
209_S213_H1.3141.00
158_Q162_R1.3051.00
182_A200_V1.3021.00
228_E264_V1.2941.00
229_D233_S1.2891.00
60_Q78_E1.2841.00
154_N161_L1.2721.00
259_L262_S1.2611.00
222_S225_S1.2611.00
206_L211_L1.2521.00
262_S272_S1.2341.00
230_Q233_S1.2341.00
198_A202_Q1.2021.00
262_S274_S1.1941.00
242_T277_R1.1931.00
178_R206_L1.1811.00
51_I92_Y1.1811.00
144_E148_S1.1751.00
207_S210_R1.1671.00
75_P78_E1.1551.00
52_R68_P1.1431.00
42_M80_H1.1241.00
46_I80_H1.1241.00
236_K240_S1.1231.00
201_A208_P1.1031.00
244_M249_V1.0981.00
151_L155_L1.0951.00
263_R267_K1.0871.00
132_D135_G1.0861.00
40_L80_H1.0711.00
233_S236_K1.0701.00
214_L217_Q1.0691.00
151_L158_Q1.0631.00
272_S275_E1.0611.00
275_E278_A1.0581.00
197_I223_V1.0521.00
195_F200_V1.0481.00
153_I157_E1.0461.00
157_E161_L1.0401.00
39_P79_I1.0371.00
191_A234_Q1.0301.00
214_L218_Q1.0291.00
178_R214_L1.0181.00
228_E267_K1.0121.00
132_D136_Q1.0101.00
274_S277_R1.0041.00
177_N181_E1.0021.00
185_Y204_V0.9931.00
115_A118_G0.9921.00
262_S266_K0.9861.00
55_G91_W0.9821.00
238_L249_V0.9771.00
194_N199_S0.9771.00
135_G139_N0.9711.00
186_I223_V0.9661.00
180_R184_Q0.9651.00
194_N256_D0.9651.00
124_E127_Q0.9631.00
181_E203_H0.9521.00
183_C226_W0.9481.00
246_I249_V0.9471.00
197_I208_P0.9471.00
209_S212_S0.9431.00
158_Q161_L0.9311.00
257_D263_R0.9301.00
199_S202_Q0.9201.00
200_V203_H0.9181.00
225_S228_E0.9181.00
136_Q140_A0.9141.00
264_V268_C0.9121.00
192_D195_F0.9101.00
204_V211_L0.9061.00
178_R204_V0.8991.00
58_K83_G0.8971.00
50_T55_G0.8971.00
231_R253_V0.8961.00
236_K265_F0.8941.00
185_Y200_V0.8911.00
275_E279_G0.8871.00
269_T276_F0.8831.00
225_S229_D0.8771.00
232_I264_V0.8751.00
56_V85_H0.8741.00
260_Y263_R0.8731.00
161_L165_E0.8621.00
106_E111_P0.8571.00
179_V214_L0.8511.00
242_T249_V0.8481.00
266_K272_S0.8421.00
48_N95_W0.8361.00
192_D199_S0.8321.00
136_Q155_L0.8231.00
181_E204_V0.8221.00
215_F219_L0.8211.00
39_P81_H0.8211.00
206_L214_L0.8121.00
55_G66_C0.8121.00
224_L260_Y0.8111.00
54_Q85_H0.8081.00
150_L154_N0.8081.00
224_L227_R0.8081.00
189_H203_H0.8071.00
228_E268_C0.8071.00
180_R183_C0.8001.00
190_L227_R0.8001.00
190_L195_F0.7991.00
226_W230_Q0.7951.00
225_S268_C0.7931.00
179_V218_Q0.7921.00
239_L249_V0.7891.00
129_H162_R0.7861.00
235_A238_L0.7831.00
162_R166_A0.7831.00
181_E184_Q0.7801.00
59_N62_R0.7791.00
215_F223_V0.7781.00
128_P132_D0.7781.00
123_D126_H0.7761.00
58_K61_G0.7751.00
239_L277_R0.7721.00
271_A276_F0.7721.00
179_V182_A0.7721.00
151_L161_L0.7681.00
45_Y73_L0.7681.00
150_L157_E0.7661.00
57_V72_L0.7621.00
190_L253_V0.7611.00
150_L153_I0.7581.00
250_G258_Q0.7531.00
251_R256_D0.7531.00
118_G121_R0.7511.00
183_C215_F0.7451.00
129_H132_D0.7441.00
212_S216_R0.7421.00
52_R90_E0.7391.00
213_H217_Q0.7391.00
55_G65_V0.7341.00
212_S222_S0.7321.00
46_I97_Y0.7321.00
175_M217_Q0.7321.00
232_I261_F0.7321.00
149_E153_I0.7321.00
195_F199_S0.7321.00
123_D127_Q0.7301.00
136_Q158_Q0.7291.00
128_P131_S0.7261.00
179_V183_C0.7221.00
182_A185_Y0.7191.00
74_F80_H0.7161.00
186_I226_W0.7151.00
240_S276_F0.7141.00
117_T121_R0.7131.00
200_V211_L0.7121.00
189_H199_S0.7111.00
182_A215_F0.7071.00
257_D260_Y0.7061.00
49_L71_I0.7061.00
145_G148_S0.7061.00
42_M46_I0.7041.00
212_S224_L0.7041.00
266_K275_E0.7021.00
50_T53_G0.7001.00
106_E109_N0.6991.00
138_I142_Q0.6951.00
66_C72_L0.6891.00
182_A186_I0.6851.00
182_A223_V0.6801.00
129_H136_Q0.6801.00
91_W95_W0.6761.00
190_L231_R0.6761.00
122_P126_H0.6751.00
245_P249_V0.6751.00
176_D214_L0.6721.00
50_T93_H0.6721.00
178_R181_E0.6681.00
41_G79_I0.6671.00
44_G97_Y0.6651.00
48_N93_H0.6561.00
133_L155_L0.6511.00
259_L272_S0.6471.00
233_S268_C0.6441.00
249_V277_R0.6431.00
221_I226_W0.6391.00
258_Q261_F0.6391.00
175_M178_R0.6371.00
140_A165_E0.6341.00
232_I255_F0.6341.00
132_D139_N0.6301.00
127_Q131_S0.6291.00
114_F118_G0.6261.00
50_T66_C0.6231.00
48_N74_F0.6231.00
148_S152_A0.6221.00
162_R165_E0.6221.00
235_A249_V0.6221.00
256_D260_Y0.6181.00
133_L136_Q0.6181.00
227_R231_R0.6161.00
49_L127_Q0.6131.00
60_Q79_I0.6061.00
151_L154_N0.6041.00
47_L71_I0.6041.00
55_G82_Y0.6041.00
195_F231_R0.6021.00
243_R249_V0.6021.00
259_L263_R0.6011.00
265_F271_A0.6011.00
126_H129_H0.5991.00
43_K99_R0.5991.00
261_F265_F0.5991.00
261_F273_P0.5981.00
200_V204_V0.5971.00
47_L73_L0.5971.00
159_L163_R0.5931.00
186_I195_F0.5931.00
228_E260_Y0.5921.00
197_I224_L0.5911.00
50_T91_W0.5871.00
106_E110_W0.5861.00
122_P125_A0.5831.00
187_S234_Q0.5821.00
48_N72_L0.5821.00
105_H109_N0.5811.00
233_S269_T0.5811.00
201_A204_V0.5771.00
176_D180_R0.5721.00
246_I274_S0.5721.00
155_L162_R0.5701.00
236_K271_A0.5691.00
100_P103_Y0.5681.00
216_R222_S0.5661.00
129_H133_L0.5651.00
185_Y199_S0.5641.00
108_L111_P0.5611.00
219_L226_W0.5591.00
239_L276_F0.5591.00
48_N57_V0.5581.00
228_E232_I0.5581.00
184_Q187_S0.5561.00
179_V211_L0.5561.00
238_L241_T0.5541.00
182_A203_H0.5531.00
107_W110_W0.5521.00
216_R219_L0.5451.00
241_T244_M0.5451.00
227_R230_Q0.5451.00
255_F260_Y0.5411.00
197_I209_S0.5411.00
175_M218_Q0.5401.00
92_Y95_W0.5381.00
136_Q139_N0.5351.00
57_V82_Y0.5331.00
173_P176_D0.5321.00
141_G144_E0.5321.00
51_I135_G0.5301.00
195_F227_R0.5291.00
151_L165_E0.5281.00
59_N74_F0.5281.00
140_A143_G0.5261.00
204_V208_P0.5241.00
257_D267_K0.5231.00
138_I141_G0.5221.00
211_L219_L0.5221.00
49_L134_F0.5211.00
237_L240_S0.5211.00
45_Y48_N0.5211.00
139_N143_G0.5211.00
54_Q89_R0.5201.00
264_V269_T0.5191.00
57_V66_C0.5181.00
189_H195_F0.5161.00
234_Q252_N0.5151.00
36_I83_G0.5151.00
185_Y190_L0.5111.00
246_I258_Q0.5101.00
255_F261_F0.5061.00
84_R91_W0.5061.00
55_G84_R0.5041.00
82_Y93_H0.5041.00
202_Q205_C0.5011.00
160_L163_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.863 100 0.235 Contact Map
3oouA 1 0.3596 100 0.472 Contact Map
1bl0A 1 0.3973 100 0.473 Contact Map
3oioA 1 0.3836 100 0.474 Contact Map
3mklA 1 0.3801 100 0.477 Contact Map
3mn2A 1 0.363 100 0.477 Contact Map
3w6vA 1 0.3801 100 0.478 Contact Map
2k9sA 1 0.3664 100 0.478 Contact Map
3lsgA 2 0.3527 100 0.488 Contact Map
1d5yA 1 0.4007 99.9 0.497 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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