GREMLIN Database
DAPD - 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
UniProt: P0A9D8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10207
Length: 274 (263)
Sequences: 937 (359)
Seq/√Len: 22.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_E226_R5.8751.00
197_E229_A5.5201.00
135_D154_K5.1391.00
152_I164_I3.8911.00
216_D255_K3.7461.00
190_V202_I3.5431.00
34_V59_L3.3241.00
57_Q174_N3.3001.00
181_N198_E3.2191.00
200_S231_S3.0971.00
48_K198_E3.0231.00
146_V158_L2.8310.99
31_V69_I2.8080.99
108_P127_Y2.8080.99
48_K52_Q2.7980.99
114_G130_I2.6460.99
116_F119_R2.6000.99
43_L59_L2.4990.98
5_Q9_E2.4490.98
37_L42_A2.4070.98
119_R136_E2.3590.97
111_V115_A2.2840.97
207_Y248_Y2.2820.97
39_D89_K2.2170.96
152_I156_V2.1950.96
14_R17_E2.1380.95
34_V43_L2.1340.95
155_N181_N2.0260.93
226_R229_A2.0200.93
237_N246_S2.0170.93
158_L191_V1.9610.92
49_I52_Q1.9600.92
199_G230_G1.9560.92
158_L162_V1.9280.92
110_A127_Y1.9110.91
144_A162_V1.8630.90
118_A135_D1.8080.89
176_T210_Q1.7680.87
105_V109_A1.7630.87
203_S235_S1.7620.87
223_H227_V1.7330.86
11_A27_T1.7280.86
37_L43_L1.6820.85
241_K244_K1.6510.83
72_N83_F1.6160.82
162_V188_S1.5910.81
240_S245_Y1.5820.81
10_T14_R1.5770.81
82_Y105_V1.5560.80
191_V208_I1.5500.79
121_T135_D1.5290.78
82_Y108_P1.5220.78
97_R100_K1.5210.78
196_V208_I1.5200.78
174_N195_I1.5120.78
140_V158_L1.4920.77
235_S248_Y1.4850.76
145_T160_G1.4810.76
36_A40_S1.4730.76
146_V156_V1.4550.75
203_S209_G1.4410.74
198_E229_A1.4190.73
7_I26_V1.4070.72
93_Y101_E1.4070.72
218_E255_K1.3990.72
229_A255_K1.3960.72
182_C200_S1.3840.71
7_I27_T1.3460.69
162_V191_V1.3220.67
179_E200_S1.3180.67
35_I66_S1.3090.67
138_T156_V1.3080.66
71_D99_Q1.2840.65
31_V87_P1.2780.65
160_G187_R1.2710.64
188_S207_Y1.2540.63
33_Q37_L1.2390.62
240_S244_K1.2280.61
39_D113_Q1.2240.61
35_I114_G1.2240.61
190_V208_I1.2090.60
234_V247_L1.2060.60
200_S235_S1.1990.60
77_G80_S1.1890.59
114_G243_G1.1850.59
247_L251_V1.1720.58
204_M209_G1.1610.57
72_N130_I1.1600.57
72_N265_G1.1480.56
258_A264_V1.1470.56
178_I196_V1.1460.56
176_T191_V1.1450.56
123_L128_V1.1410.56
27_T31_V1.1330.55
120_N135_D1.1250.55
223_H255_K1.1120.54
47_E56_H1.1020.53
242_D245_Y1.0960.53
160_G209_G1.0940.53
188_S191_V1.0930.52
216_D221_E1.0930.52
140_V162_V1.0920.52
13_E16_A1.0900.52
265_G268_E1.0860.52
145_T156_V1.0740.51
48_K54_V1.0690.51
136_E154_K1.0640.50
45_V59_L1.0620.50
133_Y154_K1.0610.50
142_T187_R1.0570.50
163_G187_R1.0470.49
202_I235_S1.0380.49
39_D93_Y1.0350.48
198_E258_A1.0330.48
142_T163_G1.0270.48
240_S243_G1.0270.48
160_G163_G1.0270.48
103_F111_V1.0230.48
152_I208_I1.0100.47
143_W187_R1.0010.46
55_T177_I0.9950.46
215_Y245_Y0.9930.46
145_T162_V0.9800.45
18_I22_N0.9790.45
194_V210_Q0.9710.44
117_I123_L0.9580.43
74_V81_R0.9570.43
83_F88_M0.9560.43
9_E174_N0.9520.43
216_D223_H0.9480.43
35_I130_I0.9390.42
32_N70_N0.9380.42
32_N113_Q0.9330.42
134_V146_V0.9300.41
101_E105_V0.9270.41
143_W160_G0.9170.41
161_G187_R0.9130.40
78_A88_M0.9040.40
191_V210_Q0.9020.40
103_F117_I0.8990.39
215_Y242_D0.8930.39
49_I56_H0.8880.39
82_Y93_Y0.8870.39
117_I121_T0.8850.38
114_G127_Y0.8850.38
181_N199_G0.8820.38
6_N10_T0.8740.38
82_Y215_Y0.8730.38
115_A136_E0.8720.38
176_T243_G0.8720.38
75_I88_M0.8690.37
194_V203_S0.8690.37
118_A136_E0.8660.37
103_F120_N0.8610.37
4_L30_A0.8600.37
121_T154_K0.8540.36
213_R238_L0.8490.36
109_A126_S0.8480.36
48_K56_H0.8460.36
213_R235_S0.8430.36
64_L171_L0.8420.36
142_T160_G0.8350.35
7_I99_Q0.8250.35
72_N174_N0.8230.35
121_T152_I0.8220.34
199_G229_A0.8220.34
120_N136_E0.8220.34
82_Y88_M0.8210.34
152_I158_L0.8200.34
260_T264_V0.8170.34
256_V261_R0.8150.34
66_S70_N0.8120.34
80_S88_M0.8040.33
203_S248_Y0.7970.33
16_A28_R0.7920.33
197_E202_I0.7920.33
254_K257_D0.7890.32
191_V259_K0.7880.32
93_Y215_Y0.7760.32
215_Y230_G0.7720.31
77_G82_Y0.7720.31
72_N82_Y0.7670.31
35_I113_Q0.7650.31
12_F88_M0.7650.31
172_Q238_L0.7590.31
215_Y240_S0.7530.30
15_R18_I0.7510.30
230_G245_Y0.7510.30
156_V160_G0.7500.30
28_R164_I0.7430.30
176_T182_C0.7420.30
178_I190_V0.7420.30
258_A262_G0.7400.30
31_V35_I0.7390.30
145_T152_I0.7390.30
186_A189_E0.7390.30
177_I195_I0.7340.29
34_V62_A0.7310.29
188_S202_I0.7290.29
76_E81_R0.7280.29
215_Y224_Y0.7280.29
209_G248_Y0.7230.29
12_F202_I0.7220.29
213_R249_C0.7210.29
42_A140_V0.7200.28
143_W163_G0.7200.28
79_E121_T0.7190.28
118_A127_Y0.7170.28
122_V139_M0.7170.28
82_Y109_A0.7160.28
45_V171_L0.7150.28
135_D152_I0.7140.28
116_F133_Y0.7130.28
189_E204_M0.7120.28
63_V111_V0.7110.28
123_L126_S0.7060.28
204_M217_R0.7060.28
12_F70_N0.7060.28
36_A113_Q0.7050.28
200_S229_A0.7040.28
191_V209_G0.7030.28
3_Q26_V0.7000.27
210_Q216_D0.6980.27
114_G215_Y0.6950.27
105_V127_Y0.6940.27
10_T26_V0.6920.27
263_K267_N0.6910.27
56_H59_L0.6900.27
35_I115_A0.6880.27
176_T208_I0.6840.27
115_A130_I0.6840.27
93_Y199_G0.6820.26
8_I73_Q0.6820.26
52_Q56_H0.6810.26
179_E198_E0.6810.26
103_F266_I0.6800.26
188_S238_L0.6730.26
216_D219_T0.6720.26
176_T216_D0.6720.26
162_V203_S0.6710.26
202_I226_R0.6690.26
255_K265_G0.6690.26
12_F36_A0.6680.26
160_G227_V0.6670.26
152_I162_V0.6670.26
48_K197_E0.6660.26
34_V37_L0.6600.25
194_V208_I0.6590.25
19_T135_D0.6580.25
9_E29_E0.6580.25
93_Y249_C0.6570.25
237_N248_Y0.6530.25
146_V237_N0.6520.25
10_T21_A0.6520.25
186_A204_M0.6510.25
202_I208_I0.6510.25
16_A19_T0.6500.25
26_V38_L0.6490.25
158_L181_N0.6480.25
176_T240_S0.6470.25
28_R70_N0.6460.25
21_A99_Q0.6440.24
215_Y244_K0.6440.24
49_I197_E0.6440.24
5_Q19_T0.6380.24
176_T200_S0.6380.24
5_Q71_D0.6380.24
220_G247_L0.6370.24
209_G224_Y0.6340.24
49_I54_V0.6340.24
28_R32_N0.6300.24
253_V258_A0.6300.24
93_Y103_F0.6300.24
12_F176_T0.6280.24
123_L190_V0.6240.23
130_I156_V0.6200.23
33_Q42_A0.6190.23
216_D253_V0.6160.23
68_R171_L0.6150.23
189_E207_Y0.6150.23
204_M207_Y0.6120.23
233_V236_G0.6120.23
220_G234_V0.6110.23
116_F136_E0.6110.23
30_A34_V0.6070.23
111_V132_A0.6070.23
189_E217_R0.6050.23
174_N209_G0.6030.22
61_K172_Q0.6030.22
12_F18_I0.6020.22
130_I243_G0.6020.22
233_V252_I0.6010.22
196_V203_S0.6010.22
129_N167_V0.5990.22
209_G235_S0.5980.22
128_V146_V0.5960.22
179_E182_C0.5960.22
63_V171_L0.5930.22
178_I252_I0.5930.22
128_V259_K0.5920.22
142_T161_G0.5910.22
103_F127_Y0.5880.22
28_R134_V0.5880.22
10_T100_K0.5860.22
203_S226_R0.5850.22
91_A200_S0.5850.22
79_E88_M0.5840.22
236_G252_I0.5830.22
6_N76_E0.5810.21
32_N63_V0.5800.21
156_V230_G0.5790.21
40_S43_L0.5780.21
216_D227_V0.5760.21
31_V70_N0.5760.21
137_G155_N0.5760.21
73_Q87_P0.5750.21
222_I238_L0.5750.21
13_E68_R0.5740.21
217_R256_V0.5740.21
127_Y215_Y0.5740.21
117_I128_V0.5720.21
97_R101_E0.5710.21
93_Y245_Y0.5680.21
17_E51_G0.5670.21
210_Q215_Y0.5660.21
102_G196_V0.5650.21
197_E203_S0.5620.21
63_V126_S0.5620.21
137_G140_V0.5610.21
12_F103_F0.5610.21
14_R26_V0.5610.21
197_E255_K0.5600.20
40_S59_L0.5600.20
234_V254_K0.5590.20
127_Y230_G0.5570.20
69_I87_P0.5550.20
26_V32_N0.5540.20
6_N100_K0.5540.20
14_R158_L0.5520.20
12_F15_R0.5510.20
12_F130_I0.5500.20
119_R122_V0.5490.20
32_N135_D0.5490.20
93_Y98_F0.5490.20
21_A40_S0.5480.20
16_A128_V0.5480.20
152_I190_V0.5460.20
83_F212_T0.5460.20
47_E102_G0.5460.20
256_V269_L0.5440.20
102_G140_V0.5440.20
8_I34_V0.5430.20
55_T144_A0.5430.20
261_R265_G0.5430.20
205_G254_K0.5410.20
36_A42_A0.5400.20
6_N50_D0.5380.20
139_M271_R0.5340.19
12_F174_N0.5330.19
114_G240_S0.5310.19
195_I226_R0.5310.19
144_A191_V0.5310.19
88_M115_A0.5300.19
82_Y199_G0.5300.19
11_A30_A0.5300.19
39_D91_A0.5290.19
197_E212_T0.5290.19
47_E258_A0.5280.19
172_Q177_I0.5270.19
14_R36_A0.5260.19
30_A102_G0.5240.19
186_A250_A0.5220.19
56_H174_N0.5220.19
59_L130_I0.5220.19
111_V128_V0.5190.19
37_L40_S0.5160.19
26_V33_Q0.5140.19
36_A268_E0.5130.18
186_A209_G0.5130.18
19_T154_K0.5120.18
37_L133_Y0.5120.18
42_A52_Q0.5100.18
251_V261_R0.5100.18
145_T187_R0.5090.18
182_C231_S0.5070.18
234_V251_V0.5070.18
201_V236_G0.5040.18
79_E199_G0.5030.18
8_I115_A0.5010.18
14_R54_V0.5000.18
52_Q174_N0.5000.18
50_D54_V0.5000.18
143_W161_G0.5000.18
60_K172_Q0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gosA 3 1 100 0.526 Contact Map
3tk8A 3 0.9416 100 0.546 Contact Map
3eg4A 3 0.9891 100 0.601 Contact Map
3fsyA 4 0.865 100 0.764 Contact Map
2rijA 4 0.9197 99.9 0.798 Contact Map
3r5dA 3 0.8577 99.9 0.804 Contact Map
2iu8A 3 0.9745 99.9 0.807 Contact Map
3r8yA 3 0.7409 99.9 0.809 Contact Map
3pmoA 3 0.9964 99.8 0.84 Contact Map
3q1xA 3 0.7336 99.6 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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