GREMLIN Database
CYSE - Serine acetyltransferase
UniProt: P0A9D4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10187
Length: 273 (241)
Sequences: 982 (603)
Seq/√Len: 38.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_V159_A5.4361.00
171_E197_R4.7851.00
197_R213_E4.6651.00
196_I214_V4.3021.00
171_E198_E3.9521.00
152_R172_N3.9031.00
197_R216_R3.8381.00
156_L162_I3.6791.00
191_D195_K3.5391.00
195_K211_N3.2551.00
172_N198_E3.2151.00
171_E213_E3.0431.00
221_G237_A2.9171.00
196_I202_I2.6051.00
14_K18_R2.5281.00
150_I170_I2.4791.00
213_E229_P2.4211.00
164_V170_I2.3581.00
202_I220_I2.2791.00
234_T243_I2.2150.99
42_G82_A2.2100.99
13_I102_L2.1900.99
70_A119_W2.1460.99
150_I164_V2.0640.99
217_G233_H2.0640.99
18_R22_D2.0320.99
173_D199_G1.9500.99
191_D211_N1.9310.98
114_Y150_I1.9210.98
231_P243_I1.9080.98
173_D198_E1.8700.98
114_Y133_Q1.8600.98
161_G179_S1.8560.98
121_W145_H1.8530.98
41_L81_A1.7980.97
150_I154_I1.7890.97
199_G217_G1.7430.97
153_G173_D1.7400.97
83_C152_R1.6890.96
113_A132_L1.6720.96
179_S205_G1.6580.96
216_R233_H1.6560.96
198_E216_R1.6280.95
218_A232_P1.6080.95
148_A178_Q1.5870.95
45_L81_A1.5840.95
95_V105_L1.5750.95
216_R232_P1.5710.94
169_V195_K1.5450.94
118_H122_N1.5420.94
78_I82_A1.5200.93
125_R129_A1.5170.93
141_Q155_M1.4960.93
230_V236_A1.4890.93
179_S207_K1.4790.92
207_K225_V1.4610.92
202_I208_I1.4590.92
151_G172_N1.4570.92
78_I81_A1.4220.91
41_L45_L1.4100.91
238_G241_A1.4060.90
89_R116_I1.3960.90
171_E216_R1.3610.89
15_A18_R1.3600.89
79_A152_R1.3520.89
71_Y77_M1.3500.89
113_A136_V1.3100.87
233_H247_P1.3020.87
8_I82_A1.3000.87
42_G78_I1.2940.86
114_Y136_V1.2820.86
55_S134_N1.2410.84
135_Q138_V1.1990.82
93_P177_L1.1960.82
83_C153_G1.1920.81
80_S83_C1.1820.81
168_A182_L1.1530.79
73_A123_Q1.1520.79
147_A166_E1.1470.79
85_I98_Y1.1440.79
77_M80_S1.1390.78
103_L204_A1.1220.77
13_I99_S1.1180.77
31_Y132_L1.1140.77
111_L154_I1.1120.77
144_I164_V1.1120.77
236_A242_R1.1060.76
88_V108_F1.1060.76
87_A91_R1.1040.76
73_A119_W1.1000.76
17_A93_P1.0890.75
168_A204_A1.0820.75
197_R229_P1.0790.74
101_P105_L1.0610.73
67_V116_I1.0540.73
135_Q139_T1.0460.72
187_K195_K1.0280.71
174_V202_I1.0250.70
111_L170_I1.0240.70
207_K237_A1.0150.70
70_A74_D1.0090.69
119_W123_Q1.0090.69
228_Q233_H1.0060.69
97_K100_T1.0010.69
161_G178_Q0.9980.68
219_K247_P0.9980.68
156_L176_I0.9940.68
136_V141_Q0.9780.67
125_R128_L0.9760.67
29_S47_Y0.9670.66
100_T178_Q0.9600.65
40_N43_S0.9580.65
142_V155_M0.9500.64
185_T195_K0.9480.64
118_H149_K0.9470.64
69_E119_W0.9450.64
110_A205_G0.9360.63
54_S57_I0.9320.63
149_K169_V0.9310.63
22_D26_M0.9300.63
219_K235_T0.9290.63
195_K213_E0.9280.63
130_I141_Q0.9190.62
155_M201_M0.9170.62
176_I196_I0.9170.62
217_G247_P0.9070.61
91_R186_G0.9050.61
46_S64_R0.9040.61
52_K55_S0.8990.60
208_I226_V0.8950.60
130_I178_Q0.8950.60
227_L237_A0.8900.59
20_L127_A0.8890.59
41_L49_L0.8820.59
49_L52_K0.8790.58
89_R189_G0.8770.58
188_S195_K0.8620.57
20_L31_Y0.8570.56
66_V125_R0.8550.56
27_L30_F0.8540.56
96_D132_L0.8430.55
177_L184_G0.8400.55
234_T245_G0.8320.54
203_G219_K0.8290.54
185_T211_N0.8290.54
80_S152_R0.8270.54
218_A234_T0.8250.54
15_A19_T0.8240.54
70_A123_Q0.8240.54
106_K137_S0.8230.53
9_V86_Q0.8200.53
111_L156_L0.8190.53
167_T193_H0.8150.53
211_N229_P0.8150.53
114_Y117_G0.8140.53
178_Q197_R0.8100.52
47_Y55_S0.8020.52
71_Y81_A0.8000.51
129_A212_I0.7980.51
149_K208_I0.7940.51
48_M221_G0.7920.51
53_L108_F0.7920.51
13_I17_A0.7820.50
79_A89_R0.7810.50
64_R68_E0.7810.50
185_T191_D0.7790.49
73_A79_A0.7780.49
89_R98_Y0.7730.49
70_A77_M0.7730.49
86_Q98_Y0.7720.49
168_A196_I0.7720.49
182_L193_H0.7710.49
43_S47_Y0.7670.48
77_M118_H0.7660.48
12_N89_R0.7650.48
225_V237_A0.7640.48
8_I89_R0.7640.48
67_V71_Y0.7580.48
81_A138_V0.7560.47
86_Q90_T0.7550.47
162_I178_Q0.7530.47
28_A34_T0.7500.47
109_H212_I0.7500.47
29_S32_H0.7450.46
44_A102_L0.7440.46
234_T246_K0.7430.46
96_D159_A0.7410.46
70_A116_I0.7390.46
132_L211_N0.7370.46
231_P234_T0.7350.46
234_T244_V0.7340.45
153_G186_G0.7280.45
198_E213_E0.7240.45
19_T23_C0.7210.44
181_T193_H0.7190.44
52_K221_G0.7180.44
77_M228_Q0.7180.44
8_I90_T0.7170.44
224_S227_L0.7160.44
187_K211_N0.7150.44
21_A33_A0.7120.43
12_N15_A0.7100.43
17_A99_S0.7090.43
174_V208_I0.7080.43
73_A76_E0.7070.43
59_P62_A0.7060.43
207_K227_L0.7000.42
12_N19_T0.7000.42
12_N16_E0.6960.42
124_G128_L0.6930.42
187_K191_D0.6910.42
131_F141_Q0.6900.42
156_L164_V0.6890.41
212_I229_P0.6890.41
191_D212_I0.6890.41
67_V171_E0.6880.41
243_I246_K0.6840.41
71_Y78_I0.6810.41
38_H47_Y0.6790.41
65_E208_I0.6790.41
183_G192_R0.6740.40
138_V161_G0.6730.40
212_I219_K0.6700.40
213_E216_R0.6620.39
46_S50_A0.6580.39
122_N147_A0.6580.39
43_S59_P0.6570.39
230_V235_T0.6560.39
30_F104_Y0.6540.38
59_P214_V0.6520.38
77_M150_I0.6520.38
101_P221_G0.6510.38
178_Q229_P0.6510.38
238_G242_R0.6500.38
212_I228_Q0.6500.38
8_I11_N0.6490.38
12_N86_Q0.6490.38
136_V179_S0.6490.38
76_E79_A0.6440.38
95_V130_I0.6430.37
176_I200_V0.6410.37
232_P240_P0.6390.37
166_E178_Q0.6390.37
72_A75_P0.6380.37
224_S237_A0.6350.37
8_I248_D0.6330.37
225_V238_G0.6320.37
22_D220_I0.6310.36
160_T179_S0.6310.36
184_G212_I0.6280.36
97_K202_I0.6280.36
12_N130_I0.6280.36
27_L36_L0.6280.36
136_V142_V0.6260.36
78_I244_V0.6240.36
174_V216_R0.6180.35
16_E97_K0.6120.35
137_S160_T0.6120.35
73_A176_I0.6120.35
106_K177_L0.6110.35
14_K123_Q0.6090.35
60_A64_R0.6060.34
201_M245_G0.6020.34
160_T221_G0.6010.34
100_T197_R0.6000.34
63_I66_V0.5990.34
85_I108_F0.5990.34
119_W122_N0.5990.34
209_L222_A0.5990.34
214_V226_V0.5950.33
45_L116_I0.5950.33
129_A211_N0.5930.33
41_L75_P0.5890.33
207_K224_S0.5890.33
59_P220_I0.5890.33
200_V220_I0.5850.33
31_Y48_M0.5850.33
76_E80_S0.5840.33
169_V191_D0.5810.32
72_A79_A0.5800.32
87_A206_A0.5790.32
156_L208_I0.5740.32
56_P60_A0.5730.32
126_R130_I0.5710.32
52_K66_V0.5710.32
188_S211_N0.5700.31
174_V197_R0.5650.31
217_G245_G0.5650.31
8_I12_N0.5620.31
46_S124_G0.5600.31
118_H182_L0.5590.31
24_E125_R0.5590.31
148_A158_H0.5580.31
39_E79_A0.5570.30
136_V236_A0.5560.30
156_L223_G0.5550.30
110_A174_V0.5540.30
13_I134_N0.5530.30
29_S38_H0.5520.30
87_A231_P0.5500.30
185_T212_I0.5500.30
72_A149_K0.5500.30
197_R218_A0.5490.30
11_N19_T0.5480.30
169_V211_N0.5470.30
66_V69_E0.5470.30
93_P157_D0.5460.30
59_P225_V0.5420.29
225_V239_V0.5390.29
13_I30_F0.5390.29
239_V242_R0.5380.29
111_L142_V0.5380.29
85_I102_L0.5380.29
114_Y129_A0.5360.29
136_V150_I0.5350.29
113_A135_Q0.5350.29
95_V221_G0.5340.29
91_R184_G0.5340.29
113_A117_G0.5320.29
110_A134_N0.5320.29
128_L209_L0.5280.28
101_P116_I0.5270.28
116_I136_V0.5260.28
88_V155_M0.5250.28
34_T41_L0.5250.28
29_S61_I0.5250.28
65_E68_E0.5240.28
96_D189_G0.5220.28
157_D192_R0.5200.28
95_V101_P0.5190.28
219_K248_D0.5190.28
32_H37_K0.5190.28
166_E193_H0.5170.28
183_G193_H0.5150.27
44_A53_L0.5130.27
95_V156_L0.5120.27
50_A58_M0.5110.27
60_A63_I0.5110.27
69_E243_I0.5100.27
94_A157_D0.5100.27
22_D80_S0.5100.27
15_A89_R0.5090.27
218_A230_V0.5090.27
183_G209_L0.5090.27
9_V12_N0.5090.27
168_A186_G0.5090.27
185_T213_E0.5080.27
230_V244_V0.5070.27
135_Q211_N0.5070.27
113_A178_Q0.5070.27
103_L109_H0.5060.27
91_R175_S0.5060.27
18_R79_A0.5050.27
8_I221_G0.5040.27
118_H231_P0.5040.27
74_D119_W0.5030.27
185_T238_G0.5030.27
69_E90_T0.5030.27
114_Y148_A0.5010.26
175_S199_G0.5010.26
49_L67_V0.5000.26
78_I88_V0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h7oA 6 0.9451 100 0.385 Contact Map
4n6aA 3 0.8938 100 0.39 Contact Map
1ssqA 6 0.9414 100 0.407 Contact Map
4hzdA 5 0.9084 100 0.443 Contact Map
3q1xA 3 0.8645 100 0.532 Contact Map
3f1xA 6 0.8608 100 0.575 Contact Map
3tk8A 3 0.685 99.9 0.767 Contact Map
3fttA 3 0.6227 99.9 0.77 Contact Map
1krrA 3 0.685 99.9 0.772 Contact Map
3srtA 3 0.63 99.9 0.777 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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