GREMLIN Database
GSTA - Glutathione S-transferase GstA
UniProt: P0A9D2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12613
Length: 201 (190)
Sequences: 22816 (15717)
Seq/√Len: 1140.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_Q95_I3.2851.00
2_K28_V3.1641.00
20_E188_R3.0811.00
144_H184_R3.0541.00
75_D91_R3.0141.00
19_R193_D2.8981.00
61_T89_I2.8971.00
18_L25_F2.7401.00
180_A184_R2.7031.00
44_F50_G2.6201.00
2_K26_T2.5511.00
137_N177_H2.3811.00
134_Q175_L2.3671.00
141_K177_H2.1961.00
151_F156_A2.0531.00
17_T70_M2.0231.00
130_E174_G1.9171.00
87_N90_S1.9001.00
19_R25_F1.8991.00
31_D34_K1.8481.00
179_A183_Q1.8451.00
93_K96_E1.8001.00
5_Y11_S1.7501.00
20_E190_E1.6941.00
41_D45_A1.6741.00
75_D95_I1.6421.00
57_L60_G1.6261.00
16_I191_V1.6241.00
97_W139_A1.6161.00
57_L62_L1.5781.00
159_F185_M1.5711.00
42_D45_A1.5391.00
46_V54_A1.5351.00
21_S74_A1.5321.00
144_H149_Q1.5241.00
23_K77_V1.5161.00
58_D72_Y1.5101.00
43_Y54_A1.5081.00
4_F30_V1.4891.00
123_P127_A1.4871.00
151_F188_R1.4841.00
119_E123_P1.4441.00
134_Q138_E1.4331.00
189_P193_D1.4131.00
182_M186_A1.4031.00
2_K57_L1.3931.00
177_H180_A1.3831.00
99_N103_T1.3731.00
118_P121_Y1.3721.00
147_C152_T1.3661.00
173_E179_A1.3571.00
43_Y46_V1.3521.00
126_R130_E1.3431.00
139_A143_E1.3271.00
17_T21_S1.3211.00
100_Y135_Y1.3121.00
146_I158_L1.2841.00
89_I93_K1.2841.00
99_N102_A1.2811.00
71_Q99_N1.2501.00
64_T96_E1.2481.00
183_Q187_E1.2461.00
58_D61_T1.2231.00
36_R40_G1.2081.00
98_L157_Y1.2021.00
135_Y139_A1.1761.00
100_Y132_K1.1731.00
39_N50_G1.1641.00
20_E151_F1.1531.00
187_E192_Q1.1471.00
151_F185_M1.1401.00
130_E175_L1.1381.00
159_F186_A1.1361.00
145_W185_M1.1351.00
5_Y9_A1.1351.00
63_L92_Y1.1201.00
76_S88_S1.1071.00
93_K139_A1.1001.00
4_F57_L1.0901.00
137_N141_K1.0901.00
13_A66_G1.0891.00
6_K9_A1.0851.00
90_S93_K1.0811.00
128_Q131_K1.0781.00
46_V62_L1.0701.00
127_A131_K1.0661.00
70_M157_Y1.0621.00
130_E134_Q1.0601.00
58_D76_S1.0571.00
85_P94_T1.0431.00
137_N176_E1.0421.00
101_I158_L1.0411.00
3_L18_L1.0361.00
70_M153_I1.0351.00
123_P126_R1.0341.00
94_T147_C1.0281.00
14_S70_M1.0191.00
134_Q174_G1.0181.00
138_E141_K1.0181.00
67_V99_N1.0161.00
127_A130_E0.9921.00
14_S69_I0.9831.00
51_Q65_E0.9801.00
98_L153_I0.9781.00
15_H19_R0.9751.00
138_E142_D0.9731.00
58_D77_V0.9721.00
144_H180_A0.9671.00
46_V57_L0.9671.00
124_T128_Q0.9611.00
131_K134_Q0.9521.00
120_E123_P0.9461.00
94_T152_T0.9431.00
108_G111_P0.9421.00
61_T93_K0.9421.00
179_A182_M0.9401.00
43_Y47_N0.9371.00
17_T156_A0.9351.00
159_F191_V0.9331.00
49_K64_T0.9201.00
88_S92_Y0.9201.00
90_S150_R0.9171.00
21_S73_L0.9161.00
91_R95_I0.9151.00
163_R186_A0.9131.00
119_E122_K0.9101.00
184_R187_E0.9081.00
162_L181_F0.9041.00
42_D46_V0.8941.00
17_T82_L0.8861.00
183_Q186_A0.8861.00
13_A70_M0.8861.00
135_Y138_E0.8841.00
67_V157_Y0.8811.00
166_Y182_M0.8791.00
139_A142_D0.8781.00
11_S52_V0.8771.00
49_K100_Y0.8761.00
40_G44_F0.8751.00
13_A157_Y0.8721.00
94_T153_I0.8701.00
54_A62_L0.8671.00
72_Y76_S0.8661.00
20_E156_A0.8561.00
16_I156_A0.8551.00
181_F185_M0.8521.00
15_H27_L0.8501.00
5_Y27_L0.8341.00
146_I154_A0.8271.00
41_D44_F0.8251.00
107_K111_P0.8251.00
110_T114_R0.8221.00
82_L156_A0.8171.00
180_A183_Q0.8151.00
145_W184_R0.8111.00
54_A64_T0.8061.00
162_L182_M0.8031.00
57_L61_T0.7911.00
137_N175_L0.7851.00
47_N50_G0.7841.00
47_N54_A0.7791.00
12_L194_A0.7771.00
16_I190_E0.7501.00
74_A81_Q0.7461.00
171_N174_G0.7401.00
142_D177_H0.7401.00
16_I160_T0.7371.00
124_T127_A0.7361.00
61_T92_Y0.7351.00
39_N44_F0.7331.00
93_K143_E0.7321.00
146_I181_F0.7271.00
92_Y95_I0.7251.00
169_K172_L0.7181.00
67_V102_A0.7151.00
137_N178_I0.7111.00
71_Q75_D0.7111.00
163_R191_V0.7101.00
121_Y125_V0.7081.00
21_S81_Q0.7041.00
78_P81_Q0.7021.00
111_P128_Q0.7001.00
21_S77_V0.6981.00
108_G132_K0.6941.00
175_L178_I0.6941.00
125_V128_Q0.6931.00
136_V158_L0.6931.00
143_E149_Q0.6891.00
73_L77_V0.6871.00
68_A96_E0.6871.00
174_G179_A0.6861.00
97_W147_C0.6831.00
63_L72_Y0.6801.00
17_T74_A0.6771.00
184_R188_R0.6761.00
78_P82_L0.6761.00
122_K126_R0.6751.00
85_P90_S0.6671.00
118_P122_K0.6651.00
90_S147_C0.6621.00
68_A92_Y0.6591.00
132_K135_Y0.6581.00
136_V146_I0.6571.00
94_T154_A0.6551.00
81_Q86_V0.6461.00
97_W146_I0.6421.00
30_V36_R0.6401.00
147_C154_A0.6361.00
114_R120_E0.6351.00
133_L178_I0.6351.00
67_V98_L0.6311.00
93_K97_W0.6301.00
120_E124_T0.6291.00
10_C13_A0.6281.00
81_Q150_R0.6281.00
3_L15_H0.6281.00
5_Y8_G0.6251.00
75_D88_S0.6251.00
145_W151_F0.6231.00
33_M36_R0.6211.00
63_L69_I0.6201.00
7_P29_S0.6181.00
139_A146_I0.6171.00
71_Q153_I0.6161.00
136_V178_I0.6151.00
91_R94_T0.6141.00
31_D36_R0.6121.00
32_L36_R0.6101.00
185_M191_V0.6051.00
133_L175_L0.6041.00
109_F129_L0.6031.00
16_I159_F0.6021.00
189_P192_Q0.6011.00
104_E132_K0.5991.00
12_L163_R0.5981.00
129_L133_L0.5981.00
74_A153_I0.5961.00
131_K135_Y0.5961.00
4_F28_V0.5931.00
176_E180_A0.5911.00
166_Y171_N0.5891.00
12_L160_T0.5861.00
31_D35_K0.5851.00
176_E179_A0.5851.00
21_S78_P0.5841.00
85_P88_S0.5811.00
93_K147_C0.5811.00
17_T153_I0.5781.00
163_R182_M0.5691.00
19_R194_A0.5671.00
35_K39_N0.5641.00
190_E193_D0.5631.00
97_W100_Y0.5631.00
111_P114_R0.5621.00
3_L14_S0.5561.00
18_L73_L0.5551.00
15_H194_A0.5521.00
19_R190_E0.5521.00
11_S27_L0.5501.00
83_L94_T0.5491.00
143_E147_C0.5461.00
168_V172_L0.5451.00
74_A78_P0.5421.00
76_S89_I0.5361.00
65_E104_E0.5351.00
88_S91_R0.5321.00
134_Q137_N0.5291.00
75_D86_V0.5261.00
13_A67_V0.5251.00
19_R22_G0.5201.00
30_V33_M0.5191.00
106_H161_V0.5161.00
143_E148_G0.5161.00
96_E139_A0.5151.00
158_L181_F0.5141.00
3_L55_L0.5131.00
70_M74_A0.5061.00
101_I105_L0.5051.00
21_S80_R0.5041.00
166_Y172_L0.5021.00
111_P125_V0.5021.00
111_P115_P0.5011.00
109_F113_F0.5011.00
32_L35_K0.5011.00
145_W148_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pmtA 2 0.995 100 0.179 Contact Map
2dsaA 2 0.99 100 0.181 Contact Map
1f2eA 3 0.995 100 0.183 Contact Map
2pvqA 2 0.99 100 0.185 Contact Map
4kgiA 2 0.99 100 0.2 Contact Map
3uarA 2 0.995 100 0.201 Contact Map
4gf0A 2 0.9851 100 0.203 Contact Map
2x64A 2 0.9751 100 0.204 Contact Map
4gciA 2 0.99 100 0.206 Contact Map
1k0dA 2 0.9751 100 0.209 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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