GREMLIN Database
GLPX - Fructose-1,6-bisphosphatase 1 class 2
UniProt: P0A9C9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11517
Length: 336 (312)
Sequences: 1121 (515)
Seq/√Len: 29.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_I174_M6.0131.00
143_L157_L4.1141.00
28_D31_T3.9681.00
50_D79_A3.9361.00
140_A173_E3.8891.00
136_N231_R3.2731.00
34_G38_N3.2101.00
146_V204_V3.1411.00
171_I183_A3.1401.00
159_V204_V3.1221.00
222_R270_G3.0811.00
139_L206_Y3.0721.00
192_S217_S3.0611.00
87_I285_I2.9881.00
174_M179_V2.8921.00
21_Y296_R2.8481.00
235_R252_E2.7971.00
50_D71_K2.7451.00
79_A109_K2.7401.00
124_I221_I2.7181.00
10_S305_T2.6851.00
228_M269_L2.6101.00
52_T71_K2.6010.99
134_D266_V2.5750.99
121_E231_R2.5180.99
135_L266_V2.4670.99
169_A173_E2.4590.99
131_G227_D2.4020.99
254_A258_A2.3230.99
52_T109_K2.3230.99
304_E319_Q2.2590.99
136_N266_V2.2190.98
208_I233_L2.1780.98
196_C221_I2.1040.98
128_G150_L2.0840.97
304_E317_R1.9780.97
135_L231_R1.9200.96
170_V206_Y1.9010.96
18_L301_A1.8970.96
129_A146_V1.8760.95
146_V157_L1.8730.95
143_L177_L1.8650.95
137_L145_N1.8420.95
172_A176_Q1.8160.94
302_T319_Q1.7980.94
123_L133_I1.7580.93
143_L204_V1.7270.93
143_L154_L1.6980.92
125_V204_V1.6570.91
162_L184_I1.6450.91
24_L286_T1.6280.90
9_F106_V1.6230.90
137_L141_D1.6220.90
108_D277_N1.6210.90
3_R309_R1.6080.90
284_G288_G1.5980.89
165_P168_D1.5830.89
222_R273_A1.5610.88
133_I146_V1.5310.87
160_T184_I1.5170.87
309_R314_T1.5160.87
20_G102_A1.5040.86
82_I106_V1.5020.86
313_R326_R1.4750.85
159_V206_Y1.4750.85
287_K292_E1.4740.85
294_I303_T1.4730.85
227_D269_L1.4640.85
168_D172_A1.4390.84
112_F273_A1.4290.83
160_T191_A1.4110.83
297_K300_I1.4060.82
29_K60_I1.4050.82
47_V109_K1.4030.82
140_A176_Q1.3720.81
41_R70_E1.3670.80
292_E319_Q1.3660.80
59_E65_M1.3520.80
262_E265_K1.3340.79
68_I115_A1.3340.79
161_I171_I1.3300.79
253_L257_K1.3160.78
115_A211_A1.2920.77
300_I324_L1.2890.76
301_A324_L1.2770.76
60_I235_R1.2730.75
140_A144_R1.2670.75
114_N118_M1.2630.75
154_L179_V1.2590.75
117_D211_A1.2590.75
68_I114_N1.2530.74
11_R309_R1.2520.74
134_D229_N1.2470.74
91_R95_M1.2330.73
107_G111_C1.2320.73
267_L271_D1.2300.73
68_I211_A1.2290.73
71_K109_K1.2270.73
44_L104_L1.2260.73
121_E208_I1.2250.73
309_R312_S1.2210.72
219_A278_V1.2200.72
105_A219_A1.2190.72
64_P90_T1.2130.72
153_P156_E1.2120.72
92_M185_P1.2020.71
141_D145_N1.2010.71
68_I117_D1.2010.71
23_W35_A1.1970.71
63_A90_T1.1940.71
130_K227_D1.1870.70
61_D90_T1.1850.70
58_G61_D1.1840.70
113_L211_A1.1790.70
142_N145_N1.1760.69
61_D65_M1.1750.69
60_I118_M1.1620.68
138_P142_N1.1470.67
182_F289_D1.1460.67
161_I207_G1.1450.67
234_A252_E1.1370.67
135_L229_N1.1320.66
152_K203_D1.1310.66
57_E61_D1.1280.66
229_N266_V1.1110.65
124_I228_M1.1080.65
302_T321_I1.1070.65
29_K84_V1.0960.64
108_D275_S1.0960.64
169_A172_A1.0950.64
48_N74_T1.0850.63
309_R316_R1.0840.63
129_A205_L1.0770.62
236_H251_Q1.0750.62
115_A255_R1.0750.62
133_I142_N1.0670.62
143_L174_M1.0640.62
125_V227_D1.0520.61
3_R8_E1.0290.59
313_R323_Y1.0260.59
211_A214_G1.0250.59
138_P141_D1.0250.59
143_L146_V1.0200.58
123_L320_S1.0190.58
90_T212_P1.0110.58
30_N87_I1.0090.57
52_T114_N1.0070.57
168_D171_I1.0050.57
251_Q254_A1.0040.57
265_K271_D1.0010.57
86_P212_P1.0000.57
223_A308_I0.9930.56
111_C274_R0.9920.56
261_I265_K0.9870.56
99_N191_A0.9840.55
205_L216_V0.9780.55
11_R316_R0.9720.55
113_L117_D0.9590.54
61_D64_P0.9550.53
32_A87_I0.9540.53
91_R186_D0.9520.53
275_S310_G0.9480.53
117_D255_R0.9300.51
59_E255_R0.9280.51
230_G272_M0.9250.51
303_T322_H0.9230.51
118_M252_E0.9190.50
20_G319_Q0.9150.50
4_E279_I0.9120.50
255_R259_M0.9080.50
32_A93_T0.9060.49
152_K310_G0.9020.49
114_N259_M0.8980.49
65_M90_T0.8920.48
85_D90_T0.8880.48
236_H252_E0.8880.48
283_T303_T0.8880.48
95_M223_A0.8840.48
132_T145_N0.8760.47
87_I93_T0.8750.47
95_M163_A0.8720.47
118_M211_A0.8710.47
60_I117_D0.8670.46
216_V227_D0.8600.46
214_G230_G0.8600.46
142_N229_N0.8580.46
16_A40_M0.8560.45
9_F190_A0.8540.45
99_N160_T0.8530.45
228_M272_M0.8530.45
3_R11_R0.8520.45
125_V129_A0.8500.45
60_I87_I0.8500.45
98_A287_K0.8430.44
33_D57_E0.8420.44
107_G112_F0.8390.44
116_P215_V0.8310.44
88_E171_I0.8300.43
278_V310_G0.8290.43
59_E90_T0.8260.43
60_I211_A0.8240.43
117_D259_M0.8210.43
68_I118_M0.8170.42
253_L264_G0.8140.42
217_S221_I0.8130.42
251_Q320_S0.8120.42
23_W31_T0.8070.42
11_R314_T0.8060.42
65_M68_I0.8050.42
138_P145_N0.8040.41
96_G100_A0.8020.41
58_G64_P0.7950.41
121_E135_L0.7940.41
8_E47_V0.7930.41
116_P211_A0.7920.41
58_G65_M0.7910.40
237_D254_A0.7910.40
124_I192_S0.7830.40
59_E64_P0.7830.40
133_I149_A0.7810.40
60_I84_V0.7800.40
4_E305_T0.7770.39
65_M255_R0.7760.39
13_T53_I0.7730.39
48_N76_R0.7720.39
98_A194_L0.7700.39
13_T283_T0.7680.39
117_D256_C0.7680.39
211_A261_I0.7660.39
223_A278_V0.7630.38
29_K90_T0.7620.38
97_Q185_P0.7610.38
10_S318_I0.7600.38
51_G72_V0.7590.38
137_L142_N0.7560.38
129_A149_A0.7550.38
59_E68_I0.7520.38
132_T227_D0.7500.37
88_E190_A0.7420.37
161_I170_V0.7410.37
254_A257_K0.7410.37
97_Q305_T0.7400.37
118_M259_M0.7390.37
125_V228_M0.7340.36
97_Q102_A0.7310.36
221_I269_L0.7280.36
114_N117_D0.7270.36
11_R14_E0.7270.36
8_E108_D0.7260.36
68_I259_M0.7260.36
97_Q104_L0.7240.36
59_E63_A0.7240.36
104_L185_P0.7230.35
282_A291_L0.7210.35
198_P317_R0.7200.35
152_K297_K0.7200.35
156_E271_D0.7170.35
68_I255_R0.7150.35
37_V59_E0.7130.35
133_I197_M0.7130.35
259_M263_A0.7080.34
96_G301_A0.7050.34
3_R189_V0.7020.34
115_A215_V0.7010.34
227_D256_C0.6980.34
22_K296_R0.6960.34
133_I158_T0.6940.33
237_D259_M0.6940.33
277_N310_G0.6920.33
174_M177_L0.6920.33
161_I181_V0.6910.33
193_I290_L0.6900.33
101_L160_T0.6900.33
295_S302_T0.6880.33
86_P90_T0.6870.33
4_E9_F0.6860.33
89_G210_G0.6850.33
114_N211_A0.6830.33
44_L91_R0.6810.33
24_L96_G0.6810.33
93_T100_A0.6800.32
123_L142_N0.6800.32
12_V44_L0.6740.32
163_A168_D0.6740.32
58_G90_T0.6690.32
208_I216_V0.6690.32
58_G63_A0.6660.31
182_F202_V0.6620.31
164_K223_A0.6610.31
53_I72_V0.6590.31
22_K301_A0.6590.31
33_D58_G0.6560.31
276_D311_K0.6560.31
6_A279_I0.6530.31
237_D253_L0.6530.31
37_V61_D0.6530.31
115_A259_M0.6510.30
222_R271_D0.6490.30
60_I68_I0.6470.30
33_D61_D0.6460.30
194_L289_D0.6440.30
3_R312_S0.6430.30
133_I145_N0.6420.30
48_N285_I0.6410.30
91_R185_P0.6410.30
24_L93_T0.6400.30
234_A263_A0.6380.30
281_S309_R0.6380.30
261_I267_L0.6380.30
31_T35_A0.6370.30
55_I63_A0.6340.29
37_V63_A0.6330.29
10_S106_V0.6330.29
144_R153_P0.6310.29
152_K256_C0.6270.29
102_A305_T0.6260.29
84_V258_A0.6260.29
108_D111_C0.6250.29
309_R322_H0.6240.29
22_K223_A0.6240.29
63_A103_V0.6240.29
175_Q303_T0.6230.29
134_D221_I0.6210.29
63_A212_P0.6200.28
184_I191_A0.6190.28
152_K157_L0.6160.28
139_L170_V0.6140.28
96_G180_R0.6140.28
177_L305_T0.6140.28
106_V320_S0.6130.28
141_D144_R0.6120.28
197_M224_L0.6110.28
123_L149_A0.6100.28
88_E233_L0.6100.28
203_D319_Q0.6090.28
44_L93_T0.6090.28
204_V325_D0.6050.28
150_L310_G0.6030.27
261_I270_G0.6030.27
63_A70_E0.6010.27
101_L151_G0.6010.27
33_D119_Y0.6000.27
151_G154_L0.5980.27
30_N60_I0.5980.27
57_E119_Y0.5970.27
32_A231_R0.5970.27
222_R274_R0.5960.27
61_D212_P0.5960.27
18_L49_I0.5960.27
299_N325_D0.5960.27
133_I169_A0.5950.27
46_Q287_K0.5920.27
24_L296_R0.5920.27
19_A39_A0.5920.27
57_E63_A0.5900.27
60_I114_N0.5900.27
28_D32_A0.5880.26
23_W32_A0.5880.26
138_P195_T0.5860.26
9_F101_L0.5850.26
132_T148_A0.5850.26
127_P201_E0.5840.26
84_V99_N0.5840.26
203_D297_K0.5840.26
21_Y93_T0.5830.26
94_A191_A0.5830.26
7_I10_S0.5780.26
76_R302_T0.5770.26
295_S300_I0.5770.26
59_E212_P0.5760.26
14_E303_T0.5760.26
192_S205_L0.5730.26
163_A185_P0.5720.26
101_L282_A0.5720.26
146_V159_V0.5700.25
87_I256_C0.5700.25
65_M212_P0.5690.25
57_E90_T0.5690.25
52_T258_A0.5680.25
121_E162_L0.5680.25
253_L263_A0.5670.25
31_T279_I0.5670.25
184_I233_L0.5660.25
57_E86_P0.5650.25
47_V189_V0.5650.25
111_C275_S0.5640.25
220_V272_M0.5640.25
83_A212_P0.5640.25
221_I228_M0.5630.25
124_I159_V0.5620.25
10_S13_T0.5610.25
120_M230_G0.5610.25
55_I83_A0.5580.25
22_K156_E0.5580.25
93_T273_A0.5580.25
30_N62_E0.5550.25
129_A133_I0.5540.24
124_I195_T0.5540.24
123_L146_V0.5520.24
65_M84_V0.5520.24
53_I308_I0.5510.24
63_A83_A0.5490.24
161_I173_E0.5490.24
134_D137_L0.5480.24
121_E233_L0.5480.24
198_P203_D0.5460.24
8_E314_T0.5460.24
194_L305_T0.5430.24
63_A85_D0.5430.24
186_D318_I0.5420.24
86_P119_Y0.5410.24
72_V193_I0.5390.24
139_L195_T0.5380.24
135_L279_I0.5380.24
37_V65_M0.5370.23
3_R314_T0.5370.23
184_I256_C0.5360.23
18_L322_H0.5360.23
199_D306_L0.5360.23
230_G288_G0.5350.23
317_R321_I0.5340.23
256_C263_A0.5340.23
33_D86_P0.5330.23
99_N193_I0.5330.23
263_A267_L0.5330.23
125_V132_T0.5320.23
99_N182_F0.5320.23
59_E66_L0.5320.23
33_D37_V0.5310.23
154_L204_V0.5300.23
197_M317_R0.5300.23
203_D302_T0.5260.23
142_N149_A0.5260.23
165_P318_I0.5260.23
8_E11_R0.5230.23
37_V92_M0.5230.23
23_W34_G0.5220.23
9_F313_R0.5210.23
231_R266_V0.5200.23
181_V297_K0.5200.23
128_G198_P0.5190.22
63_A84_V0.5190.22
106_V308_I0.5180.22
29_K91_R0.5160.22
32_A113_L0.5150.22
38_N87_I0.5140.22
32_A164_K0.5130.22
37_V57_E0.5110.22
24_L100_A0.5110.22
118_M233_L0.5110.22
138_P173_E0.5100.22
112_F219_A0.5090.22
105_A229_N0.5090.22
88_E91_R0.5090.22
205_L267_L0.5090.22
173_E206_Y0.5080.22
64_P85_D0.5080.22
8_E322_H0.5070.22
115_A261_I0.5060.22
197_M321_I0.5050.22
133_I227_D0.5040.22
87_I232_L0.5040.22
222_R278_V0.5040.22
74_T77_G0.5010.22
168_D173_E0.5010.22
88_E189_V0.5010.22
55_I70_E0.5000.21
27_G175_Q0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bigA 1 0.9554 100 0.007 Contact Map
3rojA 3 0.9881 100 0.039 Contact Map
3b8bA 1 0.6905 97.2 0.948 Contact Map
4i3yA 2 0.7143 94.4 0.959 Contact Map
3t0jA 3 0.7321 94.1 0.96 Contact Map
1ka1A 1 0.753 93.9 0.96 Contact Map
1g0hA 2 0.6637 93.8 0.96 Contact Map
1lbvA 2 0.6577 93.8 0.96 Contact Map
4n81A 2 0.6726 93.7 0.96 Contact Map
2pcrA 3 0.6577 93.4 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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