GREMLIN Database
GLNA - Glutamine synthetase
UniProt: P0A9C5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10383
Length: 469 (423)
Sequences: 6368 (3189)
Seq/√Len: 155.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
423_D448_R5.0571.00
300_G387_I4.6801.00
195_E250_F3.8271.00
96_G99_Q3.8271.00
273_M298_Y3.8101.00
298_Y379_G3.6851.00
381_D385_N3.6621.00
91_D110_K3.4731.00
115_Y384_K3.4461.00
114_D118_S3.3721.00
119_T384_K3.3251.00
297_Y386_K3.2761.00
94_E99_Q3.0011.00
8_T12_E2.9241.00
304_K385_N2.8421.00
112_A377_M2.7121.00
192_I196_M2.6991.00
134_F215_A2.6751.00
429_L437_D2.6661.00
437_D441_D2.6261.00
460_P464_E2.6181.00
308_A425_D2.5861.00
108_I439_A2.5811.00
114_D117_R2.4981.00
308_A428_F2.4611.00
282_L294_Q2.4491.00
195_E249_R2.4311.00
127_F372_F2.4231.00
243_V254_A2.4111.00
276_S280_V2.3871.00
273_M375_L2.3631.00
9_M13_H2.3471.00
293_E386_K2.3231.00
227_N231_K2.2971.00
227_N235_E2.2951.00
305_H425_D2.2591.00
305_H381_D2.2551.00
420_N448_R2.2071.00
312_L374_A2.2041.00
414_S417_E2.1871.00
231_K235_E2.1371.00
297_Y300_G2.1351.00
416_E455_R2.1301.00
296_L388_H2.1271.00
113_E230_T2.1051.00
117_R122_A2.0761.00
122_A275_L2.0721.00
311_A422_L2.0681.00
313_A371_C2.0271.00
228_T231_K1.9591.00
307_K409_P1.9541.00
135_L192_I1.9481.00
37_H201_E1.9451.00
200_M242_V1.8921.00
136_F261_M1.8871.00
113_E229_M1.8821.00
20_L90_C1.8741.00
203_M242_V1.8691.00
422_L440_I1.8511.00
413_G417_E1.8121.00
196_M243_V1.8031.00
294_Q383_I1.7811.00
421_E424_L1.7771.00
116_L125_V1.7721.00
102_D438_E1.7691.00
453_R465_L1.7651.00
16_K198_L1.7611.00
206_V225_R1.7611.00
293_E297_Y1.7411.00
297_Y387_I1.7081.00
300_G389_P1.7001.00
366_A371_C1.6781.00
276_S279_G1.6751.00
113_E228_T1.6701.00
233_A372_F1.6501.00
134_F267_S1.6501.00
430_K437_D1.6451.00
291_L295_A1.6431.00
312_L422_L1.6411.00
419_L444_I1.6251.00
44_F72_A1.6061.00
239_Y243_V1.6041.00
15_V77_I1.5951.00
305_H378_A1.5911.00
416_E420_N1.5901.00
307_K421_E1.5771.00
423_D444_I1.5771.00
131_P236_I1.5741.00
125_V376_L1.5561.00
199_V246_V1.5431.00
110_K230_T1.5431.00
417_E420_N1.5361.00
74_T89_R1.5361.00
108_I373_A1.5351.00
10_L36_A1.5301.00
69_M93_L1.5291.00
116_L380_L1.5191.00
126_L226_F1.5031.00
427_E434_V1.4951.00
304_K387_I1.4851.00
377_M434_V1.4801.00
199_V202_Q1.4341.00
21_R87_I1.4191.00
112_A373_A1.4121.00
396_N399_D1.4081.00
121_I282_L1.4011.00
297_Y388_H1.3861.00
23_T237_Q1.3641.00
395_K404_E1.3611.00
232_K235_E1.3581.00
224_T232_K1.3571.00
135_L247_A1.3521.00
309_I313_A1.3521.00
87_I238_I1.3511.00
296_L389_P1.3281.00
13_H84_S1.3251.00
426_R430_K1.3191.00
200_M205_L1.3181.00
112_A115_Y1.3111.00
287_K296_L1.3051.00
311_A419_L1.3031.00
310_N412_A1.3011.00
447_R450_E1.3011.00
273_M379_G1.2861.00
359_V375_L1.2841.00
420_N424_L1.2791.00
16_K201_E1.2731.00
5_H8_T1.2691.00
75_A86_L1.2631.00
452_D455_R1.2571.00
10_L39_V1.2561.00
293_E388_H1.2481.00
300_G390_G1.2481.00
420_N423_D1.2471.00
293_E296_L1.2421.00
215_A265_N1.2291.00
137_D252_K1.2251.00
189_A220_N1.2221.00
344_I357_I1.2121.00
104_D107_S1.1931.00
110_K114_D1.1881.00
422_L428_F1.1861.00
298_Y380_L1.1771.00
213_E221_E1.1721.00
314_N319_S1.1701.00
310_N361_F1.1661.00
299_I357_I1.1651.00
308_A421_E1.1581.00
425_D429_L1.1571.00
429_L440_I1.1571.00
51_D54_S1.1571.00
195_E199_V1.1561.00
299_I344_I1.1551.00
115_Y377_M1.1541.00
7_L40_N1.1481.00
423_D441_D1.1441.00
309_I374_A1.1421.00
294_Q297_Y1.1371.00
271_C375_L1.1301.00
307_K310_N1.1301.00
68_L92_I1.1271.00
51_D55_I1.1231.00
29_E89_R1.1141.00
454_V461_V1.1121.00
122_A276_S1.1070.99
135_L254_A1.1060.99
246_V250_F1.1060.99
8_T11_N1.1030.99
257_M318_N1.1020.99
15_V86_L1.1010.99
138_D248_H1.1000.99
49_M53_S1.0990.99
71_D91_D1.0980.99
18_V39_V1.0900.99
227_N232_K1.0840.99
209_A223_A1.0830.99
429_L441_D1.0820.99
309_I378_A1.0690.99
116_L119_T1.0670.99
298_Y375_L1.0660.99
305_H385_N1.0640.99
306_A343_S1.0610.99
217_A264_D1.0610.99
52_G55_I1.0560.99
320_Y415_L1.0520.99
68_L90_C1.0500.99
262_F458_P1.0480.99
285_G290_G1.0480.99
94_E102_D1.0450.99
307_K417_E1.0410.99
50_F53_S1.0390.99
444_I448_R1.0380.99
303_I344_I1.0370.99
242_V246_V1.0360.99
100_G107_S1.0340.99
277_K280_V1.0310.99
48_K51_D1.0300.99
319_S363_D1.0280.99
452_D456_M1.0240.99
6_V75_A1.0150.99
337_A392_A1.0120.99
309_I428_F1.0060.99
321_K462_E1.0050.99
109_A229_M0.9990.99
449_E453_R0.9990.99
311_A443_Y0.9970.99
441_D445_A0.9940.99
6_V88_I0.9910.99
199_V242_V0.9880.99
271_C371_C0.9870.99
247_A254_A0.9860.99
199_V249_R0.9850.99
208_E225_R0.9820.99
121_I294_Q0.9820.99
136_F255_T0.9800.99
62_N396_N0.9780.99
422_L444_I0.9750.99
134_F265_N0.9730.99
76_V87_I0.9720.99
343_S361_F0.9700.99
5_H9_M0.9690.99
451_D455_R0.9660.99
339_N398_Y0.9650.99
34_I43_F0.9610.99
297_Y383_I0.9550.98
49_M52_G0.9530.98
29_E237_Q0.9500.98
7_L11_N0.9440.98
425_D428_F0.9410.98
300_G388_H0.9390.98
312_L440_I0.9360.98
458_P462_E0.9350.98
214_V265_N0.9340.98
6_V72_A0.9310.98
296_L300_G0.9260.98
203_M238_I0.9210.98
258_P363_D0.9180.98
404_E407_E0.9170.98
419_L447_R0.9160.98
180_Y211_H0.9160.98
419_L451_D0.9150.98
221_E270_H0.9110.98
454_V459_H0.9080.98
405_A408_I0.9060.98
224_T239_Y0.9060.98
307_K333_L0.9030.98
73_S231_K0.9030.98
18_V36_A0.8970.98
213_E270_H0.8970.98
60_G63_E0.8960.98
258_P365_A0.8860.98
93_L100_G0.8860.98
192_I246_V0.8820.97
24_D30_Q0.8820.97
449_E452_D0.8800.97
192_I252_K0.8790.97
341_S397_L0.8780.97
283_F295_A0.8770.97
423_D437_D0.8740.97
236_I269_M0.8730.97
302_V344_I0.8720.97
81_F85_T0.8700.97
108_I112_A0.8670.97
317_T415_L0.8660.97
459_H462_E0.8650.97
127_F232_K0.8640.97
416_E451_D0.8640.97
127_F298_Y0.8620.97
275_L282_L0.8620.97
284_A290_G0.8590.97
381_D430_K0.8520.97
419_L448_R0.8510.97
103_R438_E0.8500.97
13_H77_I0.8490.97
316_T365_A0.8480.97
457_T461_V0.8420.97
302_V357_I0.8420.97
334_A342_A0.8400.97
443_Y447_R0.8390.97
334_A408_I0.8360.96
130_E213_E0.8330.96
222_V239_Y0.8300.96
129_P236_I0.8280.96
416_E448_R0.8270.96
312_L435_F0.8260.96
122_A277_K0.8230.96
116_L121_I0.8210.96
448_R452_D0.8200.96
339_N396_N0.8170.96
130_E221_E0.8160.96
125_V273_M0.8150.96
112_A434_V0.8120.96
341_S398_Y0.8100.96
139_I142_G0.8080.96
458_P461_V0.8020.96
273_M359_V0.8020.96
77_I84_S0.8010.96
116_L275_L0.8010.96
104_D108_I0.8010.96
192_I250_F0.8000.96
48_K54_S0.8000.96
119_T380_L0.8000.96
351_S354_A0.7990.95
373_A435_F0.7990.95
121_I275_L0.7980.95
347_P356_R0.7960.95
188_S248_H0.7960.95
190_Q194_S0.7950.95
139_I143_S0.7940.95
423_D426_R0.7940.95
197_C210_H0.7890.95
330_P360_R0.7870.95
38_Q41_A0.7860.95
313_A425_D0.7850.95
306_A344_I0.7840.95
440_I444_I0.7840.95
50_F54_S0.7810.95
332_M405_A0.7790.95
262_F457_T0.7760.95
435_F440_I0.7750.95
93_L107_S0.7700.94
426_R437_D0.7690.94
133_F196_M0.7690.94
191_D250_F0.7680.94
81_F191_D0.7660.94
305_H308_A0.7640.94
71_D110_K0.7640.94
107_S111_R0.7630.94
127_F233_A0.7620.94
310_N314_N0.7610.94
198_L201_E0.7590.94
274_S356_R0.7580.94
334_A397_L0.7550.94
37_H206_V0.7540.94
342_A397_L0.7520.94
113_E125_V0.7480.94
310_N411_V0.7470.94
308_A427_E0.7430.93
205_L224_T0.7370.93
112_A116_L0.7360.93
298_Y302_V0.7360.93
198_L202_Q0.7340.93
119_T282_L0.7340.93
91_D104_D0.7340.93
324_V331_V0.7300.93
195_E246_V0.7270.93
233_A368_P0.7250.93
26_K446_L0.7250.93
130_E272_H0.7230.92
453_R456_M0.7230.92
285_G288_Y0.7180.92
132_E213_E0.7180.92
391_E394_D0.7170.92
317_T454_V0.7160.92
102_D436_T0.7160.92
100_G110_K0.7160.92
49_M67_V0.7150.92
454_V465_L0.7150.92
44_F47_G0.7140.92
48_K53_S0.7080.92
193_R210_H0.7060.92
377_M428_F0.7030.91
214_V328_E0.7010.91
78_D87_I0.7010.91
271_C372_F0.7000.91
17_F197_C0.6990.91
428_F435_F0.6980.91
302_V359_V0.6980.91
325_P331_V0.6950.91
257_M321_K0.6940.91
71_D74_T0.6940.91
442_A445_A0.6930.91
174_P178_G0.6920.91
39_V88_I0.6920.91
275_L376_L0.6900.91
108_I111_R0.6900.91
107_S110_K0.6890.90
99_Q102_D0.6880.90
312_L443_Y0.6880.90
206_V235_E0.6880.90
258_P319_S0.6870.90
200_M239_Y0.6860.90
40_N45_E0.6860.90
326_G329_A0.6820.90
321_K454_V0.6820.90
437_D440_I0.6800.90
258_P316_T0.6780.90
421_E425_D0.6770.90
16_K83_D0.6770.90
381_D387_I0.6740.90
197_C207_V0.6730.89
48_K52_G0.6710.89
428_F440_I0.6710.89
430_K436_T0.6700.89
102_D107_S0.6650.89
128_G223_A0.6630.89
407_E424_L0.6610.89
125_V275_L0.6600.89
289_A337_A0.6580.88
374_A435_F0.6580.88
19_D31_H0.6560.88
297_Y389_P0.6560.88
131_P224_T0.6550.88
381_D427_E0.6540.88
111_R114_D0.6510.88
135_L196_M0.6510.88
17_F198_L0.6500.88
305_H387_I0.6490.88
25_T439_A0.6490.88
305_H309_I0.6490.88
273_M302_V0.6480.88
393_M397_L0.6470.88
454_V457_T0.6450.87
315_P319_S0.6430.87
10_L18_V0.6420.87
82_A85_T0.6420.87
236_I372_F0.6410.87
356_R360_R0.6410.87
335_Y346_I0.6410.87
21_R29_E0.6400.87
340_R360_R0.6400.87
371_C374_A0.6400.87
119_T386_K0.6390.87
94_E97_T0.6380.87
50_F55_I0.6370.87
426_R429_L0.6370.87
317_T459_H0.6360.87
213_E272_H0.6360.87
22_F68_L0.6340.86
113_E117_R0.6330.86
405_A410_Q0.6320.86
136_F260_P0.6310.86
127_F273_M0.6310.86
461_V465_L0.6300.86
13_H75_A0.6260.86
277_K294_Q0.6250.86
240_K244_H0.6210.85
94_E101_Y0.6190.85
306_A333_L0.6170.85
76_V238_I0.6170.85
178_G181_F0.6160.85
187_D245_N0.6150.85
362_P371_C0.6140.85
308_A426_R0.6140.85
302_V375_L0.6130.85
341_S396_N0.6100.84
33_T81_F0.6100.84
266_G322_R0.6100.84
20_L43_F0.6090.84
9_M75_A0.6090.84
384_K387_I0.6090.84
87_I203_M0.6080.84
49_M54_S0.6080.84
116_L376_L0.6080.84
82_A191_D0.6080.84
132_E270_H0.6080.84
39_V72_A0.6070.84
259_K266_G0.6050.84
15_V84_S0.6020.84
315_P366_A0.6010.83
388_H391_E0.6010.83
111_R115_Y0.6000.83
339_N393_M0.5990.83
50_F181_F0.5990.83
135_L252_K0.5990.83
132_E221_E0.5990.83
72_A88_I0.5990.83
422_L435_F0.5990.83
285_G296_L0.5990.83
85_T194_S0.5960.83
261_M264_D0.5960.83
34_I48_K0.5950.83
376_L380_L0.5940.83
308_A422_L0.5930.83
333_L343_S0.5930.83
397_L405_A0.5920.83
131_P239_Y0.5920.83
10_L15_V0.5910.82
330_P341_S0.5910.82
5_H10_L0.5900.82
115_Y119_T0.5900.82
272_H356_R0.5900.82
128_G211_H0.5890.82
43_F48_K0.5890.82
16_K84_S0.5880.82
205_L238_I0.5880.82
336_S342_A0.5870.82
317_T462_E0.5860.82
304_K308_A0.5860.82
304_K409_P0.5850.82
179_G182_P0.5840.82
333_L409_P0.5830.82
9_M77_I0.5830.82
318_N462_E0.5830.82
127_F229_M0.5830.82
275_L294_Q0.5800.81
196_M222_V0.5800.81
80_F242_V0.5780.81
126_L274_S0.5770.81
207_V222_V0.5760.81
200_M207_V0.5750.81
135_L189_A0.5750.81
395_K398_Y0.5740.81
312_L370_L0.5730.80
270_H358_E0.5730.80
53_S57_G0.5730.80
241_Y245_N0.5730.80
79_P203_M0.5710.80
207_V210_H0.5700.80
189_A252_K0.5700.80
54_S214_V0.5700.80
374_A428_F0.5670.80
89_R238_I0.5650.80
380_L384_K0.5640.79
61_I328_E0.5630.79
16_K202_Q0.5630.79
296_L335_Y0.5630.79
184_P190_Q0.5600.79
81_F194_S0.5600.79
285_G289_A0.5590.79
245_N248_H0.5590.79
362_P366_A0.5580.79
78_D203_M0.5580.79
19_D241_Y0.5570.79
301_G383_I0.5570.79
289_A392_A0.5550.78
211_H214_V0.5550.78
56_G59_K0.5540.78
321_K459_H0.5540.78
379_G382_G0.5530.78
306_A361_F0.5520.78
44_F88_I0.5510.78
267_S364_P0.5510.78
426_R441_D0.5510.78
329_A398_Y0.5500.78
313_A378_A0.5490.78
177_K264_D0.5480.77
317_T451_D0.5470.77
109_A373_A0.5470.77
301_G382_G0.5470.77
454_V462_E0.5460.77
287_K290_G0.5450.77
82_A198_L0.5450.77
422_L425_D0.5440.77
246_V249_R0.5440.77
129_P372_F0.5440.77
287_K293_E0.5430.77
194_S198_L0.5430.77
19_D33_T0.5430.77
22_F92_I0.5420.77
205_L236_I0.5420.77
393_M408_I0.5410.77
11_N14_E0.5400.76
205_L239_Y0.5390.76
331_V410_Q0.5390.76
208_E223_A0.5390.76
134_F264_D0.5370.76
39_V43_F0.5370.76
49_M55_I0.5370.76
38_Q206_V0.5370.76
313_A359_V0.5360.76
21_R238_I0.5350.76
134_F259_K0.5350.76
128_G226_F0.5350.76
404_E408_I0.5340.76
226_F229_M0.5340.76
308_A311_A0.5320.75
30_Q182_P0.5320.75
49_M56_G0.5320.75
138_D253_T0.5310.75
454_V458_P0.5310.75
453_R457_T0.5300.75
17_F81_F0.5300.75
397_L410_Q0.5290.75
133_F222_V0.5290.75
129_P269_M0.5290.75
208_E226_F0.5290.75
221_E358_E0.5270.75
340_R358_E0.5260.75
257_M462_E0.5250.74
324_V327_Y0.5250.74
237_Q366_A0.5250.74
214_V327_Y0.5240.74
223_A356_R0.5220.74
226_F274_S0.5220.74
201_E207_V0.5220.74
9_M14_E0.5210.74
453_R461_V0.5210.74
424_L427_E0.5210.74
425_D437_D0.5200.74
414_S455_R0.5190.74
313_A374_A0.5190.74
384_K430_K0.5190.74
6_V9_M0.5190.74
314_N320_Y0.5180.73
317_T461_V0.5180.73
75_A88_I0.5180.73
6_V13_H0.5180.73
175_A178_G0.5170.73
280_V294_Q0.5160.73
196_M242_V0.5150.73
318_N321_K0.5150.73
263_G456_M0.5140.73
111_R436_T0.5140.73
219_Q267_S0.5140.73
385_N388_H0.5130.73
34_I39_V0.5130.73
297_Y304_K0.5130.73
17_F33_T0.5130.73
125_V229_M0.5130.73
118_S424_L0.5120.73
416_E423_D0.5120.73
137_D175_A0.5110.72
281_N405_A0.5110.72
327_Y456_M0.5100.72
128_G274_S0.5090.72
130_E270_H0.5080.72
109_A230_T0.5080.72
377_M430_K0.5080.72
441_D444_I0.5070.72
38_Q225_R0.5070.72
137_D173_R0.5070.72
419_L423_D0.5070.72
180_Y214_V0.5060.72
306_A309_I0.5060.72
11_N37_H0.5050.72
130_E358_E0.5050.72
337_A394_D0.5050.72
205_L235_E0.5040.71
17_F194_S0.5020.71
276_S282_L0.5010.71
130_E340_R0.5010.71
284_A352_P0.5010.71
378_A382_G0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4s17A 5 0.9467 100 0.096 Contact Map
1f52A 5 0.9851 100 0.1 Contact Map
3ng0A 5 0.9787 100 0.102 Contact Map
4acfA 5 0.9893 100 0.108 Contact Map
4lniA 5 0.9275 100 0.111 Contact Map
4hppA 3 0.8593 100 0.165 Contact Map
2j9iA 5 0.8763 100 0.183 Contact Map
3o6xA 3 0.8145 100 0.345 Contact Map
3fkyA 8 0.6951 100 0.359 Contact Map
2ojwA 5 0.7271 100 0.365 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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