GREMLIN Database
GALM - Aldose 1-epimerase
UniProt: P0A9C3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11698
Length: 346 (315)
Sequences: 4411 (3348)
Seq/√Len: 188.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_S96_P3.4451.00
197_D251_Q3.3051.00
102_Q138_F3.2601.00
263_V306_L3.1991.00
226_K231_E2.8271.00
130_S141_N2.6271.00
141_N165_D2.5641.00
315_D319_H2.5481.00
200_L247_A2.4851.00
84_R91_T2.4631.00
28_V40_A2.4411.00
167_P330_R2.3011.00
130_S143_G2.2851.00
58_S61_C2.2751.00
88_D167_P2.1841.00
129_L135_D2.1741.00
216_A223_R2.1671.00
50_R270_L2.1651.00
283_F306_L2.0831.00
30_L127_F2.0781.00
201_P211_G2.0771.00
95_S107_P2.0691.00
113_R129_L2.0421.00
273_K342_Q2.0401.00
21_R27_V2.0111.00
27_V41_R1.9951.00
35_A72_S1.9241.00
157_S338_L1.9031.00
31_M38_L1.8961.00
118_V128_A1.8721.00
159_T338_L1.8631.00
95_S136_Q1.8481.00
87_F328_F1.8391.00
142_L170_V1.8361.00
181_D265_S1.8311.00
161_R334_E1.8191.00
159_T336_S1.7971.00
28_V156_I1.7971.00
126_L147_Q1.7941.00
315_D318_N1.7931.00
28_V37_L1.7441.00
126_L145_T1.7421.00
151_T155_R1.7281.00
262_H271_Q1.7231.00
265_S270_L1.7141.00
17_L31_M1.6931.00
145_T161_R1.6821.00
18_L117_I1.6801.00
18_L125_V1.6691.00
310_S339_T1.6641.00
76_Y317_P1.6491.00
133_D166_K1.6141.00
249_L313_L1.6091.00
167_P331_P1.6061.00
330_R333_E1.5911.00
35_A127_F1.5841.00
76_Y327_C1.5661.00
191_K225_A1.5641.00
84_R93_T1.5621.00
19_T29_T1.5521.00
201_P213_K1.5481.00
155_R340_E1.5451.00
17_L38_L1.5431.00
53_L176_V1.5421.00
90_E166_K1.5351.00
124_Q149_R1.5241.00
108_E113_R1.5091.00
86_T91_T1.5091.00
192_L263_V1.4971.00
169_P328_F1.4901.00
278_A312_F1.4801.00
29_T39_S1.4661.00
193_Q262_H1.4621.00
198_E214_S1.4571.00
83_S93_T1.4561.00
30_L125_V1.4501.00
16_R32_D1.4491.00
191_K264_W1.4491.00
39_S51_E1.4421.00
32_D114_R1.4411.00
100_V205_G1.4381.00
110_F144_A1.4351.00
161_R336_S1.4311.00
151_T157_S1.4301.00
226_K230_S1.4221.00
17_L29_T1.4191.00
78_N282_Q1.4181.00
199_Y213_K1.4171.00
40_A343_F1.4171.00
277_T337_S1.4111.00
149_R159_T1.4061.00
118_V126_L1.3961.00
73_I173_T1.3901.00
227_I230_S1.3841.00
163_T334_E1.3821.00
222_F226_K1.3791.00
252_A258_K1.3771.00
262_H273_K1.3711.00
155_R342_Q1.3661.00
202_V206_G1.3621.00
215_V223_R1.3551.00
193_Q225_A1.3411.00
312_F327_C1.3301.00
192_L222_F1.3251.00
157_S340_E1.3191.00
275_Y342_Q1.3191.00
98_Q101_N1.3191.00
72_S146_V1.2941.00
194_I283_F1.2881.00
164_V331_P1.2731.00
128_A145_T1.2711.00
121_N124_Q1.2701.00
316_S327_C1.2621.00
278_A337_S1.2591.00
88_D330_R1.2501.00
286_G289_L1.2461.00
147_Q161_R1.2371.00
26_M40_A1.2211.00
26_M150_L1.2151.00
81_A315_D1.2121.00
75_R131_S1.2071.00
131_S135_D1.1971.00
287_N303_W1.1961.00
247_A280_A1.1951.00
42_I52_A1.1901.00
286_G305_G1.1841.00
260_A276_T1.1821.00
81_A203_D1.1771.00
191_K266_A1.1691.00
37_L156_I1.1691.00
250_L260_A1.1681.00
20_L150_L1.1641.00
220_F246_H1.1581.00
44_L48_S1.1571.00
40_A178_F1.1571.00
231_E244_Y1.1541.00
242_K302_D1.1441.00
272_L343_F1.1381.00
264_W271_Q1.1361.00
265_S268_E1.1311.00
162_A170_V1.1251.00
301_A304_Q1.1201.00
93_T96_P1.1201.00
19_T27_V1.1111.00
128_A143_G1.1101.00
72_S174_N1.1051.00
192_L283_F1.1041.00
82_N101_N1.1031.00
80_I94_L1.0901.00
259_V273_K1.0791.00
250_L276_T1.0791.00
149_R157_S1.0751.00
312_F316_S1.0741.00
68_F111_D1.0661.00
169_P317_P1.0651.00
81_A207_I1.0621.00
41_R49_V1.0581.00
54_L305_G1.0551.00
37_L176_V1.0541.00
247_A282_Q1.0541.00
190_H265_S1.0491.00
259_V275_Y1.0441.00
209_H212_L1.0391.00
188_R303_W1.0371.00
192_L308_L1.0331.00
22_N154_N1.0291.00
13_Q114_R1.0201.00
113_R135_D1.0161.00
36_T71_A1.0161.00
183_E298_E1.0151.00
281_L308_L1.0111.00
26_M42_I0.9990.99
37_L53_L0.9970.99
215_V218_T0.9950.99
228_I306_L0.9940.99
280_A313_L0.9890.99
82_N100_V0.9870.99
186_D189_N0.9870.99
96_P100_V0.9870.99
259_V262_H0.9850.99
124_Q147_Q0.9830.99
31_M36_T0.9810.99
274_V310_S0.9710.99
60_E63_Q0.9670.99
172_M335_Y0.9610.99
76_Y102_Q0.9590.99
24_A152_D0.9550.99
15_Y114_R0.9470.99
25_G43_P0.9450.99
44_L270_L0.9440.99
191_K227_I0.9350.99
283_F308_L0.9270.99
68_F103_L0.9260.99
244_Y283_F0.9240.99
86_T89_G0.9230.99
22_N152_D0.9180.99
110_F129_L0.9150.99
132_D141_N0.9130.99
220_F248_F0.9120.99
101_N205_G0.9110.99
88_D328_F0.9110.99
146_V158_I0.9080.99
233_L303_W0.8970.99
15_Y59_P0.8970.99
158_I174_N0.8960.99
170_V335_Y0.8910.99
110_F131_S0.8880.99
195_L259_V0.8880.99
110_F142_L0.8790.99
197_D223_R0.8770.99
44_L47_G0.8750.99
15_Y31_M0.8750.99
189_N227_I0.8750.99
329_L334_E0.8730.99
194_I281_L0.8730.99
195_L251_Q0.8690.99
116_Q128_A0.8680.99
198_E212_L0.8660.99
84_R318_N0.8640.98
78_N247_A0.8600.98
181_D184_Q0.8590.98
183_E296_G0.8590.98
192_L228_I0.8560.98
170_V329_L0.8540.98
257_K340_E0.8540.98
146_V160_Y0.8540.98
76_Y316_S0.8500.98
310_S337_S0.8490.98
52_A343_F0.8410.98
76_Y169_P0.8400.98
29_T38_L0.8400.98
194_I261_A0.8380.98
181_D266_A0.8380.98
144_A162_A0.8380.98
275_Y340_E0.8360.98
82_N205_G0.8360.98
60_E64_D0.8330.98
119_N124_Q0.8290.98
169_P326_D0.8290.98
26_M154_N0.8270.98
143_G163_T0.8230.98
75_R142_L0.8220.98
37_L40_A0.8180.98
160_Y173_T0.8180.98
22_N150_L0.8130.98
108_E136_Q0.8120.98
190_H263_V0.8120.98
13_Q116_Q0.8110.98
40_A52_A0.8090.98
199_Y220_F0.8070.98
15_Y32_D0.8030.98
72_S148_Y0.8020.98
276_T339_T0.8010.98
117_I125_V0.7960.97
26_M52_A0.7940.97
42_I270_L0.7880.97
37_L174_N0.7810.97
277_T338_L0.7800.97
85_Y94_L0.7780.97
160_Y339_T0.7770.97
98_Q103_L0.7770.97
40_A53_L0.7760.97
79_R309_E0.7750.97
22_N25_G0.7740.97
144_A172_M0.7740.97
72_S160_Y0.7730.97
241_V303_W0.7720.97
94_L102_Q0.7710.97
123_R149_R0.7710.97
88_D166_K0.7680.97
225_A264_W0.7650.97
164_V329_L0.7640.97
79_R104_H0.7580.97
104_H309_E0.7580.97
56_C62_Y0.7570.97
18_L32_D0.7560.96
179_N190_H0.7520.96
26_M43_P0.7510.96
247_A311_E0.7500.96
188_R232_F0.7490.96
127_F148_Y0.7470.96
215_V221_D0.7460.96
180_L190_H0.7460.96
222_F231_E0.7460.96
123_R152_D0.7390.96
243_G287_N0.7390.96
187_V306_L0.7390.96
200_L313_L0.7390.96
75_R105_G0.7380.96
178_F341_Y0.7380.96
76_Y80_I0.7340.96
175_H309_E0.7290.96
263_V308_L0.7270.96
147_Q159_T0.7220.95
83_S102_Q0.7200.95
194_I222_F0.7180.95
22_N26_M0.7170.95
74_G144_A0.7090.95
228_I231_E0.7070.95
81_A319_H0.7060.95
102_Q105_G0.7060.95
201_P209_H0.7060.95
329_L333_E0.7050.95
85_Y92_V0.7040.95
209_H322_W0.7030.95
181_D267_D0.7030.95
313_L317_P0.7000.95
69_L289_L0.6970.95
96_P102_Q0.6960.94
167_P328_F0.6960.94
323_P326_D0.6950.94
148_Y158_I0.6940.94
73_I77_A0.6930.94
312_F337_S0.6930.94
187_V190_H0.6880.94
109_G136_Q0.6850.94
59_P63_Q0.6850.94
261_A281_L0.6830.94
54_L300_Y0.6810.94
162_A335_Y0.6780.94
53_L178_F0.6760.94
32_D117_I0.6730.93
317_P328_F0.6710.93
115_W144_A0.6710.93
160_Y172_M0.6710.93
44_L269_K0.6700.93
164_V168_C0.6690.93
142_L162_A0.6680.93
257_K277_T0.6670.93
285_S306_L0.6630.93
95_S102_Q0.6600.93
164_V167_P0.6590.93
80_I317_P0.6590.93
105_G138_F0.6580.93
33_W114_R0.6580.93
38_L62_Y0.6560.93
50_R265_S0.6550.92
50_R268_E0.6550.92
87_F94_L0.6550.92
56_C65_Q0.6540.92
30_L37_L0.6530.92
118_V145_T0.6520.92
86_T318_N0.6520.92
24_A154_N0.6520.92
212_L249_L0.6510.92
129_L136_Q0.6490.92
222_F244_Y0.6470.92
193_Q264_W0.6450.92
119_N126_L0.6440.92
261_A308_L0.6420.92
248_F283_F0.6380.91
17_L32_D0.6380.91
169_P327_C0.6370.91
79_R175_H0.6360.91
82_N96_P0.6350.91
41_R51_E0.6350.91
193_Q224_S0.6340.91
199_Y248_F0.6330.91
75_R136_Q0.6300.91
85_Y318_N0.6290.91
115_W129_L0.6280.91
319_H322_W0.6270.91
160_Y337_S0.6250.91
188_R191_K0.6200.90
81_A205_G0.6180.90
44_L268_E0.6170.90
94_L138_F0.6170.90
71_A111_D0.6150.90
62_Y70_G0.6120.90
84_R96_P0.6110.90
104_H175_H0.6100.90
142_L168_C0.6090.90
86_T92_V0.6090.90
289_L307_A0.6090.90
51_E55_G0.6010.89
98_Q288_F0.6000.89
198_E251_Q0.5970.89
228_I283_F0.5940.88
131_S136_Q0.5930.88
181_D270_L0.5900.88
117_I120_Q0.5880.88
245_D282_Q0.5880.88
206_G288_F0.5870.88
274_V281_L0.5870.88
73_I111_D0.5820.87
263_V283_F0.5820.87
229_A232_F0.5790.87
132_D135_D0.5790.87
44_L50_R0.5770.87
189_N267_D0.5760.87
85_Y169_P0.5760.87
195_L260_A0.5740.87
158_I341_Y0.5730.87
20_L120_Q0.5730.87
284_Y288_F0.5720.86
129_L132_D0.5720.86
30_L156_I0.5640.86
33_W59_P0.5640.86
43_P49_V0.5640.86
206_G245_D0.5630.86
233_L301_A0.5630.86
43_P270_L0.5620.85
32_D116_Q0.5600.85
56_C67_A0.5600.85
274_V339_T0.5600.85
212_L321_E0.5590.85
227_I266_A0.5560.85
199_Y246_H0.5550.85
226_K244_Y0.5540.85
29_T41_R0.5540.85
196_A215_V0.5530.85
36_T65_Q0.5520.84
83_S95_S0.5510.84
300_Y304_Q0.5510.84
103_L245_D0.5480.84
61_C64_D0.5480.84
18_L127_F0.5480.84
144_A160_Y0.5470.84
240_K303_W0.5470.84
27_V49_V0.5460.84
184_Q304_Q0.5450.84
42_I343_F0.5440.84
209_H213_K0.5440.84
82_N98_Q0.5430.83
274_V308_L0.5430.83
140_G166_K0.5430.83
202_V246_H0.5420.83
202_V247_A0.5420.83
115_W146_V0.5410.83
247_A313_L0.5400.83
189_N229_A0.5390.83
33_W36_T0.5370.83
151_T154_N0.5370.83
330_R334_E0.5360.83
81_A101_N0.5360.83
55_G62_Y0.5360.83
249_L280_A0.5360.83
179_N182_G0.5340.82
313_L323_P0.5330.82
140_G168_C0.5330.82
282_Q285_S0.5320.82
274_V307_A0.5310.82
70_G174_N0.5310.82
254_G258_K0.5300.82
192_L306_L0.5290.82
255_D258_K0.5290.82
214_S223_R0.5280.82
38_L55_G0.5280.82
77_A311_E0.5280.82
284_Y307_A0.5250.81
275_Y278_A0.5230.81
186_D304_Q0.5230.81
101_N207_I0.5200.81
242_K288_F0.5190.81
200_L249_L0.5190.81
79_R245_D0.5170.80
75_R106_G0.5160.80
163_T332_G0.5150.80
51_E300_Y0.5150.80
36_T112_K0.5120.80
50_R184_Q0.5110.80
199_Y215_V0.5100.80
105_G136_Q0.5100.80
317_P327_C0.5090.79
200_L212_L0.5080.79
316_S323_P0.5060.79
108_E112_K0.5060.79
78_N202_V0.5040.79
22_N151_T0.5040.79
313_L316_S0.5020.78
254_G257_K0.5020.78
35_A73_I0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z45A 2 0.9306 100 0.185 Contact Map
1snzA 1 0.9711 100 0.197 Contact Map
1nsxA 2 0.9566 100 0.2 Contact Map
1lurA 1 0.922 100 0.2 Contact Map
4rnlA 1 0.9538 100 0.227 Contact Map
3imhA 3 0.9364 100 0.231 Contact Map
1ygaA 2 0.9017 100 0.238 Contact Map
3os7A 2 0.9017 100 0.372 Contact Map
3mwxA 1 0.8815 100 0.372 Contact Map
3nreA 1 0.8179 100 0.395 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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