GREMLIN Database
GLPA - Anaerobic glycerol-3-phosphate dehydrogenase subunit A
UniProt: P0A9C0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10391
Length: 542 (474)
Sequences: 3803 (2515)
Seq/√Len: 115.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_I187_V5.2501.00
126_A140_A4.5951.00
9_S35_I3.8841.00
190_R197_T3.6841.00
39_R173_E3.6661.00
37_V189_V3.2731.00
173_E190_R3.2141.00
188_R199_A3.2061.00
161_A166_A3.1921.00
449_E486_F3.1301.00
189_V200_L3.0551.00
285_A304_K3.0151.00
236_M266_I2.9881.00
12_I202_A2.9491.00
107_F112_E2.9301.00
289_D293_R2.9041.00
21_A158_M2.8811.00
176_G188_R2.7941.00
12_I200_L2.7691.00
188_R197_T2.7621.00
37_V174_V2.7401.00
175_T190_R2.7331.00
172_H189_V2.7221.00
22_G358_Y2.7201.00
107_F111_C2.7081.00
8_S203_P2.6871.00
173_E192_H2.6631.00
40_H44_T2.6191.00
193_L454_N2.5851.00
206_V369_V2.5831.00
24_A34_V2.5121.00
232_S291_L2.5061.00
123_P127_R2.4931.00
42_I170_T2.4581.00
9_S167_V2.4571.00
16_G36_L2.4281.00
178_I186_G2.4161.00
289_D304_K2.3831.00
285_A289_D2.3641.00
8_S201_H2.3081.00
108_I112_E2.2961.00
441_A445_Q2.2501.00
35_I200_L2.2161.00
12_I35_I2.1911.00
14_I216_I2.1851.00
12_I37_V2.1281.00
397_L401_I2.1081.00
191_N194_T2.0701.00
209_A216_I2.0461.00
421_A450_N1.9761.00
125_Q128_I1.9621.00
158_M168_I1.9501.00
296_E302_M1.9421.00
396_T401_I1.9381.00
448_V483_L1.8931.00
178_I199_A1.8671.00
13_I23_I1.8441.00
16_G38_E1.8091.00
18_A157_N1.8091.00
441_A478_R1.7981.00
162_K168_I1.7791.00
227_F272_R1.7791.00
418_R446_Y1.7381.00
109_R112_E1.7261.00
11_V204_V1.7161.00
159_L418_R1.7061.00
396_T400_V1.7011.00
414_R463_T1.7001.00
7_Q33_R1.6991.00
175_T188_R1.6991.00
244_V247_R1.6941.00
39_R279_D1.6781.00
73_S363_E1.6411.00
25_R160_D1.6381.00
37_V187_V1.6331.00
42_I158_M1.6161.00
246_N249_R1.6111.00
10_D203_P1.6111.00
177_L205_V1.6051.00
108_I111_C1.6021.00
23_I206_V1.5891.00
122_D125_Q1.5881.00
179_R182_A1.5841.00
19_T350_I1.5791.00
37_V200_L1.5551.00
21_A154_T1.5471.00
448_V486_F1.5421.00
125_Q129_I1.5381.00
189_V198_Q1.5331.00
29_L380_T1.5291.00
169_L172_H1.5221.00
184_V205_V1.5181.00
283_V310_A1.5171.00
113_E116_I1.5031.00
204_V369_V1.5021.00
230_K271_L1.5011.00
23_I366_T1.5001.00
35_I169_L1.4951.00
478_R481_G1.4841.00
178_I185_C1.4791.00
292_L304_K1.4611.00
178_I188_R1.4491.00
404_P407_L1.4481.00
23_I208_A1.4441.00
106_T110_A1.4391.00
348_I369_V1.4381.00
283_V288_V1.4371.00
292_L302_M1.4351.00
350_I365_A1.4311.00
106_T112_E1.4291.00
9_S33_R1.4261.00
43_A151_F1.4251.00
257_L264_S1.4251.00
421_A424_S1.4211.00
460_R466_G1.4181.00
163_E418_R1.4081.00
245_I249_R1.4071.00
220_A343_G1.4061.00
26_D381_T1.4031.00
238_H262_T1.4021.00
32_L376_T1.4011.00
368_A371_R1.3951.00
251_P254_A1.3941.00
204_V373_L1.3871.00
169_L198_Q1.3741.00
172_H198_Q1.3711.00
180_E186_G1.3651.00
447_A453_V1.3501.00
107_F110_A1.3441.00
153_L355_L1.3401.00
288_V304_K1.3361.00
176_G219_Y1.3351.00
190_R195_G1.3331.00
230_K273_I1.3251.00
422_W442_G1.3241.00
119_E142_K1.3161.00
213_G226_M1.3141.00
42_I168_I1.3131.00
216_I219_Y1.3041.00
304_K307_I1.3031.00
160_D164_H1.3011.00
24_A161_A1.3001.00
26_D30_R1.2971.00
29_L164_H1.2941.00
342_D372_K1.2880.99
177_L219_Y1.2820.99
240_I245_I1.2740.99
90_N144_P1.2670.99
277_E280_D1.2650.99
177_L184_V1.2640.99
292_L296_E1.2600.99
456_L480_A1.2590.99
33_R167_V1.2560.99
400_V420_P1.2540.99
135_P300_P1.2520.99
24_A166_A1.2520.99
232_S271_L1.2510.99
43_A154_T1.2480.99
288_V310_A1.2470.99
265_L311_Y1.2430.99
175_T197_T1.2430.99
122_D126_A1.2370.99
29_L384_L1.2340.99
157_N358_Y1.2320.99
105_A109_R1.2150.99
369_V373_L1.2070.99
25_R157_N1.2070.99
11_V27_C1.2060.99
396_T399_K1.2020.99
177_L216_I1.2020.99
27_C366_T1.2010.99
123_P129_I1.1940.99
86_V146_G1.1910.99
241_N245_I1.1860.99
425_E445_Q1.1840.99
90_N142_K1.1830.99
69_R73_S1.1830.99
149_D414_R1.1810.99
445_Q486_F1.1790.99
317_L354_K1.1770.99
96_L137_L1.1690.99
121_I126_A1.1660.99
174_V187_V1.1650.99
123_P126_A1.1630.99
126_A137_L1.1570.99
240_I248_C1.1550.99
16_G42_I1.1510.99
36_L158_M1.1480.99
241_N246_N1.1450.99
295_G302_M1.1430.99
414_R443_E1.1320.99
227_F319_A1.1300.99
186_G201_H1.1270.99
160_D163_E1.1270.99
445_Q485_R1.1230.99
240_I249_R1.1160.99
433_V441_A1.1150.99
92_L140_A1.1140.99
230_K284_T1.1130.99
100_D103_F1.0970.98
363_E367_D1.0960.98
180_E185_C1.0960.98
231_G315_R1.0930.98
237_D263_I1.0930.98
106_T111_C1.0920.98
434_C438_A1.0850.98
119_E125_Q1.0840.98
9_S12_I1.0790.98
397_L400_V1.0720.98
21_A168_I1.0660.98
368_A372_K1.0660.98
460_R467_M1.0630.98
211_I314_V1.0590.98
51_H258_V1.0580.98
26_D379_C1.0530.98
458_D461_R1.0510.98
10_D32_L1.0460.98
273_I277_E1.0410.98
66_E70_E1.0410.98
78_L86_V1.0410.98
241_N244_V1.0400.98
284_T287_E1.0390.98
445_Q482_L1.0380.98
459_L474_L1.0310.98
28_A166_A1.0310.98
470_C473_E1.0270.97
186_G199_A1.0260.97
101_L139_G1.0230.97
63_T328_N1.0230.97
367_D379_C1.0220.97
64_D67_S1.0210.97
348_I365_A1.0210.97
444_V476_A1.0180.97
370_C376_T1.0170.97
242_Q246_N1.0140.97
251_P255_D1.0130.97
326_G331_R1.0070.97
348_I368_A1.0060.97
240_I246_N1.0060.97
235_I309_R1.0040.97
37_V172_H1.0020.97
242_Q247_R1.0020.97
79_K88_P1.0000.97
117_S121_I0.9990.97
418_R421_A0.9980.97
122_D129_I0.9980.97
53_L147_T0.9950.97
250_K297_K0.9930.97
126_A129_I0.9910.97
244_V248_C0.9890.97
40_H171_A0.9850.97
70_E360_L0.9850.97
47_T154_T0.9830.97
245_I248_C0.9800.97
180_E201_H0.9770.97
445_Q449_E0.9770.97
32_L370_C0.9720.96
240_I247_R0.9690.96
242_Q248_C0.9660.96
362_A379_C0.9620.96
390_Q417_D0.9570.96
481_G485_R0.9570.96
87_E147_T0.9550.96
377_R380_T0.9490.96
434_C437_E0.9450.96
204_V348_I0.9440.96
331_R335_L0.9430.96
87_E413_Y0.9400.96
26_D362_A0.9400.96
70_E364_W0.9380.96
476_A480_A0.9370.96
10_D33_R0.9360.96
202_A205_V0.9340.96
240_I257_L0.9280.95
250_K253_D0.9250.95
242_Q249_R0.9200.95
12_I205_V0.9150.95
191_N196_E0.9120.95
409_G413_Y0.9110.95
56_S143_V0.9100.95
18_A47_T0.9080.95
444_V479_A0.9080.95
208_A350_I0.9070.95
429_H432_L0.9070.95
45_G49_R0.9050.95
60_Y354_K0.9020.95
215_H278_I0.8970.95
8_S33_R0.8960.94
204_V372_K0.8950.94
257_L295_G0.8950.94
171_A454_N0.8910.94
82_A386_L0.8890.94
434_C440_T0.8880.94
363_E382_A0.8830.94
441_A482_L0.8830.94
127_R133_V0.8790.94
78_L153_L0.8780.94
46_A211_I0.8780.94
335_L365_A0.8710.94
241_N249_R0.8680.93
326_G329_V0.8660.93
482_L486_F0.8610.93
269_T315_R0.8590.93
106_T109_R0.8590.93
74_E359_R0.8560.93
85_C156_A0.8550.93
36_L168_I0.8550.93
19_T361_M0.8530.93
117_S120_A0.8500.93
51_H256_I0.8490.93
244_V249_R0.8470.93
411_A440_T0.8460.93
40_H45_G0.8440.93
237_D308_L0.8410.92
158_M170_T0.8400.92
243_H246_N0.8370.92
437_E465_V0.8330.92
273_I314_V0.8290.92
187_V202_A0.8290.92
93_F96_L0.8280.92
207_N213_G0.8260.92
192_H196_E0.8260.92
431_S441_A0.8250.92
88_P93_F0.8250.92
126_A133_V0.8240.92
398_R408_R0.8240.92
303_A306_R0.8240.92
373_L376_T0.8240.92
483_L487_N0.8230.92
92_L126_A0.8210.91
59_R268_T0.8200.91
28_A34_V0.8170.91
389_S392_P0.8150.91
263_I308_L0.8130.91
193_L196_E0.8120.91
398_R401_I0.8090.91
411_A419_T0.8090.91
442_G445_Q0.8090.91
98_E101_L0.8080.91
28_A164_H0.8060.91
315_R354_K0.8060.91
124_Q127_R0.8060.91
231_G269_T0.8060.91
350_I361_M0.8050.91
36_L42_I0.8050.91
103_F107_F0.8050.91
480_A484_Q0.8020.90
240_I244_V0.8000.90
425_E449_E0.7940.90
68_A72_I0.7930.90
26_D363_E0.7930.90
426_G430_R0.7910.90
426_G442_G0.7910.90
248_C257_L0.7900.90
89_T147_T0.7900.90
190_R196_E0.7850.90
8_S184_V0.7840.89
250_K293_R0.7840.89
293_R297_K0.7830.89
149_D260_G0.7820.89
325_S328_N0.7810.89
129_I142_K0.7810.89
158_M162_K0.7800.89
156_A386_L0.7790.89
369_V374_G0.7770.89
114_A117_S0.7770.89
446_Y450_N0.7740.89
217_A349_T0.7730.89
162_K452_N0.7720.89
340_E344_L0.7720.89
59_R354_K0.7720.89
439_V463_T0.7640.88
73_S360_L0.7640.88
424_S427_R0.7640.88
477_C481_G0.7620.88
96_L136_A0.7620.88
159_L162_K0.7610.88
177_L187_V0.7610.88
319_A323_D0.7580.88
22_G362_A0.7580.88
154_T355_L0.7580.88
77_I81_I0.7580.88
385_A389_S0.7570.88
233_L269_T0.7570.88
271_L287_E0.7560.88
242_Q245_I0.7540.88
95_T99_D0.7540.88
42_I452_N0.7530.88
439_V443_E0.7480.87
243_H247_R0.7470.87
172_H200_L0.7460.87
124_Q128_I0.7460.87
405_A409_G0.7450.87
230_K312_S0.7450.87
140_A247_R0.7430.87
250_K254_A0.7430.87
256_I268_T0.7370.86
237_D262_T0.7350.86
433_V444_V0.7330.86
121_I142_K0.7320.86
218_E221_D0.7300.86
105_A108_I0.7300.86
23_I365_A0.7280.86
428_L431_S0.7280.86
117_S123_P0.7270.86
84_H388_G0.7270.86
174_V216_I0.7260.86
99_D102_S0.7250.85
233_L270_S0.7240.85
234_L266_I0.7220.85
229_A317_L0.7210.85
23_I362_A0.7200.85
434_C472_G0.7190.85
105_A111_C0.7160.85
81_I385_A0.7160.85
118_A121_I0.7140.85
75_N86_V0.7090.84
391_E417_D0.7080.84
176_G197_T0.7080.84
229_A272_R0.7080.84
29_L160_D0.7060.84
14_I174_V0.7030.84
67_S71_C0.7000.83
22_G157_N0.7000.83
380_T384_L0.6990.83
193_L455_S0.6990.83
145_D148_V0.6990.83
403_L408_R0.6960.83
262_T468_G0.6960.83
27_C34_V0.6950.83
11_V366_T0.6950.83
186_G202_A0.6940.83
363_E379_C0.6940.83
241_N248_C0.6930.83
83_R389_S0.6920.83
116_I123_P0.6910.83
266_I295_G0.6900.83
24_A168_I0.6900.83
53_L256_I0.6890.82
469_T473_E0.6870.82
318_V322_D0.6870.82
161_A168_I0.6870.82
99_D103_F0.6870.82
220_A345_D0.6860.82
161_A362_A0.6850.82
128_I131_P0.6840.82
456_L459_L0.6840.82
388_G416_G0.6840.82
79_K86_V0.6830.82
214_Q217_A0.6830.82
472_G475_C0.6820.82
149_D261_D0.6810.82
124_Q129_I0.6810.82
46_A60_Y0.6800.82
26_D367_D0.6780.81
241_N247_R0.6770.81
370_C373_L0.6760.81
173_E215_H0.6750.81
318_V334_V0.6740.81
425_E429_H0.6740.81
424_S428_L0.6730.81
448_V453_V0.6730.81
54_L78_L0.6720.81
407_L440_T0.6710.81
17_G20_G0.6710.81
271_L286_E0.6710.81
190_R194_T0.6700.81
15_G20_G0.6640.80
325_S329_V0.6600.80
272_R329_V0.6600.80
60_Y270_S0.6580.79
194_T197_T0.6580.79
89_T244_V0.6570.79
121_I129_I0.6570.79
163_E387_P0.6540.79
57_G60_Y0.6530.79
120_A139_G0.6500.79
192_H195_G0.6490.79
335_L340_E0.6490.79
252_S255_D0.6490.79
367_D381_T0.6480.78
22_G26_D0.6470.78
407_L438_A0.6450.78
408_R419_T0.6440.78
66_E364_W0.6440.78
90_N95_T0.6420.78
84_H389_S0.6420.78
459_L479_A0.6410.78
11_V34_V0.6400.78
475_C478_R0.6400.78
175_T219_Y0.6370.77
127_R134_N0.6370.77
251_P268_T0.6360.77
360_L364_W0.6360.77
37_V169_L0.6350.77
456_L479_A0.6350.77
425_E442_G0.6340.77
422_W425_E0.6330.77
315_R353_G0.6320.77
164_H384_L0.6320.77
25_R29_L0.6310.77
433_V475_C0.6310.77
419_T423_L0.6290.76
236_M302_M0.6270.76
152_R451_L0.6250.76
253_D256_I0.6250.76
235_I265_L0.6240.76
428_L445_Q0.6220.76
213_G351_T0.6210.75
251_P256_I0.6190.75
123_P128_I0.6180.75
13_I366_T0.6180.75
30_R367_D0.6180.75
71_C357_T0.6140.75
273_I281_N0.6130.75
283_V287_E0.6120.74
121_I125_Q0.6120.74
33_R203_P0.6120.74
149_D152_R0.6110.74
333_I340_E0.6110.74
339_A344_L0.6060.74
232_S287_E0.6060.74
255_D294_E0.6060.74
484_Q487_N0.6050.74
470_C474_L0.6050.74
287_E357_T0.6050.74
269_T354_K0.6030.73
243_H249_R0.6030.73
80_R383_D0.6030.73
340_E372_K0.6020.73
436_C475_C0.6010.73
27_C32_L0.6000.73
11_V206_V0.6000.73
57_G231_G0.5980.73
476_A479_A0.5980.73
111_C118_A0.5960.72
194_T376_T0.5960.72
260_G468_G0.5950.72
340_E343_G0.5950.72
60_Y317_L0.5940.72
177_L347_F0.5930.72
270_S354_K0.5920.72
269_T317_L0.5920.72
320_S329_V0.5920.72
68_A317_L0.5900.72
102_S111_C0.5880.71
50_N150_P0.5860.71
181_G184_V0.5850.71
215_H219_Y0.5850.71
247_R254_A0.5830.71
104_Q108_I0.5830.71
47_T150_P0.5830.71
231_G354_K0.5820.71
160_D390_Q0.5820.71
366_T379_C0.5810.71
215_H218_E0.5810.71
285_A288_V0.5800.70
174_V219_Y0.5790.70
395_V405_A0.5770.70
225_R319_A0.5770.70
104_Q107_F0.5770.70
426_G432_L0.5750.70
214_Q224_I0.5750.70
316_P354_K0.5740.70
330_S334_V0.5740.70
434_C475_C0.5720.69
60_Y231_G0.5720.69
271_L284_T0.5690.69
102_S108_I0.5680.69
13_I220_A0.5660.69
364_W367_D0.5650.68
9_S200_L0.5640.68
148_V154_T0.5630.68
118_A123_P0.5630.68
436_C439_V0.5620.68
400_V427_R0.5610.68
13_I25_R0.5610.68
46_A317_L0.5610.68
109_R118_A0.5600.68
342_D368_A0.5590.68
456_L476_A0.5590.68
164_H380_T0.5580.68
52_G150_P0.5580.68
227_F329_V0.5570.67
214_Q218_E0.5570.67
329_V333_I0.5570.67
423_L427_R0.5560.67
425_E450_N0.5560.67
56_S60_Y0.5550.67
156_A387_P0.5540.67
52_G59_R0.5540.67
122_D127_R0.5520.67
177_L185_C0.5520.67
435_E438_A0.5520.67
76_Q88_P0.5510.67
101_L105_A0.5510.67
358_Y381_T0.5510.67
56_S61_A0.5500.66
220_A347_F0.5490.66
260_G355_L0.5480.66
248_C294_E0.5470.66
178_I184_V0.5460.66
475_C479_A0.5450.66
184_V347_F0.5440.66
194_T454_N0.5440.66
419_T422_W0.5440.66
217_A347_F0.5440.66
134_N137_L0.5440.66
439_V444_V0.5430.65
178_I187_V0.5410.65
432_L445_Q0.5400.65
229_A270_S0.5400.65
240_I243_H0.5400.65
168_I172_H0.5390.65
465_V472_G0.5380.65
120_A123_P0.5380.65
95_T141_V0.5380.65
398_R405_A0.5360.64
263_I468_G0.5350.64
54_L356_M0.5350.64
459_L476_A0.5350.64
422_W426_G0.5340.64
286_E289_D0.5330.64
88_P91_G0.5330.64
59_R256_I0.5310.64
55_H59_R0.5300.64
395_V402_S0.5300.64
59_R317_L0.5300.64
177_L186_G0.5290.63
34_V166_A0.5280.63
444_V453_V0.5280.63
294_E297_K0.5280.63
257_L299_A0.5270.63
56_S59_R0.5270.63
54_L355_L0.5270.63
360_L363_E0.5260.63
25_R28_A0.5260.63
234_L288_V0.5260.63
480_A483_L0.5250.63
87_E93_F0.5240.63
410_S439_V0.5240.63
427_R430_R0.5240.63
28_A161_A0.5240.63
92_L129_I0.5230.63
341_R344_L0.5230.63
55_H354_K0.5210.62
90_N93_F0.5210.62
75_N356_M0.5210.62
238_H243_H0.5200.62
362_A366_T0.5200.62
30_R381_T0.5200.62
340_E345_D0.5190.62
269_T287_E0.5190.62
51_H247_R0.5180.62
95_T101_L0.5180.62
46_A354_K0.5170.62
52_G151_F0.5170.62
45_G214_Q0.5170.62
423_L426_G0.5160.62
85_C355_L0.5160.62
409_G428_L0.5150.61
428_L432_L0.5150.61
111_C143_V0.5140.61
250_K302_M0.5140.61
477_C480_A0.5130.61
183_T346_G0.5120.61
35_I189_V0.5120.61
400_V405_A0.5120.61
81_I358_Y0.5120.61
420_P424_S0.5110.61
231_G313_G0.5110.61
26_D29_L0.5110.61
102_S105_A0.5110.61
187_V200_L0.5110.61
239_R308_L0.5100.61
134_N300_P0.5090.61
59_R270_S0.5090.61
282_R286_E0.5090.61
404_P408_R0.5080.60
363_E381_T0.5080.60
70_E74_E0.5080.60
95_T103_F0.5070.60
116_I121_I0.5070.60
149_D464_R0.5070.60
188_R198_Q0.5070.60
425_E432_L0.5070.60
353_G361_M0.5060.60
269_T316_P0.5060.60
57_G354_K0.5060.60
426_G440_T0.5060.60
429_H442_G0.5050.60
181_G449_E0.5050.60
414_R422_W0.5050.60
359_R381_T0.5040.60
399_K402_S0.5040.60
437_E469_T0.5040.60
49_R311_Y0.5040.60
105_A112_E0.5030.60
48_G150_P0.5030.60
315_R331_R0.5030.60
222_L225_R0.5030.60
103_F106_T0.5020.59
205_V346_G0.5020.59
9_S169_L0.5020.59
63_T271_L0.5020.59
122_D128_I0.5010.59
118_A129_I0.5010.59
82_A153_L0.5000.59
185_C201_H0.5000.59
55_H60_Y0.5000.59
232_S307_I0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rghA 2 0.9151 100 0.385 Contact Map
3da1A 1 0.8561 100 0.401 Contact Map
2qcuA 2 0.8856 100 0.424 Contact Map
4h1bA 1 0.6808 100 0.672 Contact Map
4x9mA 1 0.6679 100 0.672 Contact Map
3dmeA 2 0.6421 100 0.683 Contact Map
3axbA 2 0.6808 100 0.693 Contact Map
1y56B 1 0.6734 100 0.695 Contact Map
1pj5A 3 0.9391 100 0.698 Contact Map
1ryiA 4 0.6439 100 0.698 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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