GREMLIN Database
E4PD - D-erythrose-4-phosphate dehydrogenase
UniProt: P0A9B6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10368
Length: 339 (327)
Sequences: 5433 (2463)
Seq/√Len: 136.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_D225_Q4.3741.00
80_E85_S3.7251.00
174_E252_K3.4651.00
165_K169_D3.2101.00
277_D293_H3.1051.00
207_S286_V2.8191.00
140_Q332_A2.8111.00
82_S85_S2.7911.00
110_E114_A2.7841.00
254_P308_H2.7461.00
264_L297_V2.6051.00
171_Y263_L2.5321.00
170_A266_K2.4901.00
184_A205_S2.4771.00
59_W71_G2.4611.00
4_R31_T2.4041.00
295_A314_V2.3971.00
108_H111_A2.3791.00
150_V333_M2.3301.00
294_S325_R2.2611.00
64_E74_A2.2281.00
235_V244_A2.1921.00
67_Q74_A2.1841.00
105_S108_H2.1671.00
241_N289_N2.1531.00
175_S250_T2.1261.00
253_K259_E2.0471.00
136_Y140_Q2.0471.00
132_A147_H2.0241.00
22_Y57_F1.9911.00
183_S239_T1.9881.00
260_V310_I1.9561.00
83_L103_Y1.9341.00
64_E67_Q1.9201.00
49_K281_L1.9051.00
242_V288_F1.8921.00
43_G198_L1.8911.00
31_T73_D1.8901.00
54_H241_N1.8861.00
208_I235_V1.8821.00
220_T227_N1.8721.00
21_L32_V1.8531.00
164_I226_F1.8511.00
262_L266_K1.8241.00
106_R110_E1.8001.00
10_F48_L1.7981.00
18_V32_V1.7861.00
119_K148_R1.7471.00
87_P90_E1.7351.00
231_E303_R1.7291.00
121_L330_T1.7251.00
265_Q280_E1.7241.00
84_Q114_A1.7241.00
278_Y299_G1.7181.00
84_Q111_A1.6911.00
325_R328_D1.6711.00
251_V310_I1.6651.00
99_C123_S1.6431.00
277_D291_D1.6381.00
18_V48_L1.6281.00
20_A324_N1.6121.00
132_A142_Q1.5921.00
104_G122_F1.5911.00
261_N302_T1.5841.00
18_V70_V1.5801.00
164_I173_I1.5801.00
123_S326_M1.5691.00
187_D195_H1.5681.00
97_L330_T1.5641.00
254_P307_A1.5621.00
174_E250_T1.5611.00
265_Q269_Q1.5521.00
282_P300_T1.5511.00
52_T206_Q1.5251.00
76_R90_E1.5151.00
46_H201_T1.5131.00
4_R92_G1.5011.00
105_S127_S1.4861.00
67_Q76_R1.4751.00
110_E113_I1.4401.00
171_Y251_V1.4381.00
279_T288_F1.4351.00
56_R291_D1.4241.00
41_A77_V1.4211.00
174_E308_H1.4171.00
52_T286_V1.3891.00
46_H198_L1.3471.00
291_D296_I1.3441.00
24_S331_L1.3381.00
163_V314_V1.3321.00
206_Q240_I1.3261.00
190_V204_A1.3221.00
279_T283_L1.3221.00
126_G130_L1.3161.00
186_H191_I1.3141.00
23_E58_A1.3131.00
163_V295_A1.3091.00
221_R227_N1.3071.00
176_G230_F1.3021.00
78_L91_L1.2981.00
97_L326_M1.2971.00
167_L264_L1.2961.00
256_K259_E1.2931.00
99_C326_M1.2921.00
265_Q278_Y1.2891.00
257_A302_T1.2871.00
24_S28_A1.2821.00
109_G122_F1.2771.00
200_R211_V1.2691.00
175_S306_G1.2511.00
34_A78_L1.2441.00
293_H296_I1.2421.00
283_L288_F1.2401.00
95_V330_T1.2271.00
166_L276_V1.2261.00
203_A206_Q1.2161.00
166_L263_L1.2051.00
82_S111_A1.2001.00
294_S328_D1.1971.00
197_D200_R1.1951.00
86_L91_L1.1941.00
250_T308_H1.1931.00
168_D223_F1.1921.00
57_F71_G1.1911.00
280_E299_G1.1820.99
167_L312_T1.1710.99
272_F276_V1.1540.99
18_V75_I1.1460.99
170_A263_L1.1440.99
41_A63_Q1.1430.99
186_H193_A1.1380.99
86_L115_A1.1230.99
175_S308_H1.1210.99
189_Q193_A1.1120.99
251_V255_V1.1070.99
17_V326_M1.1060.99
16_N54_H1.1040.99
286_V289_N1.1020.99
320_W324_N1.0990.99
163_V264_L1.0930.99
17_V97_L1.0880.99
172_G251_V1.0870.99
48_L59_W1.0840.99
170_A174_E1.0830.99
126_G133_T1.0800.99
6_A86_L1.0790.99
301_Q313_L1.0680.99
23_E290_H1.0680.99
122_F126_G1.0670.99
17_V323_A1.0640.99
64_E69_F1.0640.99
292_P320_W1.0620.99
171_Y255_V1.0610.99
29_E331_L1.0470.99
181_I235_V1.0430.99
322_F326_M1.0420.99
45_A61_V1.0370.99
143_L148_R1.0340.99
69_F72_D1.0310.99
6_A93_V1.0290.99
163_V312_T1.0270.99
255_V304_V1.0260.99
40_D43_G1.0250.99
143_L150_V1.0210.98
255_V259_E1.0150.98
144_R147_H1.0140.98
262_L265_Q1.0120.98
244_A313_L1.0110.98
199_R298_D1.0090.98
304_V310_I1.0080.98
239_T242_V1.0080.98
50_Y281_L1.0050.98
119_K143_L1.0040.98
121_L150_V1.0030.98
304_V307_A1.0020.98
53_S240_I0.9990.98
133_T221_R0.9960.98
257_A261_N0.9960.98
233_I313_L0.9930.98
168_D252_K0.9930.98
268_A271_A0.9920.98
24_S29_E0.9910.98
95_V121_L0.9880.98
44_M77_V0.9820.98
292_P324_N0.9740.98
167_L251_V0.9740.98
69_F74_A0.9730.98
66_D76_R0.9690.98
279_T300_T0.9660.98
142_Q225_Q0.9630.98
258_N262_L0.9600.98
235_V313_L0.9520.98
166_L272_F0.9500.98
187_D200_R0.9490.98
160_I178_V0.9460.98
171_Y260_V0.9440.97
94_D118_K0.9220.97
255_V263_L0.9150.97
22_Y73_D0.9130.97
107_E110_E0.9130.97
3_V30_I0.9110.97
53_S241_N0.9100.97
134_V143_L0.9020.97
276_V295_A0.9020.97
278_Y297_V0.9020.97
135_V153_A0.9010.97
263_L266_K0.8970.97
167_L249_V0.8940.97
122_F130_L0.8930.96
290_H320_W0.8910.96
93_V96_V0.8880.96
255_V260_V0.8870.96
134_V147_H0.8860.96
175_S309_L0.8860.96
279_T299_G0.8800.96
54_H290_H0.8780.96
277_D296_I0.8770.96
76_R91_L0.8770.96
242_V289_N0.8750.96
34_A93_V0.8750.96
136_Y329_T0.8640.96
37_E194_Y0.8610.96
30_I331_L0.8610.96
159_C245_I0.8600.96
105_S129_D0.8590.96
44_M194_Y0.8520.95
186_H209_I0.8490.95
136_Y332_A0.8490.95
195_H200_R0.8470.95
78_L87_P0.8470.95
106_R130_L0.8400.95
21_L327_L0.8380.95
6_A115_A0.8350.95
54_H289_N0.8280.95
105_S111_A0.8280.95
95_V333_M0.8280.95
33_V93_V0.8270.95
49_K56_R0.8210.94
110_E149_I0.8170.94
60_E71_G0.8150.94
53_S191_I0.8130.94
261_N297_V0.8120.94
42_A63_Q0.8100.94
266_K271_A0.8010.94
136_Y275_I0.7970.93
163_V297_V0.7960.93
10_F35_I0.7960.93
63_Q69_F0.7950.93
203_A240_I0.7930.93
95_V334_A0.7890.93
39_A194_Y0.7870.93
34_A91_L0.7750.93
53_S206_Q0.7730.92
141_D332_A0.7730.92
121_L329_T0.7730.92
266_K270_G0.7680.92
105_S110_E0.7660.92
104_G108_H0.7630.92
48_L57_F0.7590.92
195_H201_T0.7580.92
153_A322_F0.7560.92
141_D271_A0.7560.92
184_A190_V0.7550.92
251_V304_V0.7530.91
177_T233_I0.7530.91
38_L194_Y0.7520.91
189_Q201_T0.7510.91
46_H50_Y0.7510.91
78_L86_L0.7500.91
198_L201_T0.7500.91
106_R129_D0.7410.91
170_A267_A0.7360.90
179_T248_S0.7350.90
106_R149_I0.7340.90
17_V327_L0.7340.90
102_V108_H0.7330.90
35_I68_L0.7330.90
61_V70_V0.7320.90
178_V245_I0.7300.90
246_D311_K0.7290.90
219_I223_F0.7290.90
81_R102_V0.7280.90
199_R301_Q0.7280.90
87_P91_L0.7250.90
49_K60_E0.7240.90
143_L332_A0.7230.90
171_Y253_K0.7220.90
111_A115_A0.7190.89
254_P306_G0.7190.89
35_I77_V0.7190.89
255_V310_I0.7180.89
62_R69_F0.7170.89
259_E262_L0.7170.89
111_A114_A0.7170.89
208_I313_L0.7160.89
37_E102_V0.7160.89
39_A44_M0.7130.89
38_L102_V0.7130.89
163_V245_I0.7120.89
269_Q273_H0.7120.89
160_I164_I0.7120.89
129_D221_R0.7100.89
3_V334_A0.7090.89
263_L267_A0.7080.89
233_I311_K0.7040.88
41_A45_A0.7010.88
145_A148_R0.7010.88
53_S203_A0.7000.88
7_I18_V0.7000.88
134_V142_Q0.6980.88
330_T333_M0.6970.88
52_T240_I0.6950.88
38_L44_M0.6930.88
34_A76_R0.6920.88
184_A240_I0.6920.88
38_L80_E0.6920.88
186_H189_Q0.6890.87
249_V310_I0.6880.87
297_V300_T0.6870.87
219_I230_F0.6860.87
270_G273_H0.6850.87
177_T305_S0.6850.87
242_V245_I0.6780.86
89_R115_A0.6780.86
132_A150_V0.6760.86
135_V138_V0.6730.86
4_R94_D0.6690.86
45_A63_Q0.6680.86
78_L90_E0.6670.86
24_S324_N0.6660.86
277_D295_A0.6650.85
164_I230_F0.6620.85
233_I303_R0.6590.85
80_E86_L0.6590.85
172_G252_K0.6580.85
212_D217_A0.6550.85
38_L81_R0.6540.84
249_V312_T0.6530.84
106_R148_R0.6520.84
99_C330_T0.6510.84
65_R69_F0.6460.84
214_K243_T0.6450.84
205_S240_I0.6450.84
122_F149_I0.6440.84
58_A71_G0.6440.84
152_N323_A0.6430.83
265_Q268_A0.6420.83
132_A144_R0.6420.83
143_L333_M0.6400.83
63_Q67_Q0.6390.83
20_A327_L0.6390.83
104_G130_L0.6310.82
46_H197_D0.6300.82
251_V260_V0.6300.82
42_A198_L0.6300.82
60_E72_D0.6290.82
179_T235_V0.6280.82
46_H283_L0.6260.82
266_K269_Q0.6250.82
264_L276_V0.6240.82
15_R19_R0.6240.82
121_L333_M0.6230.82
96_V117_A0.6220.81
30_I95_V0.6210.81
22_Y71_G0.6210.81
38_L79_H0.6210.81
3_V29_E0.6190.81
170_A253_K0.6140.81
181_I208_I0.6140.81
110_E148_R0.6120.80
242_V283_L0.6120.80
260_V264_L0.6100.80
23_E59_W0.6100.80
197_D211_V0.6080.80
6_A91_L0.6070.80
38_L86_L0.6060.80
106_R111_A0.6060.80
109_G149_I0.6040.80
136_Y152_N0.6040.80
167_L247_L0.6030.79
87_P115_A0.6010.79
6_A34_A0.5990.79
107_E114_A0.5990.79
239_T288_F0.5980.79
306_G309_L0.5970.79
160_I245_I0.5950.78
134_V329_T0.5940.78
88_W112_H0.5930.78
49_K61_V0.5930.78
5_V330_T0.5920.78
41_A66_D0.5910.78
164_I247_L0.5900.78
198_L282_P0.5900.78
18_V22_Y0.5890.78
66_D74_A0.5890.78
48_L70_V0.5890.78
136_Y328_D0.5890.78
6_A92_G0.5860.77
3_V6_A0.5860.77
113_I148_R0.5830.77
164_I223_F0.5830.77
38_L100_T0.5830.77
104_G109_G0.5820.77
208_I239_T0.5820.77
91_L115_A0.5810.77
48_L61_V0.5800.77
249_V264_L0.5790.77
153_A218_G0.5770.76
113_I149_I0.5770.76
42_A65_R0.5760.76
104_G127_S0.5760.76
81_R84_Q0.5740.76
206_Q289_N0.5730.76
166_L267_A0.5710.76
177_T231_E0.5710.76
20_A24_S0.5680.75
3_V95_V0.5670.75
264_L312_T0.5670.75
261_N299_G0.5670.75
326_M330_T0.5660.75
24_S328_D0.5650.75
176_G249_V0.5650.75
219_I231_E0.5650.75
89_R117_A0.5640.75
264_L278_Y0.5610.74
159_C314_V0.5610.74
255_V308_H0.5610.74
23_E28_A0.5590.74
184_A206_Q0.5590.74
147_H150_V0.5580.74
178_V232_A0.5560.74
68_L75_I0.5560.74
94_D117_A0.5550.74
281_L288_F0.5540.73
250_T309_L0.5530.73
265_Q299_G0.5530.73
42_A46_H0.5520.73
208_I237_V0.5490.73
16_N320_W0.5470.73
248_S309_L0.5450.72
180_T243_T0.5440.72
35_I75_I0.5420.72
86_L112_H0.5420.72
171_Y249_V0.5420.72
268_A277_D0.5400.72
170_A251_V0.5390.71
43_G194_Y0.5380.71
184_A204_A0.5380.71
43_G201_T0.5380.71
233_I301_Q0.5380.71
170_A271_A0.5370.71
179_T246_D0.5350.71
197_D201_T0.5350.71
94_D116_G0.5340.71
169_D223_F0.5330.71
322_F329_T0.5290.70
127_S130_L0.5250.69
143_L146_E0.5250.69
187_D201_T0.5240.69
39_A43_G0.5240.69
305_S309_L0.5240.69
5_V30_I0.5230.69
179_T311_K0.5230.69
4_R33_V0.5220.69
164_I249_V0.5210.69
165_K271_A0.5210.69
70_V75_I0.5210.69
20_A320_W0.5210.69
21_L24_S0.5210.69
6_A88_W0.5200.69
178_V247_L0.5190.69
168_D226_F0.5190.69
56_R281_L0.5170.68
6_A78_L0.5160.68
41_A67_Q0.5150.68
69_F73_D0.5150.68
112_H117_A0.5120.68
17_V21_L0.5100.67
164_I168_D0.5080.67
65_R68_L0.5080.67
323_A328_D0.5070.67
329_T332_A0.5070.67
176_G247_L0.5060.67
213_T243_T0.5060.67
177_T248_S0.5040.66
258_N261_N0.5020.66
176_G220_T0.5020.66
329_T333_M0.5020.66
50_Y56_R0.5000.66
152_N328_D0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4boyA 4 0.9941 100 0.201 Contact Map
3idsC 4 0.9882 100 0.214 Contact Map
2x5jO 4 0.9735 100 0.22 Contact Map
3docA 4 0.9882 100 0.221 Contact Map
1rm4O 4 0.9882 100 0.222 Contact Map
4lsmA 4 0.9735 100 0.223 Contact Map
2ep7A 4 0.9735 100 0.227 Contact Map
1obfO 4 0.9823 100 0.232 Contact Map
4o59O 4 0.9735 100 0.233 Contact Map
3cpsA 4 0.9764 100 0.235 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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