E4PD - ECOLI - GREMLIN Contacts

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E4PD - D-erythrose-4-phosphate dehydrogenase

UniProt:	P0A9B6	Sequences: MTVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRQERDQLFVGDDAIRVLHERSLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKVLFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTKLAAGITRFFPQFNDRFEAIAVRVPTINVTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMATVAFR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10368
Length:	339 (327)
Sequences:	5433 (2463)
Seq/√Len:	136.2

ECOLI - E4PD G3P1 G3P3
BACSU - G3P2 G3P1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
168_D	225_Q	4.374	1.00
80_E	85_S	3.725	1.00
174_E	252_K	3.465	1.00
165_K	169_D	3.210	1.00
277_D	293_H	3.105	1.00
207_S	286_V	2.819	1.00
140_Q	332_A	2.811	1.00
82_S	85_S	2.791	1.00
110_E	114_A	2.784	1.00
254_P	308_H	2.746	1.00
264_L	297_V	2.605	1.00
171_Y	263_L	2.532	1.00
170_A	266_K	2.490	1.00
184_A	205_S	2.477	1.00
59_W	71_G	2.461	1.00
4_R	31_T	2.404	1.00
295_A	314_V	2.397	1.00
108_H	111_A	2.379	1.00
150_V	333_M	2.330	1.00
294_S	325_R	2.261	1.00
64_E	74_A	2.228	1.00
235_V	244_A	2.192	1.00
67_Q	74_A	2.184	1.00
105_S	108_H	2.167	1.00
241_N	289_N	2.153	1.00
175_S	250_T	2.126	1.00
253_K	259_E	2.047	1.00
136_Y	140_Q	2.047	1.00
132_A	147_H	2.024	1.00
22_Y	57_F	1.991	1.00
183_S	239_T	1.988	1.00
260_V	310_I	1.956	1.00
83_L	103_Y	1.934	1.00
64_E	67_Q	1.920	1.00
49_K	281_L	1.905	1.00
242_V	288_F	1.892	1.00
43_G	198_L	1.891	1.00
31_T	73_D	1.890	1.00
54_H	241_N	1.886	1.00
208_I	235_V	1.882	1.00
220_T	227_N	1.872	1.00
21_L	32_V	1.853	1.00
164_I	226_F	1.851	1.00
262_L	266_K	1.824	1.00
106_R	110_E	1.800	1.00
10_F	48_L	1.798	1.00
18_V	32_V	1.786	1.00
119_K	148_R	1.747	1.00
87_P	90_E	1.735	1.00
231_E	303_R	1.729	1.00
121_L	330_T	1.725	1.00
265_Q	280_E	1.724	1.00
84_Q	114_A	1.724	1.00
278_Y	299_G	1.718	1.00
84_Q	111_A	1.691	1.00
325_R	328_D	1.671	1.00
251_V	310_I	1.665	1.00
99_C	123_S	1.643	1.00
277_D	291_D	1.638	1.00
18_V	48_L	1.628	1.00
20_A	324_N	1.612	1.00
132_A	142_Q	1.592	1.00
104_G	122_F	1.591	1.00
261_N	302_T	1.584	1.00
18_V	70_V	1.580	1.00
164_I	173_I	1.580	1.00
123_S	326_M	1.569	1.00
187_D	195_H	1.568	1.00
97_L	330_T	1.564	1.00
254_P	307_A	1.562	1.00
174_E	250_T	1.561	1.00
265_Q	269_Q	1.552	1.00
282_P	300_T	1.551	1.00
52_T	206_Q	1.525	1.00
76_R	90_E	1.515	1.00
46_H	201_T	1.513	1.00
4_R	92_G	1.501	1.00
105_S	127_S	1.486	1.00
67_Q	76_R	1.475	1.00
110_E	113_I	1.440	1.00
171_Y	251_V	1.438	1.00
279_T	288_F	1.435	1.00
56_R	291_D	1.424	1.00
41_A	77_V	1.421	1.00
174_E	308_H	1.417	1.00
52_T	286_V	1.389	1.00
46_H	198_L	1.347	1.00
291_D	296_I	1.344	1.00
24_S	331_L	1.338	1.00
163_V	314_V	1.332	1.00
206_Q	240_I	1.326	1.00
190_V	204_A	1.322	1.00
279_T	283_L	1.322	1.00
126_G	130_L	1.316	1.00
186_H	191_I	1.314	1.00
23_E	58_A	1.313	1.00
163_V	295_A	1.309	1.00
221_R	227_N	1.307	1.00
176_G	230_F	1.302	1.00
78_L	91_L	1.298	1.00
97_L	326_M	1.297	1.00
167_L	264_L	1.296	1.00
256_K	259_E	1.293	1.00
99_C	326_M	1.292	1.00
265_Q	278_Y	1.289	1.00
257_A	302_T	1.287	1.00
24_S	28_A	1.282	1.00
109_G	122_F	1.277	1.00
200_R	211_V	1.269	1.00
175_S	306_G	1.251	1.00
34_A	78_L	1.244	1.00
293_H	296_I	1.242	1.00
283_L	288_F	1.240	1.00
95_V	330_T	1.227	1.00
166_L	276_V	1.226	1.00
203_A	206_Q	1.216	1.00
166_L	263_L	1.205	1.00
82_S	111_A	1.200	1.00
294_S	328_D	1.197	1.00
197_D	200_R	1.195	1.00
86_L	91_L	1.194	1.00
250_T	308_H	1.193	1.00
168_D	223_F	1.192	1.00
57_F	71_G	1.191	1.00
280_E	299_G	1.182	0.99
167_L	312_T	1.171	0.99
272_F	276_V	1.154	0.99
18_V	75_I	1.146	0.99
170_A	263_L	1.144	0.99
41_A	63_Q	1.143	0.99
186_H	193_A	1.138	0.99
86_L	115_A	1.123	0.99
175_S	308_H	1.121	0.99
189_Q	193_A	1.112	0.99
251_V	255_V	1.107	0.99
17_V	326_M	1.106	0.99
16_N	54_H	1.104	0.99
286_V	289_N	1.102	0.99
320_W	324_N	1.099	0.99
163_V	264_L	1.093	0.99
17_V	97_L	1.088	0.99
172_G	251_V	1.087	0.99
48_L	59_W	1.084	0.99
170_A	174_E	1.083	0.99
126_G	133_T	1.080	0.99
6_A	86_L	1.079	0.99
301_Q	313_L	1.068	0.99
23_E	290_H	1.068	0.99
122_F	126_G	1.067	0.99
17_V	323_A	1.064	0.99
64_E	69_F	1.064	0.99
292_P	320_W	1.062	0.99
171_Y	255_V	1.061	0.99
29_E	331_L	1.047	0.99
181_I	235_V	1.043	0.99
322_F	326_M	1.042	0.99
45_A	61_V	1.037	0.99
143_L	148_R	1.034	0.99
69_F	72_D	1.031	0.99
6_A	93_V	1.029	0.99
163_V	312_T	1.027	0.99
255_V	304_V	1.026	0.99
40_D	43_G	1.025	0.99
143_L	150_V	1.021	0.98
255_V	259_E	1.015	0.98
144_R	147_H	1.014	0.98
262_L	265_Q	1.012	0.98
244_A	313_L	1.011	0.98
199_R	298_D	1.009	0.98
304_V	310_I	1.008	0.98
239_T	242_V	1.008	0.98
50_Y	281_L	1.005	0.98
119_K	143_L	1.004	0.98
121_L	150_V	1.003	0.98
304_V	307_A	1.002	0.98
53_S	240_I	0.999	0.98
133_T	221_R	0.996	0.98
257_A	261_N	0.996	0.98
233_I	313_L	0.993	0.98
168_D	252_K	0.993	0.98
268_A	271_A	0.992	0.98
24_S	29_E	0.991	0.98
95_V	121_L	0.988	0.98
44_M	77_V	0.982	0.98
292_P	324_N	0.974	0.98
167_L	251_V	0.974	0.98
69_F	74_A	0.973	0.98
66_D	76_R	0.969	0.98
279_T	300_T	0.966	0.98
142_Q	225_Q	0.963	0.98
258_N	262_L	0.960	0.98
235_V	313_L	0.952	0.98
166_L	272_F	0.950	0.98
187_D	200_R	0.949	0.98
160_I	178_V	0.946	0.98
171_Y	260_V	0.944	0.97
94_D	118_K	0.922	0.97
255_V	263_L	0.915	0.97
22_Y	73_D	0.913	0.97
107_E	110_E	0.913	0.97
3_V	30_I	0.911	0.97
53_S	241_N	0.910	0.97
134_V	143_L	0.902	0.97
276_V	295_A	0.902	0.97
278_Y	297_V	0.902	0.97
135_V	153_A	0.901	0.97
263_L	266_K	0.897	0.97
167_L	249_V	0.894	0.97
122_F	130_L	0.893	0.96
290_H	320_W	0.891	0.96
93_V	96_V	0.888	0.96
255_V	260_V	0.887	0.96
134_V	147_H	0.886	0.96
175_S	309_L	0.886	0.96
279_T	299_G	0.880	0.96
54_H	290_H	0.878	0.96
277_D	296_I	0.877	0.96
76_R	91_L	0.877	0.96
242_V	289_N	0.875	0.96
34_A	93_V	0.875	0.96
136_Y	329_T	0.864	0.96
37_E	194_Y	0.861	0.96
30_I	331_L	0.861	0.96
159_C	245_I	0.860	0.96
105_S	129_D	0.859	0.96
44_M	194_Y	0.852	0.95
186_H	209_I	0.849	0.95
136_Y	332_A	0.849	0.95
195_H	200_R	0.847	0.95
78_L	87_P	0.847	0.95
106_R	130_L	0.840	0.95
21_L	327_L	0.838	0.95
6_A	115_A	0.835	0.95
54_H	289_N	0.828	0.95
105_S	111_A	0.828	0.95
95_V	333_M	0.828	0.95
33_V	93_V	0.827	0.95
49_K	56_R	0.821	0.94
110_E	149_I	0.817	0.94
60_E	71_G	0.815	0.94
53_S	191_I	0.813	0.94
261_N	297_V	0.812	0.94
42_A	63_Q	0.810	0.94
266_K	271_A	0.801	0.94
136_Y	275_I	0.797	0.93
163_V	297_V	0.796	0.93
10_F	35_I	0.796	0.93
63_Q	69_F	0.795	0.93
203_A	240_I	0.793	0.93
95_V	334_A	0.789	0.93
39_A	194_Y	0.787	0.93
34_A	91_L	0.775	0.93
53_S	206_Q	0.773	0.92
141_D	332_A	0.773	0.92
121_L	329_T	0.773	0.92
266_K	270_G	0.768	0.92
105_S	110_E	0.766	0.92
104_G	108_H	0.763	0.92
48_L	57_F	0.759	0.92
195_H	201_T	0.758	0.92
153_A	322_F	0.756	0.92
141_D	271_A	0.756	0.92
184_A	190_V	0.755	0.92
251_V	304_V	0.753	0.91
177_T	233_I	0.753	0.91
38_L	194_Y	0.752	0.91
189_Q	201_T	0.751	0.91
46_H	50_Y	0.751	0.91
78_L	86_L	0.750	0.91
198_L	201_T	0.750	0.91
106_R	129_D	0.741	0.91
170_A	267_A	0.736	0.90
179_T	248_S	0.735	0.90
106_R	149_I	0.734	0.90
17_V	327_L	0.734	0.90
102_V	108_H	0.733	0.90
35_I	68_L	0.733	0.90
61_V	70_V	0.732	0.90
178_V	245_I	0.730	0.90
246_D	311_K	0.729	0.90
219_I	223_F	0.729	0.90
81_R	102_V	0.728	0.90
199_R	301_Q	0.728	0.90
87_P	91_L	0.725	0.90
49_K	60_E	0.724	0.90
143_L	332_A	0.723	0.90
171_Y	253_K	0.722	0.90
111_A	115_A	0.719	0.89
254_P	306_G	0.719	0.89
35_I	77_V	0.719	0.89
255_V	310_I	0.718	0.89
62_R	69_F	0.717	0.89
259_E	262_L	0.717	0.89
111_A	114_A	0.717	0.89
208_I	313_L	0.716	0.89
37_E	102_V	0.716	0.89
39_A	44_M	0.713	0.89
38_L	102_V	0.713	0.89
163_V	245_I	0.712	0.89
269_Q	273_H	0.712	0.89
160_I	164_I	0.712	0.89
129_D	221_R	0.710	0.89
3_V	334_A	0.709	0.89
263_L	267_A	0.708	0.89
233_I	311_K	0.704	0.88
41_A	45_A	0.701	0.88
145_A	148_R	0.701	0.88
53_S	203_A	0.700	0.88
7_I	18_V	0.700	0.88
134_V	142_Q	0.698	0.88
330_T	333_M	0.697	0.88
52_T	240_I	0.695	0.88
38_L	44_M	0.693	0.88
34_A	76_R	0.692	0.88
184_A	240_I	0.692	0.88
38_L	80_E	0.692	0.88
186_H	189_Q	0.689	0.87
249_V	310_I	0.688	0.87
297_V	300_T	0.687	0.87
219_I	230_F	0.686	0.87
270_G	273_H	0.685	0.87
177_T	305_S	0.685	0.87
242_V	245_I	0.678	0.86
89_R	115_A	0.678	0.86
132_A	150_V	0.676	0.86
135_V	138_V	0.673	0.86
4_R	94_D	0.669	0.86
45_A	63_Q	0.668	0.86
78_L	90_E	0.667	0.86
24_S	324_N	0.666	0.86
277_D	295_A	0.665	0.85
164_I	230_F	0.662	0.85
233_I	303_R	0.659	0.85
80_E	86_L	0.659	0.85
172_G	252_K	0.658	0.85
212_D	217_A	0.655	0.85
38_L	81_R	0.654	0.84
249_V	312_T	0.653	0.84
106_R	148_R	0.652	0.84
99_C	330_T	0.651	0.84
65_R	69_F	0.646	0.84
214_K	243_T	0.645	0.84
205_S	240_I	0.645	0.84
122_F	149_I	0.644	0.84
58_A	71_G	0.644	0.84
152_N	323_A	0.643	0.83
265_Q	268_A	0.642	0.83
132_A	144_R	0.642	0.83
143_L	333_M	0.640	0.83
63_Q	67_Q	0.639	0.83
20_A	327_L	0.639	0.83
104_G	130_L	0.631	0.82
46_H	197_D	0.630	0.82
251_V	260_V	0.630	0.82
42_A	198_L	0.630	0.82
60_E	72_D	0.629	0.82
179_T	235_V	0.628	0.82
46_H	283_L	0.626	0.82
266_K	269_Q	0.625	0.82
264_L	276_V	0.624	0.82
15_R	19_R	0.624	0.82
121_L	333_M	0.623	0.82
96_V	117_A	0.622	0.81
30_I	95_V	0.621	0.81
22_Y	71_G	0.621	0.81
38_L	79_H	0.621	0.81
3_V	29_E	0.619	0.81
170_A	253_K	0.614	0.81
181_I	208_I	0.614	0.81
110_E	148_R	0.612	0.80
242_V	283_L	0.612	0.80
260_V	264_L	0.610	0.80
23_E	59_W	0.610	0.80
197_D	211_V	0.608	0.80
6_A	91_L	0.607	0.80
38_L	86_L	0.606	0.80
106_R	111_A	0.606	0.80
109_G	149_I	0.604	0.80
136_Y	152_N	0.604	0.80
167_L	247_L	0.603	0.79
87_P	115_A	0.601	0.79
6_A	34_A	0.599	0.79
107_E	114_A	0.599	0.79
239_T	288_F	0.598	0.79
306_G	309_L	0.597	0.79
160_I	245_I	0.595	0.78
134_V	329_T	0.594	0.78
88_W	112_H	0.593	0.78
49_K	61_V	0.593	0.78
5_V	330_T	0.592	0.78
41_A	66_D	0.591	0.78
164_I	247_L	0.590	0.78
198_L	282_P	0.590	0.78
18_V	22_Y	0.589	0.78
66_D	74_A	0.589	0.78
48_L	70_V	0.589	0.78
136_Y	328_D	0.589	0.78
6_A	92_G	0.586	0.77
3_V	6_A	0.586	0.77
113_I	148_R	0.583	0.77
164_I	223_F	0.583	0.77
38_L	100_T	0.583	0.77
104_G	109_G	0.582	0.77
208_I	239_T	0.582	0.77
91_L	115_A	0.581	0.77
48_L	61_V	0.580	0.77
249_V	264_L	0.579	0.77
153_A	218_G	0.577	0.76
113_I	149_I	0.577	0.76
42_A	65_R	0.576	0.76
104_G	127_S	0.576	0.76
81_R	84_Q	0.574	0.76
206_Q	289_N	0.573	0.76
166_L	267_A	0.571	0.76
177_T	231_E	0.571	0.76
20_A	24_S	0.568	0.75
3_V	95_V	0.567	0.75
264_L	312_T	0.567	0.75
261_N	299_G	0.567	0.75
326_M	330_T	0.566	0.75
24_S	328_D	0.565	0.75
176_G	249_V	0.565	0.75
219_I	231_E	0.565	0.75
89_R	117_A	0.564	0.75
264_L	278_Y	0.561	0.74
159_C	314_V	0.561	0.74
255_V	308_H	0.561	0.74
23_E	28_A	0.559	0.74
184_A	206_Q	0.559	0.74
147_H	150_V	0.558	0.74
178_V	232_A	0.556	0.74
68_L	75_I	0.556	0.74
94_D	117_A	0.555	0.74
281_L	288_F	0.554	0.73
250_T	309_L	0.553	0.73
265_Q	299_G	0.553	0.73
42_A	46_H	0.552	0.73
208_I	237_V	0.549	0.73
16_N	320_W	0.547	0.73
248_S	309_L	0.545	0.72
180_T	243_T	0.544	0.72
35_I	75_I	0.542	0.72
86_L	112_H	0.542	0.72
171_Y	249_V	0.542	0.72
268_A	277_D	0.540	0.72
170_A	251_V	0.539	0.71
43_G	194_Y	0.538	0.71
184_A	204_A	0.538	0.71
43_G	201_T	0.538	0.71
233_I	301_Q	0.538	0.71
170_A	271_A	0.537	0.71
179_T	246_D	0.535	0.71
197_D	201_T	0.535	0.71
94_D	116_G	0.534	0.71
169_D	223_F	0.533	0.71
322_F	329_T	0.529	0.70
127_S	130_L	0.525	0.69
143_L	146_E	0.525	0.69
187_D	201_T	0.524	0.69
39_A	43_G	0.524	0.69
305_S	309_L	0.524	0.69
5_V	30_I	0.523	0.69
179_T	311_K	0.523	0.69
4_R	33_V	0.522	0.69
164_I	249_V	0.521	0.69
165_K	271_A	0.521	0.69
70_V	75_I	0.521	0.69
20_A	320_W	0.521	0.69
21_L	24_S	0.521	0.69
6_A	88_W	0.520	0.69
178_V	247_L	0.519	0.69
168_D	226_F	0.519	0.69
56_R	281_L	0.517	0.68
6_A	78_L	0.516	0.68
41_A	67_Q	0.515	0.68
69_F	73_D	0.515	0.68
112_H	117_A	0.512	0.68
17_V	21_L	0.510	0.67
164_I	168_D	0.508	0.67
65_R	68_L	0.508	0.67
323_A	328_D	0.507	0.67
329_T	332_A	0.507	0.67
176_G	247_L	0.506	0.67
213_T	243_T	0.506	0.67
177_T	248_S	0.504	0.66
258_N	261_N	0.502	0.66
176_G	220_T	0.502	0.66
329_T	333_M	0.502	0.66
50_Y	56_R	0.500	0.66
152_N	328_D	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4boyA	4	0.9941	100	0.201	Contact Map
3idsC	4	0.9882	100	0.214	Contact Map
2x5jO	4	0.9735	100	0.22	Contact Map
3docA	4	0.9882	100	0.221	Contact Map
1rm4O	4	0.9882	100	0.222	Contact Map
4lsmA	4	0.9735	100	0.223	Contact Map
2ep7A	4	0.9735	100	0.227	Contact Map
1obfO	4	0.9823	100	0.232	Contact Map
4o59O	4	0.9735	100	0.233	Contact Map
3cpsA	4	0.9764	100	0.235	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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