GREMLIN Database
G3P1 - Glyceraldehyde-3-phosphate dehydrogenase A
UniProt: P0A9B2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10367
Length: 331 (326)
Sequences: 5409 (2436)
Seq/√Len: 134.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_N221_E4.3271.00
77_E82_N3.6541.00
169_I248_E3.4651.00
160_K164_D3.2171.00
273_G289_C3.1401.00
136_F328_H2.8171.00
203_N282_T2.8101.00
107_R111_T2.7941.00
250_A304_N2.7401.00
79_D82_N2.7361.00
260_V293_F2.5841.00
56_G68_N2.5491.00
166_F259_A2.5301.00
179_T201_S2.4891.00
165_N262_A2.4431.00
4_K28_E2.4271.00
291_S310_S2.3901.00
105_T108_K2.3371.00
145_V329_I2.3211.00
290_T321_K2.2341.00
61_K71_K2.2231.00
231_F240_V2.2211.00
64_H71_K2.2111.00
102_T105_T2.1821.00
170_E246_R2.1391.00
237_N285_N2.1161.00
132_K136_F2.0791.00
256_I306_V2.0151.00
249_K255_Q2.0041.00
178_A235_T1.9661.00
22_Q54_F1.9571.00
46_K277_D1.9391.00
80_P100_F1.9291.00
61_K64_H1.9121.00
238_V284_F1.8951.00
51_H237_N1.8951.00
21_A29_I1.8821.00
40_Y194_W1.8751.00
258_A262_A1.8631.00
216_G223_N1.8601.00
28_E70_K1.8571.00
204_I231_F1.8481.00
159_A222_L1.8361.00
250_A303_D1.8171.00
10_F45_L1.8081.00
103_D107_R1.7861.00
84_K87_E1.7741.00
18_F29_I1.7721.00
116_K143_D1.7411.00
261_K276_E1.7361.00
81_A111_T1.7311.00
81_A108_K1.7311.00
227_T299_I1.7291.00
118_V326_I1.7101.00
274_Y295_A1.7071.00
247_L306_V1.6881.00
321_K324_D1.6681.00
273_G287_E1.6531.00
96_A120_T1.6501.00
18_F45_L1.6471.00
128_P138_K1.6381.00
20_A320_N1.6311.00
159_A168_I1.6201.00
94_A326_I1.5901.00
120_T322_V1.5901.00
18_F67_V1.5861.00
169_I304_N1.5741.00
278_D296_K1.5641.00
169_I246_R1.5641.00
101_L119_M1.5411.00
4_K89_G1.5381.00
257_K298_G1.5361.00
49_S202_Q1.5341.00
73_R87_E1.5111.00
102_T124_K1.5051.00
43_Y197_G1.4911.00
261_K265_E1.4761.00
107_R110_I1.4491.00
64_H73_R1.4371.00
166_F247_L1.4241.00
38_A74_V1.4181.00
49_S282_T1.4001.00
275_T284_F1.3971.00
103_D127_T1.3961.00
53_R287_E1.3861.00
287_E292_V1.3751.00
24_R327_A1.3701.00
158_L310_S1.3621.00
202_Q236_P1.3531.00
23_K55_D1.3481.00
43_Y194_W1.3341.00
275_T279_V1.3221.00
185_T200_A1.3191.00
217_K223_N1.3171.00
158_L291_S1.3111.00
170_E302_N1.3111.00
75_T88_V1.3091.00
181_A186_V1.3091.00
94_A322_V1.3051.00
252_T255_Q1.2951.00
96_A322_V1.2931.00
171_G226_L1.2901.00
162_I260_V1.2871.00
253_Y298_G1.2861.00
261_K274_Y1.2801.00
106_A119_M1.2791.00
196_G207_S1.2781.00
31_A75_T1.2771.00
289_C292_V1.2461.00
199_G202_Q1.2401.00
279_V284_F1.2331.00
246_R304_N1.2271.00
123_S126_N1.2201.00
161_V272_L1.2141.00
79_D108_K1.1991.00
163_N219_L1.1971.00
92_V326_I1.1951.00
83_L88_V1.1931.00
290_T324_D1.1890.99
276_E295_A1.1820.99
161_V259_A1.1800.99
54_F68_N1.1700.99
170_E304_N1.1680.99
193_D196_G1.1660.99
18_F72_I1.1660.99
38_A60_V1.1570.99
162_I308_L1.1540.99
181_A188_G1.1530.99
268_M272_L1.1450.99
165_N259_A1.1420.99
102_T125_D1.1400.99
282_T285_N1.1270.99
184_K188_G1.1220.99
17_V322_V1.1200.99
83_L112_A1.1140.99
158_L260_V1.1120.99
247_L251_A1.1080.99
167_G247_L1.1060.99
16_I51_H1.1030.99
17_V94_A1.1010.99
297_A309_V1.0900.99
17_V319_S1.0840.99
119_M123_S1.0800.99
316_T320_N1.0790.99
165_N169_I1.0730.99
288_V316_T1.0720.99
139_Y143_D1.0690.99
318_Y322_V1.0660.99
104_E125_D1.0620.99
23_K286_G1.0570.99
166_F251_A1.0560.99
61_K66_I1.0550.99
251_A300_A1.0540.99
66_I69_G1.0490.99
176_V231_F1.0460.99
6_G83_L1.0440.99
26_D327_A1.0380.99
47_Y277_D1.0370.99
251_A255_Q1.0360.99
45_L56_G1.0340.99
37_D40_Y1.0300.99
195_R294_D1.0270.99
158_L308_L1.0260.98
300_A306_V1.0230.98
240_V309_V1.0220.98
6_G90_V1.0190.98
139_Y145_V1.0180.98
103_D126_N1.0120.98
63_G73_R1.0110.98
229_M309_V1.0110.98
258_A261_K1.0090.98
138_K221_E1.0080.98
42_A58_V1.0080.98
92_V118_V1.0070.98
123_S129_M1.0030.98
275_T296_K1.0030.98
50_T236_P1.0000.98
41_M74_V0.9990.98
235_T238_V0.9950.98
116_K139_Y0.9940.98
182_T196_G0.9900.98
129_M217_K0.9900.98
66_I71_K0.9880.98
163_N248_E0.9870.98
162_I247_L0.9810.98
253_Y257_K0.9810.98
166_F256_I0.9700.98
155_L173_M0.9690.98
118_V145_V0.9650.98
254_E258_A0.9640.98
264_A267_E0.9620.98
231_F309_V0.9520.98
272_L291_S0.9420.97
288_V320_N0.9420.97
170_E305_F0.9420.97
300_A303_D0.9410.97
131_V148_A0.9400.97
182_T191_H0.9380.97
90_V93_V0.9320.97
161_V268_M0.9260.97
126_N217_K0.9230.97
259_A262_A0.9210.97
274_Y293_F0.9210.97
104_E107_R0.9200.97
50_T237_N0.9180.97
22_Q70_K0.9160.97
162_I245_V0.9100.97
191_H196_G0.9020.97
91_D115_K0.9010.97
286_G316_T0.9000.97
51_H286_G0.9000.97
3_I27_I0.8970.96
251_A256_I0.8910.96
273_G292_V0.8910.96
238_V285_N0.8910.96
154_C241_V0.8840.96
73_R88_V0.8840.96
75_T84_K0.8840.96
251_A259_A0.8810.96
130_F139_Y0.8790.96
132_K325_L0.8700.96
31_A90_V0.8680.96
21_A323_L0.8660.96
275_T295_A0.8650.96
41_M189_P0.8550.95
262_A267_E0.8540.95
51_H285_N0.8510.95
107_R144_I0.8490.95
6_G112_A0.8400.95
132_K328_H0.8390.95
119_M126_N0.8320.95
102_T108_K0.8290.95
181_A205_I0.8290.95
57_T68_N0.8240.94
50_T186_V0.8230.94
34_D189_P0.8220.94
46_K53_R0.8220.94
92_V329_I0.8200.94
257_K293_F0.8160.94
10_F32_I0.8150.94
118_V325_L0.8140.94
60_V66_I0.8080.94
30_V90_V0.8060.94
137_D267_E0.8050.94
132_K271_V0.8020.94
39_D60_V0.7980.93
199_G236_P0.7980.93
31_A88_V0.7910.93
50_T202_Q0.7860.93
262_A266_G0.7860.93
184_K197_G0.7850.93
27_I327_A0.7800.93
32_I65_L0.7760.92
179_T185_T0.7750.92
158_L293_F0.7730.92
36_L189_P0.7670.92
242_D307_K0.7640.92
43_Y47_Y0.7620.92
103_D144_I0.7600.92
172_L229_M0.7590.92
215_V219_L0.7580.91
45_L54_F0.7570.91
101_L105_T0.7570.91
102_T107_R0.7560.91
137_D328_H0.7560.91
99_L105_T0.7560.91
148_A318_Y0.7530.91
17_V323_L0.7490.91
247_L300_A0.7490.91
35_L189_P0.7470.91
84_K88_V0.7460.91
251_A306_V0.7400.90
78_R99_L0.7400.90
75_T83_L0.7380.90
265_E269_K0.7330.90
43_Y191_H0.7320.90
108_K112_A0.7300.90
204_I309_V0.7290.90
165_N263_A0.7270.90
36_L41_M0.7260.90
195_R297_A0.7250.90
108_K111_T0.7240.90
174_T244_T0.7230.89
173_M241_V0.7220.89
46_K57_T0.7210.89
194_W197_G0.7190.89
155_L159_A0.7190.89
31_A73_R0.7180.89
139_Y328_H0.7180.89
50_T199_G0.7170.89
44_M191_H0.7160.89
158_L241_V0.7140.89
229_M307_K0.7120.89
119_M127_T0.7120.89
166_F249_K0.7120.89
123_S127_T0.7110.89
293_F296_K0.7100.89
59_E66_I0.7100.89
42_A60_V0.7090.89
259_A263_A0.7060.88
255_Q258_A0.7050.88
35_L99_L0.7020.88
38_A42_A0.7000.88
184_K191_H0.6990.88
131_V134_A0.6920.87
49_S236_P0.6900.87
215_V226_L0.6900.87
130_F138_K0.6890.87
181_A184_K0.6880.87
266_G269_K0.6880.87
34_D99_L0.6880.87
35_L41_M0.6870.87
245_V306_V0.6870.87
167_G248_E0.6850.87
128_P140_A0.6840.87
261_K264_A0.6840.87
15_R19_R0.6820.87
273_G291_S0.6820.87
27_I92_V0.6810.86
86_D112_A0.6800.86
229_M299_I0.6780.86
245_V308_L0.6780.86
262_A265_E0.6780.86
60_V64_H0.6770.86
7_I18_F0.6770.86
179_T236_P0.6750.86
4_K91_D0.6730.86
35_L77_E0.6710.86
326_I329_I0.6690.85
62_D66_I0.6680.85
208_S213_K0.6670.85
103_D143_D0.6650.85
159_A226_L0.6640.85
128_P145_V0.6640.85
238_V241_V0.6630.85
77_E83_L0.6610.85
32_I74_V0.6600.85
20_A323_L0.6600.85
24_R320_N0.6590.85
302_N305_F0.6580.85
55_D68_N0.6580.85
75_T87_E0.6570.84
22_Q68_N0.6530.84
147_N319_S0.6510.84
58_V67_V0.6500.84
3_I26_D0.6500.84
35_L78_R0.6470.84
118_V329_I0.6470.84
119_M144_I0.6470.84
260_V272_L0.6440.83
96_A326_I0.6410.83
210_G239_S0.6410.83
174_T231_F0.6400.83
23_K56_G0.6400.83
201_S236_P0.6380.83
107_R143_D0.6330.82
247_L256_I0.6300.82
43_Y279_V0.6290.82
57_T69_G0.6280.82
35_L76_A0.6280.82
3_I92_V0.6250.81
244_T305_F0.6230.81
172_L301_L0.6220.81
93_V114_A0.6220.81
132_K147_N0.6190.81
45_L67_V0.6180.81
155_L241_V0.6170.81
39_D194_W0.6160.80
256_I260_V0.6150.80
104_E111_T0.6150.80
130_F325_L0.6150.80
162_I243_L0.6140.80
159_A219_L0.6110.80
260_V308_L0.6110.80
84_K112_A0.6100.80
238_V279_V0.6070.80
165_N249_K0.6060.79
106_A144_I0.6050.79
43_Y193_D0.6050.79
78_R81_A0.6050.79
46_K58_V0.6040.79
6_G31_A0.6010.79
63_G71_K0.5990.79
172_L227_T0.5990.79
176_V204_I0.5980.78
193_D207_S0.5960.78
159_A243_L0.5960.78
3_I6_G0.5950.78
85_W109_H0.5940.78
20_A24_R0.5920.78
35_L97_T0.5920.78
193_D197_G0.5910.78
235_T284_F0.5900.78
246_R305_F0.5900.78
65_L72_I0.5890.77
171_G245_V0.5890.77
202_Q285_N0.5880.77
35_L83_L0.5880.77
6_G88_V0.5870.77
103_D108_K0.5840.77
132_K324_D0.5830.77
88_V112_A0.5820.77
257_K295_A0.5820.77
101_L106_A0.5790.76
204_I235_T0.5780.76
91_D114_A0.5780.76
322_V326_I0.5760.76
110_I144_I0.5760.76
5_V326_I0.5750.76
6_G89_G0.5740.76
215_V227_T0.5730.76
139_Y329_I0.5730.76
204_I233_V0.5720.75
18_F22_Q0.5720.75
154_C310_S0.5710.75
161_V263_A0.5690.75
245_V260_V0.5690.75
148_A214_A0.5660.75
101_L124_K0.5650.75
110_I143_D0.5640.74
5_V27_I0.5620.74
261_K295_A0.5610.74
39_D62_D0.5590.74
194_W278_D0.5580.74
173_M243_L0.5570.73
30_V33_N0.5560.73
175_T239_S0.5560.73
166_F245_V0.5550.73
45_L58_V0.5540.73
24_R324_D0.5540.73
86_D114_A0.5530.73
260_V274_Y0.5530.73
182_T197_G0.5530.73
179_T202_Q0.5500.73
62_D65_L0.5500.73
174_T307_K0.5500.73
173_M228_G0.5490.72
179_T200_A0.5490.72
301_L305_F0.5480.72
38_A63_G0.5480.72
39_D43_Y0.5470.72
40_Y197_G0.5460.72
20_A316_T0.5460.72
174_T242_D0.5450.72
53_R277_D0.5420.71
83_L109_H0.5400.71
164_D219_L0.5390.71
165_N247_L0.5380.71
165_N267_E0.5370.71
32_I72_I0.5370.71
29_I33_N0.5360.71
133_G271_V0.5360.71
264_A273_G0.5350.70
21_A24_R0.5350.70
16_I316_T0.5350.70
91_D113_G0.5330.70
36_L40_Y0.5330.70
251_A304_N0.5330.70
40_Y189_P0.5330.70
277_D284_F0.5330.70
163_N222_L0.5280.69
191_H197_G0.5250.69
6_G85_W0.5250.69
159_A245_V0.5240.69
4_K30_V0.5220.69
171_G243_L0.5220.69
229_M297_A0.5220.69
109_H114_A0.5210.68
38_A64_H0.5210.68
17_V21_A0.5190.68
160_K267_E0.5160.68
147_N324_D0.5160.68
271_V290_T0.5150.68
6_G75_T0.5130.67
8_N33_N0.5120.67
171_G216_G0.5120.67
38_A61_K0.5120.67
254_E257_K0.5110.67
154_C291_S0.5100.67
80_P83_L0.5080.67
325_L328_H0.5080.67
136_F267_E0.5060.66
319_S324_D0.5050.66
318_Y325_L0.5050.66
47_Y53_R0.5050.66
31_A85_W0.5030.66
159_A163_N0.5020.66
166_F255_Q0.5020.66
103_D125_D0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4boyA 4 0.997 100 0.189 Contact Map
3idsC 4 1 100 0.199 Contact Map
4lsmA 4 0.997 100 0.202 Contact Map
3docA 4 0.997 100 0.203 Contact Map
1rm4O 4 0.994 100 0.207 Contact Map
2x5jO 4 0.9758 100 0.211 Contact Map
2ep7A 4 0.9909 100 0.214 Contact Map
3cpsA 4 0.9909 100 0.218 Contact Map
1obfO 4 0.9879 100 0.219 Contact Map
4o59O 4 0.9909 100 0.22 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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