GREMLIN Database
FUR - Ferric uptake regulation protein
UniProt: P0A9A9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10359
Length: 148 (133)
Sequences: 7247 (4786)
Seq/√Len: 415.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_L123_T3.9451.00
95_D132_H3.5531.00
98_K135_E3.0651.00
121_R137_D3.0641.00
26_L68_V2.7261.00
122_L129_L2.1861.00
25_V42_R2.1771.00
119_G134_A2.1401.00
94_L130_Y2.0301.00
5_N20_L1.9991.00
15_V20_L1.9901.00
63_D70_R1.9461.00
94_L132_H1.8741.00
70_R78_S1.8741.00
36_A59_L1.8341.00
96_C133_C1.8271.00
63_D68_V1.7761.00
41_K44_I1.7741.00
40_Y52_L1.7711.00
29_P42_R1.7701.00
29_P32_H1.7311.00
13_L65_A1.7211.00
60_N70_R1.6671.00
6_T10_K1.6651.00
22_I58_V1.6031.00
123_T132_H1.6021.00
89_D125_H1.5701.00
91_L100_I1.5621.00
113_E117_K1.5281.00
93_C96_C1.5091.00
96_C136_G1.5081.00
24_E28_E1.4421.00
40_Y44_I1.4081.00
100_I120_I1.3951.00
133_C136_G1.3721.00
91_L120_I1.3521.00
33_H90_H1.3411.00
93_C133_C1.3341.00
23_L62_F1.3331.00
42_R45_D1.3241.00
25_V39_L1.3171.00
77_K80_F1.3061.00
21_K24_E1.3051.00
33_H81_E1.3031.00
35_S38_D1.2751.00
7_A11_A1.2751.00
21_K46_M1.2631.00
120_I134_A1.2481.00
20_L24_E1.2421.00
25_V43_L1.2151.00
29_P34_V1.1951.00
87_H125_H1.1901.00
18_P54_T1.1651.00
109_A113_E1.1351.00
58_V61_Q1.1351.00
83_T86_H1.1341.00
121_R132_H1.0891.00
40_Y55_V1.0561.00
112_R116_A1.0511.00
34_V79_V1.0161.00
61_Q65_A1.0051.00
25_V29_P1.0041.00
92_I130_Y1.0041.00
91_L131_G0.9981.00
120_I131_G0.9971.00
25_V34_V0.9901.00
33_H88_H0.9881.00
134_A138_C0.9871.00
32_H42_R0.9751.00
34_V42_R0.9681.00
62_F67_I0.9591.00
19_R61_Q0.9541.00
88_H101_E0.9531.00
132_H137_D0.9511.00
25_V46_M0.9511.00
33_H101_E0.9431.00
7_A10_K0.9421.00
92_I128_Y0.9331.00
92_I97_G0.9301.00
100_I118_H0.9291.00
13_L61_Q0.9221.00
18_P50_I0.9201.00
104_D107_I0.9051.00
124_N130_Y0.9021.00
5_N9_K0.8991.00
106_S109_A0.8911.00
37_E41_K0.8821.00
104_D110_R0.8771.00
36_A55_V0.8701.00
41_K45_D0.8701.00
119_G137_D0.8681.00
34_V39_L0.8651.00
17_L21_K0.8631.00
93_C136_G0.8571.00
60_N63_D0.8531.00
89_D102_F0.8471.00
43_L50_I0.8381.00
23_L67_I0.8321.00
21_K47_G0.8301.00
97_G100_I0.8211.00
22_I39_L0.8191.00
26_L34_V0.8131.00
43_L47_G0.8121.00
91_L118_H0.8081.00
71_H101_E0.8051.00
89_D111_Q0.8031.00
105_D125_H0.8001.00
94_L124_N0.7991.00
33_H99_V0.7961.00
32_H38_D0.7911.00
24_E46_M0.7871.00
19_R58_V0.7851.00
89_D105_D0.7851.00
44_I52_L0.7851.00
111_Q125_H0.7761.00
28_E42_R0.7751.00
60_N64_D0.7711.00
115_A122_L0.7681.00
17_L20_L0.7561.00
79_V82_L0.7331.00
28_E46_M0.7321.00
36_A52_L0.7241.00
67_I82_L0.7181.00
38_D41_K0.7171.00
125_H129_L0.7161.00
37_E52_L0.7121.00
75_G79_V0.7111.00
9_K15_V0.7091.00
125_H130_Y0.7071.00
18_P51_G0.7061.00
54_T58_V0.7041.00
135_E138_C0.6911.00
107_I111_Q0.6911.00
18_P58_V0.6901.00
113_E116_A0.6831.00
59_L63_D0.6821.00
92_I99_V0.6680.99
90_H101_E0.6660.99
71_H128_Y0.6660.99
103_S106_S0.6650.99
107_I110_R0.6560.99
33_H51_G0.6520.99
33_H37_E0.6490.99
27_Q82_L0.6470.99
126_S130_Y0.6470.99
22_I25_V0.6430.99
40_Y50_I0.6430.99
8_L23_L0.6360.99
37_E40_Y0.6290.99
59_L68_V0.6240.99
89_D127_L0.6120.99
23_L27_Q0.6070.99
78_S82_L0.6050.99
38_D42_R0.6040.99
37_E77_K0.6020.99
69_T126_S0.6000.99
8_L61_Q0.5970.99
21_K43_L0.5940.99
39_L68_V0.5900.99
39_L55_V0.5840.99
16_T20_L0.5830.99
123_T131_G0.5830.99
105_D129_L0.5820.99
26_L39_L0.5810.99
132_H136_G0.5810.99
81_E84_Q0.5800.99
73_F126_S0.5790.99
69_T83_T0.5780.99
89_D129_L0.5780.99
111_Q114_I0.5760.98
16_T54_T0.5710.98
6_T9_K0.5690.98
109_A112_R0.5670.98
72_N76_G0.5580.98
26_L35_S0.5570.98
93_C120_I0.5540.98
5_N15_V0.5530.98
8_L13_L0.5530.98
15_V23_L0.5530.98
104_D109_A0.5480.98
35_S79_V0.5450.98
89_D107_I0.5420.98
134_A137_D0.5420.98
54_T57_R0.5390.98
87_H108_E0.5350.98
22_I62_F0.5310.97
100_I135_E0.5300.97
13_L19_R0.5300.97
26_L82_L0.5280.97
21_K25_V0.5280.97
21_K50_I0.5260.97
103_S117_K0.5260.97
87_H105_D0.5250.97
30_D83_T0.5200.97
25_V28_E0.5170.97
120_I137_D0.5160.97
39_L42_R0.5110.97
62_F68_V0.5030.96
16_T53_A0.5030.96
52_L57_R0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xigA 4 0.9459 100 0.128 Contact Map
2fe3A 2 0.9459 100 0.129 Contact Map
4mtdA 2 0.9527 100 0.139 Contact Map
4etsA 2 0.9527 100 0.141 Contact Map
3eyyA 2 0.8986 100 0.147 Contact Map
2w57A 2 0.8851 100 0.158 Contact Map
3mwmA 2 0.8514 100 0.164 Contact Map
2o03A 2 0.8716 100 0.19 Contact Map
1mzbA 4 0.8919 100 0.198 Contact Map
4lmyA 2 0.973 100 0.198 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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