FTSZ - ECOLI - GREMLIN Contacts

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FTSZ - Cell division protein FtsZ

UniProt:	P0A9A6	Sequences: MFEPMELTNDAVIKVIGVGGGGGNAVEHMVRERIEGVEFFAVNTDAQALRKTAVGQTIQIGSGITKGLGAGANPEVGRNAADEDRDALRAALEGADMVFIAAGMGGGTGTGAAPVVAEVAKDLGILTVAVVTKPFNFEGKKRMAFAEQGITELSKHVDSLITIPNDKLLKVLGRGISLLDAFGAANDVLKGAVQGIAELITRPGLMNVDFADVRTVMSEMGYAMMGSGVASGEDRAEEAAEMAISSPLLEDIDLSGARGVLVNITAGFDLRLDEFETVGNTIRAFASDNATVVIGTSLDPDMNDELRVTVVATGIGMDKRPEITLVTNKQVQQPVMDRYQQHGMAPLTQEQKPVAKVVNDNAPQTAKEPDYLDIPAFLRKQAD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10347
Length:	383 (326)
Sequences:	3233 (1395)
Seq/√Len:	77.2

ECOLI - FTSZ
BACSU - FTSZ
HALSA - FTSZ2 FTSZ1 Q9HNV2 Q9HSE9 Q9HHS0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
42_V	60_I	5.385	1.00
78_R	152_E	4.610	1.00
110_T	149_G	4.098	1.00
85_R	119_V	3.892	1.00
229_V	305_E	3.892	1.00
136_N	166_D	3.857	1.00
85_R	118_E	3.850	1.00
152_E	155_K	3.689	1.00
31_R	53_A	3.237	1.00
235_R	274_E	3.197	1.00
18_V	112_A	3.174	1.00
84_D	87_A	3.043	1.00
118_E	156_H	3.021	1.00
234_D	238_E	3.005	1.00
129_A	157_V	2.870	1.00
100_I	113_A	2.864	1.00
231_S	305_E	2.786	1.00
262_V	279_G	2.747	1.00
157_V	160_L	2.706	1.00
90_A	93_E	2.633	1.00
104_M	150_I	2.577	1.00
133_K	143_M	2.539	1.00
118_E	122_D	2.501	1.00
184_A	187_D	2.477	1.00
268_F	300_P	2.459	1.00
214_R	218_S	2.250	1.00
78_R	82_D	2.151	1.00
140_K	144_A	2.148	1.00
14_K	95_A	2.110	1.00
42_V	116_V	2.102	1.00
85_R	89_R	2.101	1.00
133_K	147_E	2.096	1.00
217_M	313_T	2.066	1.00
187_D	190_K	2.039	1.00
23_G	48_A	2.025	1.00
79_N	82_D	1.999	1.00
129_A	160_L	1.992	1.00
89_R	123_L	1.991	1.00
16_I	92_L	1.964	1.00
266_A	270_L	1.910	1.00
27_E	53_A	1.904	1.00
95_A	98_V	1.896	1.00
151_T	155_K	1.886	1.00
89_R	119_V	1.827	1.00
89_R	122_D	1.818	1.00
26_V	41_A	1.787	1.00
144_A	148_Q	1.743	1.00
229_V	307_R	1.725	1.00
237_E	277_T	1.718	1.00
92_L	123_L	1.703	1.00
58_I	91_A	1.699	1.00
237_E	241_E	1.694	1.00
190_K	194_Q	1.692	1.00
30_V	54_V	1.691	1.00
75_E	79_N	1.689	1.00
275_F	294_I	1.682	1.00
238_E	241_E	1.663	1.00
148_Q	152_E	1.657	1.00
46_A	50_R	1.655	1.00
280_N	284_A	1.644	1.00
40_F	56_Q	1.640	1.00
82_D	118_E	1.637	1.00
230_A	238_E	1.623	1.00
159_S	217_M	1.598	1.00
28_H	186_N	1.584	1.00
244_I	310_V	1.564	0.99
40_F	54_V	1.558	0.99
86_D	89_R	1.544	0.99
269_D	303_N	1.540	0.99
240_A	282_I	1.538	0.99
129_A	153_L	1.535	0.99
133_K	250_E	1.531	0.99
92_L	98_V	1.524	0.99
276_E	280_N	1.524	0.99
199_L	208_V	1.518	0.99
87_A	90_A	1.515	0.99
177_S	180_D	1.510	0.99
216_V	259_G	1.498	0.99
175_G	273_D	1.492	0.99
42_V	88_L	1.482	0.99
269_D	304_D	1.467	0.99
206_M	294_I	1.467	0.99
172_L	184_A	1.461	0.99
204_G	297_S	1.461	0.99
27_E	52_T	1.454	0.99
81_A	112_A	1.443	0.99
18_V	116_V	1.387	0.99
102_A	131_V	1.373	0.99
119_V	123_L	1.372	0.99
98_V	125_I	1.370	0.99
260_V	286_A	1.365	0.98
66_K	96_D	1.361	0.98
259_G	290_A	1.357	0.98
205_L	296_T	1.348	0.98
41_A	49_L	1.329	0.98
241_E	245_S	1.308	0.98
236_A	240_A	1.305	0.98
270_L	306_L	1.300	0.98
167_K	170_K	1.287	0.98
176_I	181_A	1.281	0.98
72_A	215_T	1.266	0.98
72_A	293_V	1.259	0.97
179_L	298_L	1.230	0.97
224_M	252_I	1.225	0.97
172_L	176_I	1.212	0.97
147_E	151_T	1.201	0.97
179_L	268_F	1.191	0.96
255_S	285_F	1.184	0.96
14_K	38_E	1.162	0.96
278_V	306_L	1.153	0.96
34_I	190_K	1.148	0.96
180_D	183_G	1.145	0.96
141_K	291_T	1.124	0.95
17_G	22_G	1.123	0.95
19_G	22_G	1.121	0.95
30_V	39_F	1.118	0.95
69_G	107_G	1.117	0.95
62_S	87_A	1.117	0.95
265_T	297_S	1.114	0.95
88_L	119_V	1.113	0.95
152_E	156_H	1.113	0.95
192_A	225_M	1.111	0.95
130_V	193_V	1.109	0.95
75_E	78_R	1.108	0.95
150_I	162_T	1.108	0.95
263_N	297_S	1.094	0.94
18_V	100_I	1.093	0.94
302_M	307_R	1.093	0.94
259_G	287_S	1.083	0.94
40_F	91_A	1.083	0.94
235_R	271_R	1.082	0.94
204_G	263_N	1.077	0.94
169_L	276_E	1.071	0.94
70_A	76_V	1.070	0.94
270_L	275_F	1.067	0.93
38_E	56_Q	1.067	0.93
258_R	287_S	1.066	0.93
159_S	220_M	1.063	0.93
16_I	42_V	1.063	0.93
58_I	88_L	1.060	0.93
95_A	125_I	1.055	0.93
175_G	271_R	1.051	0.93
73_N	215_T	1.036	0.92
178_L	296_T	1.032	0.92
176_I	273_D	1.027	0.92
194_Q	198_E	1.021	0.92
226_G	243_A	1.021	0.92
139_G	292_V	1.016	0.92
23_G	41_A	1.013	0.92
239_A	308_V	1.012	0.92
25_A	29_M	1.003	0.91
236_A	306_L	0.997	0.91
97_M	128_V	0.993	0.91
238_E	242_M	0.993	0.91
148_Q	151_T	0.982	0.90
11_A	96_D	0.979	0.90
60_I	112_A	0.978	0.90
35_E	202_R	0.973	0.90
41_A	52_T	0.972	0.90
281_T	285_F	0.970	0.90
216_V	293_V	0.964	0.89
286_A	290_A	0.961	0.89
27_E	51_K	0.957	0.89
29_M	39_F	0.947	0.89
98_V	116_V	0.945	0.88
20_G	24_N	0.941	0.88
325_L	328_N	0.940	0.88
64_I	79_N	0.933	0.88
32_E	190_K	0.930	0.88
115_V	119_V	0.922	0.87
327_T	330_Q	0.920	0.87
141_K	145_F	0.919	0.87
28_H	192_A	0.918	0.87
51_K	280_N	0.918	0.87
41_A	54_V	0.912	0.87
31_R	183_G	0.905	0.86
168_L	272_L	0.905	0.86
299_D	307_R	0.905	0.86
265_T	302_M	0.904	0.86
173_G	273_D	0.903	0.86
89_R	93_E	0.903	0.86
326_V	329_K	0.902	0.86
168_L	185_A	0.898	0.86
325_L	329_K	0.893	0.85
324_T	328_N	0.892	0.85
166_D	169_L	0.892	0.85
133_K	150_I	0.884	0.85
237_E	281_T	0.882	0.85
329_K	332_Q	0.881	0.85
102_A	113_A	0.880	0.85
178_L	182_F	0.880	0.85
183_G	186_N	0.879	0.85
86_D	90_A	0.878	0.84
228_G	239_A	0.877	0.84
81_A	88_L	0.874	0.84
96_D	169_L	0.873	0.84
325_L	332_Q	0.872	0.84
281_T	284_A	0.871	0.84
100_I	116_V	0.870	0.84
330_Q	351_Q	0.868	0.84
220_M	227_S	0.866	0.84
327_T	331_V	0.866	0.84
143_M	147_E	0.857	0.83
52_T	57_T	0.854	0.83
88_L	92_L	0.854	0.83
321_P	324_T	0.848	0.82
59_Q	62_S	0.847	0.82
326_V	331_V	0.847	0.82
81_A	115_V	0.836	0.81
38_E	95_A	0.836	0.81
280_N	283_R	0.835	0.81
91_A	95_A	0.831	0.81
151_T	154_S	0.826	0.81
324_T	327_T	0.825	0.81
177_S	271_R	0.824	0.81
73_N	79_N	0.823	0.80
259_G	291_T	0.823	0.80
279_G	294_I	0.821	0.80
234_D	277_T	0.812	0.80
166_D	170_K	0.809	0.79
41_A	57_T	0.807	0.79
62_S	84_D	0.807	0.79
154_S	222_Y	0.807	0.79
92_L	95_A	0.806	0.79
326_V	352_K	0.805	0.79
328_N	351_Q	0.804	0.79
246_S	315_I	0.804	0.79
266_A	275_F	0.798	0.78
321_P	332_Q	0.797	0.78
331_V	352_K	0.796	0.78
167_K	246_S	0.796	0.78
323_I	329_K	0.790	0.78
325_L	330_Q	0.787	0.77
104_M	131_V	0.787	0.77
133_K	164_P	0.785	0.77
324_T	329_K	0.782	0.77
71_G	107_G	0.782	0.77
11_A	208_V	0.782	0.77
43_N	70_A	0.780	0.77
56_Q	91_A	0.779	0.77
8_T	53_A	0.771	0.76
222_Y	262_V	0.767	0.76
97_M	217_M	0.767	0.76
174_R	233_E	0.764	0.75
205_L	275_F	0.764	0.75
266_A	306_L	0.762	0.75
326_V	330_Q	0.759	0.75
11_A	211_A	0.756	0.75
14_K	40_F	0.754	0.74
41_A	53_A	0.751	0.74
97_M	277_T	0.751	0.74
25_A	39_F	0.751	0.74
322_E	326_V	0.750	0.74
278_V	308_V	0.748	0.74
101_A	175_G	0.746	0.74
21_G	132_T	0.745	0.73
136_N	280_N	0.742	0.73
93_E	123_L	0.742	0.73
205_L	298_L	0.741	0.73
259_G	314_G	0.739	0.73
241_E	281_T	0.737	0.73
220_M	259_G	0.735	0.72
125_I	224_M	0.727	0.72
173_G	184_A	0.724	0.71
121_K	219_E	0.719	0.71
322_E	325_L	0.716	0.70
194_Q	227_S	0.715	0.70
155_K	328_N	0.713	0.70
311_V	315_I	0.713	0.70
133_K	311_V	0.710	0.70
186_N	279_G	0.707	0.70
28_H	42_V	0.705	0.69
228_G	243_A	0.704	0.69
51_K	203_P	0.701	0.69
43_N	107_G	0.698	0.69
115_V	118_E	0.698	0.69
215_T	293_V	0.696	0.68
94_G	125_I	0.694	0.68
119_V	122_D	0.693	0.68
144_A	147_E	0.693	0.68
32_E	183_G	0.690	0.68
30_V	55_G	0.685	0.67
260_V	312_A	0.684	0.67
268_F	298_L	0.684	0.67
320_R	323_I	0.682	0.67
324_T	332_Q	0.676	0.66
306_L	318_D	0.674	0.66
122_D	215_T	0.674	0.66
198_E	201_T	0.673	0.66
15_V	168_L	0.672	0.66
25_A	189_L	0.670	0.65
322_E	327_T	0.669	0.65
326_V	332_Q	0.668	0.65
319_K	322_E	0.666	0.65
64_I	76_V	0.666	0.65
34_I	201_T	0.664	0.65
137_F	294_I	0.663	0.65
164_P	188_V	0.662	0.64
101_A	189_L	0.661	0.64
287_S	290_A	0.658	0.64
27_E	30_V	0.657	0.64
195_G	208_V	0.657	0.64
262_V	308_V	0.656	0.64
46_A	224_M	0.654	0.64
76_V	327_T	0.653	0.63
174_R	273_D	0.653	0.63
77_G	107_G	0.652	0.63
15_V	39_F	0.650	0.63
100_I	117_A	0.650	0.63
76_V	79_N	0.647	0.63
323_I	332_Q	0.646	0.63
168_L	186_N	0.636	0.61
21_G	315_I	0.633	0.61
154_S	316_G	0.633	0.61
322_E	351_Q	0.632	0.61
323_I	328_N	0.630	0.61
265_T	313_T	0.629	0.61
282_I	285_F	0.629	0.61
225_M	259_G	0.624	0.60
43_N	71_G	0.623	0.60
325_L	331_V	0.622	0.60
145_F	148_Q	0.621	0.60
47_Q	68_L	0.621	0.60
322_E	352_K	0.620	0.59
174_R	277_T	0.620	0.59
266_A	298_L	0.619	0.59
332_Q	352_K	0.618	0.59
331_V	351_Q	0.618	0.59
30_V	52_T	0.617	0.59
100_I	129_A	0.617	0.59
195_G	225_M	0.615	0.59
34_I	104_M	0.612	0.58
137_F	182_F	0.611	0.58
321_P	328_N	0.611	0.58
42_V	91_A	0.610	0.58
99_F	223_A	0.610	0.58
321_P	329_K	0.606	0.58
16_I	125_I	0.606	0.58
324_T	352_K	0.605	0.58
323_I	326_V	0.605	0.58
276_E	283_R	0.604	0.57
79_N	83_E	0.603	0.57
27_E	54_V	0.603	0.57
33_R	308_V	0.603	0.57
320_R	326_V	0.603	0.57
202_R	297_S	0.602	0.57
219_E	258_R	0.602	0.57
43_N	47_Q	0.601	0.57
32_E	187_D	0.599	0.57
329_K	352_K	0.599	0.57
299_D	302_M	0.599	0.57
286_A	292_V	0.596	0.56
328_N	331_V	0.596	0.56
195_G	290_A	0.596	0.56
69_G	77_G	0.595	0.56
318_D	321_P	0.595	0.56
318_D	330_Q	0.594	0.56
47_Q	207_N	0.594	0.56
172_L	272_L	0.591	0.56
255_S	288_D	0.590	0.56
73_N	76_V	0.590	0.56
318_D	326_V	0.590	0.56
217_M	259_G	0.590	0.56
235_R	270_L	0.588	0.55
192_A	227_S	0.586	0.55
195_G	309_T	0.585	0.55
270_L	294_I	0.584	0.55
72_A	291_T	0.580	0.54
239_A	243_A	0.578	0.54
172_L	177_S	0.578	0.54
194_Q	299_D	0.577	0.54
72_A	145_F	0.576	0.54
231_S	304_D	0.576	0.54
26_V	48_A	0.575	0.54
267_G	271_R	0.575	0.54
332_Q	351_Q	0.575	0.54
142_R	293_V	0.574	0.54
200_I	213_V	0.572	0.53
34_I	194_Q	0.572	0.53
16_I	116_V	0.571	0.53
130_V	189_L	0.571	0.53
169_L	273_D	0.570	0.53
82_D	85_R	0.569	0.53
173_G	227_S	0.568	0.53
8_T	50_R	0.568	0.53
54_V	115_V	0.568	0.53
166_D	276_E	0.568	0.53
258_R	314_G	0.567	0.53
186_N	275_F	0.567	0.53
266_A	273_D	0.566	0.53
326_V	351_Q	0.566	0.53
31_R	324_T	0.566	0.53
43_N	69_G	0.566	0.53
258_R	316_G	0.565	0.53
320_R	329_K	0.564	0.52
86_D	91_A	0.563	0.52
39_F	186_N	0.563	0.52
121_K	158_D	0.562	0.52
253_D	260_V	0.562	0.52
113_A	116_V	0.560	0.52
253_D	285_F	0.559	0.52
164_P	204_G	0.558	0.52
28_H	32_E	0.558	0.52
226_G	239_A	0.556	0.51
199_L	311_V	0.556	0.51
232_G	235_R	0.555	0.51
131_V	162_T	0.552	0.51
72_A	80_A	0.552	0.51
196_I	213_V	0.551	0.51
216_V	290_A	0.550	0.51
36_G	122_D	0.550	0.51
97_M	161_I	0.549	0.50
85_R	122_D	0.547	0.50
144_A	289_N	0.545	0.50
12_V	94_G	0.545	0.50
199_L	233_E	0.545	0.50
12_V	198_E	0.545	0.50
37_V	97_M	0.545	0.50
39_F	104_M	0.543	0.50
327_T	352_K	0.542	0.50
11_A	68_L	0.542	0.50
230_A	308_V	0.542	0.50
60_I	84_D	0.542	0.50
322_E	329_K	0.542	0.50
205_L	264_I	0.542	0.50
50_R	57_T	0.541	0.49
162_T	199_L	0.540	0.49
321_P	326_V	0.540	0.49
84_D	297_S	0.540	0.49
141_K	144_A	0.540	0.49
328_N	352_K	0.540	0.49
222_Y	316_G	0.539	0.49
25_A	101_A	0.538	0.49
60_I	179_L	0.537	0.49
140_K	288_D	0.536	0.49
43_N	67_G	0.536	0.49
202_R	311_V	0.536	0.49
34_I	198_E	0.535	0.49
69_G	109_G	0.534	0.49
11_A	272_L	0.534	0.49
126_L	210_F	0.533	0.48
187_D	191_G	0.533	0.48
235_R	269_D	0.532	0.48
177_S	190_K	0.531	0.48
128_V	313_T	0.531	0.48
321_P	325_L	0.531	0.48
178_L	294_I	0.530	0.48
290_A	307_R	0.530	0.48
26_V	29_M	0.530	0.48
186_N	294_I	0.529	0.48
139_G	226_G	0.529	0.48
9_N	66_K	0.528	0.48
242_M	245_S	0.527	0.48
252_I	262_V	0.522	0.47
24_N	71_G	0.522	0.47
229_V	323_I	0.521	0.47
24_N	110_T	0.520	0.47
129_A	150_I	0.519	0.47
179_L	199_L	0.519	0.47
9_N	46_A	0.519	0.47
241_E	261_L	0.518	0.47
203_P	297_S	0.517	0.46
23_G	43_N	0.517	0.46
42_V	92_L	0.516	0.46
217_M	265_T	0.516	0.46
323_I	327_T	0.515	0.46
245_S	326_V	0.514	0.46
215_T	291_T	0.513	0.46
18_V	113_A	0.512	0.46
272_L	296_T	0.511	0.46
97_M	210_F	0.510	0.46
40_F	261_L	0.510	0.46
202_R	296_T	0.509	0.45
230_A	236_A	0.509	0.45
104_M	149_G	0.508	0.45
234_D	237_E	0.507	0.45
100_I	178_L	0.506	0.45
143_M	166_D	0.505	0.45
29_M	192_A	0.505	0.45
67_G	107_G	0.505	0.45
25_A	312_A	0.505	0.45
329_K	351_Q	0.504	0.45
145_F	166_D	0.504	0.45
320_R	325_L	0.503	0.45
159_S	173_G	0.502	0.45
48_A	72_A	0.501	0.44
320_R	324_T	0.501	0.44
96_D	211_A	0.501	0.44
317_M	351_Q	0.500	0.44

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vawA	1	0.8198	100	0.224	Contact Map
4m8iA	1	0.812	100	0.236	Contact Map
2vxyA	2	0.799	100	0.245	Contact Map
1rq2A	2	0.7859	100	0.246	Contact Map
2r751	1	0.8433	100	0.277	Contact Map
1w5fA	2	0.8146	100	0.288	Contact Map
1ofuA	1	0.8016	100	0.29	Contact Map
2vapA	1	0.8538	100	0.295	Contact Map
4ei7A	1	0.8747	100	0.322	Contact Map
4b45A	1	0.8172	100	0.365	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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