GREMLIN Database
FTSZ - Cell division protein FtsZ
UniProt: P0A9A6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10347
Length: 383 (326)
Sequences: 3233 (1395)
Seq/√Len: 77.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_V60_I5.3851.00
78_R152_E4.6101.00
110_T149_G4.0981.00
85_R119_V3.8921.00
229_V305_E3.8921.00
136_N166_D3.8571.00
85_R118_E3.8501.00
152_E155_K3.6891.00
31_R53_A3.2371.00
235_R274_E3.1971.00
18_V112_A3.1741.00
84_D87_A3.0431.00
118_E156_H3.0211.00
234_D238_E3.0051.00
129_A157_V2.8701.00
100_I113_A2.8641.00
231_S305_E2.7861.00
262_V279_G2.7471.00
157_V160_L2.7061.00
90_A93_E2.6331.00
104_M150_I2.5771.00
133_K143_M2.5391.00
118_E122_D2.5011.00
184_A187_D2.4771.00
268_F300_P2.4591.00
214_R218_S2.2501.00
78_R82_D2.1511.00
140_K144_A2.1481.00
14_K95_A2.1101.00
42_V116_V2.1021.00
85_R89_R2.1011.00
133_K147_E2.0961.00
217_M313_T2.0661.00
187_D190_K2.0391.00
23_G48_A2.0251.00
79_N82_D1.9991.00
129_A160_L1.9921.00
89_R123_L1.9911.00
16_I92_L1.9641.00
266_A270_L1.9101.00
27_E53_A1.9041.00
95_A98_V1.8961.00
151_T155_K1.8861.00
89_R119_V1.8271.00
89_R122_D1.8181.00
26_V41_A1.7871.00
144_A148_Q1.7431.00
229_V307_R1.7251.00
237_E277_T1.7181.00
92_L123_L1.7031.00
58_I91_A1.6991.00
237_E241_E1.6941.00
190_K194_Q1.6921.00
30_V54_V1.6911.00
75_E79_N1.6891.00
275_F294_I1.6821.00
238_E241_E1.6631.00
148_Q152_E1.6571.00
46_A50_R1.6551.00
280_N284_A1.6441.00
40_F56_Q1.6401.00
82_D118_E1.6371.00
230_A238_E1.6231.00
159_S217_M1.5981.00
28_H186_N1.5841.00
244_I310_V1.5640.99
40_F54_V1.5580.99
86_D89_R1.5440.99
269_D303_N1.5400.99
240_A282_I1.5380.99
129_A153_L1.5350.99
133_K250_E1.5310.99
92_L98_V1.5240.99
276_E280_N1.5240.99
199_L208_V1.5180.99
87_A90_A1.5150.99
177_S180_D1.5100.99
216_V259_G1.4980.99
175_G273_D1.4920.99
42_V88_L1.4820.99
269_D304_D1.4670.99
206_M294_I1.4670.99
172_L184_A1.4610.99
204_G297_S1.4610.99
27_E52_T1.4540.99
81_A112_A1.4430.99
18_V116_V1.3870.99
102_A131_V1.3730.99
119_V123_L1.3720.99
98_V125_I1.3700.99
260_V286_A1.3650.98
66_K96_D1.3610.98
259_G290_A1.3570.98
205_L296_T1.3480.98
41_A49_L1.3290.98
241_E245_S1.3080.98
236_A240_A1.3050.98
270_L306_L1.3000.98
167_K170_K1.2870.98
176_I181_A1.2810.98
72_A215_T1.2660.98
72_A293_V1.2590.97
179_L298_L1.2300.97
224_M252_I1.2250.97
172_L176_I1.2120.97
147_E151_T1.2010.97
179_L268_F1.1910.96
255_S285_F1.1840.96
14_K38_E1.1620.96
278_V306_L1.1530.96
34_I190_K1.1480.96
180_D183_G1.1450.96
141_K291_T1.1240.95
17_G22_G1.1230.95
19_G22_G1.1210.95
30_V39_F1.1180.95
69_G107_G1.1170.95
62_S87_A1.1170.95
265_T297_S1.1140.95
88_L119_V1.1130.95
152_E156_H1.1130.95
192_A225_M1.1110.95
130_V193_V1.1090.95
75_E78_R1.1080.95
150_I162_T1.1080.95
263_N297_S1.0940.94
18_V100_I1.0930.94
302_M307_R1.0930.94
259_G287_S1.0830.94
40_F91_A1.0830.94
235_R271_R1.0820.94
204_G263_N1.0770.94
169_L276_E1.0710.94
70_A76_V1.0700.94
270_L275_F1.0670.93
38_E56_Q1.0670.93
258_R287_S1.0660.93
159_S220_M1.0630.93
16_I42_V1.0630.93
58_I88_L1.0600.93
95_A125_I1.0550.93
175_G271_R1.0510.93
73_N215_T1.0360.92
178_L296_T1.0320.92
176_I273_D1.0270.92
194_Q198_E1.0210.92
226_G243_A1.0210.92
139_G292_V1.0160.92
23_G41_A1.0130.92
239_A308_V1.0120.92
25_A29_M1.0030.91
236_A306_L0.9970.91
97_M128_V0.9930.91
238_E242_M0.9930.91
148_Q151_T0.9820.90
11_A96_D0.9790.90
60_I112_A0.9780.90
35_E202_R0.9730.90
41_A52_T0.9720.90
281_T285_F0.9700.90
216_V293_V0.9640.89
286_A290_A0.9610.89
27_E51_K0.9570.89
29_M39_F0.9470.89
98_V116_V0.9450.88
20_G24_N0.9410.88
325_L328_N0.9400.88
64_I79_N0.9330.88
32_E190_K0.9300.88
115_V119_V0.9220.87
327_T330_Q0.9200.87
141_K145_F0.9190.87
28_H192_A0.9180.87
51_K280_N0.9180.87
41_A54_V0.9120.87
31_R183_G0.9050.86
168_L272_L0.9050.86
299_D307_R0.9050.86
265_T302_M0.9040.86
173_G273_D0.9030.86
89_R93_E0.9030.86
326_V329_K0.9020.86
168_L185_A0.8980.86
325_L329_K0.8930.85
324_T328_N0.8920.85
166_D169_L0.8920.85
133_K150_I0.8840.85
237_E281_T0.8820.85
329_K332_Q0.8810.85
102_A113_A0.8800.85
178_L182_F0.8800.85
183_G186_N0.8790.85
86_D90_A0.8780.84
228_G239_A0.8770.84
81_A88_L0.8740.84
96_D169_L0.8730.84
325_L332_Q0.8720.84
281_T284_A0.8710.84
100_I116_V0.8700.84
330_Q351_Q0.8680.84
220_M227_S0.8660.84
327_T331_V0.8660.84
143_M147_E0.8570.83
52_T57_T0.8540.83
88_L92_L0.8540.83
321_P324_T0.8480.82
59_Q62_S0.8470.82
326_V331_V0.8470.82
81_A115_V0.8360.81
38_E95_A0.8360.81
280_N283_R0.8350.81
91_A95_A0.8310.81
151_T154_S0.8260.81
324_T327_T0.8250.81
177_S271_R0.8240.81
73_N79_N0.8230.80
259_G291_T0.8230.80
279_G294_I0.8210.80
234_D277_T0.8120.80
166_D170_K0.8090.79
41_A57_T0.8070.79
62_S84_D0.8070.79
154_S222_Y0.8070.79
92_L95_A0.8060.79
326_V352_K0.8050.79
328_N351_Q0.8040.79
246_S315_I0.8040.79
266_A275_F0.7980.78
321_P332_Q0.7970.78
331_V352_K0.7960.78
167_K246_S0.7960.78
323_I329_K0.7900.78
325_L330_Q0.7870.77
104_M131_V0.7870.77
133_K164_P0.7850.77
324_T329_K0.7820.77
71_G107_G0.7820.77
11_A208_V0.7820.77
43_N70_A0.7800.77
56_Q91_A0.7790.77
8_T53_A0.7710.76
222_Y262_V0.7670.76
97_M217_M0.7670.76
174_R233_E0.7640.75
205_L275_F0.7640.75
266_A306_L0.7620.75
326_V330_Q0.7590.75
11_A211_A0.7560.75
14_K40_F0.7540.74
41_A53_A0.7510.74
97_M277_T0.7510.74
25_A39_F0.7510.74
322_E326_V0.7500.74
278_V308_V0.7480.74
101_A175_G0.7460.74
21_G132_T0.7450.73
136_N280_N0.7420.73
93_E123_L0.7420.73
205_L298_L0.7410.73
259_G314_G0.7390.73
241_E281_T0.7370.73
220_M259_G0.7350.72
125_I224_M0.7270.72
173_G184_A0.7240.71
121_K219_E0.7190.71
322_E325_L0.7160.70
194_Q227_S0.7150.70
155_K328_N0.7130.70
311_V315_I0.7130.70
133_K311_V0.7100.70
186_N279_G0.7070.70
28_H42_V0.7050.69
228_G243_A0.7040.69
51_K203_P0.7010.69
43_N107_G0.6980.69
115_V118_E0.6980.69
215_T293_V0.6960.68
94_G125_I0.6940.68
119_V122_D0.6930.68
144_A147_E0.6930.68
32_E183_G0.6900.68
30_V55_G0.6850.67
260_V312_A0.6840.67
268_F298_L0.6840.67
320_R323_I0.6820.67
324_T332_Q0.6760.66
306_L318_D0.6740.66
122_D215_T0.6740.66
198_E201_T0.6730.66
15_V168_L0.6720.66
25_A189_L0.6700.65
322_E327_T0.6690.65
326_V332_Q0.6680.65
319_K322_E0.6660.65
64_I76_V0.6660.65
34_I201_T0.6640.65
137_F294_I0.6630.65
164_P188_V0.6620.64
101_A189_L0.6610.64
287_S290_A0.6580.64
27_E30_V0.6570.64
195_G208_V0.6570.64
262_V308_V0.6560.64
46_A224_M0.6540.64
76_V327_T0.6530.63
174_R273_D0.6530.63
77_G107_G0.6520.63
15_V39_F0.6500.63
100_I117_A0.6500.63
76_V79_N0.6470.63
323_I332_Q0.6460.63
168_L186_N0.6360.61
21_G315_I0.6330.61
154_S316_G0.6330.61
322_E351_Q0.6320.61
323_I328_N0.6300.61
265_T313_T0.6290.61
282_I285_F0.6290.61
225_M259_G0.6240.60
43_N71_G0.6230.60
325_L331_V0.6220.60
145_F148_Q0.6210.60
47_Q68_L0.6210.60
322_E352_K0.6200.59
174_R277_T0.6200.59
266_A298_L0.6190.59
332_Q352_K0.6180.59
331_V351_Q0.6180.59
30_V52_T0.6170.59
100_I129_A0.6170.59
195_G225_M0.6150.59
34_I104_M0.6120.58
137_F182_F0.6110.58
321_P328_N0.6110.58
42_V91_A0.6100.58
99_F223_A0.6100.58
321_P329_K0.6060.58
16_I125_I0.6060.58
324_T352_K0.6050.58
323_I326_V0.6050.58
276_E283_R0.6040.57
79_N83_E0.6030.57
27_E54_V0.6030.57
33_R308_V0.6030.57
320_R326_V0.6030.57
202_R297_S0.6020.57
219_E258_R0.6020.57
43_N47_Q0.6010.57
32_E187_D0.5990.57
329_K352_K0.5990.57
299_D302_M0.5990.57
286_A292_V0.5960.56
328_N331_V0.5960.56
195_G290_A0.5960.56
69_G77_G0.5950.56
318_D321_P0.5950.56
318_D330_Q0.5940.56
47_Q207_N0.5940.56
172_L272_L0.5910.56
255_S288_D0.5900.56
73_N76_V0.5900.56
318_D326_V0.5900.56
217_M259_G0.5900.56
235_R270_L0.5880.55
192_A227_S0.5860.55
195_G309_T0.5850.55
270_L294_I0.5840.55
72_A291_T0.5800.54
239_A243_A0.5780.54
172_L177_S0.5780.54
194_Q299_D0.5770.54
72_A145_F0.5760.54
231_S304_D0.5760.54
26_V48_A0.5750.54
267_G271_R0.5750.54
332_Q351_Q0.5750.54
142_R293_V0.5740.54
200_I213_V0.5720.53
34_I194_Q0.5720.53
16_I116_V0.5710.53
130_V189_L0.5710.53
169_L273_D0.5700.53
82_D85_R0.5690.53
173_G227_S0.5680.53
8_T50_R0.5680.53
54_V115_V0.5680.53
166_D276_E0.5680.53
258_R314_G0.5670.53
186_N275_F0.5670.53
266_A273_D0.5660.53
326_V351_Q0.5660.53
31_R324_T0.5660.53
43_N69_G0.5660.53
258_R316_G0.5650.53
320_R329_K0.5640.52
86_D91_A0.5630.52
39_F186_N0.5630.52
121_K158_D0.5620.52
253_D260_V0.5620.52
113_A116_V0.5600.52
253_D285_F0.5590.52
164_P204_G0.5580.52
28_H32_E0.5580.52
226_G239_A0.5560.51
199_L311_V0.5560.51
232_G235_R0.5550.51
131_V162_T0.5520.51
72_A80_A0.5520.51
196_I213_V0.5510.51
216_V290_A0.5500.51
36_G122_D0.5500.51
97_M161_I0.5490.50
85_R122_D0.5470.50
144_A289_N0.5450.50
12_V94_G0.5450.50
199_L233_E0.5450.50
12_V198_E0.5450.50
37_V97_M0.5450.50
39_F104_M0.5430.50
327_T352_K0.5420.50
11_A68_L0.5420.50
230_A308_V0.5420.50
60_I84_D0.5420.50
322_E329_K0.5420.50
205_L264_I0.5420.50
50_R57_T0.5410.49
162_T199_L0.5400.49
321_P326_V0.5400.49
84_D297_S0.5400.49
141_K144_A0.5400.49
328_N352_K0.5400.49
222_Y316_G0.5390.49
25_A101_A0.5380.49
60_I179_L0.5370.49
140_K288_D0.5360.49
43_N67_G0.5360.49
202_R311_V0.5360.49
34_I198_E0.5350.49
69_G109_G0.5340.49
11_A272_L0.5340.49
126_L210_F0.5330.48
187_D191_G0.5330.48
235_R269_D0.5320.48
177_S190_K0.5310.48
128_V313_T0.5310.48
321_P325_L0.5310.48
178_L294_I0.5300.48
290_A307_R0.5300.48
26_V29_M0.5300.48
186_N294_I0.5290.48
139_G226_G0.5290.48
9_N66_K0.5280.48
242_M245_S0.5270.48
252_I262_V0.5220.47
24_N71_G0.5220.47
229_V323_I0.5210.47
24_N110_T0.5200.47
129_A150_I0.5190.47
179_L199_L0.5190.47
9_N46_A0.5190.47
241_E261_L0.5180.47
203_P297_S0.5170.46
23_G43_N0.5170.46
42_V92_L0.5160.46
217_M265_T0.5160.46
323_I327_T0.5150.46
245_S326_V0.5140.46
215_T291_T0.5130.46
18_V113_A0.5120.46
272_L296_T0.5110.46
97_M210_F0.5100.46
40_F261_L0.5100.46
202_R296_T0.5090.45
230_A236_A0.5090.45
104_M149_G0.5080.45
234_D237_E0.5070.45
100_I178_L0.5060.45
143_M166_D0.5050.45
29_M192_A0.5050.45
67_G107_G0.5050.45
25_A312_A0.5050.45
329_K351_Q0.5040.45
145_F166_D0.5040.45
320_R325_L0.5030.45
159_S173_G0.5020.45
48_A72_A0.5010.44
320_R324_T0.5010.44
96_D211_A0.5010.44
317_M351_Q0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vawA 1 0.8198 100 0.224 Contact Map
4m8iA 1 0.812 100 0.236 Contact Map
2vxyA 2 0.799 100 0.245 Contact Map
1rq2A 2 0.7859 100 0.246 Contact Map
2r751 1 0.8433 100 0.277 Contact Map
1w5fA 2 0.8146 100 0.288 Contact Map
1ofuA 1 0.8016 100 0.29 Contact Map
2vapA 1 0.8538 100 0.295 Contact Map
4ei7A 1 0.8747 100 0.322 Contact Map
4b45A 1 0.8172 100 0.365 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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