GREMLIN Database
GLPC - Anaerobic glycerol-3-phosphate dehydrogenase subunit C
UniProt: P0A996 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10393
Length: 396 (377)
Sequences: 4891 (3298)
Seq/√Len: 169.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
184_K392_A4.6481.00
292_K321_E4.4451.00
385_E393_Q4.3801.00
162_Q192_G4.3791.00
181_D389_T3.9881.00
270_A388_I3.9161.00
268_E276_R3.4811.00
292_K323_T3.2041.00
275_W312_E3.1301.00
182_L240_T3.0071.00
148_W180_K2.8811.00
191_T273_W2.5491.00
201_C244_C2.4961.00
366_V390_L2.4621.00
311_L324_V2.4571.00
291_L364_L2.4091.00
177_Q389_T2.3741.00
161_D191_T2.3691.00
125_L128_A2.3621.00
104_V107_P2.2691.00
239_A245_T2.2661.00
249_R272_R2.2641.00
211_F214_K2.2341.00
162_Q194_Q2.2201.00
293_V390_L2.1981.00
326_D359_E2.1601.00
343_Y347_Q2.1331.00
71_K74_D2.1071.00
202_C244_C2.0941.00
171_V179_G2.0681.00
321_E324_V2.0331.00
109_A112_V2.0041.00
350_G354_F2.0001.00
364_L385_E1.9891.00
178_L389_T1.9631.00
216_R220_I1.9341.00
311_L315_R1.9301.00
123_Q126_D1.9231.00
263_L267_I1.8781.00
219_A252_Y1.8541.00
24_V348_A1.8321.00
33_Q36_P1.8301.00
238_I273_W1.8251.00
103_S107_P1.8221.00
293_V364_L1.8041.00
354_F379_S1.7901.00
220_I224_E1.7801.00
191_T277_K1.7681.00
347_Q379_S1.7401.00
122_R126_D1.7251.00
28_Y33_Q1.6861.00
185_V388_I1.6671.00
182_L270_A1.6321.00
162_Q235_I1.6291.00
169_C201_C1.6141.00
200_K221_T1.6071.00
253_P264_R1.5891.00
291_L363_D1.5881.00
92_N96_S1.5871.00
312_E315_R1.5841.00
351_A358_E1.5781.00
163_V193_V1.5651.00
143_G148_W1.5301.00
125_L129_L1.5301.00
297_T311_L1.5211.00
41_L44_K1.5181.00
169_C244_C1.5051.00
91_R95_L1.4921.00
183_I193_V1.4881.00
115_A118_L1.4881.00
74_D254_E1.4871.00
90_L93_F1.4841.00
354_F358_E1.4731.00
165_F240_T1.4691.00
85_T213_D1.4561.00
293_V320_L1.4531.00
50_D54_K1.4381.00
188_A392_A1.4271.00
268_E272_R1.4261.00
94_V97_H1.4251.00
149_Y183_I1.4171.00
206_L214_K1.3941.00
110_P113_N1.3921.00
30_G55_Y1.3911.00
111_I115_A1.3881.00
37_D41_L1.3741.00
357_I376_I1.3711.00
350_G379_S1.3681.00
164_A229_A1.3621.00
169_C202_C1.3591.00
204_V243_T1.3461.00
164_A235_I1.3451.00
112_V115_A1.3351.00
109_A116_T1.3341.00
183_I187_N1.3261.00
273_W277_K1.3261.00
182_L186_L1.3211.00
126_D129_L1.3161.00
123_Q127_A1.3151.00
227_R262_G1.2981.00
163_V273_W1.2971.00
50_D83_Y1.2961.00
122_R125_L1.2851.00
117_S120_P1.2811.00
344_P348_A1.2771.00
31_P34_A1.2731.00
293_V366_V1.2701.00
33_Q37_D1.2691.00
298_P367_T1.2691.00
63_E71_K1.2681.00
101_M105_S1.2681.00
16_T31_P1.2571.00
241_S369_C1.2521.00
308_L312_E1.2521.00
181_D392_A1.2341.00
368_D387_P1.2311.00
274_L313_L1.2301.00
276_R309_Y1.2301.00
357_I365_V1.2261.00
22_S26_P1.2251.00
294_V360_S1.2201.00
206_L218_Q1.2181.00
272_R309_Y1.2171.00
236_P268_E1.2151.00
24_V345_T1.2071.00
308_L311_L1.2061.00
167_H179_G1.2051.00
207_I215_A1.2031.00
220_I259_D1.2021.00
262_G265_D1.2001.00
207_I247_A1.2001.00
175_H178_L1.1921.00
268_E273_W1.1901.00
99_D102_G1.1891.00
182_L388_I1.1861.00
93_F96_S1.1861.00
31_P36_P1.1801.00
290_P321_E1.1631.00
262_G266_H1.1591.00
197_S228_E1.1591.00
236_P273_W1.1531.00
111_I114_T1.1501.00
291_L393_Q1.1441.00
117_S139_K1.1361.00
343_Y378_M1.1361.00
207_I212_T1.1331.00
373_K384_C1.1301.00
145_F179_G1.1291.00
37_D40_R1.1271.00
145_F183_I1.1251.00
385_E390_L1.1221.00
89_S92_N1.1211.00
351_A355_R1.1201.00
274_L391_L1.1131.00
283_T286_L1.1131.00
239_A248_L1.1081.00
229_A234_G1.1061.00
138_P141_S1.1051.00
81_A212_T1.1041.00
385_E389_T1.1031.00
32_K36_P1.1001.00
105_S109_A1.1001.00
196_L199_E1.0951.00
31_P35_G1.0941.00
36_P42_R1.0941.00
292_K363_D1.0941.00
161_D277_K1.0941.00
185_V391_L1.0891.00
21_V35_G1.0851.00
355_R359_E1.0811.00
111_I117_S1.0661.00
347_Q351_A1.0661.00
127_A130_K1.0651.00
81_A85_T1.0621.00
294_V325_L1.0601.00
95_L98_T1.0560.99
108_F112_V1.0550.99
164_A234_G1.0550.99
183_I195_L1.0510.99
99_D103_S1.0420.99
99_D105_S1.0410.99
36_P72_I1.0400.99
118_L121_V1.0380.99
109_A113_N1.0360.99
383_R393_Q1.0340.99
185_V392_A1.0290.99
346_S375_Q1.0290.99
302_E307_T1.0280.99
322_L325_L1.0280.99
358_E380_T1.0240.99
102_G105_S1.0210.99
103_S106_T1.0190.99
32_K35_G1.0120.99
204_V208_A1.0110.99
18_A65_A1.0110.99
222_N252_Y1.0070.99
335_T339_K1.0040.99
256_L259_D0.9980.99
126_D130_K0.9980.99
90_L94_V0.9980.99
184_K187_N0.9970.99
187_N193_V0.9920.99
159_Y192_G0.9910.99
278_L316_N0.9890.99
13_T33_Q0.9810.99
158_Q161_D0.9800.99
325_L357_I0.9780.99
40_R44_K0.9700.99
34_A37_D0.9620.99
160_K192_G0.9620.99
113_N116_T0.9620.99
114_T118_L0.9620.99
102_G140_Y0.9610.99
332_I337_G0.9590.99
23_R352_P0.9590.99
229_A235_I0.9520.99
317_I320_L0.9490.99
35_G40_R0.9430.99
63_E73_G0.9430.99
163_V186_L0.9410.99
295_Y310_T0.9410.99
319_G324_V0.9410.99
224_E227_R0.9410.99
218_Q221_T0.9410.99
186_L270_A0.9400.99
39_E42_R0.9390.99
275_W313_L0.9380.99
102_G107_P0.9370.99
175_H370_E0.9370.99
180_K184_K0.9360.99
218_Q222_N0.9340.99
272_R306_W0.9330.99
120_P123_Q0.9240.99
175_H389_T0.9150.99
119_K122_R0.9150.99
155_Q187_N0.9150.99
97_H100_L0.9130.99
141_S176_P0.9070.98
208_A243_T0.9060.98
243_T369_C0.9050.98
270_A274_L0.9030.98
274_L278_L0.9020.98
309_Y312_E0.9000.98
158_Q192_G0.9000.98
137_L141_S0.8980.98
27_G30_G0.8980.98
79_A83_Y0.8960.98
102_G106_T0.8900.98
363_D382_L0.8880.98
88_P95_L0.8880.98
167_H195_L0.8870.98
34_A38_G0.8860.98
16_T28_Y0.8850.98
314_L366_V0.8850.98
184_K188_A0.8850.98
30_G52_A0.8850.98
112_V116_T0.8830.98
92_N95_L0.8830.98
144_T147_R0.8810.98
321_E325_L0.8800.98
60_K63_E0.8770.98
365_V376_I0.8770.98
330_C372_C0.8770.98
57_I349_I0.8700.98
106_T116_T0.8650.98
168_G241_S0.8620.98
223_V227_R0.8590.98
326_D356_Q0.8530.98
319_G325_L0.8520.98
91_R94_V0.8510.98
314_L320_L0.8500.98
162_Q233_K0.8490.98
237_V263_L0.8490.98
390_L393_Q0.8460.98
352_P356_Q0.8440.98
351_A354_F0.8440.98
350_G375_Q0.8410.97
89_S93_F0.8410.97
295_Y322_L0.8370.97
289_L320_L0.8360.97
50_D87_R0.8360.97
245_T267_I0.8360.97
105_S108_F0.8350.97
102_G108_F0.8280.97
206_L211_F0.8230.97
165_F193_V0.8230.97
47_A50_D0.8220.97
94_V98_T0.8190.97
124_L127_A0.8190.97
146_R172_N0.8180.97
297_T324_V0.8180.97
178_L181_D0.8160.97
93_F97_H0.8140.97
297_T307_T0.8130.97
55_Y345_T0.8120.97
229_A233_K0.8100.97
108_F115_A0.8090.97
214_K217_K0.8040.97
336_Y342_N0.8020.97
77_Q207_I0.8000.97
83_Y87_R0.7990.97
156_Q159_Y0.7970.96
339_K342_N0.7940.96
219_A255_V0.7900.96
78_R82_K0.7890.96
298_P369_C0.7850.96
289_L292_K0.7840.96
219_A256_L0.7840.96
30_G33_Q0.7810.96
110_P116_T0.7760.96
312_E316_N0.7750.96
24_V349_I0.7730.96
242_S298_P0.7730.96
63_E303_K0.7720.96
245_T304_M0.7660.96
121_V125_L0.7620.95
36_P41_L0.7570.95
224_E259_D0.7560.95
104_V108_F0.7550.95
143_G151_S0.7540.95
25_N345_T0.7530.95
286_L289_L0.7510.95
9_C15_C0.7510.95
106_T109_A0.7500.95
290_P319_G0.7500.95
116_T119_K0.7460.95
97_H101_M0.7460.95
295_Y307_T0.7460.95
214_K218_Q0.7450.95
323_T360_S0.7420.95
123_Q129_L0.7410.95
141_S144_T0.7410.95
367_T373_K0.7410.95
15_C19_C0.7410.95
107_P111_I0.7400.95
125_L137_L0.7400.95
249_R304_M0.7390.95
16_T22_S0.7380.95
116_T120_P0.7340.94
123_Q128_A0.7280.94
175_H374_W0.7270.94
28_Y70_V0.7270.94
109_A114_T0.7260.94
297_T310_T0.7220.94
275_W316_N0.7220.94
167_H196_L0.7210.94
110_P142_F0.7210.94
221_T225_S0.7210.94
383_R389_T0.7180.94
32_K37_D0.7130.94
215_A247_A0.7120.94
271_T387_P0.7120.94
110_P119_K0.7090.93
34_A57_I0.7090.93
58_N76_I0.7080.93
165_F182_L0.7080.93
272_R276_R0.7060.93
164_A196_L0.7060.93
297_T302_E0.7060.93
122_R130_K0.7030.93
354_F380_T0.7020.93
149_Y180_K0.7000.93
144_T172_N0.7000.93
109_A115_A0.6980.93
105_S112_V0.6960.93
28_Y31_P0.6950.93
88_P211_F0.6930.93
60_K73_G0.6930.93
82_K85_T0.6920.93
389_T392_A0.6910.92
322_L387_P0.6900.92
376_I380_T0.6890.92
107_P112_V0.6890.92
81_A213_D0.6890.92
49_Y53_L0.6890.92
355_R358_E0.6880.92
88_P91_R0.6860.92
47_A51_E0.6860.92
166_F222_N0.6850.92
42_R82_K0.6840.92
266_H276_R0.6830.92
60_K71_K0.6830.92
294_V365_V0.6830.92
163_V191_T0.6810.92
145_F176_P0.6810.92
306_W310_T0.6790.92
245_T269_L0.6790.92
167_H199_E0.6780.92
82_K86_T0.6780.92
354_F376_I0.6770.92
332_I375_Q0.6770.92
306_W309_Y0.6750.92
5_S8_N0.6740.92
161_D236_P0.6730.91
125_L130_K0.6730.91
135_R138_P0.6710.91
61_R65_A0.6670.91
21_V369_C0.6650.91
222_N248_L0.6650.91
154_A192_G0.6620.91
112_V117_S0.6610.91
113_N118_L0.6590.91
53_L76_I0.6590.91
279_D312_E0.6580.91
176_P180_K0.6560.90
110_P114_T0.6550.90
358_E381_S0.6520.90
29_P33_Q0.6490.90
32_K39_E0.6480.90
77_Q212_T0.6480.90
134_R343_Y0.6470.90
161_D235_I0.6450.90
154_A159_Y0.6450.90
200_K225_S0.6450.90
35_G42_R0.6430.90
9_C19_C0.6420.89
171_V240_T0.6390.89
276_R280_E0.6380.89
28_Y34_A0.6370.89
136_T139_K0.6370.89
88_P92_N0.6360.89
119_K128_A0.6350.89
279_D286_L0.6340.89
347_Q378_M0.6320.89
120_P124_L0.6310.89
361_G382_L0.6310.89
159_Y187_N0.6300.89
136_T140_Y0.6300.89
289_L394_A0.6300.89
145_F149_Y0.6270.88
12_C15_C0.6260.88
356_Q360_S0.6260.88
364_L393_Q0.6260.88
88_P93_F0.6250.88
325_L360_S0.6240.88
239_A267_I0.6230.88
284_L287_K0.6220.88
376_I379_S0.6220.88
134_R344_P0.6210.88
28_Y35_G0.6210.88
35_G369_C0.6200.88
288_P320_L0.6190.88
28_Y32_K0.6180.88
185_V313_L0.6180.88
277_K280_E0.6170.88
46_G49_Y0.6150.87
72_I76_I0.6140.87
294_V357_I0.6130.87
377_E383_R0.6120.87
119_K125_L0.6100.87
10_I16_T0.6090.87
139_K142_F0.6070.87
114_T117_S0.6070.87
180_K183_I0.6060.87
241_S367_T0.6060.87
366_V387_P0.6060.87
295_Y311_L0.6050.87
189_M317_I0.6040.86
34_A42_R0.6030.86
238_I388_I0.6020.86
118_L122_R0.5980.86
286_L316_N0.5970.86
23_R328_Q0.5960.86
33_Q42_R0.5960.86
148_W151_S0.5950.86
241_S370_E0.5950.86
18_A328_Q0.5950.86
194_Q229_A0.5940.86
356_Q359_E0.5930.85
99_D106_T0.5930.85
115_A121_V0.5900.85
17_T65_A0.5900.85
364_L390_L0.5890.85
29_P36_P0.5890.85
269_L368_D0.5880.85
9_C12_C0.5880.85
91_R339_K0.5880.85
12_C19_C0.5850.85
22_S28_Y0.5850.85
28_Y37_D0.5850.85
186_L191_T0.5840.85
275_W309_Y0.5830.84
217_K220_I0.5830.84
188_A394_A0.5830.84
187_N192_G0.5820.84
216_R257_N0.5790.84
16_T65_A0.5790.84
53_L79_A0.5780.84
308_L315_R0.5770.84
136_T141_S0.5730.83
21_V57_I0.5720.83
113_N117_S0.5700.83
323_T362_A0.5690.83
327_S353_L0.5680.83
144_T148_W0.5660.83
22_S27_G0.5660.83
178_L373_K0.5650.83
315_R321_E0.5640.82
166_F248_L0.5620.82
226_I237_V0.5620.82
99_D104_V0.5620.82
275_W279_D0.5610.82
134_R138_P0.5590.82
175_H373_K0.5580.82
45_D86_T0.5580.82
30_G35_G0.5580.82
34_A40_R0.5570.82
35_G39_E0.5560.82
72_I75_I0.5550.81
246_F251_E0.5540.81
119_K123_Q0.5500.81
222_N225_S0.5490.81
213_D217_K0.5490.81
17_T37_D0.5480.81
63_E74_D0.5460.80
162_Q193_V0.5450.80
223_V256_L0.5450.80
101_M104_V0.5440.80
284_L288_P0.5440.80
34_A39_E0.5440.80
237_V267_I0.5430.80
126_D131_I0.5420.80
303_K369_C0.5400.80
311_L322_L0.5400.80
30_G36_P0.5400.80
10_I68_S0.5390.80
121_V127_A0.5380.79
298_P337_G0.5380.79
143_G180_K0.5370.79
25_N30_G0.5370.79
17_T73_G0.5360.79
34_A41_L0.5330.79
136_T378_M0.5320.79
54_K333_A0.5310.79
243_T300_H0.5280.78
23_R348_A0.5280.78
143_G147_R0.5280.78
252_Y255_V0.5270.78
194_Q235_I0.5240.78
62_C66_C0.5230.78
328_Q352_P0.5230.78
299_C329_C0.5220.77
36_P39_E0.5180.77
13_T28_Y0.5180.77
91_R98_T0.5170.77
148_W183_I0.5150.76
186_L193_V0.5140.76
290_P320_L0.5140.76
350_G380_T0.5130.76
88_P96_S0.5130.76
201_C205_P0.5110.76
99_D113_N0.5110.76
157_A160_K0.5110.76
209_N339_K0.5080.76
56_C62_C0.5070.75
56_C66_C0.5070.75
313_L391_L0.5070.75
58_N298_P0.5050.75
110_P118_L0.5040.75
103_S108_F0.5040.75
164_A226_I0.5020.75
100_L103_S0.5010.75
109_A120_P0.5010.75
221_T224_E0.5010.75
101_M107_P0.5000.74
90_L96_S0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.8106 100 0.476 Contact Map
3cf4A 2 0.8056 100 0.579 Contact Map
3c8yA 1 0.7803 99.7 0.815 Contact Map
2wdqB 1 0.2222 99.4 0.853 Contact Map
2h88B 1 0.2197 99.4 0.855 Contact Map
4ysxB 1 0.25 99.3 0.859 Contact Map
1kf6B 1 0.2374 99.3 0.861 Contact Map
2bs2B 1 0.2172 99.3 0.864 Contact Map
4p6vA 1 0.1692 99 0.878 Contact Map
1hfeL 2 0.7323 98.5 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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