GREMLIN Database
F16PA - Fructose-1,6-bisphosphatase class 1
UniProt: P0A993 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10283
Length: 332 (315)
Sequences: 1736 (940)
Seq/√Len: 53.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_N299_D4.7611.00
199_K317_H4.5821.00
151_N296_R4.3781.00
291_S323_E4.2481.00
158_Y248_H3.7431.00
289_K320_E3.5681.00
280_A290_A3.4171.00
243_L311_F3.2491.00
289_K316_D3.2101.00
33_A159_V3.2001.00
129_S153_Q3.1691.00
196_F283_A2.9901.00
148_Q152_K2.8651.00
177_A191_Q2.8531.00
174_G285_Q2.7291.00
292_D295_E2.7251.00
70_N91_E2.7131.00
289_K323_E2.6771.00
247_F313_V2.6571.00
36_I73_L2.6191.00
122_V240_I2.6031.00
57_V60_E2.5451.00
74_K91_E2.4911.00
77_L107_V2.4441.00
83_V107_V2.3931.00
170_T281_F2.3791.00
256_I322_V2.3321.00
128_F157_G2.3181.00
243_L247_F2.2861.00
73_L126_T2.2331.00
247_F283_A2.2231.00
33_A187_F2.1961.00
87_A305_L2.1631.00
7_F176_H2.1611.00
210_Y222_K2.1431.00
218_K222_K2.0951.00
198_E317_H2.0931.00
279_M313_V1.9671.00
284_E296_R1.9571.00
179_T190_C1.9461.00
276_C311_F1.9441.00
231_T235_Y1.9100.99
312_F319_V1.8920.99
122_V242_S1.8680.99
223_F325_F1.8660.99
177_A194_M1.8550.99
316_D320_E1.8340.99
213_F221_I1.7720.99
177_A192_E1.7720.99
216_G326_I1.7550.99
170_T282_L1.7520.99
11_K14_E1.7450.99
223_F321_D1.7440.99
319_V322_V1.7090.99
172_G285_Q1.6870.99
215_N219_K1.6840.99
62_Q67_L1.6580.99
91_E95_V1.6300.98
292_D300_I1.6230.98
312_F322_V1.6210.98
195_R198_E1.6030.98
276_C309_R1.5870.98
204_S241_G1.5590.98
56_N59_G1.5160.97
210_Y218_K1.5150.97
120_V242_S1.5130.97
303_E307_Q1.5130.97
297_I300_I1.4900.97
272_L277_N1.4730.97
74_K95_V1.4730.97
51_A61_V1.4450.96
300_I307_Q1.4420.96
89_E115_S1.4270.96
290_A296_R1.4210.96
281_F298_L1.4040.96
201_K233_R1.3870.95
198_E316_D1.3650.95
207_E225_Q1.3650.95
170_T285_Q1.3640.95
292_D312_F1.3620.95
93_E143_E1.3620.95
203_Y225_Q1.3600.95
85_G106_V1.3460.95
272_L307_Q1.3450.95
320_E324_R1.3440.95
53_G61_V1.3280.94
85_G146_F1.3200.94
108_L129_S1.3190.94
296_R299_D1.3120.94
37_H165_T1.3000.94
247_F311_F1.2880.93
191_Q252_L1.2800.93
219_K325_F1.2540.92
70_N74_K1.2500.92
261_S265_H1.2380.92
12_Q23_T1.2330.92
276_C297_I1.2230.91
41_N182_P1.2220.91
59_G62_Q1.2160.91
292_D297_I1.2140.91
56_N62_Q1.2010.91
203_Y207_E1.1950.90
166_M177_A1.1930.90
51_A63_Q1.1900.90
200_G315_N1.1900.90
90_E271_R1.1890.90
123_S242_S1.1890.90
25_L105_Y1.1780.90
85_G94_I1.1660.89
215_N218_K1.1530.89
202_T253_K1.1490.88
277_N302_P1.1460.88
73_L109_M1.1400.88
209_N262_T1.1330.88
86_I109_M1.1320.88
208_G234_P1.1250.87
220_Y224_C1.1130.87
205_I258_L1.1120.87
149_P301_I1.1040.86
134_V152_K1.1000.86
66_D90_E1.1000.86
29_I77_L1.0960.86
149_P152_K1.0940.86
50_G64_K1.0830.85
258_L322_V1.0740.85
66_D115_S1.0600.84
131_Y277_N1.0450.83
20_G23_T1.0400.83
212_K263_A1.0370.83
321_D324_R1.0360.83
29_I33_A1.0310.82
258_L312_F1.0290.82
170_T174_G1.0280.82
283_A288_G1.0170.81
71_E75_A1.0150.81
246_D269_K1.0060.81
171_T176_H0.9980.80
120_V253_K0.9960.80
10_E13_H0.9910.80
196_F315_N0.9890.80
142_T145_D0.9870.79
209_N264_S0.9870.79
28_A80_R0.9870.79
271_R275_E0.9870.79
259_Y268_G0.9850.79
115_S271_R0.9830.79
123_S160_V0.9820.79
205_I221_I0.9800.79
52_S61_V0.9770.79
212_K264_S0.9740.79
208_G236_T0.9700.78
279_M311_F0.9650.78
29_I159_V0.9650.78
172_G281_F0.9610.78
293_G312_F0.9600.78
168_V177_A0.9590.77
66_D89_E0.9560.77
156_A281_F0.9510.77
56_N90_E0.9420.76
213_F262_T0.9420.76
56_N66_D0.9400.76
21_E104_K0.9370.76
291_S295_E0.9320.75
295_E299_D0.9310.75
196_F288_G0.9260.75
5_G27_S0.9260.75
150_G302_P0.9250.75
243_L313_V0.9240.75
12_Q20_G0.9210.75
42_K183_S0.9140.74
166_M191_Q0.9130.74
55_E61_V0.9130.74
141_V145_D0.9060.73
37_H180_Y0.9050.73
151_N298_L0.9010.73
241_G246_D0.8990.73
153_Q277_N0.8910.72
214_P326_I0.8870.72
34_K185_G0.8840.72
36_I69_A0.8840.72
168_V282_L0.8830.71
70_N109_M0.8830.71
283_A313_V0.8790.71
27_S31_L0.8780.71
235_Y318_M0.8760.71
90_E115_S0.8760.71
32_G72_K0.8750.71
268_G310_S0.8720.70
194_M252_L0.8720.70
86_I97_F0.8720.70
173_C285_Q0.8720.70
12_Q18_A0.8650.70
62_Q90_E0.8650.70
217_V326_I0.8620.70
89_E271_R0.8610.69
60_E308_R0.8600.69
168_V194_M0.8570.69
251_L283_A0.8560.69
105_Y154_V0.8550.69
206_N249_R0.8540.69
83_V97_F0.8510.69
77_L83_V0.8480.68
293_G310_S0.8470.68
242_S245_A0.8460.68
87_A108_L0.8390.67
210_Y225_Q0.8380.67
110_D115_S0.8370.67
280_A297_I0.8350.67
16_S20_G0.8220.66
56_N89_E0.8210.66
40_I124_V0.8210.66
297_I311_F0.8200.66
21_E82_I0.8170.65
211_I234_P0.8090.65
116_S127_I0.8060.64
322_V326_I0.8020.64
219_K223_F0.7910.63
53_G56_N0.7900.63
150_G298_L0.7900.63
317_H320_E0.7870.62
118_I124_V0.7870.62
174_G178_F0.7840.62
170_T298_L0.7800.62
89_E110_D0.7780.62
66_D110_D0.7740.61
135_T145_D0.7680.61
52_S67_L0.7660.60
199_K318_M0.7620.60
272_L297_I0.7610.60
212_K234_P0.7600.60
207_E237_S0.7580.60
321_D325_F0.7580.60
36_I109_M0.7570.59
104_K132_R0.7560.59
324_R327_R0.7550.59
64_K119_D0.7540.59
25_L83_V0.7540.59
62_Q271_R0.7520.59
141_V146_F0.7510.59
6_E10_E0.7510.59
197_P254_G0.7510.59
214_P261_S0.7460.58
50_G119_D0.7450.58
261_S310_S0.7430.58
30_K167_L0.7420.58
224_C322_V0.7410.58
159_V190_C0.7400.58
122_V160_V0.7390.58
7_F178_F0.7380.58
191_Q194_M0.7370.57
250_N253_K0.7360.57
66_D271_R0.7360.57
38_R182_P0.7330.57
206_N274_Y0.7320.57
202_T239_Y0.7300.57
59_G90_E0.7270.56
56_N60_E0.7270.56
318_M321_D0.7260.56
273_L277_N0.7220.56
243_L283_A0.7200.56
176_H193_R0.7190.56
7_F10_E0.7180.55
38_R183_S0.7160.55
108_L146_F0.7120.55
7_F13_H0.7120.55
126_T161_Y0.7110.55
231_T234_P0.7110.55
108_L305_L0.7110.55
217_V312_F0.7070.54
45_L188_C0.7010.54
56_N271_R0.6910.53
267_D304_T0.6900.53
292_D323_E0.6880.52
240_I250_N0.6870.52
56_N115_S0.6820.52
108_L273_L0.6820.52
63_Q253_K0.6810.52
177_A190_C0.6810.52
247_F279_M0.6800.51
256_I312_F0.6800.51
84_A133_R0.6790.51
292_D309_R0.6760.51
23_T30_K0.6750.51
78_K97_F0.6730.51
58_Q308_R0.6730.51
300_I309_R0.6710.51
312_F323_E0.6690.50
90_E275_E0.6670.50
19_T23_T0.6660.50
94_I146_F0.6640.50
236_T239_Y0.6630.50
35_I75_A0.6630.50
243_L257_Y0.6620.50
31_L186_V0.6620.50
239_Y253_K0.6610.49
277_N307_Q0.6580.49
77_L95_V0.6560.49
98_E102_H0.6560.49
8_I23_T0.6550.49
96_V103_A0.6540.49
247_F269_K0.6530.49
59_G271_R0.6510.48
28_A79_A0.6510.48
62_Q66_D0.6500.48
51_A283_A0.6490.48
151_N284_E0.6490.48
272_L276_C0.6490.48
109_M118_I0.6480.48
87_A146_F0.6470.48
12_Q16_S0.6460.48
200_G235_Y0.6440.48
76_A97_F0.6420.47
136_P145_D0.6410.47
22_L105_Y0.6370.47
200_G239_Y0.6370.47
207_E239_Y0.6370.47
30_K76_A0.6330.47
60_E271_R0.6320.46
217_V258_L0.6310.46
62_Q115_S0.6290.46
220_Y322_V0.6280.46
205_I245_A0.6270.46
56_N257_Y0.6270.46
203_Y237_S0.6270.46
94_I305_L0.6260.46
124_V217_V0.6250.46
143_E304_T0.6230.45
19_T22_L0.6220.45
72_K76_A0.6210.45
102_H140_P0.6200.45
254_G260_P0.6190.45
8_I18_A0.6190.45
59_G89_E0.6180.45
240_I245_A0.6160.45
30_K151_N0.6140.45
106_V134_V0.6140.45
88_S110_D0.6140.45
117_N306_H0.6130.44
209_N224_C0.6120.44
220_Y325_F0.6110.44
199_K321_D0.6100.44
277_N297_I0.6100.44
74_K78_K0.6090.44
223_F235_Y0.6070.44
31_L184_L0.6070.44
117_N206_N0.6070.44
126_T284_E0.6060.44
214_P294_K0.6050.44
44_G310_S0.6050.44
295_E312_F0.6030.43
97_F102_H0.6020.43
25_L34_K0.6010.43
130_I214_P0.5990.43
90_E111_P0.5990.43
59_G66_D0.5980.43
126_T157_G0.5970.43
165_T180_Y0.5960.43
62_Q318_M0.5950.43
291_S319_V0.5940.42
281_F285_Q0.5920.42
312_F326_I0.5910.42
208_G312_F0.5900.42
160_V245_A0.5890.42
200_G252_L0.5860.42
155_A169_Y0.5850.42
102_H141_V0.5840.41
73_L87_A0.5840.41
89_E116_S0.5830.41
110_D271_R0.5830.41
88_S115_S0.5810.41
29_I126_T0.5810.41
241_G326_I0.5790.41
272_L300_I0.5790.41
292_D310_S0.5740.40
121_N129_S0.5730.40
12_Q19_T0.5710.40
63_Q118_I0.5700.40
85_G141_V0.5690.40
6_E80_R0.5690.40
94_I143_E0.5660.40
246_D326_I0.5660.40
219_K222_K0.5660.40
29_I73_L0.5650.39
38_R184_L0.5630.39
178_F272_L0.5600.39
173_C281_F0.5600.39
223_F322_V0.5590.39
206_N306_H0.5550.38
5_G30_K0.5550.38
112_L121_N0.5550.38
90_E259_Y0.5540.38
115_S274_Y0.5530.38
257_Y269_K0.5520.38
151_N295_E0.5510.38
42_K181_D0.5500.38
176_H189_L0.5500.38
35_I39_D0.5500.38
40_I123_S0.5490.38
323_E327_R0.5490.38
142_T320_E0.5490.38
57_V92_D0.5480.38
259_Y306_H0.5470.38
85_G108_L0.5470.38
76_A82_I0.5460.38
8_I26_L0.5460.38
111_P114_G0.5450.37
216_G325_F0.5450.37
9_V14_E0.5450.37
39_D72_K0.5440.37
22_L26_L0.5430.37
28_A186_V0.5410.37
113_D271_R0.5410.37
54_A67_L0.5410.37
290_A297_I0.5410.37
207_E241_G0.5400.37
151_N282_L0.5400.37
58_Q70_N0.5400.37
225_Q237_S0.5400.37
26_L171_T0.5380.37
62_Q89_E0.5370.37
156_A161_Y0.5370.37
183_S186_V0.5350.37
110_D114_G0.5330.36
155_A235_Y0.5320.36
35_I38_R0.5310.36
80_R159_V0.5310.36
88_S271_R0.5310.36
128_F180_Y0.5310.36
205_I217_V0.5300.36
230_S233_R0.5300.36
274_Y308_R0.5290.36
20_G186_V0.5290.36
177_A252_L0.5270.36
175_V186_V0.5270.36
98_E101_E0.5270.36
94_I141_V0.5260.36
231_T318_M0.5260.36
60_E89_E0.5240.35
163_S183_S0.5240.35
111_P271_R0.5240.35
22_L154_V0.5240.35
106_V131_Y0.5230.35
117_N242_S0.5220.35
124_V164_S0.5220.35
107_V147_L0.5210.35
231_T241_G0.5210.35
181_D188_C0.5200.35
203_Y224_C0.5200.35
59_G115_S0.5190.35
21_E145_D0.5190.35
59_G270_L0.5180.35
31_L76_A0.5170.35
292_D326_I0.5160.35
27_S80_R0.5160.35
245_A256_I0.5150.35
34_K184_L0.5150.35
57_V308_R0.5120.34
150_G272_L0.5100.34
7_F11_K0.5090.34
14_E17_H0.5080.34
50_G56_N0.5080.34
116_S269_K0.5060.34
65_L118_I0.5060.34
239_Y269_K0.5050.34
213_F306_H0.5050.34
222_K225_Q0.5040.34
131_Y148_Q0.5040.34
36_I40_I0.5040.34
42_K257_Y0.5020.33
176_H192_E0.5010.33
69_A72_K0.5010.33
74_K86_I0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dcuA 4 0.9548 100 0.334 Contact Map
2fhyA 4 0.9488 100 0.372 Contact Map
2gq1A 3 0.9337 100 0.399 Contact Map
1nuwA 3 0.9819 100 0.425 Contact Map
4ir8A 2 0.9367 100 0.449 Contact Map
1lbvA 2 0.75 99.9 0.805 Contact Map
2bjiA 2 0.7952 99.9 0.805 Contact Map
1xi6A 1 0.6958 99.9 0.806 Contact Map
4i3yA 2 0.7681 99.9 0.806 Contact Map
3t0jA 3 0.7681 99.9 0.812 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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