GREMLIN Database
CSPH - Cold shock-like protein CspH
UniProt: P0A982 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14281
Length: 70 (62)
Sequences: 3271 (1169)
Seq/√Len: 148.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_V67_V4.5821.00
56_V65_A3.7111.00
54_C66_N2.9221.00
14_R46_I2.4741.00
24_S50_R2.4041.00
8_I50_R2.0861.00
23_P28_K2.0841.00
6_T52_E2.0291.00
46_I49_L1.8461.00
58_G63_T1.8341.00
5_M23_P1.8181.00
57_N62_P1.7611.00
6_T50_R1.6511.00
38_T66_N1.6211.00
36_A65_A1.5581.00
14_R44_V1.4351.00
37_F42_A1.2141.00
14_R42_A1.1310.99
7_G21_I1.1250.99
36_A56_V1.1190.99
21_I51_V1.1160.99
23_P26_G1.1120.99
6_T24_S1.1080.99
28_K62_P1.1000.99
21_I53_F1.0970.99
32_V45_L1.0630.99
45_L51_V1.0620.99
58_G62_P1.0410.99
10_K29_E1.0180.99
23_P53_F1.0180.99
5_M25_D0.9950.99
7_G64_A0.9940.99
8_I22_I0.9730.98
34_I43_E0.9540.98
36_A66_N0.9460.98
12_F34_I0.9080.98
55_R62_P0.8950.97
11_T16_S0.8910.97
37_F43_E0.8870.97
58_G61_G0.8620.97
10_K16_S0.8610.97
53_F64_A0.8250.96
20_F33_H0.7850.94
13_D31_Q0.7670.94
37_F41_D0.7590.93
56_V63_T0.7500.93
21_I64_A0.7350.92
30_V55_R0.7280.92
23_P55_R0.7060.91
23_P30_V0.6990.90
9_V45_L0.6950.90
34_I37_F0.6890.90
22_I28_K0.6750.89
39_P43_E0.6710.88
16_S29_E0.6640.88
11_T29_E0.6600.87
18_K30_V0.6590.87
59_L62_P0.6410.86
10_K17_G0.6300.85
37_F40_R0.6290.85
15_K46_I0.6260.85
28_K57_N0.6070.83
39_P42_A0.6030.82
30_V64_A0.6020.82
5_M53_F0.6000.82
54_C65_A0.5980.82
11_T17_G0.5870.81
12_F42_A0.5820.80
43_E51_V0.5800.80
34_I60_R0.5800.80
21_I32_V0.5740.79
11_T41_D0.5730.79
30_V56_V0.5710.79
50_R57_N0.5710.79
31_Q49_L0.5690.79
47_P63_T0.5640.78
19_G32_V0.5600.77
35_S60_R0.5570.77
17_G29_E0.5410.75
22_I30_V0.5410.75
16_S41_D0.5370.74
18_K45_L0.5290.73
34_I38_T0.5290.73
7_G34_I0.5270.73
15_K63_T0.5240.73
14_R40_R0.5210.72
30_V62_P0.5200.72
7_G53_F0.5200.72
18_K33_H0.5140.71
45_L49_L0.5100.71
49_L52_E0.5060.70
8_I24_S0.5050.70
5_M55_R0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lssA 1 1 99.8 0.144 Contact Map
1h95A 1 1 99.7 0.188 Contact Map
3i2zB 2 1 99.7 0.19 Contact Map
2mqhA 1 0.9714 99.7 0.194 Contact Map
3camA 2 0.9571 99.7 0.211 Contact Map
2ytyA 1 0.9571 99.7 0.211 Contact Map
1wfqA 1 0.9571 99.7 0.213 Contact Map
4qqbX 1 0.9571 99.7 0.223 Contact Map
1x65A 1 0.9429 99.6 0.224 Contact Map
3uljA 3 1 99.6 0.228 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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