GREMLIN Database
CSPG - Cold shock-like protein CspG
UniProt: P0A978 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14243
Length: 70 (63)
Sequences: 3916 (1542)
Seq/√Len: 194.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_V67_V3.6721.00
56_E65_A3.3961.00
54_S66_N2.7471.00
52_E68_V2.2971.00
14_A46_N2.2191.00
24_D50_K1.9731.00
8_L50_K1.9601.00
38_Q68_V1.9421.00
6_T52_E1.8921.00
5_M23_P1.8161.00
57_Q62_P1.6631.00
23_P28_K1.6311.00
58_G63_A1.6201.00
6_T50_K1.6131.00
38_Q66_N1.5641.00
46_N49_Q1.5521.00
36_A65_A1.5101.00
32_V45_L1.4361.00
14_A42_F1.4341.00
23_P26_G1.3301.00
58_G62_P1.2521.00
23_P53_F1.2151.00
14_A44_T1.1691.00
28_K62_P1.1441.00
6_T24_D1.0921.00
30_V55_I1.0711.00
34_F43_R1.0701.00
8_L22_T1.0631.00
10_K29_D1.0601.00
37_I42_F1.0441.00
55_I62_P1.0411.00
7_G64_A1.0371.00
7_G21_I1.0241.00
36_A56_E0.9430.99
45_L51_V0.9330.99
21_I53_F0.9320.99
58_G61_G0.9060.99
21_I51_V0.9030.99
53_F64_A0.8780.99
36_A66_N0.8550.99
11_W16_K0.8490.98
5_M25_D0.8450.98
37_I40_N0.8400.98
10_K16_K0.8380.98
37_I43_R0.8200.98
34_F37_I0.8080.98
12_F34_F0.7840.97
20_F33_H0.7600.97
56_E63_A0.7580.97
59_Q62_P0.7250.96
13_N31_F0.7210.96
5_M53_F0.7040.95
9_V45_L0.6990.95
23_P55_I0.6910.95
5_M54_S0.6880.95
15_D49_Q0.6730.94
34_F60_R0.6620.93
16_K29_D0.6610.93
21_I32_V0.6500.93
11_W29_D0.6470.93
15_D63_A0.6450.92
21_I64_A0.6430.92
39_S43_R0.6410.92
19_G32_V0.6400.92
18_F33_H0.6330.92
22_T30_V0.6250.91
18_F30_V0.6170.91
30_V56_E0.6080.90
30_V36_A0.6010.90
8_L24_D0.6000.90
39_S42_F0.5950.89
17_G29_D0.5750.87
28_K57_Q0.5700.87
35_T60_R0.5680.87
5_M68_V0.5640.86
30_V64_A0.5630.86
7_G53_F0.5600.86
15_D46_N0.5590.86
11_W17_G0.5590.86
10_K17_G0.5570.86
39_S44_T0.5500.85
20_F29_D0.5460.85
47_E63_A0.5440.84
60_R63_A0.5400.84
25_D35_T0.5390.84
22_T28_K0.5390.84
44_T49_Q0.5310.83
22_T48_N0.5220.82
32_V49_Q0.5130.81
54_S65_A0.5100.81
16_K41_E0.5080.80
18_F29_D0.5040.80
36_A53_F0.5040.80
15_D36_A0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lssA 1 1 99.7 0.146 Contact Map
1h95A 1 1 99.7 0.161 Contact Map
3i2zB 2 1 99.7 0.162 Contact Map
2mqhA 1 0.9714 99.7 0.178 Contact Map
3camA 2 0.9571 99.7 0.181 Contact Map
1wfqA 1 0.9571 99.7 0.193 Contact Map
2ytyA 1 0.9571 99.7 0.195 Contact Map
1g6pA 1 0.9286 99.7 0.202 Contact Map
1x65A 1 0.9429 99.7 0.204 Contact Map
4qqbX 1 0.9571 99.7 0.205 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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