GREMLIN Database
CSPF - Cold shock-like protein CspF
UniProt: P0A976 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12205
Length: 70 (63)
Sequences: 2393 (976)
Seq/√Len: 122.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_L67_V5.1111.00
56_I65_A3.5331.00
54_C66_N2.7621.00
24_S50_R2.4961.00
14_G46_T2.3941.00
52_E68_Y2.2271.00
6_T52_E2.1481.00
58_G63_S1.8181.00
38_N68_Y1.7541.00
6_T50_R1.6261.00
14_G44_E1.5911.00
23_P27_R1.5881.00
46_T49_L1.5851.00
8_I50_R1.5071.00
57_N62_P1.4711.00
28_I62_P1.4481.00
23_P26_G1.3771.00
23_P28_I1.3091.00
7_G21_I1.2811.00
38_N66_N1.2290.99
36_A56_I1.1270.99
20_L33_H1.0940.99
58_G62_P1.0910.99
10_K29_D1.0800.99
21_I51_V1.0740.98
32_L45_I1.0690.98
21_I53_F1.0310.98
11_T16_S1.0230.98
20_L31_Q1.0060.98
7_G64_A0.9980.98
45_I51_V0.9870.97
8_I22_T0.9410.96
13_D31_Q0.9360.96
36_A65_A0.9360.96
23_P53_F0.8810.95
53_F64_A0.8640.94
39_L44_E0.8640.94
55_R62_P0.8510.94
10_K16_S0.8340.93
34_V43_E0.8310.93
35_S54_C0.8170.92
47_T63_S0.8150.92
12_F34_V0.8130.92
9_V45_I0.8060.92
14_G42_A0.8000.92
37_L40_R0.7950.91
18_K33_H0.7920.91
22_T28_I0.7790.91
28_I57_N0.7720.90
37_L42_A0.7620.90
16_S29_D0.7510.89
7_G51_V0.7460.89
6_T24_S0.7040.86
36_A66_N0.6920.85
37_L43_E0.6910.85
7_G34_V0.6850.84
58_G61_G0.6850.84
48_G59_L0.6770.83
40_R68_Y0.6680.83
28_I59_L0.6460.80
21_I32_L0.6450.80
11_T29_D0.6430.80
39_L43_E0.6370.79
30_V64_A0.6360.79
16_S61_G0.6340.79
36_A53_F0.6200.78
15_K46_T0.6140.77
34_V37_L0.6090.76
11_T17_G0.6050.76
20_L29_D0.5950.75
37_L41_D0.5890.74
19_G32_L0.5860.74
22_T30_V0.5860.74
11_T41_D0.5800.73
18_K45_I0.5750.72
28_I63_S0.5750.72
30_V36_A0.5640.71
10_K17_G0.5580.70
17_G37_L0.5530.69
31_Q49_L0.5520.69
34_V38_N0.5500.69
18_K31_Q0.5470.68
34_V67_V0.5370.67
23_P30_V0.5370.67
30_V59_L0.5360.67
22_T58_G0.5310.66
41_D45_I0.5270.66
8_I26_G0.5240.65
35_S53_F0.5220.65
18_K30_V0.5200.65
15_K62_P0.5200.65
13_D65_A0.5130.64
11_T61_G0.5120.63
56_I63_S0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lssA 1 1 99.7 0.166 Contact Map
1h95A 1 1 99.6 0.206 Contact Map
3i2zB 2 1 99.6 0.208 Contact Map
2mqhA 1 0.9714 99.6 0.21 Contact Map
3camA 2 0.9571 99.6 0.228 Contact Map
1wfqA 1 0.9571 99.6 0.228 Contact Map
2ytyA 1 0.9571 99.6 0.23 Contact Map
1x65A 1 0.9429 99.6 0.237 Contact Map
4qqbX 1 0.9571 99.6 0.242 Contact Map
1g6pA 1 0.9286 99.6 0.243 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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