GREMLIN Database
CSPE - Cold shock-like protein CspE
UniProt: P0A972 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12179
Length: 69 (63)
Sequences: 3893 (1525)
Seq/√Len: 192.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_V66_V3.9261.00
55_T64_A3.3611.00
53_E65_N2.8521.00
51_E67_I2.2801.00
13_E45_A2.2311.00
7_N49_R2.1421.00
23_E49_R2.0421.00
5_K51_E1.9551.00
4_I22_P1.9241.00
37_Q67_I1.8751.00
22_P27_K1.7321.00
45_A48_Q1.6981.00
56_N61_P1.5711.00
37_Q65_N1.5621.00
57_G62_S1.5391.00
5_K49_R1.5351.00
35_A64_A1.5331.00
13_E41_F1.4241.00
57_G61_P1.2821.00
27_K61_P1.2501.00
22_P25_G1.2061.00
13_E43_T1.1961.00
31_V44_L1.1921.00
22_P52_F1.1691.00
7_N21_T1.1401.00
5_K23_E1.1061.00
54_I61_P1.0831.00
33_F42_K1.0601.00
35_A55_T1.0431.00
36_I41_F1.0241.00
6_G20_I0.9870.99
20_I52_F0.9750.99
29_V54_I0.9640.99
10_W15_K0.9540.99
44_L50_V0.9270.99
20_I50_V0.9180.99
36_I42_K0.9110.99
36_I39_N0.9020.99
11_F33_F0.8840.99
57_G60_G0.8740.99
9_K28_D0.8650.99
4_I24_D0.8440.98
6_G63_A0.8420.98
35_A65_N0.8380.98
55_T62_S0.8090.98
9_K15_K0.8000.98
4_I52_F0.7810.97
52_F63_A0.7760.97
33_F36_I0.7710.97
12_N30_F0.7500.97
21_T29_V0.7270.96
17_F29_V0.7200.96
8_V44_L0.7080.95
14_S48_Q0.7070.95
10_W28_D0.7050.95
4_I67_I0.7020.95
4_I54_I0.7010.95
38_T41_F0.6960.95
20_I63_A0.6820.94
16_G28_D0.6390.92
20_I31_V0.6280.91
15_K28_D0.6190.91
21_T47_G0.6190.91
38_T42_K0.6050.90
10_W16_G0.5890.88
30_F48_Q0.5860.88
33_F59_K0.5840.88
29_V63_A0.5820.88
29_V35_A0.5810.88
27_K56_N0.5780.87
18_G31_V0.5780.87
11_F41_F0.5640.86
58_A61_P0.5540.85
29_V55_T0.5530.85
39_N67_I0.5520.85
19_F32_H0.5500.85
7_N23_E0.5470.84
19_F47_G0.5460.84
17_F28_D0.5390.84
11_F15_K0.5330.83
16_G36_I0.5320.83
6_G52_F0.5320.83
33_F41_F0.5290.82
53_E64_A0.5270.82
46_E62_S0.5250.82
33_F37_Q0.5230.82
10_W40_G0.5220.82
22_P54_I0.5170.81
34_S59_K0.5060.80
14_S62_S0.5040.79
38_T43_T0.5040.79
16_G60_G0.5010.79
9_K16_G0.5000.79
14_S59_K0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i2zB 2 1 99.7 0.14 Contact Map
2lssA 1 1 99.7 0.178 Contact Map
3camA 2 0.971 99.7 0.184 Contact Map
1h95A 1 1 99.7 0.187 Contact Map
3uljA 3 1 99.7 0.188 Contact Map
2mqhA 1 0.971 99.7 0.188 Contact Map
3ts2A 1 1 99.7 0.202 Contact Map
1c9oA 2 0.9565 99.7 0.208 Contact Map
1g6pA 1 0.942 99.7 0.208 Contact Map
2ytyA 1 0.9565 99.6 0.211 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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