GREMLIN Database
CSPD - Cold shock-like protein CspD
UniProt: P0A968 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11111
Length: 74 (63)
Sequences: 3853 (1499)
Seq/√Len: 188.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_A64_I3.7271.00
53_H62_S3.2661.00
46_Q66_P2.6681.00
51_D63_V2.6431.00
49_Q65_V2.3561.00
5_T47_S2.0521.00
21_E47_S2.0521.00
11_N43_K2.0471.00
35_Q65_V1.9901.00
3_K49_Q1.8631.00
3_K47_S1.8131.00
20_P25_E1.7131.00
55_G58_G1.6681.00
54_Q59_N1.5191.00
43_K46_Q1.5071.00
25_E59_N1.4941.00
11_N39_Y1.4921.00
20_P24_G1.4871.00
55_G60_H1.4821.00
36_M66_P1.4391.00
33_T62_S1.3921.00
11_N41_T1.3321.00
35_Q63_V1.3231.00
5_T19_C1.3171.00
20_P50_F1.2951.00
52_V59_N1.1961.00
3_K21_E1.1301.00
34_I39_Y1.1161.00
29_A42_L1.0741.00
31_Y40_R1.0161.00
34_I40_R1.0141.00
18_I50_F0.9550.99
4_G18_I0.9360.99
33_T53_H0.9230.99
27_I52_V0.9050.99
33_T63_V0.8860.99
42_L48_V0.8390.98
18_I48_V0.8360.98
34_I37_D0.8330.98
53_H60_H0.8300.98
31_Y34_I0.7990.97
9_F31_Y0.7930.97
15_F27_I0.7770.97
17_F30_H0.7690.97
20_P52_V0.7560.97
36_M40_R0.7360.96
10_N28_F0.7350.96
44_A60_H0.7330.96
18_I61_A0.7190.95
5_T21_E0.7150.95
4_G61_A0.7150.95
8_W13_K0.7100.95
51_D62_S0.6910.94
50_F61_A0.6850.94
18_I29_A0.6690.93
12_A60_H0.6430.92
7_K26_D0.6390.92
14_G26_D0.6240.91
14_G58_G0.6200.90
17_F45_G0.6120.90
22_G51_D0.6060.89
19_C25_E0.5970.89
7_K13_K0.5950.88
33_T50_F0.5910.88
19_C27_I0.5790.87
45_G56_P0.5680.86
27_I53_H0.5650.86
4_G48_V0.5620.85
31_Y39_Y0.5590.85
43_K66_P0.5550.85
27_I61_A0.5540.85
18_I64_I0.5530.85
25_E54_Q0.5520.84
13_K26_D0.5510.84
32_S57_K0.5480.84
37_D40_R0.5470.84
28_F46_Q0.5420.83
16_G29_A0.5370.83
54_Q62_S0.5340.82
15_F42_L0.5290.82
12_A33_T0.5290.82
31_Y37_D0.5270.82
19_C55_G0.5220.81
36_M41_T0.5210.81
4_G50_F0.5210.81
21_E24_G0.5180.81
25_E60_H0.5170.80
4_G32_S0.5170.80
14_G34_I0.5160.80
27_I33_T0.5110.80
9_F13_K0.5050.79
37_D48_V0.5050.79
12_A46_Q0.5020.78
48_V66_P0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3camA 2 0.9054 99.8 0.221 Contact Map
2lxjA 1 0.8919 99.7 0.242 Contact Map
3i2zB 2 0.9054 99.7 0.243 Contact Map
1c9oA 2 0.8919 99.7 0.244 Contact Map
2ytxA 1 0.9595 99.7 0.245 Contact Map
1x65A 1 0.9459 99.7 0.253 Contact Map
1g6pA 1 0.8919 99.7 0.262 Contact Map
2lssA 1 0.9054 99.7 0.262 Contact Map
3a0jA 1 0.9595 99.7 0.262 Contact Map
2mqhA 1 0.8784 99.7 0.264 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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