GREMLIN Database
CHEW - Chemotaxis protein CheW
UniProt: P0A964 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10149
Length: 167 (142)
Sequences: 5383 (3787)
Seq/√Len: 317.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_E140_R3.6781.00
117_R136_A3.1421.00
18_E110_S2.8711.00
38_E62_R2.8221.00
88_V99_G2.7941.00
111_L135_G2.7571.00
23_T104_G2.7381.00
37_Q92_N2.6771.00
56_K70_D2.5691.00
56_K73_I2.4161.00
112_T115_Q2.3711.00
116_I133_G2.3681.00
35_K148_E2.3051.00
56_K101_V2.2941.00
73_I79_D2.0661.00
60_N63_G2.0441.00
91_L100_I2.0301.00
68_I88_V1.9481.00
132_T146_N1.9131.00
72_R103_D1.9031.00
17_Q32_D1.8441.00
42_Y45_V1.8391.00
82_Y86_T1.6831.00
129_E149_K1.6641.00
64_V97_V1.6511.00
80_V83_N1.6091.00
23_T106_S1.5881.00
53_A73_I1.5471.00
25_G72_R1.5201.00
60_N65_I1.5141.00
15_S113_A1.4951.00
28_E106_S1.4921.00
137_L140_R1.4621.00
19_F144_L1.4621.00
37_Q97_V1.4121.00
32_D132_T1.3911.00
68_I99_G1.3781.00
41_G87_V1.3721.00
42_Y88_V1.3701.00
66_V90_V1.3661.00
32_D35_K1.3271.00
83_N86_T1.3161.00
21_V28_E1.3111.00
131_L143_I1.2741.00
31_I91_L1.2631.00
56_K82_Y1.2551.00
23_T26_D1.2441.00
17_Q113_A1.2411.00
37_Q64_V1.2361.00
14_P114_E1.2321.00
59_T88_V1.2091.00
116_I144_L1.1901.00
71_L150_L1.1861.00
74_K155_E1.1691.00
70_D73_I1.1601.00
45_V68_I1.1571.00
19_F111_L1.1231.00
20_L39_I1.0971.00
22_F89_I1.0961.00
21_V109_L1.0701.00
20_L89_I1.0501.00
42_Y101_V1.0401.00
146_N149_K1.0311.00
70_D79_D1.0181.00
19_F135_G1.0121.00
21_V107_D1.0111.00
135_G144_L1.0101.00
115_Q137_L1.0091.00
59_T68_I1.0091.00
30_G142_L1.0071.00
20_L87_V0.9891.00
21_V142_L0.9811.00
25_G77_Q0.9781.00
86_T101_V0.9751.00
43_D88_V0.9741.00
119_A131_L0.9691.00
35_K132_T0.9651.00
40_R43_D0.9611.00
89_I102_V0.9491.00
16_G110_S0.9471.00
72_R77_Q0.9411.00
61_L90_V0.9391.00
21_V106_S0.9361.00
36_V89_I0.9311.00
30_G135_G0.9291.00
120_P123_A0.9121.00
15_S112_T0.9111.00
16_G113_A0.9051.00
54_F74_K0.9051.00
94_G148_E0.9021.00
18_E33_I0.8911.00
16_G112_T0.8901.00
91_L147_I0.8811.00
31_I147_I0.8811.00
70_D74_K0.8591.00
88_V101_V0.8541.00
23_T28_E0.8531.00
92_N97_V0.8511.00
55_I69_V0.8471.00
71_L100_I0.8451.00
149_K153_S0.8371.00
17_Q132_T0.8021.00
100_I147_I0.7991.00
40_R64_V0.7881.00
22_F31_I0.7851.00
19_F30_G0.7761.00
45_V59_T0.7731.00
40_R88_V0.7690.99
38_E105_V0.7640.99
30_G144_L0.7640.99
134_L141_M0.7580.99
152_N155_E0.7460.99
66_V97_V0.7420.99
137_L142_L0.7390.99
136_A141_M0.7360.99
149_K152_N0.7340.99
45_V88_V0.7320.99
33_I108_V0.7300.99
29_Y75_F0.7280.99
42_Y87_V0.7270.99
70_D80_V0.7210.99
80_V103_D0.7150.99
48_I58_V0.7150.99
86_T103_D0.7100.99
82_Y101_V0.7070.99
51_T55_I0.7050.99
60_N136_A0.6980.99
46_T65_I0.6970.99
24_L71_L0.6910.99
55_I67_P0.6900.99
50_N53_A0.6900.99
145_V150_L0.6900.99
31_I100_I0.6780.99
72_R78_V0.6780.99
133_G144_L0.6780.99
15_S114_E0.6770.99
40_R105_V0.6750.99
129_E153_S0.6730.99
103_D108_V0.6660.99
48_I51_T0.6610.98
151_L155_E0.6550.98
65_I143_I0.6530.98
14_P26_D0.6490.98
21_V30_G0.6430.98
40_R61_L0.6400.98
41_G141_M0.6400.98
35_K147_I0.6390.98
48_I122_F0.6360.98
46_T49_A0.6340.98
51_T54_F0.6310.98
126_L145_V0.6300.98
87_V104_G0.6300.98
143_I146_N0.6300.98
74_K154_E0.6270.98
45_V90_V0.6270.98
15_S53_A0.6270.98
116_I135_G0.6180.98
66_V99_G0.6150.98
35_K146_N0.6140.98
102_V105_V0.6140.98
115_Q135_G0.6130.98
14_P17_Q0.6070.97
56_K79_D0.6050.97
115_Q138_G0.6030.97
65_I89_I0.5990.97
111_L116_I0.5990.97
20_L36_V0.5900.97
23_T109_L0.5900.97
43_D59_T0.5890.97
72_R79_D0.5800.97
52_P69_V0.5770.96
58_V143_I0.5740.96
67_P86_T0.5740.96
14_P112_T0.5730.96
22_F38_E0.5730.96
36_V117_R0.5710.96
39_I60_N0.5620.96
34_L37_Q0.5590.96
26_D80_V0.5560.96
90_V97_V0.5530.95
119_A123_A0.5510.95
80_V114_E0.5500.95
18_E40_R0.5490.95
33_I39_I0.5490.95
20_L134_L0.5460.95
24_L98_V0.5450.95
33_I40_R0.5440.95
139_D152_N0.5420.95
83_N114_E0.5410.95
42_Y82_Y0.5410.95
20_L41_G0.5400.95
29_Y127_S0.5390.95
111_L137_L0.5370.95
125_T128_T0.5360.95
132_T145_V0.5250.94
120_P141_M0.5250.94
74_K153_S0.5250.94
95_Q125_T0.5250.94
128_T149_K0.5240.94
59_T90_V0.5230.94
81_D86_T0.5220.94
22_F106_S0.5190.94
109_L140_R0.5180.94
45_V56_K0.5180.94
40_R59_T0.5120.93
47_R51_T0.5120.93
93_L145_V0.5100.93
70_D87_V0.5070.93
42_Y86_T0.5070.93
28_E142_L0.5050.93
58_V65_I0.5020.93
78_V81_D0.5000.92
44_Q93_L0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ho9A 1 1 100 0.15 Contact Map
2qdlA 1 0.9281 100 0.21 Contact Map
4jpbW 1 0.8383 100 0.236 Contact Map
1b3qA 2 0.8443 99.4 0.576 Contact Map
2dqwA 2 0.3952 3.3 0.941 Contact Map
2xheA 1 0.3174 3.3 0.941 Contact Map
3fdjA 1 0.3713 2.6 0.944 Contact Map
1pm3A 2 0.2515 2.4 0.945 Contact Map
4dmiA 5 0.7784 2.4 0.945 Contact Map
3i4wA 1 0.4551 2.4 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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