ALAA - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

ALAA - Glutamate-pyruvate aminotransferase AlaA

UniProt:	P0A959	Sequences: MSPIEKSSKLENVCYDIRGPVLKEAKRLEEEGNKVLKLNIGNPAPFGFDAPDEILVDVIRNLPTAQGYCDSKGLYSARKAIMQHYQARGMRDVTVEDIYIGNGVSELIVQAMQALLNSGDEMLVPAPDYPLWTAAVSLSSGKAVHYLCDESSDWFPDLDDIRAKITPRTRGIVIINPNNPTGAVYSKELLMEIVEIARQHNLIIFADEIYDKILYDDAEHHSIAPLAPDLLTITFNGLSKTYRVAGFRQGWMVLNGPKKHAKGYIEGLEMLASMRLCANVPAQHAIQTALGGYQSISEFITPGGRLYEQRNRAWELINDIPGVSCVKPRGALYMFPKIDAKRFNIHDDQKMVLDFLLQEKVLLVQGTAFNWPWPDHFRIVTLPRVDDIELSLSKFARFLSGYHQL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14101
Length:	405 (347)
Sequences:	42750 (29377)
Seq/√Len:	1577.0

ECOLI - ALAA ALAC YBDL YJIR YDCR MALY AVTA HIS8
BACSU - AAT1 MTNE AAT2 YUGH YDFD PATA YISV YHDI GABR YDEL AAT3 YDEF YCXD CBL HIS8
HALSA - Q9HQK2 Q9HRM6 Q9HRX4 Q9HQW2 HIS8 Q9HPL0
SULSO - AAT Y104 Q97TY7 Q97YX5 HIS8 Q97ZX4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
121_E	142_K	2.968	1.00
80_A	291_G	2.882	1.00
101_G	107_L	2.854	1.00
308_E	385_V	2.835	1.00
312_R	389_E	2.781	1.00
116_L	141_G	2.722	1.00
359_E	397_R	2.715	1.00
307_Y	311_N	2.688	1.00
187_K	191_M	2.579	1.00
86_Q	92_D	2.568	1.00
324_S	337_K	2.555	1.00
59_I	63_P	2.554	1.00
162_R	199_Q	2.440	1.00
76_S	287_Q	2.413	1.00
120_D	170_R	2.408	1.00
390_L	394_K	2.301	1.00
354_D	358_Q	2.211	1.00
121_E	144_V	2.109	1.00
186_S	189_L	2.108	1.00
314_W	318_N	2.108	1.00
314_W	327_K	2.095	1.00
109_V	113_Q	2.071	1.00
52_D	56_V	2.068	1.00
316_L	319_D	2.007	1.00
126_A	145_H	1.961	1.00
316_L	392_L	1.959	1.00
79_K	95_V	1.943	1.00
80_A	83_Q	1.903	1.00
249_Q	286_I	1.879	1.00
191_M	195_E	1.846	1.00
83_Q	291_G	1.841	1.00
155_F	189_L	1.820	1.00
312_R	316_L	1.798	1.00
160_D	164_K	1.794	1.00
75_Y	79_K	1.787	1.00
316_L	396_A	1.784	1.00
316_L	320_I	1.765	1.00
157_D	160_D	1.762	1.00
56_V	60_R	1.749	1.00
205_F	235_F	1.745	1.00
136_V	141_G	1.716	1.00
82_M	95_V	1.713	1.00
312_R	385_V	1.702	1.00
390_L	393_S	1.692	1.00
197_A	204_I	1.691	1.00
162_R	192_E	1.686	1.00
133_T	137_S	1.653	1.00
79_K	83_Q	1.646	1.00
111_A	233_I	1.641	1.00
316_L	393_S	1.639	1.00
320_I	396_A	1.638	1.00
160_D	163_A	1.631	1.00
80_A	287_Q	1.631	1.00
187_K	221_H	1.612	1.00
201_N	231_L	1.611	1.00
384_R	387_D	1.606	1.00
318_N	325_C	1.599	1.00
198_R	229_D	1.598	1.00
315_E	319_D	1.590	1.00
359_E	394_K	1.585	1.00
209_I	237_G	1.574	1.00
122_M	136_V	1.552	1.00
192_E	195_E	1.552	1.00
38_L	391_S	1.551	1.00
279_N	282_A	1.544	1.00
311_N	315_E	1.539	1.00
121_E	168_R	1.535	1.00
81_I	251_W	1.519	1.00
133_T	145_H	1.517	1.00
158_L	192_E	1.515	1.00
126_A	147_L	1.505	1.00
97_D	258_K	1.497	1.00
227_A	230_L	1.496	1.00
74_L	284_H	1.492	1.00
159_D	192_E	1.489	1.00
112_M	136_V	1.475	1.00
314_W	325_C	1.474	1.00
111_A	205_F	1.465	1.00
313_A	334_M	1.461	1.00
121_E	166_T	1.458	1.00
305_R	385_V	1.452	1.00
383_P	387_D	1.452	1.00
354_D	398_F	1.452	1.00
93_V	253_V	1.450	1.00
123_L	169_T	1.438	1.00
363_L	377_F	1.435	1.00
55_L	59_I	1.434	1.00
355_F	358_Q	1.425	1.00
347_D	350_K	1.422	1.00
149_D	189_L	1.422	1.00
318_N	327_K	1.418	1.00
104_V	235_F	1.408	1.00
319_D	396_A	1.402	1.00
305_R	309_Q	1.398	1.00
189_L	192_E	1.397	1.00
58_V	62_L	1.395	1.00
118_S	140_S	1.394	1.00
56_V	59_I	1.394	1.00
238_L	286_I	1.392	1.00
57_D	60_R	1.385	1.00
171_G	205_F	1.382	1.00
287_Q	291_G	1.378	1.00
85_Y	253_V	1.367	1.00
75_Y	95_V	1.365	1.00
124_V	143_A	1.363	1.00
316_L	389_E	1.359	1.00
314_W	334_M	1.344	1.00
385_V	389_E	1.343	1.00
305_R	308_E	1.341	1.00
351_M	355_F	1.338	1.00
252_M	264_Y	1.324	1.00
353_L	357_L	1.324	1.00
313_A	392_L	1.323	1.00
121_E	169_T	1.322	1.00
197_A	202_L	1.320	1.00
83_Q	87_A	1.318	1.00
33_N	360_K	1.312	1.00
158_L	196_I	1.312	1.00
57_D	288_T	1.302	1.00
147_L	160_D	1.298	1.00
165_I	196_I	1.297	1.00
195_E	199_Q	1.291	1.00
76_S	291_G	1.291	1.00
96_E	258_K	1.291	1.00
162_R	200_H	1.285	1.00
335_F	366_G	1.281	1.00
337_K	376_H	1.281	1.00
236_N	251_W	1.274	1.00
337_K	375_D	1.272	1.00
162_R	166_T	1.267	1.00
94_T	97_D	1.264	1.00
310_R	314_W	1.260	1.00
196_I	200_H	1.257	1.00
113_Q	139_S	1.249	1.00
162_R	196_I	1.242	1.00
195_E	198_R	1.234	1.00
350_K	354_D	1.229	1.00
299_F	302_P	1.229	1.00
188_E	191_M	1.227	1.00
347_D	351_M	1.223	1.00
191_M	226_L	1.216	1.00
117_N	120_D	1.216	1.00
102_N	106_E	1.214	1.00
196_I	202_L	1.211	1.00
72_K	78_R	1.209	1.00
60_R	288_T	1.200	1.00
254_L	257_P	1.194	1.00
149_D	160_D	1.189	1.00
393_S	397_R	1.179	1.00
288_T	291_G	1.176	1.00
76_S	284_H	1.176	1.00
304_G	307_Y	1.167	1.00
387_D	390_L	1.159	1.00
389_E	393_S	1.157	1.00
336_P	379_I	1.151	1.00
188_E	192_E	1.149	1.00
310_R	381_T	1.149	1.00
187_K	225_P	1.136	1.00
107_L	252_M	1.135	1.00
123_L	146_Y	1.133	1.00
78_R	82_M	1.133	1.00
216_D	329_R	1.131	1.00
320_I	393_S	1.121	1.00
304_G	308_E	1.118	1.00
112_M	116_L	1.114	1.00
187_K	226_L	1.110	1.00
149_D	157_D	1.105	1.00
112_M	173_V	1.104	1.00
163_A	167_P	1.103	1.00
52_D	55_L	1.093	1.00
203_I	233_I	1.092	1.00
284_H	287_Q	1.086	1.00
81_I	100_I	1.080	1.00
172_I	202_L	1.075	1.00
349_Q	367_T	1.065	1.00
312_R	315_E	1.061	1.00
55_L	63_P	1.059	1.00
309_Q	312_R	1.055	1.00
116_L	122_M	1.051	1.00
53_E	56_V	1.050	1.00
354_D	357_L	1.049	1.00
288_T	292_G	1.049	1.00
53_E	292_G	1.045	1.00
222_S	225_P	1.044	1.00
76_S	79_K	1.039	1.00
58_V	285_A	1.035	1.00
355_F	359_E	1.033	1.00
339_D	375_D	1.031	1.00
263_G	267_G	1.031	1.00
165_I	202_L	1.031	1.00
298_E	302_P	1.031	1.00
85_Y	251_W	1.020	1.00
34_K	360_K	1.020	1.00
166_T	200_H	1.020	1.00
348_D	351_M	1.015	1.00
77_A	100_I	1.006	1.00
311_N	327_K	1.006	1.00
351_M	354_D	1.005	1.00
122_M	171_G	1.003	1.00
293_Y	298_E	0.997	1.00
136_V	143_A	0.994	1.00
99_Y	261_A	0.992	1.00
48_F	305_R	0.991	1.00
323_V	338_I	0.988	1.00
233_I	252_M	0.979	1.00
254_L	261_A	0.979	1.00
194_V	232_T	0.979	1.00
166_T	169_T	0.977	1.00
81_I	98_I	0.976	1.00
215_Y	307_Y	0.970	1.00
214_L	220_H	0.963	1.00
301_T	304_G	0.962	1.00
158_L	162_R	0.960	1.00
146_Y	164_K	0.957	1.00
315_E	318_N	0.957	1.00
355_F	398_F	0.957	1.00
203_I	231_L	0.957	1.00
324_S	339_D	0.950	1.00
258_K	262_K	0.946	1.00
57_D	61_N	0.941	1.00
82_M	98_I	0.935	1.00
359_E	398_F	0.926	1.00
34_K	390_L	0.917	1.00
97_D	261_A	0.917	1.00
254_L	264_Y	0.916	1.00
98_I	253_V	0.912	1.00
116_L	171_G	0.912	1.00
82_M	94_T	0.909	1.00
115_L	171_G	0.908	1.00
137_S	143_A	0.907	1.00
94_T	258_K	0.905	1.00
159_D	163_A	0.900	1.00
348_D	367_T	0.892	1.00
83_Q	86_Q	0.891	1.00
84_H	88_R	0.887	1.00
204_I	223_I	0.885	1.00
123_L	164_K	0.884	1.00
338_I	377_F	0.883	1.00
115_L	203_I	0.881	1.00
107_L	235_F	0.880	1.00
198_R	231_L	0.879	1.00
74_L	287_Q	0.877	1.00
84_H	212_K	0.876	1.00
352_V	355_F	0.874	1.00
55_L	62_L	0.873	1.00
310_R	328_P	0.868	1.00
235_F	252_M	0.865	1.00
249_Q	278_A	0.864	1.00
191_M	229_D	0.856	1.00
102_N	279_N	0.855	1.00
350_K	353_L	0.853	1.00
128_D	175_I	0.852	1.00
104_V	237_G	0.852	1.00
394_K	397_R	0.852	1.00
169_T	202_L	0.851	1.00
125_P	156_P	0.846	1.00
75_Y	78_R	0.845	1.00
60_R	64_T	0.844	1.00
91_R	224_A	0.841	1.00
50_A	54_I	0.841	1.00
32_G	360_K	0.834	1.00
187_K	219_E	0.832	1.00
61_N	288_T	0.829	1.00
302_P	305_R	0.828	1.00
134_A	137_S	0.828	1.00
320_I	392_L	0.827	1.00
221_H	225_P	0.825	1.00
88_R	212_K	0.825	1.00
308_E	312_R	0.822	1.00
126_A	372_P	0.822	1.00
223_I	232_T	0.820	1.00
53_E	288_T	0.820	1.00
87_A	294_Q	0.818	1.00
348_D	374_P	0.817	1.00
49_D	55_L	0.817	1.00
158_L	193_I	0.815	1.00
352_V	377_F	0.811	1.00
223_I	226_L	0.808	1.00
125_P	146_Y	0.807	1.00
203_I	260_H	0.806	1.00
349_Q	353_L	0.806	1.00
148_C	178_N	0.800	1.00
99_Y	252_M	0.796	1.00
194_V	204_I	0.796	1.00
74_L	283_Q	0.796	1.00
249_Q	282_A	0.794	1.00
313_A	316_L	0.794	1.00
99_Y	264_Y	0.794	1.00
347_D	374_P	0.793	1.00
361_V	395_F	0.793	1.00
159_D	162_R	0.791	1.00
347_D	352_V	0.790	1.00
34_K	387_D	0.790	1.00
386_D	389_E	0.789	1.00
144_V	164_K	0.787	1.00
218_A	329_R	0.787	1.00
105_S	131_L	0.781	1.00
315_E	389_E	0.780	1.00
106_E	275_R	0.779	1.00
104_V	209_I	0.777	1.00
363_L	379_I	0.776	1.00
309_Q	384_R	0.774	1.00
158_L	189_L	0.773	1.00
300_I	303_G	0.772	1.00
198_R	228_P	0.771	1.00
313_A	388_I	0.769	1.00
51_P	54_I	0.765	1.00
78_R	95_V	0.764	1.00
233_I	260_H	0.763	1.00
298_E	301_T	0.760	1.00
294_Q	298_E	0.760	1.00
123_L	161_I	0.757	1.00
311_N	314_W	0.757	1.00
379_I	391_S	0.755	1.00
224_A	234_T	0.753	1.00
60_R	63_P	0.752	1.00
313_A	381_T	0.748	1.00
43_P	306_L	0.746	1.00
308_E	311_N	0.745	1.00
224_A	230_L	0.743	1.00
114_A	264_Y	0.741	1.00
259_K	262_K	0.741	1.00
106_E	110_Q	0.740	1.00
307_Y	310_R	0.737	1.00
165_I	169_T	0.736	1.00
367_T	374_P	0.732	1.00
146_Y	160_D	0.732	1.00
126_A	370_N	0.729	1.00
110_Q	264_Y	0.727	1.00
212_K	241_T	0.727	1.00
221_H	226_L	0.724	1.00
165_I	200_H	0.723	1.00
155_F	186_S	0.722	1.00
214_L	217_D	0.719	1.00
121_E	170_R	0.719	1.00
109_V	274_M	0.715	1.00
393_S	396_A	0.711	1.00
361_V	394_K	0.709	1.00
49_D	54_I	0.704	1.00
352_V	363_L	0.704	1.00
335_F	376_H	0.703	1.00
178_N	181_T	0.703	1.00
114_A	268_L	0.700	1.00
109_V	139_S	0.700	1.00
206_A	223_I	0.699	1.00
309_Q	385_V	0.691	1.00
122_M	141_G	0.682	1.00
259_K	263_G	0.682	1.00
310_R	327_K	0.681	1.00
349_Q	365_Q	0.680	1.00
124_V	136_V	0.678	1.00
155_F	183_A	0.677	1.00
194_V	230_L	0.677	1.00
149_D	155_F	0.676	1.00
262_K	266_E	0.674	1.00
226_L	230_L	0.673	1.00
80_A	290_L	0.672	1.00
323_V	336_P	0.669	1.00
216_D	307_Y	0.668	1.00
303_G	307_Y	0.668	1.00
144_V	169_T	0.666	1.00
284_H	288_T	0.666	1.00
82_M	93_V	0.665	1.00
317_I	336_P	0.665	1.00
174_I	190_L	0.665	1.00
208_E	234_T	0.665	1.00
156_P	189_L	0.665	1.00
280_V	284_H	0.660	1.00
123_L	172_I	0.659	1.00
185_Y	189_L	0.658	1.00
132_W	136_V	0.656	1.00
84_H	242_Y	0.651	1.00
65_A	284_H	0.650	1.00
38_L	388_I	0.650	1.00
350_K	367_T	0.649	1.00
97_D	230_L	0.648	1.00
336_P	376_H	0.645	1.00
238_L	251_W	0.644	1.00
72_K	266_E	0.643	1.00
59_I	62_L	0.641	1.00
111_A	264_Y	0.641	1.00
312_R	392_L	0.640	1.00
161_I	172_I	0.638	1.00
198_R	227_A	0.637	1.00
84_H	89_G	0.636	1.00
147_L	164_K	0.636	1.00
211_D	236_N	0.631	1.00
238_L	290_L	0.629	1.00
224_A	227_A	0.629	1.00
177_P	330_G	0.628	1.00
192_E	196_I	0.627	1.00
125_P	178_N	0.625	1.00
56_V	63_P	0.624	1.00
388_I	391_S	0.623	1.00
163_A	166_T	0.623	1.00
161_I	196_I	0.622	1.00
79_K	82_M	0.622	1.00
225_P	229_D	0.621	1.00
225_P	230_L	0.620	1.00
32_G	35_V	0.619	1.00
262_K	267_G	0.618	1.00
58_V	281_P	0.617	1.00
116_L	120_D	0.616	1.00
356_L	395_F	0.614	1.00
109_V	135_A	0.610	1.00
55_L	58_V	0.610	1.00
35_V	362_L	0.609	1.00
352_V	356_L	0.608	1.00
346_H	354_D	0.606	1.00
84_H	293_Y	0.606	1.00
346_H	351_M	0.605	1.00
190_L	223_I	0.605	1.00
151_S	155_F	0.603	1.00
348_D	375_D	0.601	1.00
226_L	229_D	0.600	1.00
53_E	298_E	0.599	1.00
70_D	75_Y	0.598	1.00
85_Y	234_T	0.598	1.00
172_I	197_A	0.597	1.00
100_I	249_Q	0.597	1.00
53_E	294_Q	0.596	1.00
197_A	201_N	0.594	1.00
124_V	145_H	0.592	1.00
144_V	166_T	0.590	1.00
166_T	199_Q	0.590	1.00
105_S	129_Y	0.587	1.00
285_A	288_T	0.586	1.00
176_N	208_E	0.586	1.00
101_G	252_M	0.585	1.00
325_C	334_M	0.584	1.00
69_C	74_L	0.581	1.00
119_G	142_K	0.581	1.00
185_Y	190_L	0.581	1.00
353_L	365_Q	0.581	1.00
169_T	172_I	0.579	1.00
36_L	390_L	0.576	1.00
112_M	171_G	0.574	1.00
77_A	286_I	0.573	1.00
210_Y	333_Y	0.573	1.00
319_D	389_E	0.572	1.00
37_K	42_N	0.572	1.00
89_G	211_D	0.571	1.00
103_G	248_R	0.570	1.00
361_V	391_S	0.570	1.00
112_M	141_G	0.569	1.00
241_T	300_I	0.569	1.00
215_Y	310_R	0.568	1.00
147_L	157_D	0.567	1.00
112_M	139_S	0.566	1.00
73_G	78_R	0.565	1.00
322_G	339_D	0.564	1.00
366_G	369_F	0.563	1.00
183_A	329_R	0.562	1.00
283_Q	287_Q	0.562	1.00
254_L	260_H	0.560	1.00
93_V	97_D	0.558	1.00
112_M	135_A	0.558	1.00
102_N	278_A	0.557	1.00
384_R	389_E	0.557	1.00
216_D	310_R	0.554	1.00
74_L	280_V	0.552	1.00
257_P	260_H	0.551	1.00
76_S	80_A	0.550	1.00
50_A	53_E	0.549	1.00
107_L	250_G	0.549	1.00
156_P	161_I	0.549	1.00
69_C	280_V	0.548	1.00
108_I	135_A	0.547	1.00
64_T	284_H	0.546	1.00
208_E	222_S	0.546	1.00
77_A	81_I	0.545	1.00
130_P	368_A	0.544	1.00
176_N	184_V	0.544	1.00
208_E	211_D	0.542	1.00
309_Q	388_I	0.540	1.00
390_L	397_R	0.540	1.00
326_V	337_K	0.539	1.00
312_R	388_I	0.538	1.00
58_V	61_N	0.538	1.00
356_L	363_L	0.536	1.00
99_Y	254_L	0.535	1.00
81_I	238_L	0.530	1.00
313_A	379_I	0.529	1.00
184_V	214_L	0.528	1.00
164_K	167_P	0.528	1.00
213_I	306_L	0.527	1.00
197_A	231_L	0.527	1.00
173_V	205_F	0.526	1.00
120_D	168_R	0.524	1.00
229_D	232_T	0.523	1.00
366_G	376_H	0.521	1.00
150_E	337_K	0.519	1.00
394_K	398_F	0.519	1.00
84_H	211_D	0.519	1.00
357_L	362_L	0.518	1.00
282_A	285_A	0.518	1.00
111_A	171_G	0.516	1.00
52_D	63_P	0.516	1.00
39_N	362_L	0.513	1.00
150_E	324_S	0.512	1.00
371_W	374_P	0.512	1.00
111_A	235_F	0.512	1.00
54_I	289_A	0.512	1.00
154_W	376_H	0.511	1.00
370_N	373_W	0.511	1.00
185_Y	193_I	0.509	1.00
194_V	198_R	0.509	1.00
79_K	291_G	0.508	1.00
124_V	133_T	0.507	1.00
171_G	203_I	0.506	1.00
340_A	346_H	0.505	1.00
223_I	230_L	0.504	1.00
117_N	170_R	0.503	1.00
61_N	285_A	0.503	1.00
261_A	264_Y	0.503	1.00
350_K	365_Q	0.502	1.00
162_R	165_I	0.501	1.00
146_Y	156_P	0.501	1.00
194_V	197_A	0.501	1.00
227_A	231_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cvqA	2	0.9975	100	0.283	Contact Map
3dydA	2	0.9333	100	0.303	Contact Map
3piuA	2	0.9358	100	0.315	Contact Map
1xi9A	4	0.9654	100	0.318	Contact Map
3ihjA	2	0.9506	100	0.318	Contact Map
2x5dA	3	0.9284	100	0.32	Contact Map
3h14A	2	0.9111	100	0.322	Contact Map
3jtxA	2	0.9309	100	0.324	Contact Map
1bw0A	2	0.9654	100	0.324	Contact Map
3tcmA	2	0.9901	100	0.325	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0123 seconds.