GREMLIN Database
ALAA - Glutamate-pyruvate aminotransferase AlaA
UniProt: P0A959 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14101
Length: 405 (347)
Sequences: 42750 (29377)
Seq/√Len: 1577.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_E142_K2.9681.00
80_A291_G2.8821.00
101_G107_L2.8541.00
308_E385_V2.8351.00
312_R389_E2.7811.00
116_L141_G2.7221.00
359_E397_R2.7151.00
307_Y311_N2.6881.00
187_K191_M2.5791.00
86_Q92_D2.5681.00
324_S337_K2.5551.00
59_I63_P2.5541.00
162_R199_Q2.4401.00
76_S287_Q2.4131.00
120_D170_R2.4081.00
390_L394_K2.3011.00
354_D358_Q2.2111.00
121_E144_V2.1091.00
186_S189_L2.1081.00
314_W318_N2.1081.00
314_W327_K2.0951.00
109_V113_Q2.0711.00
52_D56_V2.0681.00
316_L319_D2.0071.00
126_A145_H1.9611.00
316_L392_L1.9591.00
79_K95_V1.9431.00
80_A83_Q1.9031.00
249_Q286_I1.8791.00
191_M195_E1.8461.00
83_Q291_G1.8411.00
155_F189_L1.8201.00
312_R316_L1.7981.00
160_D164_K1.7941.00
75_Y79_K1.7871.00
316_L396_A1.7841.00
316_L320_I1.7651.00
157_D160_D1.7621.00
56_V60_R1.7491.00
205_F235_F1.7451.00
136_V141_G1.7161.00
82_M95_V1.7131.00
312_R385_V1.7021.00
390_L393_S1.6921.00
197_A204_I1.6911.00
162_R192_E1.6861.00
133_T137_S1.6531.00
79_K83_Q1.6461.00
111_A233_I1.6411.00
316_L393_S1.6391.00
320_I396_A1.6381.00
160_D163_A1.6311.00
80_A287_Q1.6311.00
187_K221_H1.6121.00
201_N231_L1.6111.00
384_R387_D1.6061.00
318_N325_C1.5991.00
198_R229_D1.5981.00
315_E319_D1.5901.00
359_E394_K1.5851.00
209_I237_G1.5741.00
122_M136_V1.5521.00
192_E195_E1.5521.00
38_L391_S1.5511.00
279_N282_A1.5441.00
311_N315_E1.5391.00
121_E168_R1.5351.00
81_I251_W1.5191.00
133_T145_H1.5171.00
158_L192_E1.5151.00
126_A147_L1.5051.00
97_D258_K1.4971.00
227_A230_L1.4961.00
74_L284_H1.4921.00
159_D192_E1.4891.00
112_M136_V1.4751.00
314_W325_C1.4741.00
111_A205_F1.4651.00
313_A334_M1.4611.00
121_E166_T1.4581.00
305_R385_V1.4521.00
383_P387_D1.4521.00
354_D398_F1.4521.00
93_V253_V1.4501.00
123_L169_T1.4381.00
363_L377_F1.4351.00
55_L59_I1.4341.00
355_F358_Q1.4251.00
347_D350_K1.4221.00
149_D189_L1.4221.00
318_N327_K1.4181.00
104_V235_F1.4081.00
319_D396_A1.4021.00
305_R309_Q1.3981.00
189_L192_E1.3971.00
58_V62_L1.3951.00
118_S140_S1.3941.00
56_V59_I1.3941.00
238_L286_I1.3921.00
57_D60_R1.3851.00
171_G205_F1.3821.00
287_Q291_G1.3781.00
85_Y253_V1.3671.00
75_Y95_V1.3651.00
124_V143_A1.3631.00
316_L389_E1.3591.00
314_W334_M1.3441.00
385_V389_E1.3431.00
305_R308_E1.3411.00
351_M355_F1.3381.00
252_M264_Y1.3241.00
353_L357_L1.3241.00
313_A392_L1.3231.00
121_E169_T1.3221.00
197_A202_L1.3201.00
83_Q87_A1.3181.00
33_N360_K1.3121.00
158_L196_I1.3121.00
57_D288_T1.3021.00
147_L160_D1.2981.00
165_I196_I1.2971.00
195_E199_Q1.2911.00
76_S291_G1.2911.00
96_E258_K1.2911.00
162_R200_H1.2851.00
335_F366_G1.2811.00
337_K376_H1.2811.00
236_N251_W1.2741.00
337_K375_D1.2721.00
162_R166_T1.2671.00
94_T97_D1.2641.00
310_R314_W1.2601.00
196_I200_H1.2571.00
113_Q139_S1.2491.00
162_R196_I1.2421.00
195_E198_R1.2341.00
350_K354_D1.2291.00
299_F302_P1.2291.00
188_E191_M1.2271.00
347_D351_M1.2231.00
191_M226_L1.2161.00
117_N120_D1.2161.00
102_N106_E1.2141.00
196_I202_L1.2111.00
72_K78_R1.2091.00
60_R288_T1.2001.00
254_L257_P1.1941.00
149_D160_D1.1891.00
393_S397_R1.1791.00
288_T291_G1.1761.00
76_S284_H1.1761.00
304_G307_Y1.1671.00
387_D390_L1.1591.00
389_E393_S1.1571.00
336_P379_I1.1511.00
188_E192_E1.1491.00
310_R381_T1.1491.00
187_K225_P1.1361.00
107_L252_M1.1351.00
123_L146_Y1.1331.00
78_R82_M1.1331.00
216_D329_R1.1311.00
320_I393_S1.1211.00
304_G308_E1.1181.00
112_M116_L1.1141.00
187_K226_L1.1101.00
149_D157_D1.1051.00
112_M173_V1.1041.00
163_A167_P1.1031.00
52_D55_L1.0931.00
203_I233_I1.0921.00
284_H287_Q1.0861.00
81_I100_I1.0801.00
172_I202_L1.0751.00
349_Q367_T1.0651.00
312_R315_E1.0611.00
55_L63_P1.0591.00
309_Q312_R1.0551.00
116_L122_M1.0511.00
53_E56_V1.0501.00
354_D357_L1.0491.00
288_T292_G1.0491.00
53_E292_G1.0451.00
222_S225_P1.0441.00
76_S79_K1.0391.00
58_V285_A1.0351.00
355_F359_E1.0331.00
339_D375_D1.0311.00
263_G267_G1.0311.00
165_I202_L1.0311.00
298_E302_P1.0311.00
85_Y251_W1.0201.00
34_K360_K1.0201.00
166_T200_H1.0201.00
348_D351_M1.0151.00
77_A100_I1.0061.00
311_N327_K1.0061.00
351_M354_D1.0051.00
122_M171_G1.0031.00
293_Y298_E0.9971.00
136_V143_A0.9941.00
99_Y261_A0.9921.00
48_F305_R0.9911.00
323_V338_I0.9881.00
233_I252_M0.9791.00
254_L261_A0.9791.00
194_V232_T0.9791.00
166_T169_T0.9771.00
81_I98_I0.9761.00
215_Y307_Y0.9701.00
214_L220_H0.9631.00
301_T304_G0.9621.00
158_L162_R0.9601.00
146_Y164_K0.9571.00
315_E318_N0.9571.00
355_F398_F0.9571.00
203_I231_L0.9571.00
324_S339_D0.9501.00
258_K262_K0.9461.00
57_D61_N0.9411.00
82_M98_I0.9351.00
359_E398_F0.9261.00
34_K390_L0.9171.00
97_D261_A0.9171.00
254_L264_Y0.9161.00
98_I253_V0.9121.00
116_L171_G0.9121.00
82_M94_T0.9091.00
115_L171_G0.9081.00
137_S143_A0.9071.00
94_T258_K0.9051.00
159_D163_A0.9001.00
348_D367_T0.8921.00
83_Q86_Q0.8911.00
84_H88_R0.8871.00
204_I223_I0.8851.00
123_L164_K0.8841.00
338_I377_F0.8831.00
115_L203_I0.8811.00
107_L235_F0.8801.00
198_R231_L0.8791.00
74_L287_Q0.8771.00
84_H212_K0.8761.00
352_V355_F0.8741.00
55_L62_L0.8731.00
310_R328_P0.8681.00
235_F252_M0.8651.00
249_Q278_A0.8641.00
191_M229_D0.8561.00
102_N279_N0.8551.00
350_K353_L0.8531.00
128_D175_I0.8521.00
104_V237_G0.8521.00
394_K397_R0.8521.00
169_T202_L0.8511.00
125_P156_P0.8461.00
75_Y78_R0.8451.00
60_R64_T0.8441.00
91_R224_A0.8411.00
50_A54_I0.8411.00
32_G360_K0.8341.00
187_K219_E0.8321.00
61_N288_T0.8291.00
302_P305_R0.8281.00
134_A137_S0.8281.00
320_I392_L0.8271.00
221_H225_P0.8251.00
88_R212_K0.8251.00
308_E312_R0.8221.00
126_A372_P0.8221.00
223_I232_T0.8201.00
53_E288_T0.8201.00
87_A294_Q0.8181.00
348_D374_P0.8171.00
49_D55_L0.8171.00
158_L193_I0.8151.00
352_V377_F0.8111.00
223_I226_L0.8081.00
125_P146_Y0.8071.00
203_I260_H0.8061.00
349_Q353_L0.8061.00
148_C178_N0.8001.00
99_Y252_M0.7961.00
194_V204_I0.7961.00
74_L283_Q0.7961.00
249_Q282_A0.7941.00
313_A316_L0.7941.00
99_Y264_Y0.7941.00
347_D374_P0.7931.00
361_V395_F0.7931.00
159_D162_R0.7911.00
347_D352_V0.7901.00
34_K387_D0.7901.00
386_D389_E0.7891.00
144_V164_K0.7871.00
218_A329_R0.7871.00
105_S131_L0.7811.00
315_E389_E0.7801.00
106_E275_R0.7791.00
104_V209_I0.7771.00
363_L379_I0.7761.00
309_Q384_R0.7741.00
158_L189_L0.7731.00
300_I303_G0.7721.00
198_R228_P0.7711.00
313_A388_I0.7691.00
51_P54_I0.7651.00
78_R95_V0.7641.00
233_I260_H0.7631.00
298_E301_T0.7601.00
294_Q298_E0.7601.00
123_L161_I0.7571.00
311_N314_W0.7571.00
379_I391_S0.7551.00
224_A234_T0.7531.00
60_R63_P0.7521.00
313_A381_T0.7481.00
43_P306_L0.7461.00
308_E311_N0.7451.00
224_A230_L0.7431.00
114_A264_Y0.7411.00
259_K262_K0.7411.00
106_E110_Q0.7401.00
307_Y310_R0.7371.00
165_I169_T0.7361.00
367_T374_P0.7321.00
146_Y160_D0.7321.00
126_A370_N0.7291.00
110_Q264_Y0.7271.00
212_K241_T0.7271.00
221_H226_L0.7241.00
165_I200_H0.7231.00
155_F186_S0.7221.00
214_L217_D0.7191.00
121_E170_R0.7191.00
109_V274_M0.7151.00
393_S396_A0.7111.00
361_V394_K0.7091.00
49_D54_I0.7041.00
352_V363_L0.7041.00
335_F376_H0.7031.00
178_N181_T0.7031.00
114_A268_L0.7001.00
109_V139_S0.7001.00
206_A223_I0.6991.00
309_Q385_V0.6911.00
122_M141_G0.6821.00
259_K263_G0.6821.00
310_R327_K0.6811.00
349_Q365_Q0.6801.00
124_V136_V0.6781.00
155_F183_A0.6771.00
194_V230_L0.6771.00
149_D155_F0.6761.00
262_K266_E0.6741.00
226_L230_L0.6731.00
80_A290_L0.6721.00
323_V336_P0.6691.00
216_D307_Y0.6681.00
303_G307_Y0.6681.00
144_V169_T0.6661.00
284_H288_T0.6661.00
82_M93_V0.6651.00
317_I336_P0.6651.00
174_I190_L0.6651.00
208_E234_T0.6651.00
156_P189_L0.6651.00
280_V284_H0.6601.00
123_L172_I0.6591.00
185_Y189_L0.6581.00
132_W136_V0.6561.00
84_H242_Y0.6511.00
65_A284_H0.6501.00
38_L388_I0.6501.00
350_K367_T0.6491.00
97_D230_L0.6481.00
336_P376_H0.6451.00
238_L251_W0.6441.00
72_K266_E0.6431.00
59_I62_L0.6411.00
111_A264_Y0.6411.00
312_R392_L0.6401.00
161_I172_I0.6381.00
198_R227_A0.6371.00
84_H89_G0.6361.00
147_L164_K0.6361.00
211_D236_N0.6311.00
238_L290_L0.6291.00
224_A227_A0.6291.00
177_P330_G0.6281.00
192_E196_I0.6271.00
125_P178_N0.6251.00
56_V63_P0.6241.00
388_I391_S0.6231.00
163_A166_T0.6231.00
161_I196_I0.6221.00
79_K82_M0.6221.00
225_P229_D0.6211.00
225_P230_L0.6201.00
32_G35_V0.6191.00
262_K267_G0.6181.00
58_V281_P0.6171.00
116_L120_D0.6161.00
356_L395_F0.6141.00
109_V135_A0.6101.00
55_L58_V0.6101.00
35_V362_L0.6091.00
352_V356_L0.6081.00
346_H354_D0.6061.00
84_H293_Y0.6061.00
346_H351_M0.6051.00
190_L223_I0.6051.00
151_S155_F0.6031.00
348_D375_D0.6011.00
226_L229_D0.6001.00
53_E298_E0.5991.00
70_D75_Y0.5981.00
85_Y234_T0.5981.00
172_I197_A0.5971.00
100_I249_Q0.5971.00
53_E294_Q0.5961.00
197_A201_N0.5941.00
124_V145_H0.5921.00
144_V166_T0.5901.00
166_T199_Q0.5901.00
105_S129_Y0.5871.00
285_A288_T0.5861.00
176_N208_E0.5861.00
101_G252_M0.5851.00
325_C334_M0.5841.00
69_C74_L0.5811.00
119_G142_K0.5811.00
185_Y190_L0.5811.00
353_L365_Q0.5811.00
169_T172_I0.5791.00
36_L390_L0.5761.00
112_M171_G0.5741.00
77_A286_I0.5731.00
210_Y333_Y0.5731.00
319_D389_E0.5721.00
37_K42_N0.5721.00
89_G211_D0.5711.00
103_G248_R0.5701.00
361_V391_S0.5701.00
112_M141_G0.5691.00
241_T300_I0.5691.00
215_Y310_R0.5681.00
147_L157_D0.5671.00
112_M139_S0.5661.00
73_G78_R0.5651.00
322_G339_D0.5641.00
366_G369_F0.5631.00
183_A329_R0.5621.00
283_Q287_Q0.5621.00
254_L260_H0.5601.00
93_V97_D0.5581.00
112_M135_A0.5581.00
102_N278_A0.5571.00
384_R389_E0.5571.00
216_D310_R0.5541.00
74_L280_V0.5521.00
257_P260_H0.5511.00
76_S80_A0.5501.00
50_A53_E0.5491.00
107_L250_G0.5491.00
156_P161_I0.5491.00
69_C280_V0.5481.00
108_I135_A0.5471.00
64_T284_H0.5461.00
208_E222_S0.5461.00
77_A81_I0.5451.00
130_P368_A0.5441.00
176_N184_V0.5441.00
208_E211_D0.5421.00
309_Q388_I0.5401.00
390_L397_R0.5401.00
326_V337_K0.5391.00
312_R388_I0.5381.00
58_V61_N0.5381.00
356_L363_L0.5361.00
99_Y254_L0.5351.00
81_I238_L0.5301.00
313_A379_I0.5291.00
184_V214_L0.5281.00
164_K167_P0.5281.00
213_I306_L0.5271.00
197_A231_L0.5271.00
173_V205_F0.5261.00
120_D168_R0.5241.00
229_D232_T0.5231.00
366_G376_H0.5211.00
150_E337_K0.5191.00
394_K398_F0.5191.00
84_H211_D0.5191.00
357_L362_L0.5181.00
282_A285_A0.5181.00
111_A171_G0.5161.00
52_D63_P0.5161.00
39_N362_L0.5131.00
150_E324_S0.5121.00
371_W374_P0.5121.00
111_A235_F0.5121.00
54_I289_A0.5121.00
154_W376_H0.5111.00
370_N373_W0.5111.00
185_Y193_I0.5091.00
194_V198_R0.5091.00
79_K291_G0.5081.00
124_V133_T0.5071.00
171_G203_I0.5061.00
340_A346_H0.5051.00
223_I230_L0.5041.00
117_N170_R0.5031.00
61_N285_A0.5031.00
261_A264_Y0.5031.00
350_K365_Q0.5021.00
162_R165_I0.5011.00
146_Y156_P0.5011.00
194_V197_A0.5011.00
227_A231_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cvqA 2 0.9975 100 0.283 Contact Map
3dydA 2 0.9333 100 0.303 Contact Map
3piuA 2 0.9358 100 0.315 Contact Map
1xi9A 4 0.9654 100 0.318 Contact Map
3ihjA 2 0.9506 100 0.318 Contact Map
2x5dA 3 0.9284 100 0.32 Contact Map
3h14A 2 0.9111 100 0.322 Contact Map
3jtxA 2 0.9309 100 0.324 Contact Map
1bw0A 2 0.9654 100 0.324 Contact Map
3tcmA 2 0.9901 100 0.325 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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