GREMLIN Database
ALKH - KHG/KDPG aldolase
UniProt: P0A955 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10256
Length: 213 (199)
Sequences: 3749 (2679)
Seq/√Len: 189.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_A89_Q3.6901.00
196_D199_R2.9121.00
38_A201_T2.7971.00
98_E123_L2.6681.00
76_N79_Q2.5441.00
34_K63_E2.4091.00
55_D58_R2.3791.00
97_T126_D2.3411.00
33_A60_I2.2971.00
84_T109_I2.2781.00
201_T205_R2.1251.00
199_R202_K2.1041.00
54_V82_E2.0981.00
30_V63_E2.0321.00
58_R62_K2.0181.00
81_A103_A2.0001.00
35_A39_G1.9831.00
48_L54_V1.9171.00
170_R174_A1.8561.00
124_G132_F1.8501.00
121_L156_V1.8021.00
102_K127_Y1.8001.00
101_L111_L1.7781.00
116_S140_N1.7731.00
25_K28_H1.7721.00
81_A85_E1.7701.00
34_K38_A1.7401.00
74_V91_A1.7231.00
37_V67_A1.7161.00
93_S111_L1.7131.00
140_N145_A1.7081.00
145_A149_I1.6891.00
115_I121_L1.6791.00
57_I71_A1.6711.00
78_Q82_E1.6691.00
191_A199_R1.6661.00
199_R203_L1.6661.00
30_V59_A1.6541.00
125_M156_V1.6491.00
83_V88_A1.6181.00
95_G122_M1.6101.00
91_A104_A1.6051.00
105_T130_K1.6031.00
28_H195_G1.5891.00
117_T120_E1.5831.00
96_L101_L1.5751.00
115_I132_F1.5671.00
96_L127_Y1.5561.00
103_A107_G1.5451.00
104_A111_L1.5331.00
165_S168_N1.5301.00
39_G201_T1.5251.00
79_Q82_E1.5241.00
202_K206_E1.4981.00
70_G90_F1.4831.00
80_L91_A1.4681.00
99_P126_D1.4601.00
46_V60_I1.4451.00
26_L52_C1.4361.00
205_R209_E1.4091.00
125_M155_Q1.3921.00
34_K64_V1.3911.00
118_V149_I1.3871.00
121_L153_F1.3851.00
134_F158_F1.3491.00
99_P102_K1.3391.00
52_C55_D1.3381.00
146_L177_S1.3191.00
92_I112_I1.2941.00
21_I44_L1.2831.00
134_F140_N1.2651.00
98_E127_Y1.2521.00
18_V159_C1.2471.00
35_A201_T1.2451.00
103_A106_E1.2361.00
80_L103_A1.2261.00
139_A145_A1.2101.00
138_E148_A1.2051.00
57_I69_V1.2031.00
80_L100_L1.1941.00
37_V64_V1.1931.00
81_A107_G1.1811.00
96_L115_I1.1691.00
98_E102_K1.1601.00
138_E144_K1.1431.00
122_M153_F1.1371.00
59_A62_K1.1301.00
37_V42_R1.1291.00
55_D59_A1.1291.00
13_T157_R1.1111.00
138_E172_Y1.1111.00
48_L83_V1.1031.00
93_S113_P1.1031.00
198_D202_K1.0891.00
190_D194_A1.0871.00
33_A44_L1.0761.00
121_L149_I1.0701.00
10_S14_T1.0511.00
59_A63_E1.0451.00
68_I89_Q1.0381.00
75_L79_Q1.0341.00
15_G42_R1.0341.00
71_A83_V1.0331.00
116_S145_A1.0271.00
102_K106_E1.0181.00
137_A164_I1.0081.00
10_S13_T0.9990.99
84_T103_A0.9900.99
84_T107_G0.9890.99
202_K205_R0.9850.99
83_V91_A0.9830.99
185_W207_A0.9820.99
139_A148_A0.9690.99
77_P103_A0.9570.99
200_I204_A0.9550.99
15_G41_V0.9450.99
171_D174_A0.9450.99
30_V64_V0.9440.99
82_E85_E0.9430.99
166_P206_E0.9410.99
97_T122_M0.9390.99
169_Y180_C0.9280.99
33_A64_V0.9260.99
27_E59_A0.9240.99
75_L155_Q0.9210.99
24_K189_A0.9200.99
115_I124_G0.9190.99
54_V83_V0.9070.99
26_L56_A0.9060.99
160_P177_S0.9040.99
78_Q81_A0.8950.99
91_A109_I0.8890.99
191_A203_L0.8890.99
206_E209_E0.8870.99
134_F145_A0.8740.99
119_S123_L0.8740.99
123_L127_Y0.8690.99
20_V92_I0.8660.99
191_A196_D0.8650.99
80_L104_A0.8640.99
77_P99_P0.8580.98
23_V56_A0.8560.98
188_P191_A0.8560.98
58_R85_E0.8540.98
43_V68_I0.8500.98
159_C179_L0.8490.98
189_A193_E0.8440.98
111_L129_L0.8350.98
52_C56_A0.8340.98
96_L124_G0.8310.98
30_V34_K0.8240.98
101_L129_L0.8080.98
168_N171_D0.8050.98
116_S149_I0.7900.97
76_N126_D0.7870.97
197_Y200_I0.7860.97
61_A86_A0.7840.97
144_K148_A0.7770.97
15_G43_V0.7710.97
83_V86_A0.7700.97
20_V161_T0.7600.97
49_R154_S0.7530.96
96_L123_L0.7520.96
17_V41_V0.7490.96
11_I14_T0.7480.96
31_P34_K0.7460.96
77_P81_A0.7450.96
54_V86_A0.7440.96
204_A208_V0.7380.96
121_L158_F0.7360.96
165_S185_W0.7260.96
197_Y201_T0.7250.96
182_G207_A0.7230.96
71_A91_A0.7220.96
36_L187_V0.7200.95
26_L59_A0.7170.95
35_A197_Y0.7160.95
23_V49_R0.7130.95
50_T53_A0.7070.95
198_D201_T0.7060.95
41_V204_A0.7060.95
37_V66_E0.7050.95
56_A59_A0.7040.95
14_T68_I0.7040.95
64_V69_V0.7030.95
14_T42_R0.7010.95
30_V60_I0.6860.94
95_G100_L0.6850.94
146_L158_F0.6810.94
161_T181_I0.6810.94
143_V175_L0.6800.94
81_A84_T0.6770.94
144_K171_D0.6770.94
11_I68_I0.6770.94
129_L132_F0.6760.94
124_G127_Y0.6750.94
17_V207_A0.6640.93
29_A60_I0.6640.93
104_A109_I0.6610.93
192_L197_Y0.6560.93
28_H192_L0.6560.93
112_I131_E0.6550.93
43_V90_F0.6530.93
160_P178_V0.6520.92
165_S169_Y0.6480.92
101_L127_Y0.6480.92
134_F146_L0.6470.92
44_L67_A0.6470.92
16_P173_L0.6470.92
48_L79_Q0.6450.92
49_R161_T0.6440.92
91_A111_L0.6440.92
162_G183_G0.6420.92
12_L179_L0.6340.91
20_V47_T0.6330.91
30_V56_A0.6330.91
28_H31_P0.6290.91
195_G200_I0.6280.91
196_D202_K0.6280.91
41_V186_L0.6260.91
60_I69_V0.6250.91
153_F156_V0.6230.91
58_R61_A0.6230.91
102_K126_D0.6210.91
148_A161_T0.6210.91
61_A69_V0.6200.90
190_D199_R0.6190.90
150_A178_V0.6160.90
150_A158_F0.6140.90
38_A198_D0.6140.90
120_E153_F0.6130.90
21_I187_V0.6120.90
200_I203_L0.6060.89
161_T182_G0.6060.89
190_D193_E0.6050.89
48_L53_A0.6010.89
47_T151_G0.6000.89
31_P36_L0.5970.89
123_L126_D0.5970.89
46_V53_A0.5940.89
131_E179_L0.5920.88
97_T119_S0.5920.88
203_L206_E0.5910.88
192_L200_I0.5900.88
85_E107_G0.5900.88
164_I168_N0.5850.88
23_V28_H0.5840.88
28_H193_E0.5820.88
121_L132_F0.5810.87
96_L129_L0.5810.87
167_A171_D0.5770.87
144_K147_Q0.5700.86
142_G145_A0.5700.86
78_Q106_E0.5690.86
80_L109_I0.5630.86
17_V169_Y0.5630.86
137_A172_Y0.5610.86
191_A200_I0.5600.85
118_V153_F0.5590.85
29_A56_A0.5580.85
58_R86_A0.5560.85
167_A206_E0.5560.85
33_A69_V0.5540.85
42_R66_E0.5530.85
46_V57_I0.5500.84
20_V49_R0.5470.84
132_F156_V0.5430.84
169_Y173_L0.5420.84
73_T94_P0.5420.84
118_V145_A0.5410.83
57_I86_A0.5390.83
22_V189_A0.5370.83
93_S104_A0.5320.82
54_V58_R0.5310.82
92_I114_G0.5280.82
148_A160_P0.5270.82
153_F181_I0.5260.82
42_R208_V0.5250.82
46_V71_A0.5240.81
166_P169_Y0.5230.81
19_P41_V0.5230.81
37_V44_L0.5210.81
31_P195_G0.5200.81
116_S120_E0.5190.81
80_L107_G0.5170.81
139_A142_G0.5150.80
188_P192_L0.5130.80
26_L29_A0.5110.80
169_Y207_A0.5110.80
97_T100_L0.5100.80
36_L204_A0.5100.80
22_V176_K0.5100.80
115_I149_I0.5080.79
203_L207_A0.5070.79
93_S97_T0.5070.79
31_P38_A0.5030.79
47_T152_P0.5030.79
35_A204_A0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhcA 3 1 100 0.454 Contact Map
1wbhA 3 1 100 0.457 Contact Map
3vcrA 3 0.9812 100 0.467 Contact Map
1mxsA 3 1 100 0.473 Contact Map
2yw3A 4 0.939 100 0.486 Contact Map
4bk9A 3 0.9484 100 0.494 Contact Map
4e38A 3 0.9859 100 0.512 Contact Map
1wa3A 3 0.9437 100 0.54 Contact Map
2v82A 3 0.9343 100 0.594 Contact Map
4qccA 6 0.9202 100 0.599 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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