ALKH - ECOLI - GREMLIN Contacts

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ALKH - KHG/KDPG aldolase

UniProt:	P0A955	Sequences: MKNWKTSAESILTTGPVVPVIVVKKLEHAVPMAKALVAGGVRVLEVTLRTECAVDAIRAIAKEVPEAIVGAGTVLNPQQLAEVTEAGAQFAISPGLTEPLLKAATEGTIPLIPGISTVSELMLGMDYGLKEFKFFPAEANGGVKALQAIAGPFSQVRFCPTGGISPANYRDYLALKSVLCIGGSWLVPADALEAGDYDRITKLAREAVEGAKL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10256
Length:	213 (199)
Sequences:	3749 (2679)
Seq/√Len:	189.9

ECOLI - ALKH DGOA
BACSU - ALKH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
61_A	89_Q	3.690	1.00
196_D	199_R	2.912	1.00
38_A	201_T	2.797	1.00
98_E	123_L	2.668	1.00
76_N	79_Q	2.544	1.00
34_K	63_E	2.409	1.00
55_D	58_R	2.379	1.00
97_T	126_D	2.341	1.00
33_A	60_I	2.297	1.00
84_T	109_I	2.278	1.00
201_T	205_R	2.125	1.00
199_R	202_K	2.104	1.00
54_V	82_E	2.098	1.00
30_V	63_E	2.032	1.00
58_R	62_K	2.018	1.00
81_A	103_A	2.000	1.00
35_A	39_G	1.983	1.00
48_L	54_V	1.917	1.00
170_R	174_A	1.856	1.00
124_G	132_F	1.850	1.00
121_L	156_V	1.802	1.00
102_K	127_Y	1.800	1.00
101_L	111_L	1.778	1.00
116_S	140_N	1.773	1.00
25_K	28_H	1.772	1.00
81_A	85_E	1.770	1.00
34_K	38_A	1.740	1.00
74_V	91_A	1.723	1.00
37_V	67_A	1.716	1.00
93_S	111_L	1.713	1.00
140_N	145_A	1.708	1.00
145_A	149_I	1.689	1.00
115_I	121_L	1.679	1.00
57_I	71_A	1.671	1.00
78_Q	82_E	1.669	1.00
191_A	199_R	1.666	1.00
199_R	203_L	1.666	1.00
30_V	59_A	1.654	1.00
125_M	156_V	1.649	1.00
83_V	88_A	1.618	1.00
95_G	122_M	1.610	1.00
91_A	104_A	1.605	1.00
105_T	130_K	1.603	1.00
28_H	195_G	1.589	1.00
117_T	120_E	1.583	1.00
96_L	101_L	1.575	1.00
115_I	132_F	1.567	1.00
96_L	127_Y	1.556	1.00
103_A	107_G	1.545	1.00
104_A	111_L	1.533	1.00
165_S	168_N	1.530	1.00
39_G	201_T	1.525	1.00
79_Q	82_E	1.524	1.00
202_K	206_E	1.498	1.00
70_G	90_F	1.483	1.00
80_L	91_A	1.468	1.00
99_P	126_D	1.460	1.00
46_V	60_I	1.445	1.00
26_L	52_C	1.436	1.00
205_R	209_E	1.409	1.00
125_M	155_Q	1.392	1.00
34_K	64_V	1.391	1.00
118_V	149_I	1.387	1.00
121_L	153_F	1.385	1.00
134_F	158_F	1.349	1.00
99_P	102_K	1.339	1.00
52_C	55_D	1.338	1.00
146_L	177_S	1.319	1.00
92_I	112_I	1.294	1.00
21_I	44_L	1.283	1.00
134_F	140_N	1.265	1.00
98_E	127_Y	1.252	1.00
18_V	159_C	1.247	1.00
35_A	201_T	1.245	1.00
103_A	106_E	1.236	1.00
80_L	103_A	1.226	1.00
139_A	145_A	1.210	1.00
138_E	148_A	1.205	1.00
57_I	69_V	1.203	1.00
80_L	100_L	1.194	1.00
37_V	64_V	1.193	1.00
81_A	107_G	1.181	1.00
96_L	115_I	1.169	1.00
98_E	102_K	1.160	1.00
138_E	144_K	1.143	1.00
122_M	153_F	1.137	1.00
59_A	62_K	1.130	1.00
37_V	42_R	1.129	1.00
55_D	59_A	1.129	1.00
13_T	157_R	1.111	1.00
138_E	172_Y	1.111	1.00
48_L	83_V	1.103	1.00
93_S	113_P	1.103	1.00
198_D	202_K	1.089	1.00
190_D	194_A	1.087	1.00
33_A	44_L	1.076	1.00
121_L	149_I	1.070	1.00
10_S	14_T	1.051	1.00
59_A	63_E	1.045	1.00
68_I	89_Q	1.038	1.00
75_L	79_Q	1.034	1.00
15_G	42_R	1.034	1.00
71_A	83_V	1.033	1.00
116_S	145_A	1.027	1.00
102_K	106_E	1.018	1.00
137_A	164_I	1.008	1.00
10_S	13_T	0.999	0.99
84_T	103_A	0.990	0.99
84_T	107_G	0.989	0.99
202_K	205_R	0.985	0.99
83_V	91_A	0.983	0.99
185_W	207_A	0.982	0.99
139_A	148_A	0.969	0.99
77_P	103_A	0.957	0.99
200_I	204_A	0.955	0.99
15_G	41_V	0.945	0.99
171_D	174_A	0.945	0.99
30_V	64_V	0.944	0.99
82_E	85_E	0.943	0.99
166_P	206_E	0.941	0.99
97_T	122_M	0.939	0.99
169_Y	180_C	0.928	0.99
33_A	64_V	0.926	0.99
27_E	59_A	0.924	0.99
75_L	155_Q	0.921	0.99
24_K	189_A	0.920	0.99
115_I	124_G	0.919	0.99
54_V	83_V	0.907	0.99
26_L	56_A	0.906	0.99
160_P	177_S	0.904	0.99
78_Q	81_A	0.895	0.99
91_A	109_I	0.889	0.99
191_A	203_L	0.889	0.99
206_E	209_E	0.887	0.99
134_F	145_A	0.874	0.99
119_S	123_L	0.874	0.99
123_L	127_Y	0.869	0.99
20_V	92_I	0.866	0.99
191_A	196_D	0.865	0.99
80_L	104_A	0.864	0.99
77_P	99_P	0.858	0.98
23_V	56_A	0.856	0.98
188_P	191_A	0.856	0.98
58_R	85_E	0.854	0.98
43_V	68_I	0.850	0.98
159_C	179_L	0.849	0.98
189_A	193_E	0.844	0.98
111_L	129_L	0.835	0.98
52_C	56_A	0.834	0.98
96_L	124_G	0.831	0.98
30_V	34_K	0.824	0.98
101_L	129_L	0.808	0.98
168_N	171_D	0.805	0.98
116_S	149_I	0.790	0.97
76_N	126_D	0.787	0.97
197_Y	200_I	0.786	0.97
61_A	86_A	0.784	0.97
144_K	148_A	0.777	0.97
15_G	43_V	0.771	0.97
83_V	86_A	0.770	0.97
20_V	161_T	0.760	0.97
49_R	154_S	0.753	0.96
96_L	123_L	0.752	0.96
17_V	41_V	0.749	0.96
11_I	14_T	0.748	0.96
31_P	34_K	0.746	0.96
77_P	81_A	0.745	0.96
54_V	86_A	0.744	0.96
204_A	208_V	0.738	0.96
121_L	158_F	0.736	0.96
165_S	185_W	0.726	0.96
197_Y	201_T	0.725	0.96
182_G	207_A	0.723	0.96
71_A	91_A	0.722	0.96
36_L	187_V	0.720	0.95
26_L	59_A	0.717	0.95
35_A	197_Y	0.716	0.95
23_V	49_R	0.713	0.95
50_T	53_A	0.707	0.95
198_D	201_T	0.706	0.95
41_V	204_A	0.706	0.95
37_V	66_E	0.705	0.95
56_A	59_A	0.704	0.95
14_T	68_I	0.704	0.95
64_V	69_V	0.703	0.95
14_T	42_R	0.701	0.95
30_V	60_I	0.686	0.94
95_G	100_L	0.685	0.94
146_L	158_F	0.681	0.94
161_T	181_I	0.681	0.94
143_V	175_L	0.680	0.94
81_A	84_T	0.677	0.94
144_K	171_D	0.677	0.94
11_I	68_I	0.677	0.94
129_L	132_F	0.676	0.94
124_G	127_Y	0.675	0.94
17_V	207_A	0.664	0.93
29_A	60_I	0.664	0.93
104_A	109_I	0.661	0.93
192_L	197_Y	0.656	0.93
28_H	192_L	0.656	0.93
112_I	131_E	0.655	0.93
43_V	90_F	0.653	0.93
160_P	178_V	0.652	0.92
165_S	169_Y	0.648	0.92
101_L	127_Y	0.648	0.92
134_F	146_L	0.647	0.92
44_L	67_A	0.647	0.92
16_P	173_L	0.647	0.92
48_L	79_Q	0.645	0.92
49_R	161_T	0.644	0.92
91_A	111_L	0.644	0.92
162_G	183_G	0.642	0.92
12_L	179_L	0.634	0.91
20_V	47_T	0.633	0.91
30_V	56_A	0.633	0.91
28_H	31_P	0.629	0.91
195_G	200_I	0.628	0.91
196_D	202_K	0.628	0.91
41_V	186_L	0.626	0.91
60_I	69_V	0.625	0.91
153_F	156_V	0.623	0.91
58_R	61_A	0.623	0.91
102_K	126_D	0.621	0.91
148_A	161_T	0.621	0.91
61_A	69_V	0.620	0.90
190_D	199_R	0.619	0.90
150_A	178_V	0.616	0.90
150_A	158_F	0.614	0.90
38_A	198_D	0.614	0.90
120_E	153_F	0.613	0.90
21_I	187_V	0.612	0.90
200_I	203_L	0.606	0.89
161_T	182_G	0.606	0.89
190_D	193_E	0.605	0.89
48_L	53_A	0.601	0.89
47_T	151_G	0.600	0.89
31_P	36_L	0.597	0.89
123_L	126_D	0.597	0.89
46_V	53_A	0.594	0.89
131_E	179_L	0.592	0.88
97_T	119_S	0.592	0.88
203_L	206_E	0.591	0.88
192_L	200_I	0.590	0.88
85_E	107_G	0.590	0.88
164_I	168_N	0.585	0.88
23_V	28_H	0.584	0.88
28_H	193_E	0.582	0.88
121_L	132_F	0.581	0.87
96_L	129_L	0.581	0.87
167_A	171_D	0.577	0.87
144_K	147_Q	0.570	0.86
142_G	145_A	0.570	0.86
78_Q	106_E	0.569	0.86
80_L	109_I	0.563	0.86
17_V	169_Y	0.563	0.86
137_A	172_Y	0.561	0.86
191_A	200_I	0.560	0.85
118_V	153_F	0.559	0.85
29_A	56_A	0.558	0.85
58_R	86_A	0.556	0.85
167_A	206_E	0.556	0.85
33_A	69_V	0.554	0.85
42_R	66_E	0.553	0.85
46_V	57_I	0.550	0.84
20_V	49_R	0.547	0.84
132_F	156_V	0.543	0.84
169_Y	173_L	0.542	0.84
73_T	94_P	0.542	0.84
118_V	145_A	0.541	0.83
57_I	86_A	0.539	0.83
22_V	189_A	0.537	0.83
93_S	104_A	0.532	0.82
54_V	58_R	0.531	0.82
92_I	114_G	0.528	0.82
148_A	160_P	0.527	0.82
153_F	181_I	0.526	0.82
42_R	208_V	0.525	0.82
46_V	71_A	0.524	0.81
166_P	169_Y	0.523	0.81
19_P	41_V	0.523	0.81
37_V	44_L	0.521	0.81
31_P	195_G	0.520	0.81
116_S	120_E	0.519	0.81
80_L	107_G	0.517	0.81
139_A	142_G	0.515	0.80
188_P	192_L	0.513	0.80
26_L	29_A	0.511	0.80
169_Y	207_A	0.511	0.80
97_T	100_L	0.510	0.80
36_L	204_A	0.510	0.80
22_V	176_K	0.510	0.80
115_I	149_I	0.508	0.79
203_L	207_A	0.507	0.79
93_S	97_T	0.507	0.79
31_P	38_A	0.503	0.79
47_T	152_P	0.503	0.79
35_A	204_A	0.500	0.78

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vhcA	3	1	100	0.454	Contact Map
1wbhA	3	1	100	0.457	Contact Map
3vcrA	3	0.9812	100	0.467	Contact Map
1mxsA	3	1	100	0.473	Contact Map
2yw3A	4	0.939	100	0.486	Contact Map
4bk9A	3	0.9484	100	0.494	Contact Map
4e38A	3	0.9859	100	0.512	Contact Map
1wa3A	3	0.9437	100	0.54	Contact Map
2v82A	3	0.9343	100	0.594	Contact Map
4qccA	6	0.9202	100	0.599	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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