GREMLIN Database
FABB - 3-oxoacyl-[acyl-carrier-protein] synthase 1
UniProt: P0A953 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10274
Length: 406 (386)
Sequences: 20947 (13517)
Seq/√Len: 688.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
278_V315_E3.2271.00
258_V402_R3.0821.00
18_N21_E2.8881.00
346_S385_V2.8611.00
98_R183_D2.7561.00
171_G260_Y2.7301.00
24_A28_E2.6831.00
255_A347_L2.6801.00
224_A363_E2.6571.00
224_A366_E2.5791.00
384_T402_R2.5691.00
354_F377_T2.5011.00
254_Y351_E2.3651.00
82_A239_V2.2701.00
85_D254_Y2.2691.00
222_Y297_S2.2501.00
242_E245_H2.2451.00
27_R354_F2.2421.00
25_S32_G2.2001.00
78_S235_G2.1541.00
177_I242_E2.1521.00
221_T329_A2.1091.00
25_S30_R2.0921.00
349_M356_A2.0911.00
291_P384_T2.0741.00
343_A401_M2.0551.00
102_I176_Q2.0441.00
170_I343_A2.0441.00
3_R258_V2.0101.00
278_V282_K1.9891.00
241_E251_A1.9691.00
354_F379_D1.9491.00
357_P377_T1.9451.00
175_E179_L1.9391.00
225_H363_E1.9311.00
371_L378_T1.9191.00
105_S142_V1.9021.00
323_A378_T1.8971.00
241_E249_R1.8351.00
80_E84_A1.8201.00
100_G185_V1.8171.00
216_E227_D1.8161.00
79_M146_L1.8151.00
372_N378_T1.8091.00
383_T403_K1.7911.00
60_I68_M1.7811.00
33_I50_G1.7601.00
79_M186_F1.7591.00
13_S341_Q1.7481.00
288_V384_T1.7381.00
243_L247_L1.7301.00
103_A237_M1.7201.00
98_R283_M1.7191.00
6_I343_A1.7031.00
245_H248_A1.7001.00
236_G340_V1.6921.00
355_I374_V1.6911.00
35_F48_V1.6911.00
17_N21_E1.6871.00
348_L351_E1.6751.00
348_L352_H1.6651.00
225_H362_E1.6631.00
35_F47_H1.6521.00
182_Q185_V1.6491.00
174_V257_I1.6371.00
188_G237_M1.6261.00
34_T53_K1.6101.00
278_V316_V1.5981.00
6_I347_L1.5941.00
31_S218_A1.5931.00
174_V178_Q1.5921.00
22_V327_T1.5891.00
343_A387_S1.5861.00
232_A334_S1.5811.00
252_H351_E1.5671.00
104_G165_T1.5651.00
238_V343_A1.5621.00
10_G78_S1.5601.00
186_F239_V1.5461.00
89_S92_A1.5341.00
176_Q182_Q1.5311.00
55_D58_G1.5271.00
263_T396_N1.5261.00
147_A156_N1.5251.00
327_T341_Q1.5211.00
75_A146_L1.5151.00
295_L313_I1.5121.00
323_A372_N1.5111.00
78_S237_M1.5071.00
258_V384_T1.4981.00
223_D361_I1.4881.00
75_A103_A1.4771.00
168_H397_A1.4731.00
175_E181_K1.4691.00
161_S164_A1.4601.00
236_G344_I1.4521.00
70_D74_Y1.4491.00
22_V345_Y1.4481.00
27_R377_T1.4391.00
9_L19_Q1.4351.00
99_V184_I1.4221.00
85_D252_H1.4221.00
94_Q151_K1.4111.00
45_R202_D1.4081.00
80_E149_P1.4061.00
260_Y399_L1.4041.00
294_Y355_I1.3941.00
184_I239_V1.3931.00
329_A359_I1.3821.00
292_I384_T1.3751.00
353_G383_T1.3741.00
216_E220_R1.3731.00
157_Y172_N1.3711.00
234_G334_S1.3711.00
314_R369_A1.3711.00
75_A237_M1.3711.00
100_G182_Q1.3661.00
153_H279_R1.3611.00
323_A374_V1.3551.00
279_R283_M1.3361.00
3_R256_E1.3351.00
220_R225_H1.3321.00
168_H395_T1.3321.00
386_M400_V1.3211.00
323_A355_I1.3111.00
176_Q181_K1.3021.00
100_G155_V1.2961.00
223_D363_E1.2941.00
24_A30_R1.2931.00
4_A240_V1.2921.00
75_A142_V1.2911.00
21_E24_A1.2881.00
358_S361_I1.2881.00
310_L324_I1.2801.00
175_E178_Q1.2761.00
144_A393_G1.2721.00
263_T280_C1.2691.00
238_V340_V1.2691.00
223_D362_E1.2681.00
143_S158_S1.2661.00
15_I32_G1.2621.00
254_Y347_L1.2611.00
386_M398_T1.2611.00
361_I364_L1.2601.00
4_A174_V1.2571.00
294_Y325_S1.2531.00
329_A358_S1.2501.00
9_L344_I1.2381.00
355_I380_R1.2361.00
353_G403_K1.2311.00
380_R383_T1.2221.00
388_N398_T1.2221.00
24_A27_R1.2221.00
350_L401_M1.2221.00
208_S227_D1.2211.00
261_G280_C1.2201.00
280_C284_A1.2091.00
282_K286_H1.1981.00
183_D245_H1.1931.00
37_Q40_K1.1881.00
261_G284_A1.1851.00
238_V344_I1.1771.00
11_I19_Q1.1691.00
103_A188_G1.1671.00
331_T341_Q1.1601.00
220_R227_D1.1501.00
365_D368_A1.1501.00
13_S236_G1.1441.00
168_H262_A1.1441.00
294_Y346_S1.1421.00
334_S341_Q1.1401.00
215_P227_D1.1391.00
79_M237_M1.1361.00
8_G85_D1.1221.00
170_I240_V1.1201.00
361_I373_I1.1201.00
243_L256_E1.1061.00
313_I324_I1.1041.00
156_N264_S1.1031.00
26_L345_Y1.1011.00
189_G340_V1.0981.00
293_D383_T1.0981.00
82_A237_M1.0971.00
327_T331_T1.0911.00
310_L368_A1.0911.00
3_R243_L1.0861.00
9_L254_Y1.0861.00
167_A397_A1.0831.00
291_P381_E1.0821.00
20_Q85_D1.0801.00
23_L352_H1.0781.00
288_V291_P1.0751.00
11_I344_I1.0741.00
330_M359_I1.0621.00
33_I48_V1.0621.00
346_S350_L1.0601.00
31_S360_N1.0591.00
281_M316_V1.0581.00
293_D380_R1.0551.00
50_G232_A1.0541.00
285_M292_I1.0511.00
173_A187_A1.0481.00
80_E150_F1.0441.00
11_I22_V1.0411.00
147_A264_S1.0361.00
374_V378_T1.0331.00
37_Q51_N1.0331.00
311_A315_E1.0271.00
58_G80_E1.0271.00
82_A186_F1.0231.00
362_E375_T1.0231.00
290_T320_K1.0171.00
159_I172_N1.0101.00
170_I399_L1.0031.00
317_F386_M0.9991.00
7_T241_E0.9961.00
83_I150_F0.9951.00
78_S81_Q0.9951.00
217_K362_E0.9891.00
167_A399_L0.9761.00
281_M386_M0.9751.00
102_I185_V0.9751.00
346_S387_S0.9741.00
10_G82_A0.9731.00
303_P367_Q0.9681.00
244_E247_L0.9651.00
293_D381_E0.9651.00
183_D242_E0.9621.00
170_I187_A0.9611.00
99_V152_I0.9601.00
177_I240_V0.9561.00
23_L356_A0.9541.00
171_G181_K0.9511.00
361_I375_T0.9511.00
17_N53_K0.9501.00
9_L347_L0.9431.00
231_I335_L0.9431.00
256_E402_R0.9431.00
281_M388_N0.9411.00
307_V311_A0.9371.00
350_L353_G0.9361.00
285_M317_F0.9361.00
36_S41_D0.9311.00
283_M286_H0.9291.00
172_N175_E0.9211.00
347_L401_M0.9151.00
353_G381_E0.9151.00
246_A253_I0.9131.00
27_R352_H0.9081.00
44_M202_D0.9071.00
20_Q24_A0.9051.00
234_G341_Q0.9031.00
342_E387_S0.8991.00
296_N342_E0.8991.00
173_A185_V0.8971.00
16_G25_S0.8971.00
13_S344_I0.8961.00
141_G269_M0.8921.00
5_V243_L0.8911.00
5_V256_E0.8901.00
166_S340_V0.8901.00
74_Y235_G0.8891.00
174_V260_Y0.8851.00
171_G175_E0.8821.00
297_S324_I0.8811.00
83_I186_F0.8791.00
292_I317_F0.8781.00
52_V74_Y0.8781.00
274_G311_A0.8741.00
285_M288_V0.8731.00
75_A188_G0.8711.00
29_G357_P0.8691.00
166_S189_G0.8671.00
23_L27_R0.8641.00
161_S168_H0.8581.00
271_A304_V0.8561.00
295_L386_M0.8561.00
284_A400_V0.8521.00
299_G305_G0.8521.00
364_L373_I0.8511.00
10_G81_Q0.8511.00
108_G139_A0.8501.00
29_G376_E0.8421.00
372_N375_T0.8401.00
101_L152_I0.8401.00
299_G326_A0.8381.00
350_L382_L0.8321.00
153_H275_E0.8321.00
9_L85_D0.8311.00
263_T279_R0.8311.00
275_E278_V0.8301.00
3_R244_E0.8301.00
292_I400_V0.8301.00
167_A339_G0.8271.00
31_S359_I0.8261.00
22_V331_T0.8251.00
12_V81_Q0.8241.00
242_E247_L0.8241.00
18_N81_Q0.8221.00
32_G50_G0.8221.00
208_S220_R0.8201.00
61_D64_V0.8171.00
134_V200_E0.8161.00
310_L372_N0.8151.00
23_L348_L0.8141.00
9_L348_L0.8101.00
288_V400_V0.8081.00
245_H249_R0.8061.00
184_I187_A0.8021.00
12_V77_L0.8011.00
105_S139_A0.7981.00
144_A156_N0.7971.00
326_A358_S0.7961.00
54_L77_L0.7961.00
346_S349_M0.7961.00
16_G32_G0.7951.00
282_K316_V0.7941.00
281_M312_A0.7931.00
243_L253_I0.7911.00
275_E279_R0.7901.00
277_A390_F0.7901.00
279_R282_K0.7871.00
282_K315_E0.7831.00
76_F149_P0.7821.00
33_I230_V0.7821.00
334_S337_A0.7801.00
347_L350_L0.7791.00
186_F237_M0.7781.00
20_Q352_H0.7761.00
258_V288_V0.7761.00
15_I25_S0.7751.00
106_G336_G0.7721.00
310_L314_R0.7711.00
41_D47_H0.7701.00
318_G321_S0.7691.00
79_M82_A0.7681.00
83_I239_V0.7661.00
293_D384_T0.7621.00
155_V182_Q0.7611.00
102_I182_Q0.7581.00
298_H302_T0.7561.00
170_I340_V0.7521.00
5_V253_I0.7511.00
184_I245_H0.7511.00
17_N25_S0.7481.00
86_A239_V0.7471.00
296_N345_Y0.7461.00
97_P183_D0.7451.00
21_E25_S0.7431.00
285_M400_V0.7391.00
281_M285_M0.7351.00
263_T283_M0.7311.00
167_A387_S0.7241.00
34_T51_N0.7241.00
190_G235_G0.7241.00
381_E403_K0.7221.00
187_A240_V0.7211.00
281_M313_I0.7211.00
46_S202_D0.7181.00
262_A397_A0.7181.00
302_T305_G0.7181.00
371_L375_T0.7181.00
282_K319_D0.7161.00
69_S112_F0.7151.00
105_S158_S0.7151.00
206_A229_F0.7121.00
79_M150_F0.7121.00
25_S28_E0.7121.00
19_Q348_L0.7111.00
3_R178_Q0.7101.00
374_V377_T0.7081.00
170_I238_V0.7061.00
314_R370_G0.7051.00
102_I157_Y0.7051.00
358_S373_I0.7011.00
12_V78_S0.7011.00
97_P153_H0.7011.00
294_Y385_V0.6951.00
36_S51_N0.6941.00
70_D73_I0.6941.00
314_R318_G0.6911.00
255_A401_M0.6911.00
170_I257_I0.6881.00
274_G278_V0.6851.00
83_I93_Y0.6851.00
350_L403_K0.6831.00
4_A242_E0.6821.00
307_V367_Q0.6821.00
101_L146_L0.6811.00
280_C398_T0.6801.00
259_G284_A0.6791.00
129_V199_C0.6781.00
355_I382_L0.6771.00
45_R205_G0.6771.00
71_A190_G0.6731.00
310_L369_A0.6711.00
140_S162_A0.6711.00
152_I186_F0.6711.00
38_E70_D0.6711.00
304_V308_K0.6701.00
36_S39_L0.6671.00
257_I399_L0.6661.00
167_A389_S0.6661.00
274_G312_A0.6661.00
293_D382_L0.6661.00
247_L253_I0.6661.00
14_S334_S0.6651.00
201_F206_A0.6651.00
199_C202_D0.6641.00
106_G109_S0.6641.00
347_L351_E0.6631.00
327_T345_Y0.6611.00
22_V341_Q0.6611.00
219_S229_F0.6571.00
49_W52_V0.6561.00
138_M141_G0.6561.00
15_I34_T0.6551.00
313_I371_L0.6541.00
184_I241_E0.6531.00
109_S113_Q0.6501.00
72_S141_G0.6491.00
244_E248_A0.6471.00
353_G379_D0.6471.00
83_I152_I0.6461.00
37_Q41_D0.6451.00
19_Q85_D0.6421.00
226_R365_D0.6421.00
96_N151_K0.6401.00
8_G82_A0.6401.00
81_Q85_D0.6391.00
311_A367_Q0.6391.00
355_I378_T0.6381.00
229_F335_L0.6371.00
191_E335_L0.6371.00
263_T276_G0.6341.00
323_A380_R0.6321.00
26_L348_L0.6311.00
220_R362_E0.6311.00
201_F392_F0.6301.00
349_M380_R0.6281.00
141_G392_F0.6271.00
77_L81_Q0.6271.00
370_G373_I0.6251.00
369_A372_N0.6241.00
42_S45_R0.6241.00
48_V218_A0.6241.00
187_A238_V0.6231.00
75_A79_M0.6221.00
237_M340_V0.6191.00
157_Y161_S0.6171.00
187_A340_V0.6151.00
274_G308_K0.6131.00
176_Q185_V0.6131.00
262_A395_T0.6121.00
331_T334_S0.6121.00
72_S142_V0.6101.00
19_Q22_V0.6091.00
98_R279_R0.6081.00
6_I401_M0.6041.00
380_R385_V0.6031.00
100_G176_Q0.6021.00
220_R360_N0.6001.00
241_E245_H0.6001.00
54_L59_L0.5991.00
22_V26_L0.5961.00
90_P93_Y0.5961.00
172_N176_Q0.5951.00
275_E315_E0.5951.00
4_A177_I0.5941.00
93_Y99_V0.5941.00
153_H276_G0.5941.00
36_S49_W0.5941.00
296_N346_S0.5941.00
278_V312_A0.5931.00
285_M398_T0.5891.00
14_S50_G0.5881.00
103_A143_S0.5881.00
382_L402_R0.5881.00
206_A392_F0.5861.00
96_N153_H0.5841.00
7_T184_I0.5841.00
16_G53_K0.5821.00
208_S216_E0.5821.00
35_F41_D0.5821.00
350_L385_V0.5811.00
310_L371_L0.5801.00
68_M145_C0.5801.00
15_I22_V0.5781.00
288_V292_I0.5781.00
82_A86_A0.5781.00
7_T251_A0.5781.00
324_I371_L0.5771.00
81_Q84_A0.5771.00
102_I172_N0.5751.00
236_G337_A0.5731.00
162_A392_F0.5731.00
297_S326_A0.5721.00
177_I245_H0.5721.00
370_G375_T0.5701.00
219_S301_S0.5701.00
323_A373_I0.5631.00
323_A371_L0.5611.00
371_L374_V0.5611.00
19_Q344_I0.5601.00
71_A142_V0.5591.00
274_G315_E0.5591.00
257_I401_M0.5581.00
325_S356_A0.5561.00
297_S313_I0.5551.00
343_A347_L0.5541.00
93_Y97_P0.5521.00
349_M385_V0.5511.00
60_I77_L0.5491.00
173_A240_V0.5451.00
277_A312_A0.5441.00
216_E230_V0.5411.00
88_L184_I0.5401.00
88_L239_V0.5401.00
312_A316_V0.5391.00
38_E51_N0.5391.00
165_T169_C0.5381.00
221_T229_F0.5371.00
273_S276_G0.5371.00
91_E94_Q0.5331.00
319_D370_G0.5331.00
168_H172_N0.5331.00
171_G262_A0.5321.00
131_P200_E0.5311.00
219_S230_V0.5311.00
12_V74_Y0.5291.00
294_Y349_M0.5271.00
16_G21_E0.5271.00
60_I65_V0.5271.00
176_Q179_L0.5261.00
43_G199_C0.5261.00
225_H361_I0.5251.00
382_L403_K0.5241.00
105_S108_G0.5241.00
180_G242_E0.5221.00
59_L77_L0.5221.00
340_V344_I0.5221.00
322_P369_A0.5221.00
330_M357_P0.5211.00
325_S355_I0.5201.00
346_S401_M0.5201.00
88_L251_A0.5201.00
143_S156_N0.5190.99
305_G308_K0.5180.99
8_G254_Y0.5180.99
342_E346_S0.5180.99
13_S334_S0.5150.99
88_L241_E0.5150.99
58_G84_A0.5140.99
387_S399_L0.5140.99
155_V176_Q0.5130.99
291_P383_T0.5130.99
223_D360_N0.5120.99
342_E389_S0.5120.99
289_D320_K0.5110.99
285_M316_V0.5100.99
88_L92_A0.5090.99
72_S145_C0.5080.99
74_Y192_E0.5080.99
64_V149_P0.5070.99
222_Y299_G0.5060.99
338_A389_S0.5060.99
90_P94_Q0.5060.99
48_V51_N0.5060.99
246_A251_A0.5050.99
106_G139_A0.5040.99
13_S22_V0.5040.99
93_Y96_N0.5030.99
187_A237_M0.5030.99
126_L129_V0.5020.99
11_I341_Q0.5020.99
13_S16_G0.5010.99
344_I348_L0.5010.99
268_D273_S0.5000.99
15_I30_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vz8A 2 0.9507 100 0.08 Contact Map
3mqdA 2 0.9926 100 0.151 Contact Map
4na1A 2 0.9631 100 0.151 Contact Map
4qyrA 2 0.9606 100 0.164 Contact Map
4oqjA 2 0.9729 100 0.172 Contact Map
4tktA 1 0.9631 100 0.172 Contact Map
2vbaA 2 1 100 0.173 Contact Map
2hg4A 2 0.9631 100 0.175 Contact Map
4wkyA 2 0.9729 100 0.176 Contact Map
4mz0A 2 0.9606 100 0.176 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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