GREMLIN Database
ATDA - Spermidine N(1)-acetyltransferase
UniProt: P0A951 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12447
Length: 186 (164)
Sequences: 19550 (15102)
Seq/√Len: 1179.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_L135_Y2.8871.00
101_T137_K2.7901.00
10_R63_E2.5701.00
10_R16_D2.4761.00
143_E163_C2.4101.00
28_S92_P2.2831.00
84_A117_L2.2691.00
74_L111_G2.1931.00
6_S102_R2.1801.00
142_V145_E2.1661.00
142_V160_I2.1431.00
124_V132_I2.1381.00
124_V135_Y2.0121.00
133_H136_R2.0011.00
4_A106_L2.0001.00
132_I136_R1.9351.00
109_D113_T1.8841.00
4_A102_R1.8251.00
26_N92_P1.8021.00
86_F104_A1.7771.00
108_M140_F1.7701.00
108_M120_L1.7261.00
61_V68_K1.7251.00
12_L61_V1.7121.00
118_Y148_H1.6991.00
145_E160_I1.6791.00
18_R41_F1.6551.00
132_I142_V1.6411.00
19_Y68_K1.6301.00
91_S94_Y1.6241.00
41_F45_S1.5961.00
104_A138_L1.5811.00
126_K158_N1.5761.00
14_R49_D1.5701.00
132_I160_I1.5621.00
151_F156_Y1.5511.00
72_V103_A1.5481.00
106_L109_D1.5161.00
136_R142_V1.5151.00
17_L45_S1.5091.00
40_A43_E1.4841.00
90_I100_A1.4761.00
63_E66_G1.4271.00
129_E132_I1.3831.00
119_K163_C1.3811.00
64_C69_A1.3471.00
88_I135_Y1.3391.00
62_V103_A1.3221.00
118_Y156_Y1.3111.00
132_I162_M1.3041.00
101_T134_I1.2991.00
19_Y67_E1.2951.00
110_Y114_V1.2851.00
72_V107_A1.2721.00
8_K63_E1.2671.00
69_A94_Y1.2631.00
111_G120_L1.2621.00
149_E159_A1.2531.00
126_K145_E1.2511.00
3_S8_K1.2381.00
62_V90_I1.2301.00
146_L161_R1.2291.00
127_E157_R1.1841.00
64_C99_L1.1761.00
88_I131_A1.1661.00
67_E93_E1.1471.00
71_L89_I1.1401.00
100_A134_I1.1341.00
23_L89_I1.1121.00
85_E123_I1.1121.00
111_G115_L1.1101.00
23_L91_S1.1011.00
131_A135_Y1.0981.00
124_V162_M1.0981.00
95_Q130_K1.0971.00
4_A7_V1.0921.00
110_Y115_L1.0821.00
92_P95_Q1.0681.00
17_L48_Y1.0681.00
67_E94_Y1.0651.00
145_E158_N1.0611.00
45_S49_D1.0561.00
21_H41_F1.0501.00
39_E43_E1.0401.00
119_K143_E1.0331.00
19_Y22_Q1.0321.00
28_S31_R1.0291.00
142_V162_M1.0281.00
118_Y166_Q1.0241.00
108_M164_I1.0111.00
83_R121_Y1.0101.00
46_D50_K1.0091.00
78_N81_H1.0021.00
14_R45_S0.9961.00
122_L140_F0.9951.00
29_V95_Q0.9911.00
148_H158_N0.9871.00
17_L41_F0.9621.00
134_I138_L0.9611.00
147_M158_N0.9601.00
101_T105_K0.9541.00
60_F107_A0.9471.00
125_D157_R0.9441.00
8_K66_G0.9351.00
60_F110_Y0.9311.00
38_Y44_L0.9261.00
63_E68_K0.9231.00
135_Y140_F0.9161.00
147_M163_C0.9131.00
108_M138_L0.9061.00
140_F164_I0.8971.00
74_L107_A0.8961.00
64_C67_E0.8951.00
126_K160_I0.8941.00
129_E133_H0.8871.00
111_G117_L0.8811.00
105_K109_D0.8761.00
12_L71_L0.8671.00
7_V103_A0.8671.00
28_S95_Q0.8671.00
96_G130_K0.8561.00
22_Q91_S0.8441.00
7_V99_L0.8391.00
116_N166_Q0.8331.00
101_T138_L0.8291.00
102_R106_L0.8281.00
90_I99_L0.8231.00
83_R119_K0.8221.00
18_R22_Q0.8191.00
67_E91_S0.8191.00
24_D89_I0.8171.00
21_H44_L0.8151.00
83_R149_E0.8141.00
88_I100_A0.8141.00
14_R17_L0.8141.00
64_C97_K0.8081.00
16_D63_E0.8061.00
147_M165_F0.8041.00
46_D49_D0.7991.00
82_R156_Y0.7971.00
42_V45_S0.7951.00
85_E121_Y0.7951.00
105_K138_L0.7801.00
82_R151_F0.7761.00
17_L21_H0.7731.00
146_L149_E0.7721.00
143_E147_M0.7691.00
22_Q67_E0.7681.00
124_V131_A0.7561.00
119_K165_F0.7561.00
4_A9_L0.7551.00
94_Y97_K0.7541.00
64_C94_Y0.7411.00
32_Y125_D0.7411.00
151_F155_Q0.7401.00
30_M33_W0.7381.00
44_L47_L0.7351.00
23_L68_K0.7351.00
129_E136_R0.7301.00
136_R162_M0.7281.00
19_Y91_S0.7221.00
123_I146_L0.7141.00
148_H156_Y0.7121.00
96_G101_T0.7121.00
41_F44_L0.7011.00
32_Y127_E0.6991.00
104_A134_I0.6931.00
122_L131_A0.6931.00
26_N91_S0.6921.00
125_D152_I0.6901.00
123_I159_A0.6811.00
22_Q93_E0.6801.00
124_V160_I0.6801.00
96_G133_H0.6771.00
88_I104_A0.6711.00
59_R73_E0.6521.00
39_E44_L0.6511.00
69_A99_L0.6471.00
26_N95_Q0.6471.00
100_A104_A0.6451.00
21_H25_N0.6441.00
6_S98_G0.6411.00
5_H102_R0.6411.00
101_T130_K0.6381.00
43_E46_D0.6351.00
130_K133_H0.6341.00
47_L51_H0.6311.00
133_H137_K0.6211.00
42_V46_D0.6201.00
88_I134_I0.6191.00
84_A111_G0.6151.00
62_V99_L0.6131.00
127_E155_Q0.6071.00
10_R61_V0.6051.00
99_L102_R0.6031.00
72_V104_A0.6031.00
96_G134_I0.5991.00
135_Y162_M0.5991.00
27_A31_R0.5991.00
138_L164_I0.5961.00
74_L84_A0.5921.00
126_K132_I0.5921.00
7_V102_R0.5911.00
119_K149_E0.5871.00
10_R13_E0.5841.00
148_H165_F0.5831.00
84_A120_L0.5801.00
30_M35_E0.5741.00
13_E16_D0.5721.00
122_L162_M0.5711.00
152_I155_Q0.5701.00
33_W89_I0.5691.00
141_S147_M0.5681.00
121_Y146_L0.5671.00
104_A140_F0.5661.00
44_L48_Y0.5651.00
82_R118_Y0.5641.00
62_V72_V0.5591.00
33_W36_E0.5511.00
51_H57_E0.5501.00
73_E87_Q0.5461.00
109_D114_V0.5411.00
123_I161_R0.5411.00
29_V89_I0.5331.00
12_L20_V0.5311.00
90_I95_Q0.5291.00
150_F159_A0.5281.00
68_K71_L0.5271.00
9_L106_L0.5271.00
19_Y23_L0.5261.00
151_F154_G0.5261.00
20_V71_L0.5261.00
5_H8_K0.5231.00
77_I84_A0.5231.00
90_I94_Y0.5191.00
120_L140_F0.5141.00
22_Q25_N0.5131.00
16_D19_Y0.5121.00
148_H166_Q0.5121.00
86_F120_L0.5101.00
112_F166_Q0.5091.00
82_R116_N0.5091.00
152_I157_R0.5081.00
18_R21_H0.5041.00
112_F164_I0.5001.00
51_H59_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yreA 2 0.9355 100 0.306 Contact Map
3pzjA 2 0.914 100 0.309 Contact Map
2z10A 2 0.9677 100 0.311 Contact Map
2vzyA 3 0.9032 100 0.314 Contact Map
4r9mA 5 0.9032 100 0.318 Contact Map
3tcvA 2 1 100 0.333 Contact Map
3r9fA 1 0.8925 100 0.336 Contact Map
1nslA 3 0.9086 100 0.338 Contact Map
3tthA 5 0.8763 100 0.341 Contact Map
2fckA 2 0.8763 100 0.354 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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