GREMLIN Database
RIMI - Ribosomal-protein-alanine acetyltransferase
UniProt: P0A944 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10850
Length: 148 (128)
Sequences: 11454 (9002)
Seq/√Len: 795.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_I120_F3.1301.00
21_R72_D3.0751.00
5_S46_T2.9301.00
55_A88_L2.5181.00
82_R117_S2.4451.00
82_R118_L2.3981.00
45_L80_L2.3361.00
122_E125_I2.2581.00
5_S11_D2.2391.00
57_T88_L2.0661.00
86_E118_L2.0611.00
52_A75_Y2.0351.00
112_I116_E1.8251.00
89_I100_L1.8111.00
53_A71_V1.8011.00
7_L15_A1.7901.00
116_E122_E1.7821.00
13_P29_E1.7751.00
43_F87_H1.7721.00
113_A116_E1.7311.00
22_A70_A1.6931.00
75_Y78_Q1.6461.00
44_Q51_M1.6441.00
21_R73_P1.5881.00
87_H90_D1.5841.00
91_E94_K1.5841.00
16_Y20_Q1.5721.00
64_A92_L1.5671.00
47_Q75_Y1.5271.00
42_N56_I1.5161.00
85_L118_L1.5071.00
76_Q110_A1.4981.00
14_A17_H1.4481.00
112_I122_E1.3991.00
91_E95_R1.3711.00
11_D46_T1.3581.00
7_L44_Q1.3481.00
102_L115_Y1.3321.00
106_A125_I1.3271.00
29_E33_A1.3221.00
59_V97_V1.2621.00
50_K72_D1.2561.00
71_V80_L1.2471.00
14_A51_M1.2331.00
82_R86_E1.1971.00
50_K74_D1.1901.00
47_Q78_Q1.1841.00
17_H21_R1.1781.00
41_L91_E1.1691.00
43_F91_E1.1641.00
16_Y29_E1.1611.00
46_T51_M1.1591.00
41_L95_R1.1491.00
28_S31_T1.1281.00
63_E101_W1.1271.00
21_R74_D1.1141.00
87_H91_E1.0821.00
109_A112_I1.0761.00
83_A86_E1.0711.00
47_Q52_A1.0461.00
9_T33_A1.0421.00
79_G82_R1.0311.00
46_T49_G1.0261.00
109_A113_A1.0071.00
104_V108_N1.0011.00
55_A84_L0.9931.00
92_L100_L0.9891.00
64_A97_V0.9801.00
23_H70_A0.9791.00
4_I87_H0.9771.00
57_T92_L0.9721.00
111_A115_Y0.9711.00
55_A66_L0.9681.00
100_L120_F0.9661.00
18_I22_A0.9611.00
9_T37_G0.9571.00
77_R110_A0.9491.00
22_A76_Q0.9411.00
90_D94_K0.9311.00
4_I83_A0.9281.00
72_D75_Y0.9251.00
66_L85_L0.9161.00
14_A50_K0.9061.00
108_N111_A0.9031.00
19_E54_F0.8841.00
63_E99_T0.8801.00
101_W123_A0.8771.00
18_I72_D0.8741.00
65_T101_W0.8731.00
58_Q67_F0.8681.00
4_I43_F0.8671.00
30_K34_S0.8601.00
19_E23_H0.8591.00
13_P17_H0.8561.00
52_A80_L0.8491.00
8_E11_D0.8371.00
19_E32_F0.8291.00
22_A73_P0.8281.00
114_L118_L0.8221.00
83_A87_H0.8201.00
33_A37_G0.8131.00
47_Q50_K0.8081.00
18_I51_M0.8021.00
7_L42_N0.7991.00
50_K75_Y0.7971.00
17_H50_K0.7931.00
104_V111_A0.7921.00
17_H72_D0.7881.00
92_L97_V0.7851.00
89_I118_L0.7831.00
102_L111_A0.7771.00
99_T123_A0.7721.00
41_L57_T0.7681.00
35_N56_I0.7681.00
19_E68_N0.7651.00
65_T103_E0.7541.00
85_L114_L0.7431.00
59_V95_R0.7301.00
66_L120_F0.7251.00
89_I93_E0.7201.00
86_E90_D0.7161.00
12_L16_Y0.7081.00
30_K33_A0.7031.00
116_E121_N0.7031.00
6_S43_F0.6941.00
5_S8_E0.6891.00
35_N40_Y0.6871.00
77_R113_A0.6851.00
5_S44_Q0.6751.00
45_L52_A0.6751.00
71_V81_G0.6751.00
23_H68_N0.6661.00
7_L11_D0.6661.00
56_I67_F0.6661.00
15_A54_F0.6591.00
28_S32_F0.6421.00
12_L36_Q0.6411.00
80_L83_A0.6401.00
18_I70_A0.6331.00
34_S38_E0.6331.00
110_A113_A0.6311.00
73_P76_Q0.6241.00
25_F31_T0.6211.00
41_L59_V0.6181.00
14_A72_D0.6131.00
87_H94_K0.6071.00
109_A116_E0.6061.00
77_R117_S0.6041.00
45_L84_L0.6031.00
6_S41_L0.6011.00
75_Y80_L0.6001.00
55_A69_I0.5981.00
71_V84_L0.5941.00
53_A84_L0.5941.00
31_T58_Q0.5921.00
7_L12_L0.5891.00
9_T12_L0.5831.00
12_L29_E0.5821.00
53_A80_L0.5821.00
27_W32_F0.5821.00
86_E89_I0.5791.00
32_F35_N0.5761.00
85_L115_Y0.5761.00
57_T91_E0.5751.00
69_I115_Y0.5711.00
59_V64_A0.5691.00
13_P16_Y0.5651.00
60_V63_E0.5631.00
32_F56_I0.5591.00
27_W35_N0.5591.00
81_G114_L0.5531.00
34_S37_G0.5481.00
14_A46_T0.5451.00
90_D93_E0.5451.00
69_I85_L0.5441.00
57_T64_A0.5431.00
98_A131_P0.5421.00
58_Q65_T0.5371.00
111_A114_L0.5361.00
106_A112_I0.5341.00
54_F70_A0.5301.00
45_L53_A0.5301.00
16_Y32_F0.5271.00
103_E130_Y0.5251.00
54_F68_N0.5241.00
31_T35_N0.5221.00
15_A51_M0.5201.00
56_I68_N0.5161.00
6_S91_E0.5141.00
32_F54_F0.5081.00
15_A44_Q0.5001.00
69_I81_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cntA 1 1 99.9 0.24 Contact Map
2ob0A 1 0.9932 99.9 0.263 Contact Map
3dr6A 2 1 99.9 0.278 Contact Map
2j8mA 2 1 99.9 0.28 Contact Map
4kvxA 1 0.9595 99.9 0.283 Contact Map
3kkwA 1 0.9865 99.9 0.29 Contact Map
2reeA 1 1 99.9 0.29 Contact Map
4l8aA 1 0.9865 99.9 0.296 Contact Map
4r3lA 1 0.9662 99.9 0.302 Contact Map
2r7hA 2 0.973 99.9 0.303 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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