MLTA - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

MLTA - Membrane-bound lytic murein transglycosylase A

UniProt:	P0A935	Sequences: MKGRWVKYLLMGTVVAMLAACSSKPTDRGQQYKDGKFTQPFSLVNQPDAVGAPINAGDFAEQINHIRNSSPRLYGNQSNVYNAVQEWLRAGGDTRNMRQFGIDAWQMEGADNYGNVQFTGYYTPVIQARHTRQGEFQYPIYRMPPKRGRLPSRAEIYAGALSDKYILAYSNSLMDNFIMDVQGSGYIDFGDGSPLNFFSYAGKNGHAYRSIGKVLIDRGEVKKEDMSMQAIRHWGETHSEAEVRELLEQNPSFVFFKPQSFAPVKGASAVPLVGRASVASDRSIIPPGTTLLAEVPLLDNNGKFNGQYELRLMVALDVGGAIKGQHFDIYQGIGPEAGHRAGWYNHYGRVWVLKTAPGAGNVFSG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13085
Length:	365 (310)
Sequences:	1080 (724)
Seq/√Len:	41.1

ECOLI - MLTA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
128_A	187_I	4.473	1.00
146_K	150_L	4.119	1.00
152_S	155_E	3.958	1.00
209_R	251_P	3.958	1.00
216_I	223_K	3.583	1.00
226_M	230_A	3.275	1.00
130_H	258_P	3.207	1.00
140_I	176_N	3.146	1.00
130_H	193_S	3.046	1.00
168_A	187_I	2.984	1.00
135_E	171_N	2.967	1.00
118_F	348_G	2.900	1.00
179_M	185_G	2.896	1.00
215_L	220_E	2.795	1.00
203_K	252_S	2.793	1.00
130_H	189_F	2.781	1.00
222_K	225_D	2.689	1.00
278_V	327_F	2.649	1.00
243_V	247_L	2.512	1.00
233_H	237_T	2.484	1.00
117_Q	345_N	2.430	1.00
133_Q	137_Q	2.352	1.00
57_G	276_A	2.343	1.00
132_R	137_Q	2.316	1.00
129_R	133_Q	2.242	1.00
163_D	166_I	2.235	1.00
70_S	81_Y	2.228	1.00
278_V	291_L	2.166	0.99
83_A	101_G	2.145	0.99
134_G	137_Q	2.134	0.99
123_T	186_Y	2.127	0.99
143_M	201_A	2.110	0.99
221_V	226_M	2.068	0.99
123_T	330_Y	2.050	0.99
203_K	320_G	2.045	0.99
170_S	176_N	2.027	0.99
127_Q	171_N	2.017	0.99
199_S	259_Q	2.017	0.99
157_Y	248_E	1.981	0.99
143_M	202_G	1.971	0.99
175_D	232_R	1.865	0.98
235_G	246_L	1.850	0.98
200_Y	252_S	1.842	0.98
228_M	231_I	1.832	0.98
273_V	316_L	1.795	0.98
220_E	242_E	1.792	0.98
213_K	217_D	1.763	0.98
218_R	249_Q	1.739	0.97
176_N	253_F	1.719	0.97
327_F	350_V	1.703	0.97
254_V	320_G	1.654	0.97
58_D	61_E	1.650	0.96
168_A	195_L	1.643	0.96
127_Q	188_D	1.636	0.96
252_S	320_G	1.630	0.96
123_T	263_P	1.608	0.96
142_R	166_I	1.606	0.96
216_I	226_M	1.605	0.96
54_I	99_Q	1.591	0.96
313_M	329_I	1.584	0.96
195_L	258_P	1.581	0.95
268_S	287_P	1.579	0.95
180_D	254_V	1.567	0.95
235_G	243_V	1.567	0.95
132_R	169_Y	1.560	0.95
103_D	356_A	1.553	0.95
275_R	311_R	1.551	0.95
124_P	338_G	1.538	0.95
62_Q	66_I	1.538	0.95
162_S	166_I	1.525	0.94
129_R	169_Y	1.511	0.94
278_V	313_M	1.501	0.94
140_I	198_F	1.491	0.94
90_A	93_D	1.476	0.93
123_T	196_N	1.474	0.93
196_N	263_P	1.459	0.93
218_R	242_E	1.446	0.93
172_S	236_E	1.436	0.92
62_Q	276_A	1.433	0.92
140_I	168_A	1.424	0.92
49_A	104_A	1.423	0.92
181_V	210_S	1.418	0.92
280_S	315_A	1.415	0.92
178_I	229_Q	1.409	0.92
52_A	292_L	1.406	0.92
244_R	248_E	1.405	0.92
238_H	242_E	1.398	0.91
263_P	330_Y	1.382	0.91
58_D	91_G	1.354	0.90
106_Q	349_R	1.354	0.90
47_P	51_G	1.342	0.90
184_S	266_G	1.337	0.89
126_I	170_S	1.335	0.89
84_V	97_M	1.330	0.89
214_V	218_R	1.319	0.89
69_S	314_V	1.318	0.89
294_E	349_R	1.305	0.88
77_Q	81_Y	1.305	0.88
208_Y	212_G	1.303	0.88
178_I	228_M	1.297	0.88
177_F	211_I	1.284	0.87
66_I	97_M	1.280	0.87
186_Y	330_Y	1.272	0.87
127_Q	136_F	1.271	0.87
294_E	310_L	1.260	0.86
272_L	277_S	1.248	0.86
128_A	170_S	1.244	0.86
218_R	245_E	1.228	0.85
118_F	329_I	1.217	0.84
186_Y	194_P	1.216	0.84
214_V	249_Q	1.215	0.84
62_Q	70_S	1.209	0.84
221_V	225_D	1.203	0.84
242_E	245_E	1.191	0.83
225_D	230_A	1.185	0.83
121_Y	266_G	1.181	0.83
160_A	163_D	1.163	0.82
162_S	165_Y	1.161	0.82
273_V	277_S	1.158	0.81
141_Y	165_Y	1.150	0.81
120_G	344_Y	1.145	0.81
208_Y	252_S	1.135	0.80
98_R	102_I	1.122	0.79
267_A	287_P	1.119	0.79
154_A	248_E	1.113	0.79
128_A	189_F	1.103	0.78
218_R	246_L	1.089	0.77
142_R	201_A	1.072	0.76
94_T	98_R	1.055	0.75
121_Y	184_S	1.054	0.75
179_M	204_N	1.052	0.75
154_A	158_A	1.052	0.75
177_F	212_G	1.051	0.75
140_I	179_M	1.045	0.74
80_V	97_M	1.041	0.74
212_G	231_I	1.041	0.74
125_V	333_I	1.038	0.74
214_V	217_D	1.035	0.73
189_F	195_L	1.030	0.73
66_I	84_V	1.030	0.73
278_V	350_V	1.029	0.73
331_Q	344_Y	1.025	0.73
142_R	165_Y	1.020	0.72
271_P	274_G	1.020	0.72
291_L	350_V	1.014	0.72
125_V	188_D	1.013	0.72
185_G	204_N	1.012	0.72
214_V	246_L	1.006	0.71
66_I	314_V	0.998	0.71
151_P	155_E	0.997	0.71
167_L	258_P	0.996	0.71
206_H	252_S	0.994	0.70
220_E	234_W	0.993	0.70
177_F	247_L	0.984	0.70
126_I	171_N	0.983	0.70
216_I	224_E	0.977	0.69
66_I	70_S	0.969	0.68
212_G	227_S	0.969	0.68
159_G	166_I	0.965	0.68
118_F	292_L	0.961	0.68
199_S	265_K	0.959	0.68
181_V	344_Y	0.957	0.67
138_Y	176_N	0.957	0.67
211_I	246_L	0.953	0.67
190_G	194_P	0.939	0.66
156_I	253_F	0.939	0.66
224_E	227_S	0.917	0.64
222_K	226_M	0.912	0.64
229_Q	342_G	0.909	0.63
102_I	354_K	0.909	0.63
69_S	270_V	0.909	0.63
173_L	244_R	0.905	0.63
181_V	271_P	0.899	0.63
234_W	238_H	0.898	0.62
228_M	342_G	0.897	0.62
141_Y	253_F	0.896	0.62
177_F	181_V	0.887	0.61
151_P	181_V	0.887	0.61
133_Q	190_G	0.886	0.61
65_H	69_S	0.886	0.61
290_T	312_L	0.885	0.61
130_H	195_L	0.880	0.61
212_G	342_G	0.879	0.61
57_G	62_Q	0.876	0.60
211_I	342_G	0.876	0.60
200_Y	205_G	0.876	0.60
285_I	315_A	0.875	0.60
58_D	274_G	0.875	0.60
285_I	291_L	0.874	0.60
221_V	230_A	0.873	0.60
69_S	316_L	0.871	0.60
142_R	258_P	0.871	0.60
176_N	180_D	0.868	0.60
282_R	285_I	0.866	0.60
293_A	344_Y	0.866	0.60
95_R	99_Q	0.865	0.60
293_A	313_M	0.861	0.59
215_L	226_M	0.854	0.59
179_M	198_F	0.849	0.58
98_R	290_T	0.844	0.58
62_Q	314_V	0.839	0.57
84_V	98_R	0.835	0.57
160_A	166_I	0.833	0.57
322_I	326_H	0.830	0.56
48_D	51_G	0.826	0.56
216_I	222_K	0.825	0.56
259_Q	265_K	0.824	0.56
171_N	187_I	0.820	0.55
47_P	351_W	0.808	0.54
335_P	339_H	0.807	0.54
130_H	191_D	0.805	0.54
187_I	198_F	0.804	0.54
268_S	316_L	0.804	0.54
344_Y	348_G	0.802	0.54
206_H	251_P	0.798	0.53
179_M	251_P	0.795	0.53
295_V	348_G	0.791	0.53
180_D	253_F	0.787	0.52
120_G	154_A	0.786	0.52
124_P	350_V	0.786	0.52
295_V	344_Y	0.781	0.52
136_F	190_G	0.780	0.52
126_I	187_I	0.780	0.52
286_P	289_T	0.780	0.52
232_R	236_E	0.778	0.52
210_S	247_L	0.774	0.51
69_S	268_S	0.771	0.51
129_R	189_F	0.769	0.51
66_I	94_T	0.766	0.50
291_L	352_V	0.766	0.50
188_D	194_P	0.759	0.50
49_A	99_Q	0.759	0.50
280_S	287_P	0.757	0.50
235_G	338_G	0.754	0.49
64_N	67_R	0.752	0.49
208_Y	211_I	0.750	0.49
315_A	352_V	0.749	0.49
90_A	96_N	0.748	0.49
118_F	295_V	0.744	0.48
54_I	59_F	0.744	0.48
113_Y	216_I	0.742	0.48
149_R	232_R	0.741	0.48
210_S	243_V	0.736	0.48
226_M	231_I	0.734	0.47
59_F	62_Q	0.733	0.47
151_P	156_I	0.727	0.47
81_Y	84_V	0.726	0.47
133_Q	136_F	0.726	0.47
68_N	71_P	0.725	0.47
96_N	100_F	0.725	0.47
86_E	93_D	0.722	0.46
80_V	102_I	0.719	0.46
95_R	104_A	0.716	0.46
116_V	280_S	0.714	0.46
179_M	344_Y	0.712	0.45
125_V	232_R	0.705	0.45
109_G	113_Y	0.705	0.45
150_L	205_G	0.700	0.44
152_S	232_R	0.700	0.44
229_Q	344_Y	0.699	0.44
140_I	170_S	0.698	0.44
157_Y	253_F	0.697	0.44
235_G	247_L	0.696	0.44
309_E	329_I	0.695	0.44
62_Q	69_S	0.694	0.44
123_T	333_I	0.691	0.43
216_I	246_L	0.690	0.43
153_R	177_F	0.689	0.43
295_V	298_L	0.689	0.43
73_L	348_G	0.689	0.43
116_V	355_T	0.687	0.43
87_W	93_D	0.681	0.43
40_P	240_E	0.680	0.42
160_A	164_K	0.679	0.42
68_N	262_A	0.679	0.42
63_I	66_I	0.678	0.42
208_Y	250_N	0.678	0.42
220_E	246_L	0.677	0.42
208_Y	216_I	0.676	0.42
200_Y	203_K	0.676	0.42
70_S	77_Q	0.674	0.42
97_M	355_T	0.674	0.42
127_Q	187_I	0.673	0.42
222_K	230_A	0.673	0.42
257_K	265_K	0.669	0.41
291_L	315_A	0.669	0.41
161_L	166_I	0.664	0.41
70_S	355_T	0.664	0.41
168_A	176_N	0.663	0.41
172_S	175_D	0.662	0.41
129_R	132_R	0.662	0.41
141_Y	163_D	0.662	0.41
292_L	309_E	0.661	0.41
45_N	108_E	0.661	0.41
121_Y	204_N	0.660	0.41
200_Y	215_L	0.655	0.40
181_V	231_I	0.654	0.40
45_N	106_Q	0.652	0.40
167_L	257_K	0.652	0.40
125_V	194_P	0.652	0.40
204_N	266_G	0.650	0.40
156_I	180_D	0.649	0.40
53_P	272_L	0.649	0.40
55_N	58_D	0.649	0.40
212_G	229_Q	0.648	0.40
266_G	287_P	0.648	0.40
175_D	338_G	0.647	0.40
116_V	348_G	0.645	0.39
125_V	170_S	0.643	0.39
134_G	245_E	0.641	0.39
118_F	350_V	0.640	0.39
297_L	331_Q	0.639	0.39
195_L	238_H	0.638	0.39
107_M	325_Q	0.638	0.39
287_P	323_K	0.633	0.38
181_V	250_N	0.633	0.38
201_A	210_S	0.631	0.38
177_F	208_Y	0.630	0.38
207_A	353_L	0.627	0.38
170_S	290_T	0.622	0.37
227_S	231_I	0.618	0.37
319_G	328_D	0.618	0.37
274_G	299_D	0.617	0.37
291_L	327_F	0.616	0.37
62_Q	72_R	0.616	0.37
277_S	316_L	0.616	0.37
127_Q	190_G	0.616	0.37
58_D	313_M	0.615	0.37
333_I	338_G	0.614	0.37
67_R	72_R	0.613	0.37
201_A	257_K	0.611	0.36
120_G	250_N	0.609	0.36
115_N	349_R	0.609	0.36
142_R	176_N	0.607	0.36
282_R	323_K	0.606	0.36
208_Y	320_G	0.604	0.36
161_L	164_K	0.603	0.36
230_A	237_T	0.603	0.36
208_Y	342_G	0.603	0.36
62_Q	98_R	0.600	0.35
81_Y	355_T	0.598	0.35
50_V	89_R	0.597	0.35
336_E	339_H	0.597	0.35
199_S	266_G	0.593	0.35
200_Y	342_G	0.593	0.35
275_R	336_E	0.591	0.35
216_I	285_I	0.591	0.35
126_I	140_I	0.591	0.35
74_Y	213_K	0.590	0.35
289_T	352_V	0.588	0.34
172_S	331_Q	0.588	0.34
99_Q	104_A	0.587	0.34
118_F	294_E	0.587	0.34
296_P	346_H	0.584	0.34
185_G	251_P	0.584	0.34
54_I	104_A	0.583	0.34
174_M	243_V	0.582	0.34
158_A	162_S	0.582	0.34
134_G	171_N	0.582	0.34
185_G	344_Y	0.581	0.34
177_F	250_N	0.580	0.34
49_A	354_K	0.580	0.34
59_F	278_V	0.580	0.34
137_Q	275_R	0.580	0.34
199_S	330_Y	0.577	0.33
216_I	221_V	0.576	0.33
177_F	252_S	0.576	0.33
151_P	160_A	0.576	0.33
80_V	83_A	0.574	0.33
231_I	316_L	0.574	0.33
145_P	166_I	0.572	0.33
284_I	297_L	0.572	0.33
186_Y	263_P	0.571	0.33
215_L	254_V	0.571	0.33
194_P	333_I	0.570	0.33
63_I	346_H	0.569	0.33
166_I	176_N	0.568	0.33
167_L	213_K	0.568	0.33
243_V	278_V	0.566	0.33
120_G	208_Y	0.563	0.32
54_I	66_I	0.561	0.32
321_A	326_H	0.560	0.32
208_Y	254_V	0.559	0.32
159_G	164_K	0.558	0.32
224_E	230_A	0.558	0.32
168_A	189_F	0.558	0.32
77_Q	179_M	0.555	0.32
156_I	159_G	0.554	0.32
120_G	331_Q	0.553	0.32
158_A	248_E	0.553	0.32
82_N	352_V	0.552	0.31
222_K	247_L	0.551	0.31
133_Q	222_K	0.549	0.31
61_E	154_A	0.549	0.31
204_N	254_V	0.549	0.31
267_A	318_V	0.549	0.31
234_W	242_E	0.549	0.31
319_G	322_I	0.548	0.31
122_Y	126_I	0.547	0.31
152_S	251_P	0.547	0.31
180_D	264_V	0.545	0.31
138_Y	177_F	0.543	0.31
107_M	352_V	0.543	0.31
266_G	269_A	0.543	0.31
178_I	208_Y	0.542	0.31
176_N	239_S	0.540	0.30
298_L	344_Y	0.537	0.30
231_I	267_A	0.536	0.30
221_V	231_I	0.536	0.30
59_F	94_T	0.535	0.30
184_S	208_Y	0.532	0.30
199_S	253_F	0.532	0.30
54_I	280_S	0.532	0.30
117_Q	185_G	0.532	0.30
292_L	312_L	0.531	0.30
122_Y	131_T	0.530	0.30
84_V	94_T	0.529	0.30
348_G	354_K	0.529	0.30
125_V	338_G	0.529	0.30
54_I	327_F	0.528	0.30
275_R	331_Q	0.528	0.30
70_S	280_S	0.528	0.30
282_R	287_P	0.527	0.29
195_L	348_G	0.527	0.29
208_Y	297_L	0.526	0.29
129_R	136_F	0.526	0.29
99_Q	312_L	0.523	0.29
213_K	223_K	0.521	0.29
157_Y	244_R	0.521	0.29
154_A	244_R	0.520	0.29
66_I	290_T	0.520	0.29
41_F	167_L	0.518	0.29
268_S	327_F	0.517	0.29
276_A	327_F	0.516	0.29
175_D	234_W	0.515	0.29
297_L	309_E	0.514	0.28
57_G	95_R	0.514	0.28
82_N	132_R	0.513	0.28
252_S	284_I	0.513	0.28
45_N	149_R	0.513	0.28
48_D	110_A	0.512	0.28
278_V	314_V	0.512	0.28
72_R	75_G	0.512	0.28
174_M	235_G	0.512	0.28
138_Y	141_Y	0.512	0.28
272_L	285_I	0.512	0.28
145_P	240_E	0.512	0.28
63_I	67_R	0.511	0.28
274_G	333_I	0.511	0.28
252_S	321_A	0.510	0.28
127_Q	168_A	0.509	0.28
181_V	252_S	0.509	0.28
136_F	153_R	0.508	0.28
210_S	216_I	0.507	0.28
185_G	282_R	0.507	0.28
94_T	97_M	0.506	0.28
160_A	202_G	0.506	0.28
186_Y	333_I	0.505	0.28
170_S	187_I	0.505	0.28
207_A	251_P	0.504	0.28
278_V	292_L	0.503	0.28
154_A	233_H	0.503	0.28
123_T	324_G	0.502	0.28
227_S	246_L	0.500	0.27
225_D	273_V	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2pnwA	1	0.8493	100	0.211	Contact Map
2g5dA	1	0.9096	100	0.212	Contact Map
3czbA	2	0.8192	100	0.23	Contact Map
2ae0X	1	0.9151	100	0.242	Contact Map
4wjtA	2	0.3233	99.8	0.844	Contact Map
3zbiC	1	0.0767	66	0.97	Contact Map
4fybB	1	0.4082	55	0.972	Contact Map
3utkA	1	0.189	42.8	0.974	Contact Map
2hyxA	2	0.6356	36.9	0.975	Contact Map
3m6wA	2	0.3507	27.3	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0103 seconds.