GREMLIN Database
MLTA - Membrane-bound lytic murein transglycosylase A
UniProt: P0A935 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13085
Length: 365 (310)
Sequences: 1080 (724)
Seq/√Len: 41.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_A187_I4.4731.00
146_K150_L4.1191.00
152_S155_E3.9581.00
209_R251_P3.9581.00
216_I223_K3.5831.00
226_M230_A3.2751.00
130_H258_P3.2071.00
140_I176_N3.1461.00
130_H193_S3.0461.00
168_A187_I2.9841.00
135_E171_N2.9671.00
118_F348_G2.9001.00
179_M185_G2.8961.00
215_L220_E2.7951.00
203_K252_S2.7931.00
130_H189_F2.7811.00
222_K225_D2.6891.00
278_V327_F2.6491.00
243_V247_L2.5121.00
233_H237_T2.4841.00
117_Q345_N2.4301.00
133_Q137_Q2.3521.00
57_G276_A2.3431.00
132_R137_Q2.3161.00
129_R133_Q2.2421.00
163_D166_I2.2351.00
70_S81_Y2.2281.00
278_V291_L2.1660.99
83_A101_G2.1450.99
134_G137_Q2.1340.99
123_T186_Y2.1270.99
143_M201_A2.1100.99
221_V226_M2.0680.99
123_T330_Y2.0500.99
203_K320_G2.0450.99
170_S176_N2.0270.99
127_Q171_N2.0170.99
199_S259_Q2.0170.99
157_Y248_E1.9810.99
143_M202_G1.9710.99
175_D232_R1.8650.98
235_G246_L1.8500.98
200_Y252_S1.8420.98
228_M231_I1.8320.98
273_V316_L1.7950.98
220_E242_E1.7920.98
213_K217_D1.7630.98
218_R249_Q1.7390.97
176_N253_F1.7190.97
327_F350_V1.7030.97
254_V320_G1.6540.97
58_D61_E1.6500.96
168_A195_L1.6430.96
127_Q188_D1.6360.96
252_S320_G1.6300.96
123_T263_P1.6080.96
142_R166_I1.6060.96
216_I226_M1.6050.96
54_I99_Q1.5910.96
313_M329_I1.5840.96
195_L258_P1.5810.95
268_S287_P1.5790.95
180_D254_V1.5670.95
235_G243_V1.5670.95
132_R169_Y1.5600.95
103_D356_A1.5530.95
275_R311_R1.5510.95
124_P338_G1.5380.95
62_Q66_I1.5380.95
162_S166_I1.5250.94
129_R169_Y1.5110.94
278_V313_M1.5010.94
140_I198_F1.4910.94
90_A93_D1.4760.93
123_T196_N1.4740.93
196_N263_P1.4590.93
218_R242_E1.4460.93
172_S236_E1.4360.92
62_Q276_A1.4330.92
140_I168_A1.4240.92
49_A104_A1.4230.92
181_V210_S1.4180.92
280_S315_A1.4150.92
178_I229_Q1.4090.92
52_A292_L1.4060.92
244_R248_E1.4050.92
238_H242_E1.3980.91
263_P330_Y1.3820.91
58_D91_G1.3540.90
106_Q349_R1.3540.90
47_P51_G1.3420.90
184_S266_G1.3370.89
126_I170_S1.3350.89
84_V97_M1.3300.89
214_V218_R1.3190.89
69_S314_V1.3180.89
294_E349_R1.3050.88
77_Q81_Y1.3050.88
208_Y212_G1.3030.88
178_I228_M1.2970.88
177_F211_I1.2840.87
66_I97_M1.2800.87
186_Y330_Y1.2720.87
127_Q136_F1.2710.87
294_E310_L1.2600.86
272_L277_S1.2480.86
128_A170_S1.2440.86
218_R245_E1.2280.85
118_F329_I1.2170.84
186_Y194_P1.2160.84
214_V249_Q1.2150.84
62_Q70_S1.2090.84
221_V225_D1.2030.84
242_E245_E1.1910.83
225_D230_A1.1850.83
121_Y266_G1.1810.83
160_A163_D1.1630.82
162_S165_Y1.1610.82
273_V277_S1.1580.81
141_Y165_Y1.1500.81
120_G344_Y1.1450.81
208_Y252_S1.1350.80
98_R102_I1.1220.79
267_A287_P1.1190.79
154_A248_E1.1130.79
128_A189_F1.1030.78
218_R246_L1.0890.77
142_R201_A1.0720.76
94_T98_R1.0550.75
121_Y184_S1.0540.75
179_M204_N1.0520.75
154_A158_A1.0520.75
177_F212_G1.0510.75
140_I179_M1.0450.74
80_V97_M1.0410.74
212_G231_I1.0410.74
125_V333_I1.0380.74
214_V217_D1.0350.73
189_F195_L1.0300.73
66_I84_V1.0300.73
278_V350_V1.0290.73
331_Q344_Y1.0250.73
142_R165_Y1.0200.72
271_P274_G1.0200.72
291_L350_V1.0140.72
125_V188_D1.0130.72
185_G204_N1.0120.72
214_V246_L1.0060.71
66_I314_V0.9980.71
151_P155_E0.9970.71
167_L258_P0.9960.71
206_H252_S0.9940.70
220_E234_W0.9930.70
177_F247_L0.9840.70
126_I171_N0.9830.70
216_I224_E0.9770.69
66_I70_S0.9690.68
212_G227_S0.9690.68
159_G166_I0.9650.68
118_F292_L0.9610.68
199_S265_K0.9590.68
181_V344_Y0.9570.67
138_Y176_N0.9570.67
211_I246_L0.9530.67
190_G194_P0.9390.66
156_I253_F0.9390.66
224_E227_S0.9170.64
222_K226_M0.9120.64
229_Q342_G0.9090.63
102_I354_K0.9090.63
69_S270_V0.9090.63
173_L244_R0.9050.63
181_V271_P0.8990.63
234_W238_H0.8980.62
228_M342_G0.8970.62
141_Y253_F0.8960.62
177_F181_V0.8870.61
151_P181_V0.8870.61
133_Q190_G0.8860.61
65_H69_S0.8860.61
290_T312_L0.8850.61
130_H195_L0.8800.61
212_G342_G0.8790.61
57_G62_Q0.8760.60
211_I342_G0.8760.60
200_Y205_G0.8760.60
285_I315_A0.8750.60
58_D274_G0.8750.60
285_I291_L0.8740.60
221_V230_A0.8730.60
69_S316_L0.8710.60
142_R258_P0.8710.60
176_N180_D0.8680.60
282_R285_I0.8660.60
293_A344_Y0.8660.60
95_R99_Q0.8650.60
293_A313_M0.8610.59
215_L226_M0.8540.59
179_M198_F0.8490.58
98_R290_T0.8440.58
62_Q314_V0.8390.57
84_V98_R0.8350.57
160_A166_I0.8330.57
322_I326_H0.8300.56
48_D51_G0.8260.56
216_I222_K0.8250.56
259_Q265_K0.8240.56
171_N187_I0.8200.55
47_P351_W0.8080.54
335_P339_H0.8070.54
130_H191_D0.8050.54
187_I198_F0.8040.54
268_S316_L0.8040.54
344_Y348_G0.8020.54
206_H251_P0.7980.53
179_M251_P0.7950.53
295_V348_G0.7910.53
180_D253_F0.7870.52
120_G154_A0.7860.52
124_P350_V0.7860.52
295_V344_Y0.7810.52
136_F190_G0.7800.52
126_I187_I0.7800.52
286_P289_T0.7800.52
232_R236_E0.7780.52
210_S247_L0.7740.51
69_S268_S0.7710.51
129_R189_F0.7690.51
66_I94_T0.7660.50
291_L352_V0.7660.50
188_D194_P0.7590.50
49_A99_Q0.7590.50
280_S287_P0.7570.50
235_G338_G0.7540.49
64_N67_R0.7520.49
208_Y211_I0.7500.49
315_A352_V0.7490.49
90_A96_N0.7480.49
118_F295_V0.7440.48
54_I59_F0.7440.48
113_Y216_I0.7420.48
149_R232_R0.7410.48
210_S243_V0.7360.48
226_M231_I0.7340.47
59_F62_Q0.7330.47
151_P156_I0.7270.47
81_Y84_V0.7260.47
133_Q136_F0.7260.47
68_N71_P0.7250.47
96_N100_F0.7250.47
86_E93_D0.7220.46
80_V102_I0.7190.46
95_R104_A0.7160.46
116_V280_S0.7140.46
179_M344_Y0.7120.45
125_V232_R0.7050.45
109_G113_Y0.7050.45
150_L205_G0.7000.44
152_S232_R0.7000.44
229_Q344_Y0.6990.44
140_I170_S0.6980.44
157_Y253_F0.6970.44
235_G247_L0.6960.44
309_E329_I0.6950.44
62_Q69_S0.6940.44
123_T333_I0.6910.43
216_I246_L0.6900.43
153_R177_F0.6890.43
295_V298_L0.6890.43
73_L348_G0.6890.43
116_V355_T0.6870.43
87_W93_D0.6810.43
40_P240_E0.6800.42
160_A164_K0.6790.42
68_N262_A0.6790.42
63_I66_I0.6780.42
208_Y250_N0.6780.42
220_E246_L0.6770.42
208_Y216_I0.6760.42
200_Y203_K0.6760.42
70_S77_Q0.6740.42
97_M355_T0.6740.42
127_Q187_I0.6730.42
222_K230_A0.6730.42
257_K265_K0.6690.41
291_L315_A0.6690.41
161_L166_I0.6640.41
70_S355_T0.6640.41
168_A176_N0.6630.41
172_S175_D0.6620.41
129_R132_R0.6620.41
141_Y163_D0.6620.41
292_L309_E0.6610.41
45_N108_E0.6610.41
121_Y204_N0.6600.41
200_Y215_L0.6550.40
181_V231_I0.6540.40
45_N106_Q0.6520.40
167_L257_K0.6520.40
125_V194_P0.6520.40
204_N266_G0.6500.40
156_I180_D0.6490.40
53_P272_L0.6490.40
55_N58_D0.6490.40
212_G229_Q0.6480.40
266_G287_P0.6480.40
175_D338_G0.6470.40
116_V348_G0.6450.39
125_V170_S0.6430.39
134_G245_E0.6410.39
118_F350_V0.6400.39
297_L331_Q0.6390.39
195_L238_H0.6380.39
107_M325_Q0.6380.39
287_P323_K0.6330.38
181_V250_N0.6330.38
201_A210_S0.6310.38
177_F208_Y0.6300.38
207_A353_L0.6270.38
170_S290_T0.6220.37
227_S231_I0.6180.37
319_G328_D0.6180.37
274_G299_D0.6170.37
291_L327_F0.6160.37
62_Q72_R0.6160.37
277_S316_L0.6160.37
127_Q190_G0.6160.37
58_D313_M0.6150.37
333_I338_G0.6140.37
67_R72_R0.6130.37
201_A257_K0.6110.36
120_G250_N0.6090.36
115_N349_R0.6090.36
142_R176_N0.6070.36
282_R323_K0.6060.36
208_Y320_G0.6040.36
161_L164_K0.6030.36
230_A237_T0.6030.36
208_Y342_G0.6030.36
62_Q98_R0.6000.35
81_Y355_T0.5980.35
50_V89_R0.5970.35
336_E339_H0.5970.35
199_S266_G0.5930.35
200_Y342_G0.5930.35
275_R336_E0.5910.35
216_I285_I0.5910.35
126_I140_I0.5910.35
74_Y213_K0.5900.35
289_T352_V0.5880.34
172_S331_Q0.5880.34
99_Q104_A0.5870.34
118_F294_E0.5870.34
296_P346_H0.5840.34
185_G251_P0.5840.34
54_I104_A0.5830.34
174_M243_V0.5820.34
158_A162_S0.5820.34
134_G171_N0.5820.34
185_G344_Y0.5810.34
177_F250_N0.5800.34
49_A354_K0.5800.34
59_F278_V0.5800.34
137_Q275_R0.5800.34
199_S330_Y0.5770.33
216_I221_V0.5760.33
177_F252_S0.5760.33
151_P160_A0.5760.33
80_V83_A0.5740.33
231_I316_L0.5740.33
145_P166_I0.5720.33
284_I297_L0.5720.33
186_Y263_P0.5710.33
215_L254_V0.5710.33
194_P333_I0.5700.33
63_I346_H0.5690.33
166_I176_N0.5680.33
167_L213_K0.5680.33
243_V278_V0.5660.33
120_G208_Y0.5630.32
54_I66_I0.5610.32
321_A326_H0.5600.32
208_Y254_V0.5590.32
159_G164_K0.5580.32
224_E230_A0.5580.32
168_A189_F0.5580.32
77_Q179_M0.5550.32
156_I159_G0.5540.32
120_G331_Q0.5530.32
158_A248_E0.5530.32
82_N352_V0.5520.31
222_K247_L0.5510.31
133_Q222_K0.5490.31
61_E154_A0.5490.31
204_N254_V0.5490.31
267_A318_V0.5490.31
234_W242_E0.5490.31
319_G322_I0.5480.31
122_Y126_I0.5470.31
152_S251_P0.5470.31
180_D264_V0.5450.31
138_Y177_F0.5430.31
107_M352_V0.5430.31
266_G269_A0.5430.31
178_I208_Y0.5420.31
176_N239_S0.5400.30
298_L344_Y0.5370.30
231_I267_A0.5360.30
221_V231_I0.5360.30
59_F94_T0.5350.30
184_S208_Y0.5320.30
199_S253_F0.5320.30
54_I280_S0.5320.30
117_Q185_G0.5320.30
292_L312_L0.5310.30
122_Y131_T0.5300.30
84_V94_T0.5290.30
348_G354_K0.5290.30
125_V338_G0.5290.30
54_I327_F0.5280.30
275_R331_Q0.5280.30
70_S280_S0.5280.30
282_R287_P0.5270.29
195_L348_G0.5270.29
208_Y297_L0.5260.29
129_R136_F0.5260.29
99_Q312_L0.5230.29
213_K223_K0.5210.29
157_Y244_R0.5210.29
154_A244_R0.5200.29
66_I290_T0.5200.29
41_F167_L0.5180.29
268_S327_F0.5170.29
276_A327_F0.5160.29
175_D234_W0.5150.29
297_L309_E0.5140.28
57_G95_R0.5140.28
82_N132_R0.5130.28
252_S284_I0.5130.28
45_N149_R0.5130.28
48_D110_A0.5120.28
278_V314_V0.5120.28
72_R75_G0.5120.28
174_M235_G0.5120.28
138_Y141_Y0.5120.28
272_L285_I0.5120.28
145_P240_E0.5120.28
63_I67_R0.5110.28
274_G333_I0.5110.28
252_S321_A0.5100.28
127_Q168_A0.5090.28
181_V252_S0.5090.28
136_F153_R0.5080.28
210_S216_I0.5070.28
185_G282_R0.5070.28
94_T97_M0.5060.28
160_A202_G0.5060.28
186_Y333_I0.5050.28
170_S187_I0.5050.28
207_A251_P0.5040.28
278_V292_L0.5030.28
154_A233_H0.5030.28
123_T324_G0.5020.28
227_S246_L0.5000.27
225_D273_V0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pnwA 1 0.8493 100 0.211 Contact Map
2g5dA 1 0.9096 100 0.212 Contact Map
3czbA 2 0.8192 100 0.23 Contact Map
2ae0X 1 0.9151 100 0.242 Contact Map
4wjtA 2 0.3233 99.8 0.844 Contact Map
3zbiC 1 0.0767 66 0.97 Contact Map
4fybB 1 0.4082 55 0.972 Contact Map
3utkA 1 0.189 42.8 0.974 Contact Map
2hyxA 2 0.6356 36.9 0.975 Contact Map
3m6wA 2 0.3507 27.3 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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