GREMLIN Database
GFCE - Putative polysaccharide export protein GfcE
UniProt: P0A932 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13728
Length: 379 (333)
Sequences: 1649 (1274)
Seq/√Len: 69.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_I120_V8.4431.00
87_I144_V8.4351.00
136_V144_V6.7121.00
139_K147_E5.6341.00
120_V136_V4.2871.00
179_V249_I4.0821.00
121_N125_A3.9171.00
197_A241_L3.3481.00
281_A334_L3.1541.00
144_V163_V3.1151.00
195_M238_N3.0471.00
86_R140_T2.9211.00
147_E151_R2.6521.00
194_I247_L2.5551.00
30_S33_N2.4651.00
300_V332_F2.4311.00
234_D237_Q2.3211.00
212_N223_K2.3061.00
215_L247_L2.2661.00
55_V59_L2.2221.00
29_L34_K2.1841.00
263_V342_V2.1211.00
144_V147_E2.0881.00
316_Y332_F2.0201.00
175_V179_V1.9821.00
300_V340_V1.9711.00
125_A135_K1.9621.00
148_I161_V1.8881.00
278_L340_V1.8661.00
86_R143_Q1.8461.00
136_V147_E1.8291.00
139_K144_V1.8211.00
46_L49_M1.8051.00
351_N355_S1.7941.00
263_V266_Q1.7461.00
26_G29_L1.7131.00
139_K143_Q1.7051.00
89_I137_A1.6901.00
351_N359_P1.6861.00
29_L33_N1.6741.00
214_V250_P1.6731.00
217_Q245_D1.6670.99
31_T35_D1.6460.99
37_I41_D1.6380.99
33_N37_I1.6190.99
319_N322_D1.6150.99
88_G170_S1.6150.99
300_V318_L1.6130.99
296_T319_N1.6050.99
30_S34_K1.6020.99
25_P29_L1.5850.99
213_V247_L1.5630.99
182_S248_F1.5490.99
12_T15_V1.5340.99
28_N34_K1.5170.99
151_R154_S1.5090.99
279_A329_G1.4910.99
227_Y231_Q1.4660.99
259_V285_A1.4510.99
130_Y160_Q1.4430.99
97_V161_V1.4430.99
128_Y152_L1.4410.99
178_E205_T1.4360.98
26_G33_N1.4270.98
28_N33_N1.4230.98
11_L15_V1.4140.98
45_D49_M1.4090.98
55_V63_L1.4090.98
126_I144_V1.4040.98
214_V223_K1.3820.98
299_F343_T1.3790.98
93_L136_V1.3740.98
358_V362_S1.3720.98
93_L144_V1.3620.98
255_L271_M1.3600.98
180_S205_T1.3590.98
24_V28_N1.3590.98
354_I360_T1.3590.98
93_L120_V1.3590.98
143_Q147_E1.3430.98
9_S16_L1.3400.98
97_V152_L1.3320.98
165_V168_F1.3130.97
57_P61_D1.3120.97
54_P317_Q1.3090.97
169_R178_E1.3050.97
30_S36_V1.2820.97
355_S362_S1.2810.97
44_Y47_D1.2800.97
194_I215_L1.2750.97
212_N250_P1.2730.97
258_F262_E1.2670.97
125_A133_R1.2600.97
348_A356_L1.2550.96
14_A17_S1.2540.96
350_W354_I1.2510.96
11_L19_T1.2440.96
173_A241_L1.2380.96
21_C25_P1.2370.96
196_D238_N1.2310.96
282_L314_N1.2210.96
22_T25_P1.2200.96
95_V163_V1.2170.96
278_L300_V1.2160.96
244_G315_I1.2150.96
12_T16_L1.2130.96
216_T221_K1.2110.96
93_L126_I1.2070.96
225_N228_A1.2010.95
43_Q48_K1.1960.95
50_V55_V1.1950.95
72_A75_E1.1900.95
173_A197_A1.1890.95
18_L22_T1.1840.95
24_V30_S1.1840.95
42_N45_D1.1800.95
288_M293_A1.1730.95
158_S215_L1.1680.95
241_L247_L1.1650.95
147_E150_A1.1610.94
215_L239_K1.1580.94
32_S37_I1.1570.94
59_L63_L1.1540.94
102_E130_Y1.1480.94
228_A232_R1.1460.94
211_R227_Y1.1420.94
33_N36_V1.1260.94
211_R225_N1.1230.93
25_P30_S1.1220.93
299_F341_Y1.1180.93
134_L147_E1.1180.93
148_I163_V1.1080.93
20_A25_P1.1030.93
78_Q81_A1.1030.93
297_G346_P1.0920.92
145_R162_D1.0850.92
56_T59_L1.0820.92
259_V263_V1.0780.92
26_G31_T1.0640.91
298_I340_V1.0630.91
9_S14_A1.0580.91
94_M166_A1.0580.91
145_R149_T1.0570.91
44_Y48_K1.0510.91
50_V54_P1.0430.91
24_V29_L1.0410.91
134_L144_V1.0350.90
25_P28_N1.0340.90
279_A330_T1.0330.90
13_L16_L1.0330.90
26_G30_S1.0310.90
149_T161_V1.0310.90
214_V221_K1.0140.89
175_V271_M1.0110.89
193_T196_D1.0110.89
188_T192_L1.0070.89
41_D49_M1.0070.89
28_N32_S1.0040.89
344_T352_R0.9960.88
95_V293_A0.9950.88
19_T42_N0.9900.88
169_R172_K0.9890.88
12_T17_S0.9830.88
42_N46_L0.9820.88
13_L41_D0.9800.88
140_T143_Q0.9770.88
276_M284_N0.9760.87
12_T18_L0.9760.87
262_E336_P0.9750.87
97_V103_L0.9550.86
208_A250_P0.9470.86
347_L356_L0.9450.86
356_L360_T0.9410.85
84_E142_T0.9360.85
32_S36_V0.9310.85
9_S12_T0.9290.85
42_N56_T0.9250.84
182_S217_Q0.9190.84
141_L144_V0.9180.84
131_I155_V0.9160.84
198_I204_L0.9150.84
11_L65_A0.9150.84
182_S266_Q0.9140.84
269_L334_L0.9130.84
176_T248_F0.9100.84
18_L21_C0.9090.83
315_I323_A0.9080.83
92_V106_P0.9050.83
210_W225_N0.9050.83
179_V203_G0.8930.82
350_W357_L0.8900.82
259_V318_L0.8900.82
152_L315_I0.8890.82
56_T61_D0.8870.82
269_L285_A0.8870.82
224_V229_L0.8770.81
238_N290_Q0.8760.81
213_V249_I0.8760.81
213_V223_K0.8730.81
173_A187_I0.8700.81
41_D48_K0.8670.80
256_K280_E0.8660.80
101_P104_T0.8650.80
11_L14_A0.8640.80
192_L196_D0.8630.80
299_F317_Q0.8620.80
100_H106_P0.8610.80
68_I194_I0.8600.80
29_L32_S0.8580.80
45_D51_N0.8570.80
141_L165_V0.8570.80
16_L19_T0.8560.80
182_S249_I0.8550.80
177_G201_A0.8500.79
55_V315_I0.8500.79
17_S48_K0.8490.79
173_A334_L0.8490.79
51_N54_P0.8480.79
60_I140_T0.8460.79
350_W360_T0.8450.79
47_D51_N0.8410.78
179_V182_S0.8400.78
68_I71_Q0.8370.78
186_P200_A0.8370.78
316_Y323_A0.8340.78
93_L298_I0.8340.78
57_P60_I0.8320.78
278_L334_L0.8310.78
268_T284_N0.8300.77
121_N319_N0.8300.77
28_N341_Y0.8280.77
262_E344_T0.8270.77
104_T214_V0.8240.77
288_M298_I0.8240.77
232_R283_G0.8240.77
353_V357_L0.8210.77
126_I134_L0.8170.76
60_I328_L0.8160.76
60_I63_L0.8140.76
60_I64_R0.8130.76
29_L35_D0.8080.76
10_V13_L0.8070.75
271_M276_M0.8050.75
298_I332_F0.8040.75
215_L224_V0.7980.75
258_F339_I0.7960.74
99_D130_Y0.7950.74
55_V60_I0.7930.74
58_G62_Q0.7920.74
16_L21_C0.7900.74
87_I165_V0.7900.74
49_M52_I0.7860.74
15_V21_C0.7830.73
304_T314_N0.7820.73
93_L226_L0.7820.73
203_G249_I0.7780.73
136_V139_K0.7770.73
150_A153_D0.7750.72
176_T196_D0.7750.72
244_G247_L0.7740.72
46_L50_V0.7700.72
37_I44_Y0.7680.72
28_N31_T0.7680.72
129_P132_G0.7680.72
238_N246_I0.7670.72
29_L36_V0.7630.71
44_Y51_N0.7620.71
71_Q150_A0.7590.71
204_L208_A0.7580.71
26_G32_S0.7570.71
175_V220_V0.7570.71
25_P32_S0.7570.71
193_T285_A0.7560.71
119_W167_A0.7540.70
31_T34_K0.7540.70
103_L106_P0.7470.70
131_I151_R0.7470.70
297_G317_Q0.7470.70
275_G280_E0.7460.70
329_G332_F0.7450.69
178_E251_R0.7450.69
75_E79_Q0.7450.69
30_S35_D0.7410.69
302_R338_D0.7410.69
30_S49_M0.7410.69
349_R354_I0.7380.69
227_Y337_Y0.7380.69
352_R356_L0.7370.69
297_G343_T0.7310.68
50_V58_G0.7300.68
302_R332_F0.7290.68
269_L276_M0.7270.68
172_K243_P0.7270.68
16_L36_V0.7260.67
17_S21_C0.7250.67
141_L194_I0.7240.67
289_N293_A0.7240.67
105_T118_N0.7210.67
146_N150_A0.7180.67
131_I283_G0.7150.66
25_P52_I0.7140.66
127_F162_D0.7140.66
235_L238_N0.7110.66
95_V128_Y0.7110.66
86_R171_Q0.7080.66
168_F189_N0.7070.65
136_V163_V0.7050.65
230_M234_D0.7040.65
76_L80_I0.7030.65
137_A305_Q0.6980.64
178_E302_R0.6910.64
49_M55_V0.6900.64
182_S286_E0.6900.64
194_I239_K0.6890.63
44_Y50_V0.6840.63
224_V237_Q0.6840.63
224_V275_G0.6810.63
46_L52_I0.6810.63
14_A146_N0.6790.62
49_M58_G0.6780.62
15_V31_T0.6770.62
353_V356_L0.6720.62
262_E300_V0.6720.62
105_T156_I0.6710.61
26_G42_N0.6690.61
101_P159_P0.6670.61
89_I238_N0.6670.61
98_W145_R0.6650.61
187_I243_P0.6640.61
95_V161_V0.6640.61
214_V248_F0.6630.60
51_N62_Q0.6620.60
288_M320_A0.6610.60
262_E352_R0.6590.60
294_D319_N0.6590.60
49_M53_Y0.6580.60
141_L163_V0.6570.60
256_K284_N0.6550.60
278_L318_L0.6540.59
274_S319_N0.6540.59
16_L20_A0.6540.59
19_T22_T0.6510.59
348_A353_V0.6500.59
258_F268_T0.6490.59
354_I358_V0.6480.59
22_T26_G0.6480.59
11_L146_N0.6470.59
327_I352_R0.6460.58
131_I223_K0.6450.58
282_L297_G0.6450.58
337_Y356_L0.6430.58
34_K37_I0.6420.58
24_V27_Q0.6420.58
15_V23_L0.6410.58
85_Y257_V0.6400.58
213_V339_I0.6400.58
86_R242_H0.6380.58
44_Y142_T0.6370.57
304_T335_E0.6370.57
92_V167_A0.6340.57
16_L33_N0.6320.57
325_A328_L0.6300.57
17_S26_G0.6280.56
71_Q74_P0.6250.56
9_S22_T0.6230.56
260_M341_Y0.6210.56
10_V14_A0.6210.56
42_N47_D0.6210.56
222_T239_K0.6200.55
43_Q47_D0.6200.55
95_V118_N0.6200.55
27_Q33_N0.6190.55
188_T196_D0.6180.55
207_D291_D0.6170.55
227_Y353_V0.6170.55
161_V334_L0.6140.55
357_L362_S0.6130.55
75_E80_I0.6120.54
24_V33_N0.6080.54
48_K55_V0.6040.53
122_A243_P0.6040.53
10_V15_V0.6020.53
200_A241_L0.6000.53
44_Y66_K0.6000.53
347_L353_V0.6000.53
24_V32_S0.5980.53
358_V361_I0.5980.53
42_N51_N0.5970.53
54_P59_L0.5960.53
187_I192_L0.5960.53
87_I136_V0.5950.52
256_K268_T0.5950.52
61_D64_R0.5920.52
195_M246_I0.5910.52
330_T337_Y0.5900.52
32_S35_D0.5890.52
265_K270_K0.5890.52
47_D52_I0.5880.52
142_T146_N0.5880.52
251_R305_Q0.5870.51
87_I141_L0.5830.51
185_Q293_A0.5810.51
267_S361_I0.5810.51
90_G202_G0.5790.50
59_L62_Q0.5790.50
106_P156_I0.5770.50
141_L145_R0.5770.50
242_H282_L0.5760.50
288_M295_A0.5760.50
29_L41_D0.5760.50
131_I323_A0.5750.50
299_F316_Y0.5740.50
44_Y49_M0.5740.50
129_P163_V0.5710.49
350_W356_L0.5690.49
303_A313_A0.5690.49
198_I237_Q0.5680.49
13_L18_L0.5680.49
183_G202_G0.5670.49
280_E337_Y0.5670.49
156_I281_A0.5660.49
23_L26_G0.5660.49
290_Q344_T0.5660.49
350_W355_S0.5650.49
65_A333_Q0.5630.49
170_S186_P0.5620.48
125_A218_N0.5610.48
233_G275_G0.5600.48
123_D133_R0.5590.48
126_I180_S0.5580.48
154_S293_A0.5580.48
43_Q46_L0.5570.48
14_A66_K0.5570.48
43_Q52_I0.5560.48
58_G63_L0.5550.48
10_V17_S0.5540.47
165_V200_A0.5530.47
100_H103_L0.5510.47
140_T250_P0.5500.47
87_I241_L0.5500.47
37_I47_D0.5500.47
162_D176_T0.5480.47
347_L350_W0.5480.47
75_E78_Q0.5480.47
347_L358_V0.5460.46
98_W317_Q0.5460.46
52_I323_A0.5460.46
131_I145_R0.5450.46
278_L332_F0.5440.46
42_N48_K0.5440.46
10_V16_L0.5430.46
159_P339_I0.5420.46
356_L359_P0.5410.46
50_V57_P0.5410.46
57_P226_L0.5410.46
154_S181_K0.5410.46
354_I359_P0.5390.46
168_F359_P0.5390.46
15_V30_S0.5390.46
17_S23_L0.5370.45
291_D335_E0.5350.45
74_P77_E0.5350.45
140_T152_L0.5350.45
83_Y137_A0.5340.45
61_D65_A0.5310.45
209_D212_N0.5310.45
66_K339_I0.5300.45
11_L17_S0.5290.44
46_L59_L0.5280.44
17_S140_T0.5280.44
163_V316_Y0.5280.44
167_A361_I0.5280.44
27_Q34_K0.5280.44
74_P80_I0.5260.44
20_A28_N0.5220.44
12_T43_Q0.5210.43
157_E160_Q0.5210.43
150_A315_I0.5200.43
27_Q37_I0.5190.43
193_T240_L0.5180.43
68_I73_N0.5180.43
215_L229_L0.5170.43
349_R352_R0.5160.43
351_N360_T0.5150.43
200_A267_S0.5120.42
169_R197_A0.5110.42
51_N55_V0.5110.42
104_T277_T0.5110.42
199_N332_F0.5090.42
85_Y359_P0.5090.42
209_D270_K0.5070.42
28_N35_D0.5060.42
282_L288_M0.5050.42
350_W361_I0.5050.42
12_T32_S0.5020.41
55_V64_R0.5010.41
10_V33_N0.5010.41
37_I42_N0.5010.41
15_V147_E0.5000.41
157_E297_G0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j58A 5 0.9367 100 0.195 Contact Map
3p42A 2 0.4908 100 0.674 Contact Map
2hyxA 2 0.6464 67.5 0.954 Contact Map
4jg9A 2 0.2718 45.8 0.96 Contact Map
3zbiC 1 0.0739 38.6 0.962 Contact Map
4fybB 1 0.3061 29.9 0.964 Contact Map
3u7zA 1 0.248 29.4 0.964 Contact Map
4bkgA 1 0.1873 26.3 0.965 Contact Map
4p6vA 1 0.7414 19.2 0.967 Contact Map
4n4rB 1 0.343 16.9 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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