GREMLIN Database
WZA - Putative polysaccharide export protein wza
UniProt: P0A930 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13566
Length: 379 (336)
Sequences: 1618 (1240)
Seq/√Len: 67.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_V144_I8.6841.00
87_V120_V8.3781.00
136_V144_I6.3461.00
139_K147_D5.5091.00
179_V249_V4.0751.00
120_V136_V4.0501.00
121_Q125_T4.0361.00
197_A241_L3.5121.00
195_L238_N3.2611.00
30_S33_G3.1251.00
144_I163_V3.0051.00
86_R140_T2.8341.00
281_A336_L2.8131.00
55_L59_L2.3931.00
147_D151_R2.3701.00
30_S34_K2.3571.00
194_I247_L2.3011.00
318_Y334_F2.2871.00
212_N223_R2.2561.00
148_I161_V2.2481.00
234_D237_Q2.2401.00
215_L247_L2.2241.00
300_V334_F2.2111.00
263_V344_V2.1701.00
28_N34_K2.1281.00
86_R143_E2.1161.00
125_T135_H2.1001.00
300_V342_V1.9791.00
29_M33_G1.9551.00
88_G170_S1.8991.00
175_I179_V1.8691.00
144_I147_D1.8481.00
213_V247_L1.8471.00
139_K143_E1.8371.00
97_V161_V1.8201.00
139_K144_I1.7871.00
194_I215_L1.7691.00
93_L136_V1.7521.00
89_P137_V1.7371.00
24_L29_M1.7041.00
279_T331_A1.6961.00
353_N361_P1.6790.99
362_T365_G1.6780.99
296_S321_D1.6440.99
93_L144_I1.6360.99
11_L15_V1.5890.99
215_L239_R1.5860.99
136_V147_D1.5830.99
26_G29_M1.5690.99
33_G36_V1.5660.99
60_I64_R1.5640.99
11_L19_S1.5580.99
353_N357_N1.5430.99
11_L14_S1.5420.99
55_L63_L1.5400.99
217_H245_D1.5380.99
130_Y160_Q1.5280.99
278_L342_V1.5230.99
182_S248_Y1.5100.99
31_T34_K1.4570.98
26_G33_G1.4500.98
263_V266_Q1.4270.98
259_V285_A1.4090.98
255_L271_M1.3810.98
54_P319_Q1.3790.98
356_I362_T1.3740.98
188_T192_L1.3570.98
225_S228_A1.3510.97
299_F345_T1.3480.97
151_R154_T1.3360.97
134_V147_D1.3320.97
128_Y152_L1.3240.97
173_A241_L1.3230.97
46_L49_M1.3190.97
214_V223_R1.3180.97
25_P29_M1.3160.97
143_E147_D1.3120.97
278_L300_V1.3060.97
178_Q205_T1.3030.97
31_T35_D1.2950.97
227_Q231_Q1.2940.97
148_I163_V1.2930.97
169_R178_Q1.2860.97
299_F343_Y1.2760.96
357_N364_S1.2750.96
321_D324_D1.2720.96
180_N205_T1.2720.96
103_L106_P1.2690.96
149_T161_V1.2660.96
196_D238_N1.2650.96
62_Q65_P1.2630.96
87_V136_V1.2530.96
45_D48_K1.2520.96
300_V320_L1.2520.96
126_M144_I1.2370.96
13_V16_T1.2360.96
173_A197_A1.2250.95
214_V250_P1.2240.95
24_L33_G1.2230.95
216_T221_E1.2180.95
18_I22_T1.2120.95
288_I293_S1.2090.95
92_V106_P1.2070.95
179_V203_G1.2070.95
350_S358_Q1.2070.95
147_D150_G1.1910.95
42_A45_D1.1830.95
297_G348_P1.1800.94
360_L364_S1.1780.94
21_C25_P1.1780.94
360_L365_G1.1750.94
94_N166_A1.1680.94
241_L247_L1.1620.94
258_F262_E1.1580.94
211_R227_Q1.1580.94
175_I271_M1.1510.94
165_I168_F1.1500.94
131_I151_R1.1480.94
93_L126_M1.1450.94
12_L16_T1.1450.94
14_S18_I1.1420.93
48_K52_V1.1420.93
125_T133_K1.1400.93
39_Q42_A1.1380.93
26_G31_T1.1360.93
141_L165_I1.1360.93
40_Q43_D1.1360.93
25_P33_G1.1350.93
352_W356_I1.1340.93
349_V358_Q1.1290.93
173_A336_L1.1290.93
93_L120_V1.1160.93
50_V55_L1.1140.93
23_V26_G1.1140.93
95_V163_V1.1130.93
43_D150_G1.1120.93
40_Q44_F1.0980.92
279_T332_T1.0930.92
198_I204_L1.0910.92
24_L30_S1.0780.91
28_N343_Y1.0750.91
25_P32_M1.0710.91
214_V221_E1.0660.91
224_I237_Q1.0630.91
29_M35_D1.0620.91
28_N33_G1.0610.91
44_F47_D1.0590.91
269_L276_M1.0580.91
276_M284_N1.0550.90
20_G25_P1.0500.90
17_L21_C1.0410.90
26_G30_S1.0370.90
84_Q142_A1.0360.90
40_Q49_M1.0350.90
141_L144_I1.0310.89
95_V128_Y1.0250.89
10_P15_V1.0130.89
256_K284_N1.0060.88
158_D215_L1.0040.88
51_N62_Q0.9990.88
126_M134_V0.9980.88
352_W362_T0.9970.88
346_T354_R0.9970.88
211_R225_S0.9970.88
358_Q362_T0.9970.88
173_A187_I0.9960.88
10_P17_L0.9920.87
10_P13_V0.9910.87
146_S150_G0.9840.87
55_L317_I0.9840.87
208_A250_P0.9770.87
104_T107_A0.9760.87
125_T218_N0.9690.86
129_P132_G0.9690.86
52_V56_T0.9610.86
144_I148_I0.9600.86
356_I361_P0.9580.86
288_I298_I0.9520.85
24_L28_N0.9510.85
228_A232_N0.9460.85
150_G317_I0.9430.85
12_L15_V0.9360.84
12_L17_L0.9350.84
28_N31_T0.9320.84
102_E106_P0.9300.84
45_D49_M0.9290.84
176_S248_Y0.9290.84
131_I155_Y0.9280.84
282_L316_N0.9270.84
95_V105_T0.9250.83
43_D48_K0.9210.83
288_I295_A0.9170.83
302_R340_D0.9160.83
269_L336_L0.9160.83
256_K280_E0.9150.83
95_V293_S0.9130.83
140_T143_E0.9120.83
182_S217_H0.9080.82
30_S36_V0.9060.82
269_L285_A0.9060.82
145_R149_T0.8990.82
10_P16_T0.8980.82
358_Q365_G0.8980.82
53_Y57_P0.8980.82
44_F51_N0.8960.81
85_Y257_V0.8950.81
22_T26_G0.8890.81
15_V19_S0.8870.81
278_L336_L0.8870.81
235_L238_N0.8820.80
356_I365_G0.8730.80
27_S33_G0.8720.80
97_V103_L0.8720.80
317_I325_A0.8620.79
134_V144_I0.8610.79
352_W359_L0.8570.79
55_L60_I0.8560.78
212_N250_P0.8520.78
298_I342_V0.8500.78
60_I330_M0.8480.78
102_E130_Y0.8450.78
46_L50_V0.8450.78
93_L226_L0.8390.77
97_V152_L0.8390.77
193_T285_A0.8380.77
169_R172_K0.8360.77
268_T284_N0.8250.76
355_L359_L0.8230.76
98_W195_L0.8220.76
46_L52_V0.8210.75
27_S35_D0.8210.75
145_R162_D0.8170.75
29_M36_V0.8130.75
335_R338_P0.8120.75
194_I239_R0.8100.75
58_R61_D0.8090.74
19_S42_A0.8090.74
203_G249_V0.8070.74
172_K243_P0.8050.74
98_W101_P0.8040.74
179_V182_S0.8040.74
297_G345_T0.8030.74
29_M34_K0.8000.74
59_L64_R0.7990.73
121_Q321_D0.7970.73
192_L196_D0.7950.73
224_I229_L0.7940.73
136_V139_K0.7940.73
259_V320_L0.7930.73
15_V35_D0.7890.73
230_M234_D0.7890.73
150_G153_A0.7880.72
47_D51_N0.7860.72
87_V165_I0.7840.72
224_I275_G0.7790.72
204_L208_A0.7760.71
280_E339_Y0.7760.71
256_K268_T0.7760.71
274_S321_D0.7750.71
169_R182_S0.7740.71
18_I21_C0.7730.71
198_I249_V0.7720.71
127_F162_D0.7720.71
57_P61_D0.7720.71
47_D57_P0.7700.71
238_N246_I0.7670.70
51_N54_P0.7640.70
136_V163_V0.7640.70
271_M276_M0.7630.70
260_M343_Y0.7610.70
40_Q64_R0.7600.70
299_F318_Y0.7580.70
210_W225_S0.7570.69
182_S266_Q0.7570.69
320_L325_A0.7560.69
56_T59_L0.7550.69
259_V263_V0.7550.69
59_L62_Q0.7550.69
22_T35_D0.7540.69
141_L145_R0.7530.69
215_L229_L0.7520.69
25_P30_S0.7490.69
50_V57_P0.7470.68
66_R72_P0.7470.68
282_L297_G0.7450.68
35_D298_I0.7430.68
352_W355_L0.7420.68
98_W346_T0.7370.67
14_S17_L0.7350.67
86_R171_Q0.7340.67
302_R334_F0.7330.67
10_P23_V0.7300.67
179_V198_I0.7260.66
131_I158_D0.7190.65
87_V337_Q0.7170.65
332_T339_Y0.7160.65
22_T25_P0.7150.65
213_V249_V0.7120.65
17_L23_V0.7120.65
142_A219_G0.7100.64
27_S30_S0.7060.64
258_F341_V0.7040.64
87_V141_L0.7020.64
193_T196_D0.7020.64
195_L246_I0.6980.63
215_L224_I0.6980.63
99_D130_Y0.6970.63
232_N283_G0.6950.63
358_Q361_P0.6950.63
222_E239_R0.6940.63
96_T128_Y0.6930.63
288_I322_M0.6920.62
39_Q62_Q0.6880.62
15_V23_V0.6880.62
32_M35_D0.6850.62
61_D333_E0.6830.61
133_K247_L0.6810.61
186_A200_A0.6800.61
24_L32_M0.6800.61
85_Y259_V0.6790.61
54_P59_L0.6780.61
258_F268_T0.6780.61
211_R270_K0.6780.61
11_L146_S0.6780.61
327_S330_M0.6760.61
331_A334_F0.6760.61
227_Q339_Y0.6750.61
199_N233_G0.6720.60
131_I194_I0.6710.60
95_V161_V0.6680.60
39_Q43_D0.6670.60
126_M180_N0.6650.59
255_L277_T0.6640.59
126_M232_N0.6640.59
128_Y163_V0.6630.59
11_L65_P0.6620.59
193_T240_L0.6580.59
90_G202_G0.6580.59
50_V210_W0.6570.58
354_R358_Q0.6570.58
126_M301_I0.6570.58
182_S286_E0.6540.58
87_V276_M0.6530.58
93_L148_I0.6530.58
329_V354_R0.6520.58
104_T180_N0.6510.58
98_W145_R0.6490.58
262_E354_R0.6480.57
49_M55_L0.6470.57
40_Q60_I0.6460.57
120_V160_Q0.6450.57
131_I149_T0.6450.57
265_K286_E0.6430.57
49_M53_Y0.6420.57
262_E300_V0.6420.57
168_F189_N0.6380.56
213_V223_R0.6370.56
182_S203_G0.6350.56
100_H103_L0.6350.56
51_N55_L0.6350.56
352_W363_I0.6340.56
20_G23_V0.6330.56
88_G139_K0.6320.56
49_M52_V0.6320.56
185_Q293_S0.6310.55
127_F143_E0.6290.55
18_I24_L0.6290.55
175_I314_I0.6290.55
175_I243_P0.6280.55
140_T302_R0.6260.55
121_Q188_T0.6260.55
119_W275_G0.6250.55
264_K290_M0.6240.55
298_I344_V0.6230.55
262_E338_P0.6210.54
294_N321_D0.6210.54
68_N71_R0.6180.54
192_L197_A0.6160.54
216_T246_I0.6150.54
148_I329_V0.6130.53
290_M346_T0.6130.53
182_S249_V0.6120.53
360_L363_I0.6100.53
233_G246_I0.6100.53
18_I218_N0.6100.53
225_S273_F0.6100.53
140_T240_L0.6070.53
130_Y325_A0.6070.53
41_D45_D0.6070.53
73_N214_V0.6040.52
191_P352_W0.6020.52
272_D284_N0.6020.52
227_Q355_L0.6010.52
45_D51_N0.5990.52
32_M36_V0.5980.52
280_E283_G0.5970.51
24_L27_S0.5960.51
51_N220_R0.5950.51
61_D64_R0.5950.51
50_V58_R0.5950.51
299_F330_M0.5950.51
304_L314_I0.5920.51
167_A365_G0.5910.51
154_T247_L0.5910.51
351_R356_I0.5900.51
234_D238_N0.5900.51
244_G317_I0.5890.50
143_E146_S0.5880.50
70_A277_T0.5870.50
42_A47_D0.5860.50
21_C30_S0.5860.50
177_G201_A0.5850.50
66_R70_A0.5810.50
276_M280_E0.5790.49
159_P253_D0.5780.49
242_Y282_L0.5760.49
66_R359_L0.5760.49
169_R197_A0.5760.49
87_V241_L0.5750.49
318_Y325_A0.5750.49
142_A146_S0.5750.49
359_L364_S0.5720.48
239_R271_M0.5720.48
41_D44_F0.5720.48
270_K357_N0.5710.48
92_V166_A0.5710.48
328_L355_L0.5690.48
153_A338_P0.5680.48
85_Y209_D0.5680.48
101_P159_P0.5650.48
25_P321_D0.5630.47
19_S23_V0.5610.47
183_G202_G0.5600.47
25_P34_K0.5570.47
66_R220_R0.5550.46
260_M283_G0.5550.46
15_V18_I0.5530.46
295_A328_L0.5520.46
211_R363_I0.5510.46
87_V139_K0.5490.46
178_Q251_R0.5490.46
242_Y305_K0.5480.46
11_L44_F0.5480.46
40_Q47_D0.5480.46
206_D249_V0.5470.45
48_K57_P0.5460.45
131_I325_A0.5460.45
83_Y137_V0.5450.45
157_A160_Q0.5440.45
50_V54_P0.5420.45
165_I195_L0.5420.45
200_A241_L0.5410.45
44_F48_K0.5370.44
26_G34_K0.5360.44
176_S196_D0.5360.44
352_W357_N0.5350.44
57_P60_I0.5340.44
339_Y358_Q0.5340.44
247_L344_V0.5340.44
356_I360_L0.5340.44
353_N362_T0.5320.44
143_E259_V0.5310.44
22_T27_S0.5310.44
85_Y169_R0.5300.43
152_L317_I0.5280.43
65_P194_I0.5260.43
198_I237_Q0.5250.43
267_S363_I0.5250.43
61_D65_P0.5250.43
252_N263_V0.5230.43
24_L34_K0.5230.43
222_E262_E0.5220.43
24_L48_K0.5220.43
157_A297_G0.5210.42
89_P238_N0.5210.42
207_T291_T0.5210.42
163_V318_Y0.5180.42
76_L80_I0.5170.42
159_P341_V0.5160.42
55_L64_R0.5160.42
51_N148_I0.5160.42
32_M39_Q0.5150.42
168_F361_P0.5140.42
79_E82_N0.5140.42
95_V107_A0.5140.42
88_G286_E0.5130.41
59_L63_L0.5130.41
361_P365_G0.5120.41
322_M343_Y0.5110.41
71_R150_G0.5110.41
12_L31_T0.5100.41
208_A251_R0.5100.41
103_L128_Y0.5100.41
187_I192_L0.5090.41
185_Q365_G0.5090.41
148_I152_L0.5080.41
97_V246_I0.5080.41
13_V17_L0.5080.41
36_V134_V0.5050.41
334_F345_T0.5040.40
266_Q275_G0.5030.40
18_I52_V0.5020.40
85_Y361_P0.5020.40
140_T298_I0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j58A 5 0.9367 100 0.21 Contact Map
3p42A 2 0.4881 100 0.676 Contact Map
4jg9A 2 0.285 82.5 0.949 Contact Map
2hyxA 2 0.6201 54.4 0.958 Contact Map
4p6vA 1 0.7414 47.6 0.96 Contact Map
4fybB 1 0.3034 46 0.96 Contact Map
3zbiC 1 0.0739 39.1 0.962 Contact Map
4u9oA 1 0.6781 26.4 0.965 Contact Map
2pptA 2 0.3615 26.2 0.965 Contact Map
1ryjA 1 0.1821 17.1 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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