GREMLIN Database
TSX - Nucleoside-specific channel-forming protein tsx
UniProt: P0A927 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11035
Length: 294 (264)
Sequences: 181 (95)
Seq/√Len: 5.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_K154_D3.9190.92
21_N24_E3.6840.90
23_A26_D3.6560.89
118_F121_F3.4600.86
163_M187_F3.3990.85
24_E27_K3.3940.85
251_Y290_V3.3780.85
135_G141_R3.2330.82
23_A27_K3.2310.82
70_F106_F3.1210.80
70_F111_L3.0710.79
21_N26_D2.9860.77
203_L242_L2.9570.76
127_A151_T2.9530.76
215_S263_Q2.7960.72
45_Y288_L2.7320.70
30_Y248_H2.7050.69
4_T10_A2.6940.69
20_V24_E2.5830.65
264_W267_D2.5650.65
126_F147_M2.5590.64
21_N25_N2.5380.64
41_V82_F2.4230.60
30_Y67_K2.4200.60
20_V23_A2.4190.60
20_V26_D2.4040.59
51_P280_R2.3560.58
21_N27_K2.3440.57
106_F111_L2.3050.56
146_Y168_K2.1780.51
6_L16_S2.1450.50
205_Y240_H2.1360.50
268_A279_V2.1200.49
131_I146_Y2.0050.45
264_W279_V1.9920.45
48_R282_T1.8610.40
264_W281_S1.8590.40
144_T168_K1.8330.39
20_V27_K1.8220.39
267_D279_V1.8050.39
232_T264_W1.7710.37
20_V25_N1.7220.36
48_R280_R1.6640.34
125_Y152_D1.6610.34
29_Q110_K1.6390.33
161_L205_Y1.6380.33
257_Y284_W1.6300.33
83_G177_A1.6290.33
44_S54_R1.6150.32
159_M193_V1.5970.32
4_T16_S1.5700.31
45_Y55_N1.5690.31
157_L193_V1.5610.31
15_S23_A1.5240.30
96_S141_R1.5090.29
268_A278_N1.4970.29
261_G266_D1.4680.28
48_R54_R1.4250.27
19_T24_E1.4200.27
51_P285_G1.4170.27
97_P142_Q1.3990.26
14_L21_N1.3690.25
127_A205_Y1.3540.25
128_N147_M1.3520.25
151_T163_M1.3430.25
41_V55_N1.3150.24
67_K248_H1.2800.23
158_P161_L1.2680.23
145_W168_K1.2530.22
149_L265_N1.2530.22
6_L10_A1.2440.22
278_N290_V1.2370.22
151_T187_F1.2120.21
9_G163_M1.1960.21
43_G97_P1.1940.21
28_P113_N1.1720.20
183_D186_R1.1560.20
170_Q186_R1.1520.20
15_S25_N1.1480.20
15_S21_N1.1410.20
128_N133_D1.1410.20
168_K285_G1.1380.20
47_T56_D1.1350.20
5_L8_A1.1270.19
15_S26_D1.1220.19
140_G251_Y1.1160.19
5_L25_N1.1100.19
43_G285_G1.0970.19
22_A33_D1.0910.19
70_F102_I1.0880.19
97_P143_S1.0860.19
216_D219_D1.0790.18
29_Q251_Y1.0760.18
100_M143_S1.0630.18
5_L9_G1.0590.18
151_T203_L1.0560.18
231_R264_W1.0520.18
141_R234_N1.0420.18
153_I165_V1.0400.18
57_T285_G1.0380.18
127_A161_L1.0370.18
57_T98_L1.0350.18
80_V93_N1.0340.17
11_V14_L1.0240.17
145_W285_G1.0210.17
264_W268_A1.0150.17
128_N145_W1.0150.17
14_L23_A1.0140.17
10_A199_W1.0130.17
186_R262_G1.0100.17
46_H55_N1.0100.17
215_S218_G1.0040.17
111_L127_A0.9980.17
257_Y282_T0.9980.17
106_F282_T0.9970.17
13_A290_V0.9940.17
127_A233_N0.9890.17
181_E238_S0.9880.17
205_Y238_S0.9780.16
126_F203_L0.9700.16
39_V61_Y0.9670.16
102_I106_F0.9600.16
126_F130_Y0.9600.16
64_F252_S0.9570.16
46_H285_G0.9560.16
108_I288_L0.9440.16
12_L23_A0.9420.16
38_S244_L0.9420.16
6_L15_S0.9400.16
4_T18_F0.9370.16
205_Y242_L0.9260.15
48_R122_K0.9260.15
163_M214_G0.9030.15
131_I168_K0.9020.15
69_W106_F0.8970.15
4_T14_L0.8930.15
46_H49_F0.8930.15
118_F124_W0.8910.15
4_T9_G0.8890.15
43_G128_N0.8860.15
51_P55_N0.8860.15
124_W187_F0.8840.15
165_V233_N0.8840.15
65_A68_D0.8820.15
16_S27_K0.8800.15
183_D235_S0.8800.15
232_T267_D0.8770.15
10_A18_F0.8680.14
25_N197_D0.8670.14
52_Q278_N0.8610.14
13_A289_V0.8610.14
85_N249_W0.8600.14
197_D290_V0.8590.14
281_S285_G0.8570.14
230_T279_V0.8550.14
9_G197_D0.8550.14
124_W151_T0.8550.14
121_F248_H0.8510.14
46_H50_G0.8490.14
22_A109_D0.8450.14
57_T97_P0.8440.14
51_P127_A0.8420.14
161_L246_Y0.8400.14
127_A209_T0.8400.14
56_D97_P0.8390.14
159_M245_N0.8370.14
158_P257_Y0.8330.14
112_T118_F0.8300.14
93_N289_V0.8250.14
219_D233_N0.8250.14
157_L245_N0.8220.14
94_H265_N0.8210.14
106_F128_N0.8140.13
147_M177_A0.8120.13
26_D31_L0.8110.13
76_A204_S0.8110.13
151_T238_S0.8050.13
94_H126_F0.8010.13
206_I241_I0.8010.13
232_T268_A0.7980.13
46_H250_H0.7980.13
216_D281_S0.7970.13
15_S20_V0.7940.13
16_S26_D0.7940.13
126_F281_S0.7930.13
139_D220_D0.7930.13
179_E268_A0.7920.13
43_G142_Q0.7900.13
108_I149_L0.7890.13
158_P205_Y0.7870.13
267_D281_S0.7850.13
67_K121_F0.7810.13
7_A204_S0.7750.13
197_D204_S0.7720.13
5_L16_S0.7710.13
81_F132_Y0.7700.13
259_H265_N0.7690.13
59_L143_S0.7690.13
132_Y143_S0.7690.13
44_S51_P0.7680.13
31_L205_Y0.7650.13
16_S25_N0.7640.13
44_S98_L0.7630.13
5_L10_A0.7620.13
18_F25_N0.7600.13
20_V154_D0.7580.13
14_L20_V0.7560.13
12_L255_A0.7560.13
158_P218_G0.7540.13
237_A261_G0.7540.13
51_P215_S0.7540.13
237_A258_W0.7530.13
18_F21_N0.7530.13
127_A238_S0.7510.12
183_D262_G0.7500.12
186_R261_G0.7500.12
234_N259_H0.7500.12
38_S246_Y0.7500.12
15_S24_E0.7480.12
145_W177_A0.7480.12
15_S18_F0.7450.12
189_I240_H0.7430.12
141_R284_W0.7410.12
19_T25_N0.7400.12
7_A12_L0.7310.12
70_F110_K0.7280.12
81_F209_T0.7240.12
122_K280_R0.7220.12
4_T19_T0.7210.12
16_S24_E0.7200.12
158_P239_S0.7180.12
85_N135_G0.7160.12
131_I145_W0.7160.12
59_L86_S0.7160.12
4_T8_A0.7160.12
96_S135_G0.7140.12
97_P144_T0.7130.12
98_L133_D0.7120.12
199_W267_D0.7110.12
109_D123_E0.7100.12
165_V187_F0.7100.12
163_M189_I0.7070.12
198_L282_T0.7050.12
82_F257_Y0.7040.12
4_T11_V0.7030.12
7_A11_V0.7030.12
135_G139_D0.7030.12
201_G205_Y0.7020.12
253_V288_L0.7000.12
234_N265_N0.7000.12
100_M132_Y0.6980.12
97_P212_D0.6970.12
83_G145_W0.6970.12
19_T106_F0.6960.12
44_S260_D0.6950.12
100_M126_F0.6940.12
83_G178_N0.6930.12
11_V15_S0.6930.12
149_L260_D0.6920.12
10_A19_T0.6910.12
50_G183_D0.6870.12
56_D179_E0.6860.12
41_V87_D0.6860.12
95_G135_G0.6850.11
132_Y167_A0.6850.11
19_T197_D0.6820.11
144_T177_A0.6820.11
5_L19_T0.6800.11
214_G282_T0.6780.11
10_A149_L0.6780.11
10_A16_S0.6770.11
235_S262_G0.6750.11
128_N143_S0.6720.11
78_A285_G0.6710.11
130_Y147_M0.6700.11
179_E220_D0.6630.11
267_D278_N0.6550.11
189_I209_T0.6540.11
10_A86_S0.6490.11
14_L37_Q0.6480.11
124_W149_L0.6440.11
86_S242_L0.6420.11
44_S82_F0.6390.11
127_A196_T0.6380.11
179_E216_D0.6350.11
126_F145_W0.6320.11
43_G57_T0.6320.11
5_L26_D0.6320.11
22_A28_P0.6320.11
143_S281_S0.6310.11
127_A240_H0.6310.11
106_F196_T0.6310.11
14_L163_M0.6290.11
14_L278_N0.6280.11
10_A21_N0.6270.11
4_T15_S0.6270.11
76_A288_L0.6260.11
43_G130_Y0.6260.11
129_N146_Y0.6260.11
43_G178_N0.6250.11
68_D244_L0.6220.11
53_I280_R0.6200.11
239_S243_A0.6190.11
42_V65_A0.6180.11
55_N280_R0.6160.11
215_S260_D0.6130.11
9_G16_S0.6110.10
23_A86_S0.6100.10
4_T21_N0.6100.10
14_L19_T0.6100.10
94_H259_H0.6080.10
84_G168_K0.6080.10
108_I197_D0.6070.10
76_A100_M0.6070.10
111_L133_D0.6050.10
16_S19_T0.6050.10
130_Y143_S0.5990.10
140_G179_E0.5990.10
34_W248_H0.5980.10
59_L62_E0.5960.10
7_A10_A0.5950.10
82_F142_Q0.5950.10
206_I252_S0.5940.10
144_T285_G0.5940.10
9_G187_F0.5930.10
211_F236_I0.5910.10
241_I252_S0.5890.10
142_Q168_K0.5880.10
63_A68_D0.5860.10
9_G205_Y0.5840.10
13_A251_Y0.5820.10
221_S268_A0.5810.10
52_Q133_D0.5780.10
167_A237_A0.5760.10
6_L18_F0.5750.10
196_T204_S0.5740.10
185_Y249_W0.5740.10
206_I253_V0.5720.10
11_V111_L0.5700.10
40_N188_K0.5690.10
101_E188_K0.5680.10
239_S285_G0.5670.10
159_M286_G0.5660.10
11_V204_S0.5660.10
19_T26_D0.5650.10
94_H211_F0.5650.10
146_Y186_R0.5630.10
163_M209_T0.5620.10
26_D111_L0.5600.10
102_I196_T0.5600.10
191_Y254_V0.5600.10
96_S140_G0.5580.10
51_P54_R0.5580.10
118_F248_H0.5580.10
214_G267_D0.5560.10
53_I167_A0.5560.10
40_N243_A0.5550.10
34_W282_T0.5550.10
16_S21_N0.5540.10
206_I254_V0.5510.10
108_I123_E0.5510.10
14_L189_I0.5450.10
132_Y142_Q0.5450.10
56_D236_I0.5440.10
140_G265_N0.5430.10
115_D195_I0.5420.10
146_Y177_A0.5410.10
109_D242_L0.5400.10
160_S253_V0.5400.10
108_I203_L0.5370.10
123_E185_Y0.5370.10
57_T143_S0.5360.10
156_G191_Y0.5360.10
265_N285_G0.5350.10
112_T160_S0.5330.09
105_R207_G0.5310.09
74_G99_F0.5240.09
76_A217_L0.5240.09
39_V254_V0.5210.09
222_G231_R0.5200.09
137_N140_G0.5190.09
56_D81_F0.5190.09
121_F124_W0.5170.09
100_M204_S0.5170.09
199_W249_W0.5150.09
5_L20_V0.5150.09
105_R152_D0.5140.09
130_Y145_W0.5090.09
114_T213_W0.5080.09
84_G131_I0.5080.09
93_N113_N0.5060.09
127_A149_L0.5060.09
161_L240_H0.5040.09
8_A18_F0.5040.09
230_T265_N0.5010.09
139_D165_V0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tlyA 1 0.8435 100 0.479 Contact Map
3nb3A 2 0.4354 93 0.958 Contact Map
2x9kA 1 0.6088 32 0.975 Contact Map
2vdaB 1 0.0714 18.4 0.978 Contact Map
3zbiC 1 0.0952 16.9 0.978 Contact Map
2msrA 1 0.0714 11.2 0.98 Contact Map
1y0gA 2 0.466 5 0.983 Contact Map
2ju0B 1 0.0714 3.7 0.984 Contact Map
3j46n 1 0.3333 3.3 0.984 Contact Map
4fp5D 3 0.119 2.8 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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