GREMLIN Database
PGPB - Phosphatidylglycerophosphatase B
UniProt: P0A924 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10705
Length: 254 (212)
Sequences: 1554 (1129)
Seq/√Len: 77.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_K165_M3.7491.00
58_L62_G3.5601.00
27_W30_Q3.4801.00
144_P147_L3.1631.00
168_A198_M2.9901.00
164_T198_M2.8621.00
98_D157_F2.6481.00
110_L155_T2.4841.00
112_K146_Y2.4621.00
106_F110_L2.4511.00
172_L220_W2.3391.00
34_Q40_A2.2131.00
198_M216_T2.1151.00
9_A12_A2.0571.00
106_F155_T2.0291.00
54_V58_L2.0111.00
168_A216_T2.0021.00
202_L212_L1.9811.00
160_P218_I1.9471.00
51_P55_I1.9381.00
38_L42_F1.9031.00
42_F45_T1.8731.00
81_I173_L1.8391.00
42_F46_E1.8381.00
45_T48_V1.7961.00
28_R31_P1.7681.00
34_Q39_K1.7341.00
55_I59_I1.7321.00
114_H117_P1.7301.00
54_V62_G1.7031.00
34_Q37_L1.7011.00
26_G29_W1.6641.00
102_E210_R1.6631.00
32_G40_A1.6621.00
46_E50_Q1.5941.00
11_G27_W1.5740.99
47_T50_Q1.5550.99
145_Q152_Q1.5480.99
37_L41_A1.5370.99
41_A45_T1.5220.99
37_L40_A1.5220.99
56_T60_L1.5020.99
106_F206_M1.4800.99
85_A169_S1.4720.99
33_E37_L1.4660.99
147_L152_Q1.4590.99
32_G38_L1.4350.99
97_K104_R1.4350.99
39_K42_F1.4060.99
36_W40_A1.4050.99
109_W112_K1.4000.99
159_F214_V1.3890.99
162_G207_H1.3830.99
92_V222_L1.3790.99
60_L64_F1.3770.99
32_G37_L1.3600.98
92_V218_I1.3410.98
33_E38_L1.3380.98
163_H207_H1.3120.98
42_F47_T1.3110.98
37_L42_F1.2970.98
37_L45_T1.2860.98
144_P148_R1.2840.98
46_E49_T1.2820.98
128_E131_N1.2740.98
41_A44_V1.2670.98
196_G200_S1.2530.97
44_V47_T1.2510.97
40_A46_E1.2500.97
103_P156_G1.2430.97
11_G22_V1.2410.97
19_P23_W1.2170.97
34_Q38_L1.2110.97
154_E206_M1.2030.97
167_A197_V1.1990.97
51_P59_I1.1980.97
42_F50_Q1.1970.97
143_I146_Y1.1950.97
158_A208_W1.1920.96
23_W31_P1.1910.96
21_A27_W1.1780.96
55_I58_L1.1730.96
175_V179_W1.1650.96
22_V25_S1.1590.96
52_W62_G1.1550.96
20_V25_S1.1540.96
97_K207_H1.1520.96
58_L61_F1.1430.96
35_S38_L1.1370.95
27_W31_P1.1310.95
26_G31_P1.1280.95
34_Q45_T1.1180.95
38_L41_A1.1180.95
57_H61_F1.0970.94
76_F80_A1.0890.94
18_M22_V1.0860.94
40_A47_T1.0840.94
45_T49_T1.0800.94
61_F65_L1.0780.94
202_L209_P1.0720.94
172_L191_L1.0570.93
40_A43_W1.0510.93
194_A216_T1.0510.93
32_G35_S1.0420.93
11_G18_M1.0420.93
100_V159_F1.0400.93
11_G16_L1.0380.93
26_G30_Q1.0340.92
35_S40_A1.0260.92
52_W56_T1.0180.92
127_A131_N1.0150.92
59_I63_W1.0120.92
32_G41_A1.0100.92
19_P31_P1.0080.91
210_R214_V1.0030.91
11_G14_L1.0000.91
107_V156_G0.9980.91
25_S28_R0.9920.91
224_A228_W0.9880.91
97_K162_G0.9870.91
37_L108_I0.9830.90
135_E142_N0.9670.90
219_S223_V0.9550.89
102_E205_G0.9540.89
11_G19_P0.9530.89
40_A45_T0.9470.89
39_K46_E0.9390.88
11_G31_P0.9380.88
15_L19_P0.9370.88
215_A219_S0.9210.87
69_R72_I0.9070.86
168_A194_A0.9040.86
227_T231_Q0.8960.86
107_V111_E0.8930.86
16_L20_V0.8900.85
32_G43_W0.8890.85
16_L25_S0.8890.85
50_Q58_L0.8880.85
149_S153_K0.8840.85
188_A192_V0.8820.85
102_E208_W0.8800.85
112_K145_Q0.8770.85
96_I214_V0.8770.85
41_A46_E0.8740.84
143_I147_L0.8720.84
163_H200_S0.8710.84
130_G135_E0.8650.84
179_W187_I0.8620.84
34_Q41_A0.8620.84
41_A47_T0.8580.83
54_V63_W0.8560.83
23_W29_W0.8450.82
104_R162_G0.8450.82
40_A44_V0.8410.82
164_T216_T0.8390.82
165_M215_A0.8360.82
32_G46_E0.8340.81
23_W27_W0.8330.81
11_G30_Q0.8310.81
35_S46_E0.8250.81
164_T168_A0.8250.81
163_H201_R0.8250.81
15_L22_V0.8220.81
93_K171_A0.8220.81
168_A172_L0.8160.80
33_E40_A0.8110.80
11_G23_W0.8110.80
38_L50_Q0.8100.80
51_P54_V0.8030.79
32_G36_W0.8030.79
106_F154_E0.8000.79
55_I60_L0.7970.78
11_G29_W0.7970.78
94_S166_F0.7930.78
66_W70_F0.7920.78
9_A23_W0.7910.78
43_W50_Q0.7880.78
33_E42_F0.7880.78
53_G61_F0.7870.78
217_L221_A0.7820.77
159_F177_L0.7800.77
49_T52_W0.7800.77
34_Q43_W0.7770.77
40_A50_Q0.7750.76
170_W173_L0.7710.76
14_L17_V0.7650.76
34_Q44_V0.7630.75
15_L25_S0.7600.75
32_G44_V0.7590.75
43_W48_V0.7570.75
25_S29_W0.7570.75
111_E204_L0.7560.75
35_S39_K0.7550.75
41_A48_V0.7520.74
104_R207_H0.7440.74
97_K163_H0.7420.73
33_E41_A0.7410.73
32_G39_K0.7370.73
32_G42_F0.7370.73
227_T232_R0.7350.73
56_T59_I0.7320.72
43_W47_T0.7310.72
97_K200_S0.7300.72
32_G45_T0.7290.72
57_H60_L0.7240.71
35_S42_F0.7210.71
89_G222_L0.7190.71
191_L195_T0.7160.71
200_S207_H0.7160.71
103_P107_V0.7150.71
11_G28_R0.7100.70
158_A211_D0.7090.70
39_K44_V0.7070.70
101_Q156_G0.7050.69
42_F48_V0.7010.69
36_W41_A0.7000.69
37_L44_V0.6990.69
58_L64_F0.6980.69
168_A190_L0.6910.68
12_A16_L0.6890.68
9_A16_L0.6870.67
37_L46_E0.6840.67
96_I100_V0.6750.66
10_V15_L0.6620.65
45_T50_Q0.6600.64
44_V48_V0.6580.64
143_I148_R0.6550.64
146_Y151_W0.6550.64
36_W39_K0.6530.64
21_A25_S0.6490.63
36_W50_Q0.6480.63
22_V28_R0.6470.63
18_M28_R0.6460.63
37_L50_Q0.6440.62
95_W99_K0.6430.62
18_M21_A0.6410.62
48_V52_W0.6410.62
82_L169_S0.6410.62
52_W55_I0.6410.62
67_C221_A0.6380.62
61_F64_F0.6370.62
193_W196_G0.6350.61
55_I62_G0.6340.61
74_A231_Q0.6300.61
60_L63_W0.6220.60
102_E156_G0.6140.59
73_K77_V0.6130.59
12_A27_W0.6100.58
39_K45_T0.6070.58
130_G133_V0.6070.58
209_P213_V0.6060.58
11_G21_A0.6040.58
201_R207_H0.6040.58
229_L232_R0.6020.57
175_V187_I0.5990.57
38_L43_W0.5990.57
174_A190_L0.5960.57
78_L171_A0.5950.56
89_G93_K0.5950.56
53_G57_H0.5940.56
144_P152_Q0.5930.56
144_P151_W0.5910.56
12_A15_L0.5890.56
92_V160_P0.5880.56
129_R133_V0.5850.55
96_I199_G0.5840.55
165_M204_L0.5830.55
171_A175_V0.5830.55
157_F206_M0.5800.55
20_V24_I0.5790.54
18_M31_P0.5790.54
33_E39_K0.5780.54
231_Q234_C0.5720.54
111_E219_S0.5680.53
68_L71_R0.5680.53
172_L224_A0.5670.53
88_V222_L0.5630.52
111_E215_A0.5610.52
54_V59_I0.5600.52
218_I222_L0.5580.52
89_G218_I0.5550.51
99_K209_P0.5520.51
35_S41_A0.5510.51
110_L157_F0.5490.51
39_K47_T0.5490.51
17_V21_A0.5480.50
74_A78_L0.5470.50
43_W46_E0.5440.50
15_L30_Q0.5420.50
14_L23_W0.5410.50
9_A15_L0.5390.49
53_G56_T0.5370.49
25_S31_P0.5350.49
128_E133_V0.5320.48
67_C71_R0.5320.48
39_K50_Q0.5300.48
13_A24_I0.5280.48
103_P175_V0.5260.48
47_T51_P0.5240.47
71_R74_A0.5240.47
58_L65_L0.5230.47
38_L45_T0.5220.47
148_R151_W0.5200.47
38_L46_E0.5200.47
93_K157_F0.5190.47
35_S45_T0.5180.47
110_L179_W0.5180.47
34_Q47_T0.5180.47
109_W151_W0.5170.47
90_Q166_F0.5170.47
103_P210_R0.5140.46
11_G25_S0.5120.46
34_Q48_V0.5080.45
131_N134_K0.5050.45
78_L110_L0.5050.45
159_F209_P0.5050.45
23_W30_Q0.5020.45
100_V199_G0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4px7A 1 0.9724 100 0.425 Contact Map
4citA 1 0.748 99.9 0.661 Contact Map
1qi9A 2 0.878 99.8 0.699 Contact Map
1d2tA 5 0.8031 99.8 0.701 Contact Map
1up8A 9 0.8346 99.8 0.705 Contact Map
2ipbA 2 0.7795 99.7 0.706 Contact Map
3w36A 2 0.7598 99.6 0.743 Contact Map
3bb0A 1 0.8386 99.4 0.773 Contact Map
2kluA 1 0.1969 61.7 0.938 Contact Map
2m20A 2 0.185 24.7 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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