GREMLIN Database
PA1 - Phospholipase A1
UniProt: P0A921 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10738
Length: 289 (259)
Sequences: 609 (412)
Seq/√Len: 25.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_K260_Q5.1151.00
194_K216_Q4.9971.00
249_Y257_L4.9701.00
231_K242_G4.8931.00
242_G262_Y4.7641.00
131_E270_I4.2811.00
87_V120_L3.9621.00
261_V277_T3.8141.00
161_N179_Y3.8081.00
159_G179_Y3.6841.00
114_Q134_Y3.4991.00
198_V203_D3.4911.00
234_Y239_G3.2861.00
263_S275_N3.0991.00
191_V217_L3.0671.00
62_Y121_S2.6960.99
263_S277_T2.6800.99
135_E161_N2.5820.99
139_F159_G2.5320.99
116_S132_T2.4790.99
106_S140_L2.4480.99
160_Y176_N2.3810.98
128_P172_S2.3610.98
108_L140_L2.3530.98
110_A138_L2.2280.98
189_W221_Y2.1410.97
55_Y94_A2.1020.96
197_Y200_G2.0520.96
160_Y178_L2.0000.95
71_E74_A1.9700.95
150_G186_N1.9690.95
261_V279_V1.8860.93
233_Q242_G1.8800.93
228_L245_L1.8760.93
117_W278_R1.7950.92
230_A243_A1.7500.91
226_A247_L1.7460.90
113_T281_V1.6940.89
172_S204_D1.6610.88
135_E163_D1.6410.87
250_P257_L1.6310.87
236_W239_G1.6180.87
210_K237_N1.5800.85
88_K267_E1.5590.85
61_I258_Y1.5330.84
246_G258_Y1.5290.83
210_K214_Y1.5220.83
128_P204_D1.5120.83
163_D255_V1.4640.81
109_G183_M1.4600.80
223_L228_L1.4600.80
83_R122_N1.4550.80
212_M242_G1.4300.79
94_A121_S1.4210.79
38_I53_Y1.3960.77
63_T121_S1.3870.77
63_T85_D1.3830.77
210_K238_T1.3440.74
198_V201_N1.3410.74
241_G262_Y1.3310.74
244_E260_Q1.3270.74
38_I42_M1.3200.73
161_N208_I1.3160.73
160_Y199_V1.3080.72
197_Y201_N1.3030.72
120_L123_S1.2940.72
98_W101_I1.2940.72
249_Y286_N1.2780.71
209_T251_I1.2740.70
208_I212_M1.2740.70
221_Y228_L1.2690.70
144_T153_L1.2670.70
106_S142_F1.2550.69
267_E271_D1.2480.69
163_D175_W1.2430.68
246_G284_M1.2410.68
41_N48_N1.2330.68
246_G260_Q1.2270.67
74_A170_P1.2220.67
111_S137_Q1.2210.67
94_A109_G1.2130.67
64_Q68_L1.2090.66
69_N72_A1.2010.66
56_D137_Q1.1990.66
201_N204_D1.1950.65
211_Y245_L1.1890.65
86_E130_R1.1880.65
120_L160_Y1.1810.64
151_W189_W1.1720.64
58_N203_D1.1680.64
157_E181_R1.1410.62
39_I96_P1.1340.61
209_T212_M1.1210.60
235_N239_G1.1190.60
88_K117_W1.1150.60
65_T68_L1.1010.59
178_L230_A1.0800.57
60_L110_A1.0710.57
259_T281_V1.0670.56
93_L134_Y1.0650.56
52_L285_L1.0490.55
138_L160_Y1.0350.54
33_A36_G1.0310.54
267_E278_R1.0250.53
189_W219_I1.0200.53
139_F179_Y1.0140.53
53_Y57_T1.0040.52
56_D135_E1.0020.52
228_L247_L1.0000.52
96_P107_V0.9910.51
133_N167_R0.9880.51
91_L283_V0.9820.50
65_T276_Q0.9790.50
55_Y60_L0.9730.50
86_E119_Q0.9690.49
131_E269_L0.9690.49
112_Y267_E0.9570.48
243_A263_S0.9430.47
62_Y250_P0.9420.47
41_N96_P0.9390.47
258_Y280_G0.9360.47
203_D206_P0.9320.47
153_L156_V0.9300.46
159_G180_T0.9290.46
62_Y85_D0.9200.46
69_N271_D0.9060.45
235_N240_Y0.9040.45
219_I227_V0.9030.44
191_V219_I0.9020.44
141_G155_D0.9000.44
120_L127_S0.8960.44
89_F131_E0.8900.44
106_S179_Y0.8860.43
118_W175_W0.8850.43
256_R287_D0.8820.43
268_S271_D0.8800.43
158_M180_T0.8740.42
55_Y114_Q0.8620.42
140_L267_E0.8610.41
90_Q113_T0.8580.41
142_F151_W0.8560.41
52_L97_L0.8560.41
40_A48_N0.8490.41
60_L80_E0.8480.41
96_P99_R0.8450.40
96_P139_F0.8360.40
103_G140_L0.8330.39
214_Y236_W0.8330.39
144_T150_G0.8330.39
122_N148_F0.8260.39
35_R160_Y0.8260.39
115_K135_E0.8230.39
249_Y254_H0.8200.39
177_R196_W0.8150.38
112_Y134_Y0.8150.38
167_R285_L0.8140.38
116_S129_F0.8120.38
61_I280_G0.8110.38
112_Y142_F0.8080.38
144_T156_V0.8070.38
84_K194_K0.8000.37
262_Y278_R0.7960.37
64_Q280_G0.7950.37
96_P260_Q0.7840.36
198_V206_P0.7840.36
33_A40_A0.7800.36
119_Q130_R0.7700.35
110_A243_A0.7660.35
93_L228_L0.7640.35
133_N270_I0.7640.35
55_Y169_D0.7600.34
204_D269_L0.7590.34
175_W198_V0.7560.34
47_D107_V0.7550.34
97_L138_L0.7540.34
163_D212_M0.7530.34
112_Y140_L0.7530.34
117_W268_S0.7530.34
96_P109_G0.7510.34
101_I108_L0.7480.34
119_Q280_G0.7470.34
134_Y139_F0.7470.34
127_S169_D0.7460.34
94_A137_Q0.7450.33
41_N107_V0.7430.33
59_Y131_E0.7430.33
229_S246_G0.7420.33
60_L248_S0.7400.33
103_G106_S0.7350.33
86_E137_Q0.7330.33
60_L220_G0.7330.33
243_A269_L0.7300.33
95_F255_V0.7300.33
232_G239_G0.7290.32
105_N142_F0.7280.32
154_R185_E0.7260.32
88_K115_K0.7250.32
65_T69_N0.7250.32
167_R195_P0.7230.32
256_R284_M0.7220.32
194_K247_L0.7200.32
262_Y267_E0.7160.32
94_A257_L0.7160.32
152_T178_L0.7130.31
138_L253_K0.7100.31
76_Y110_A0.7100.31
180_T224_G0.7090.31
137_Q177_R0.7080.31
188_N221_Y0.7070.31
176_N213_G0.7040.31
190_L220_G0.7030.31
31_A71_E0.7000.31
116_S211_Y0.6980.30
76_Y180_T0.6980.30
204_D233_Q0.6970.30
179_Y194_K0.6940.30
48_N99_R0.6930.30
209_T214_Y0.6920.30
201_N206_P0.6900.30
235_N238_T0.6890.30
91_L97_L0.6890.30
108_L138_L0.6860.30
52_L252_T0.6860.30
51_T54_P0.6850.30
67_D170_P0.6850.30
140_L179_Y0.6810.29
116_S134_Y0.6800.29
45_E53_Y0.6780.29
87_V280_G0.6770.29
156_V182_L0.6760.29
273_N276_Q0.6750.29
68_L181_R0.6740.29
212_M235_N0.6710.29
67_D277_T0.6710.29
41_N183_M0.6710.29
216_Q233_Q0.6700.29
93_L287_D0.6690.29
152_T278_R0.6670.29
42_M48_N0.6670.29
232_G236_W0.6610.28
146_Y153_L0.6570.28
86_E269_L0.6550.28
151_W232_G0.6510.28
227_V257_L0.6500.28
153_L182_L0.6490.28
55_Y134_Y0.6480.27
68_L122_N0.6470.27
123_S158_M0.6450.27
95_F110_A0.6440.27
204_D235_N0.6430.27
58_N198_V0.6400.27
216_Q231_K0.6400.27
84_K138_L0.6390.27
122_N284_M0.6370.27
71_E76_Y0.6370.27
87_V123_S0.6360.27
39_I139_F0.6350.27
86_E278_R0.6350.27
91_L249_Y0.6340.27
212_M233_Q0.6290.26
214_Y244_E0.6270.26
230_A245_L0.6270.26
48_N96_P0.6260.26
39_I42_M0.6250.26
55_Y167_R0.6240.26
42_M109_G0.6240.26
85_D121_S0.6240.26
116_S198_V0.6210.26
193_V215_Y0.6210.26
104_P144_T0.6170.26
189_W211_Y0.6160.26
264_G282_G0.6150.26
189_W195_P0.6140.26
41_N252_T0.6110.25
180_T215_Y0.6100.25
164_S205_N0.6080.25
61_I270_I0.6070.25
107_V140_L0.6070.25
54_P267_E0.6050.25
61_I285_L0.6040.25
143_A153_L0.6030.25
103_G268_S0.6030.25
168_S172_S0.6020.25
236_W287_D0.6010.25
227_V287_D0.6000.25
63_T110_A0.5990.25
183_M187_G0.5980.25
259_T279_V0.5980.25
57_T227_V0.5980.25
135_E151_W0.5970.25
194_K269_L0.5950.24
52_L217_L0.5940.24
177_R208_I0.5920.24
231_K244_E0.5920.24
73_I77_D0.5910.24
61_I121_S0.5890.24
56_D210_K0.5880.24
58_N206_P0.5880.24
255_V285_L0.5870.24
46_H247_L0.5850.24
202_T279_V0.5830.24
82_A274_F0.5810.24
94_A250_P0.5810.24
178_L197_Y0.5800.24
185_E189_W0.5800.24
69_N274_F0.5790.24
208_I239_G0.5790.24
194_K262_Y0.5790.24
114_Q215_Y0.5780.24
119_Q177_R0.5770.24
91_L210_K0.5740.23
158_M194_K0.5720.23
158_M189_W0.5720.23
135_E234_Y0.5720.23
41_N99_R0.5720.23
203_D250_P0.5710.23
54_P286_N0.5690.23
142_F227_V0.5680.23
140_L161_N0.5680.23
82_A125_E0.5670.23
110_A210_K0.5670.23
132_T266_G0.5660.23
161_N176_N0.5650.23
36_G100_G0.5650.23
118_W174_S0.5620.23
81_N97_L0.5620.23
118_W129_F0.5600.23
67_D70_K0.5590.23
218_K229_S0.5590.23
56_D232_G0.5540.22
122_N161_N0.5540.22
214_Y235_N0.5530.22
66_S71_E0.5530.22
201_N233_Q0.5520.22
119_Q137_Q0.5500.22
140_L148_F0.5500.22
63_T261_V0.5480.22
104_P195_P0.5470.22
209_T273_N0.5460.22
93_L155_D0.5460.22
276_Q280_G0.5460.22
134_Y265_Y0.5430.22
121_S251_I0.5420.22
108_L147_R0.5420.22
128_P235_N0.5410.22
129_F250_P0.5400.22
239_G242_G0.5400.22
175_W196_W0.5400.22
153_L230_A0.5370.21
228_L257_L0.5350.21
139_F261_V0.5350.21
93_L193_V0.5340.21
72_A154_R0.5340.21
107_V244_E0.5330.21
87_V156_V0.5330.21
182_L193_V0.5310.21
208_I285_L0.5290.21
123_S202_T0.5290.21
167_R171_T0.5280.21
180_T246_G0.5270.21
110_A167_R0.5250.21
89_F134_Y0.5230.21
130_R137_Q0.5210.21
118_W163_D0.5200.21
142_F184_A0.5200.21
87_V230_A0.5180.21
42_M51_T0.5180.21
174_S240_Y0.5150.20
151_W186_N0.5150.20
197_Y268_S0.5150.20
105_N143_A0.5140.20
162_H165_N0.5130.20
162_H166_G0.5130.20
121_S215_Y0.5130.20
30_D75_S0.5110.20
201_N240_Y0.5110.20
77_D243_A0.5070.20
115_K195_P0.5070.20
224_G237_N0.5070.20
277_T285_L0.5060.20
127_S176_N0.5050.20
225_D256_R0.5040.20
138_L142_F0.5030.20
87_V267_E0.5020.20
115_K178_L0.5020.20
48_N51_T0.5020.20
36_G111_S0.5010.20
114_Q151_W0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qd5A 1 0.8893 100 0.116 Contact Map
1qd6C 2 0.8304 100 0.152 Contact Map
1ormA 1 0.5052 20.5 0.972 Contact Map
2o4vA 3 0.3702 17.3 0.973 Contact Map
4e1sA 1 0.564 8.9 0.976 Contact Map
3qraA 1 0.526 8.7 0.976 Contact Map
4fqeA 1 0.2837 8.2 0.977 Contact Map
2wjrA 1 0.301 5.9 0.978 Contact Map
1svdM 3 0.2007 5.8 0.978 Contact Map
2x9kA 1 0.4567 5 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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