GREMLIN Database
OMPX - Outer membrane protein X
UniProt: P0A917 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12135
Length: 171 (166)
Sequences: 234 (164)
Seq/√Len: 12.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_K147_D4.2851.00
137_Q147_D3.9590.99
52_R101_S3.5780.99
27_T145_A3.2180.98
61_G93_A2.9880.96
152_Q162_T2.8430.95
89_T131_S2.7910.95
55_E61_G2.7660.94
95_R139_N2.4970.90
54_E101_S2.4910.90
66_F86_Y2.4340.89
50_K137_Q2.3500.87
52_R95_R2.3020.86
69_T162_T2.2480.85
48_N65_S2.2400.85
54_E95_R2.2390.85
50_K153_S2.1790.83
54_E139_N2.1330.82
137_Q145_A2.0370.78
140_P167_V2.0090.77
52_R93_A1.9970.77
24_A62_V1.9460.75
95_R101_S1.9070.73
3_K6_C1.9000.73
52_R139_N1.8680.72
35_S69_T1.8640.72
71_K162_T1.7990.69
137_Q166_G1.7580.67
67_T85_Y1.7270.66
37_A40_Q1.6900.64
147_D153_S1.6450.62
24_A45_G1.6430.62
64_G141_M1.6260.61
9_A12_A1.6250.61
27_T102_I1.5780.58
85_Y151_E1.5700.58
149_S164_I1.5690.58
34_Q45_G1.5130.55
36_D138_F1.5130.55
12_A66_F1.4650.53
149_S154_R1.4100.50
34_Q44_M1.3800.48
27_T94_Y1.3630.47
89_T104_G1.3520.47
109_G153_S1.3420.46
141_M153_S1.3370.46
50_K155_I1.2920.44
129_G157_S1.2730.43
68_Y86_Y1.2670.42
90_A144_V1.2540.42
60_L164_I1.2510.42
18_A28_V1.2310.41
27_T67_T1.2310.41
148_F165_A1.2290.40
91_G107_G1.2260.40
30_G126_S1.2110.40
109_G131_S1.1940.39
101_S139_N1.1830.38
62_V156_R1.1820.38
49_L68_Y1.1810.38
149_S162_T1.1690.37
55_E93_A1.1590.37
133_G169_Y1.1580.37
35_S162_T1.1270.35
44_M71_K1.1150.35
68_Y132_Y1.1100.35
60_L96_I1.0790.33
98_D104_G1.0580.32
37_A86_Y1.0550.32
154_R159_D1.0520.32
26_S51_Y1.0470.32
4_I8_S1.0340.31
55_E58_S1.0230.31
69_T161_G1.0100.30
68_Y104_G1.0090.30
7_L12_A1.0040.30
111_G166_G0.9990.30
9_A142_E0.9910.29
154_R158_V0.9900.29
30_G100_A0.9840.29
33_A162_T0.9630.28
5_A146_L0.9530.28
7_L10_L0.9520.28
6_C9_A0.9500.28
61_G111_G0.9490.28
64_G132_Y0.9400.27
49_L54_E0.9350.27
63_I75_A0.9300.27
96_I143_N0.9290.27
56_D170_R0.9110.26
64_G99_W0.9090.26
69_T160_V0.9070.26
89_T163_W0.9050.26
131_S164_I0.8760.25
71_K152_Q0.8700.24
52_R112_K0.8630.24
13_V16_F0.8600.24
142_E149_S0.8590.24
108_V128_Y0.8480.24
35_S160_V0.8460.23
37_A160_V0.8420.23
60_L93_A0.8400.23
152_Q163_W0.8370.23
42_N83_N0.8320.23
149_S155_I0.8250.23
15_A67_T0.8240.23
62_V67_T0.8160.22
77_S123_H0.8120.22
13_V109_G0.8100.22
61_G80_Y0.8090.22
38_Q153_S0.8010.22
130_F153_S0.8010.22
14_L138_F0.7960.22
152_Q161_G0.7920.22
133_G151_E0.7870.21
77_S136_L0.7840.21
43_K138_F0.7840.21
5_A153_S0.7840.21
26_S35_S0.7750.21
40_Q70_E0.7740.21
133_G149_S0.7660.21
97_N139_N0.7640.21
29_T87_G0.7590.20
63_I137_Q0.7580.20
147_D166_G0.7500.20
155_I160_V0.7490.20
38_Q152_Q0.7440.20
29_T137_Q0.7430.20
120_T165_A0.7380.20
28_V134_A0.7360.20
98_D121_Y0.7360.20
50_K145_A0.7350.20
8_S64_G0.7320.19
69_T132_Y0.7280.19
63_I105_V0.7270.19
64_G131_S0.7270.19
16_F100_A0.7260.19
88_I146_L0.7260.19
92_P169_Y0.7260.19
27_T139_N0.7260.19
59_P93_A0.7250.19
132_Y162_T0.7170.19
33_A85_Y0.7150.19
24_A63_I0.7150.19
8_S11_A0.7140.19
100_A113_F0.7080.19
104_G142_E0.7070.19
113_F128_Y0.7040.19
103_Y150_Y0.7010.19
100_A165_A0.7000.18
6_C16_F0.6990.18
106_V167_V0.6900.18
132_Y152_Q0.6890.18
47_F83_N0.6870.18
33_A133_G0.6860.18
26_S102_I0.6810.18
23_A56_D0.6800.18
71_K161_G0.6800.18
45_G124_D0.6780.18
8_S63_I0.6730.18
7_L15_A0.6690.18
151_E168_G0.6670.17
92_P101_S0.6670.17
50_K111_G0.6650.17
58_S124_D0.6570.17
104_G141_M0.6570.17
5_A13_V0.6560.17
19_G22_V0.6550.17
87_G155_I0.6540.17
127_D155_I0.6440.17
9_A13_V0.6420.17
22_V67_T0.6420.17
46_G135_G0.6400.17
98_D145_A0.6390.17
92_P95_R0.6380.17
29_T147_D0.6350.17
79_D116_T0.6330.16
140_P154_R0.6320.16
147_D154_R0.6290.16
111_G131_S0.6280.16
86_Y112_K0.6270.16
125_T165_A0.6260.16
88_I130_F0.6210.16
96_I106_V0.6190.16
5_A100_A0.6180.16
161_G164_I0.6150.16
115_T126_S0.6090.16
93_A150_Y0.6090.16
82_K114_Q0.6080.16
11_A19_G0.6050.16
44_M61_G0.6020.16
49_L117_E0.6010.16
49_L108_V0.6010.16
9_A80_Y0.5990.16
14_L27_T0.5990.16
81_N148_F0.5950.15
102_I157_S0.5940.15
7_L11_A0.5930.15
149_S158_V0.5900.15
48_N105_V0.5880.15
147_D155_I0.5850.15
83_N87_G0.5830.15
115_T120_T0.5820.15
49_L100_A0.5820.15
28_V104_G0.5800.15
10_L60_L0.5790.15
68_Y166_G0.5740.15
5_A11_A0.5740.15
4_I15_A0.5740.15
148_F162_T0.5700.15
5_A25_T0.5690.15
23_A139_N0.5680.15
109_G147_D0.5660.15
117_E123_H0.5660.15
71_K163_W0.5650.15
8_S49_L0.5650.15
26_S53_Y0.5600.15
6_C109_G0.5600.15
14_L18_A0.5570.14
132_Y140_P0.5570.14
105_V164_I0.5570.14
35_S47_F0.5530.14
37_A125_T0.5450.14
66_F130_F0.5440.14
60_L124_D0.5410.14
14_L30_G0.5390.14
16_F124_D0.5390.14
79_D158_V0.5390.14
27_T54_E0.5300.14
141_M144_V0.5290.14
34_Q169_Y0.5260.14
9_A15_A0.5260.14
72_S130_F0.5250.14
46_G168_G0.5180.13
135_G168_G0.5180.13
71_K164_I0.5170.13
109_G115_T0.5160.13
4_I10_L0.5160.13
132_Y169_Y0.5110.13
140_P143_N0.5110.13
78_G153_S0.5100.13
50_K104_G0.5090.13
150_Y168_G0.5050.13
7_L129_G0.5050.13
62_V99_W0.5040.13
74_T86_Y0.5040.13
15_A19_G0.5030.13
26_S52_R0.5000.13
58_S156_R0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ormA 1 0.8596 99.9 0.578 Contact Map
3qraA 1 0.8655 99.9 0.616 Contact Map
3nb3A 2 0.7719 99.7 0.7 Contact Map
2k0lA 1 0.9532 99.6 0.74 Contact Map
1qjpA 1 0.7836 99.5 0.751 Contact Map
2jmmA 1 0.8129 99.5 0.754 Contact Map
1p4tA 2 0.848 99.2 0.786 Contact Map
2lhfA 1 0.8246 99.2 0.79 Contact Map
4rlcA 1 0.7602 99.2 0.79 Contact Map
2x27X 1 0.9006 99.1 0.793 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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