GREMLIN Database
OMPW - Outer membrane protein W
UniProt: P0A915 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11124
Length: 212 (202)
Sequences: 1301 (896)
Seq/√Len: 63.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_F161_V4.9821.00
76_L104_L4.6691.00
170_L209_G3.9161.00
117_F163_Y3.7311.00
181_D198_R2.8961.00
166_N169_W2.7861.00
83_R96_T2.7141.00
165_I171_V2.6231.00
169_W210_Y2.5711.00
86_I97_V2.5541.00
34_A205_M2.4991.00
65_T73_G2.4891.00
121_V159_V2.4571.00
123_A157_G2.4171.00
67_M73_G2.3891.00
68_A74_V2.3131.00
111_G118_R2.2841.00
72_I106_A2.2101.00
120_Y172_N2.1931.00
125_I153_W2.1171.00
111_G115_S2.0291.00
85_K93_D2.0231.00
80_T131_F2.0161.00
54_V199_L1.9681.00
103_T156_A1.8901.00
37_R56_N1.8441.00
157_G177_Y1.8241.00
27_F64_F1.8171.00
129_T151_D1.8091.00
169_W208_A1.7801.00
77_L105_M1.7601.00
175_V202_W1.7490.99
35_T58_T1.7420.99
33_S58_T1.7100.99
183_T196_S1.6860.99
105_M176_W1.6320.99
83_R98_H1.6030.99
69_T72_I1.5880.99
28_F170_L1.5570.99
181_D200_D1.5500.99
27_F66_Y1.5310.99
79_A82_F1.4820.98
65_T107_Q1.4610.98
118_R170_L1.4360.98
168_D210_Y1.4280.98
149_L182_T1.4230.98
28_F65_T1.4180.98
157_G179_D1.4140.98
146_D187_K1.3920.97
34_A203_V1.3630.97
81_P99_H1.3450.97
85_K96_T1.3440.97
37_R204_F1.3350.97
23_E70_D1.3270.96
112_D115_S1.3170.96
77_L176_W1.3150.96
68_A72_I1.2930.96
120_Y158_Q1.2920.96
188_L191_A1.2860.96
32_G61_G1.2650.95
32_G63_T1.2410.95
111_G114_S1.2320.95
16_S20_F1.2320.95
116_K163_Y1.2280.95
50_G88_T1.2240.94
38_P84_H1.2230.94
97_V149_L1.2210.94
126_N152_S1.2120.94
59_Q80_T1.1940.94
81_P98_H1.1920.94
30_R162_D1.1910.94
25_G70_D1.1850.93
110_F118_R1.1770.93
61_G205_M1.1640.93
40_E53_S1.1370.92
129_T132_D1.1320.92
59_Q82_F1.1200.91
54_V84_H1.1180.91
177_Y200_D1.1100.91
150_K182_T1.1030.91
42_A195_D1.0960.90
30_R209_G1.0770.90
172_N207_S1.0770.90
75_E158_Q1.0700.89
149_L197_V1.0670.89
107_Q176_W1.0660.89
127_Y151_D1.0510.89
162_D172_N1.0370.88
155_A179_D1.0330.88
174_S205_M1.0330.88
176_W205_M1.0320.88
135_F186_Y1.0310.88
187_K190_G1.0280.87
150_K183_T1.0250.87
52_F197_V1.0210.87
40_E54_V1.0120.87
170_L210_Y1.0100.86
30_R172_N1.0040.86
35_T56_N1.0030.86
128_T152_S0.9950.86
8_A14_L0.9920.85
95_A147_L0.9880.85
186_Y194_H0.9870.85
183_T194_H0.9710.84
27_F78_A0.9700.84
39_T177_Y0.9700.84
152_S180_I0.9650.84
34_A59_Q0.9640.84
98_H132_D0.9590.83
17_G20_F0.9550.83
148_S151_D0.9430.82
28_F67_M0.9410.82
161_V165_I0.9280.81
93_D136_N0.9260.81
116_K164_L0.9230.81
12_T16_S0.9140.80
63_T77_L0.9130.80
150_K185_N0.9070.80
30_R120_Y0.9060.80
32_G81_P0.9010.79
56_N132_D0.8820.78
71_N115_S0.8800.78
54_V197_V0.8750.77
142_A145_S0.8730.77
39_T43_G0.8700.77
25_G28_F0.8610.76
129_T133_N0.8590.76
60_L109_Y0.8520.76
91_T94_I0.8520.76
39_T42_A0.8470.75
175_V204_F0.8470.75
45_T50_G0.8460.75
13_T17_G0.8450.75
74_V78_A0.8440.75
159_V175_V0.8420.75
73_G107_Q0.8370.74
157_G202_W0.8360.74
186_Y193_Q0.8340.74
112_D118_R0.8280.73
65_T109_Y0.8270.73
51_G88_T0.8250.73
59_Q79_A0.8250.73
178_M203_V0.8240.73
86_I147_L0.8220.73
61_G174_S0.8220.73
77_L99_H0.8170.72
8_A15_L0.8150.72
84_H99_H0.8110.72
70_D111_G0.8100.72
86_I95_A0.8060.71
158_Q207_S0.8040.71
99_H180_I0.8020.71
23_E26_E0.8020.71
109_Y174_S0.7980.71
67_M109_Y0.7950.70
154_G180_I0.7920.70
34_A176_W0.7910.70
53_S89_R0.7810.69
183_T200_D0.7690.68
120_Y209_G0.7690.68
61_G77_L0.7670.68
94_I142_A0.7650.67
127_Y153_W0.7630.67
10_A13_T0.7580.67
55_T87_G0.7530.66
73_G109_Y0.7520.66
75_E78_A0.7400.65
57_N81_P0.7380.65
83_R132_D0.7350.64
102_P126_N0.7300.64
23_E68_A0.7260.63
84_H101_P0.7230.63
66_Y108_W0.7210.63
107_Q207_S0.7190.63
43_G195_D0.7150.62
145_S188_L0.7130.62
103_T203_V0.7040.61
77_L102_P0.7040.61
82_F100_L0.7020.61
34_A61_G0.7020.61
67_M118_R0.7000.61
155_A177_Y0.7000.61
53_S87_G0.6980.60
84_H100_L0.6960.60
78_A100_L0.6940.60
145_S186_Y0.6930.60
97_V130_F0.6900.59
66_Y101_P0.6880.59
148_S183_T0.6880.59
79_A203_V0.6860.59
10_A14_L0.6860.59
28_F172_N0.6860.59
38_P56_N0.6860.59
39_T202_W0.6860.59
45_T48_S0.6690.57
84_H103_T0.6650.57
35_T206_F0.6640.56
46_L49_L0.6550.55
61_G176_W0.6550.55
28_F120_Y0.6540.55
55_T96_T0.6530.55
149_L184_A0.6510.55
25_G67_M0.6500.55
105_M156_A0.6470.55
65_T172_N0.6460.54
9_L20_F0.6410.54
32_G78_A0.6410.54
82_F176_W0.6390.54
71_N111_G0.6300.53
9_L12_T0.6270.52
117_F159_V0.6270.52
77_L100_L0.6230.52
14_L17_G0.6220.52
63_T174_S0.6170.51
30_R128_T0.6170.51
185_N194_H0.6160.51
63_T205_M0.6150.51
32_G77_L0.6130.51
32_G59_Q0.6110.50
106_A126_N0.6090.50
97_V133_N0.6090.50
48_S88_T0.6080.50
118_R204_F0.6080.50
56_N87_G0.6070.50
88_T194_H0.6060.50
34_A63_T0.6050.50
163_Y173_M0.6040.50
155_A159_V0.5970.49
5_T8_A0.5960.49
32_G176_W0.5950.49
6_V157_G0.5950.49
120_Y176_W0.5940.48
81_P102_P0.5900.48
144_L188_L0.5890.48
129_T153_W0.5890.48
206_F209_G0.5850.47
77_L82_F0.5830.47
173_M204_F0.5820.47
24_A70_D0.5820.47
51_G89_R0.5810.47
170_L207_S0.5810.47
53_S72_I0.5810.47
144_L189_G0.5790.47
7_A16_S0.5750.46
187_K191_A0.5750.46
188_L193_Q0.5740.46
24_A69_T0.5730.46
15_L18_S0.5710.46
95_A177_Y0.5690.46
20_F23_E0.5670.45
136_N145_S0.5660.45
30_R65_T0.5650.45
55_T196_S0.5640.45
94_I195_D0.5630.45
86_I94_I0.5630.45
93_D96_T0.5630.45
135_F142_A0.5610.45
30_R67_M0.5600.45
62_L80_T0.5590.44
26_E70_D0.5530.44
165_I208_A0.5510.44
111_G116_K0.5510.44
180_I199_L0.5500.43
38_P103_T0.5450.43
9_L16_S0.5440.43
117_F121_V0.5430.43
96_T134_G0.5430.43
135_F144_L0.5420.43
78_A102_P0.5410.42
100_L131_F0.5390.42
42_A183_T0.5380.42
88_T91_T0.5370.42
63_T176_W0.5370.42
126_N156_A0.5370.42
30_R158_Q0.5360.42
71_N110_F0.5310.41
103_T180_I0.5310.41
126_N154_G0.5300.41
77_L81_P0.5290.41
128_T180_I0.5260.41
123_A155_A0.5250.41
30_R207_S0.5250.41
161_V173_M0.5220.40
36_V84_H0.5190.40
8_A18_S0.5190.40
163_Y175_V0.5190.40
72_I169_W0.5190.40
29_M62_L0.5160.40
100_L103_T0.5160.40
163_Y166_N0.5160.40
75_E105_M0.5140.39
65_T68_A0.5140.39
8_A13_T0.5130.39
59_Q62_L0.5130.39
12_T20_F0.5120.39
32_G82_F0.5090.39
172_N209_G0.5090.39
82_F172_N0.5070.39
9_L13_T0.5020.38
35_T161_V0.5020.38
9_L19_A0.5020.38
59_Q203_V0.5010.38
158_Q172_N0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f1vA 4 0.8538 100 0.363 Contact Map
2x27X 1 0.9198 100 0.468 Contact Map
2lhfA 1 0.7972 99.9 0.658 Contact Map
3nb3A 2 0.6368 99.9 0.659 Contact Map
2k0lA 1 0.8868 99.8 0.677 Contact Map
4rlcA 1 0.6368 99.8 0.682 Contact Map
1qjpA 1 0.6415 99.8 0.705 Contact Map
2mafA 1 0.8302 99.8 0.707 Contact Map
1p4tA 2 0.7311 99.7 0.713 Contact Map
3qraA 1 0.7075 99.7 0.716 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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