GREMLIN Database
PAL - Peptidoglycan-associated lipoprotein
UniProt: P0A912 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10684
Length: 173 (151)
Sequences: 8581 (6602)
Seq/√Len: 537.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_D117_Y3.5971.00
74_D81_R3.5771.00
106_E148_Y3.3241.00
122_G147_S2.9731.00
157_G162_A2.9291.00
89_D136_K2.7561.00
120_S124_R2.6831.00
155_V162_A2.6491.00
112_R163_Y2.6201.00
75_L112_R2.6091.00
123_E127_N2.5691.00
108_H152_K2.5551.00
89_D132_Y2.5251.00
88_L132_Y2.4541.00
148_Y152_K2.3921.00
78_Y124_R2.3791.00
119_I123_E2.3531.00
130_K145_I2.2881.00
156_L162_A2.1391.00
115_P150_K1.9311.00
155_V165_K1.9241.00
105_V169_A1.8251.00
159_D162_A1.7651.00
115_P151_E1.6231.00
132_Y136_K1.6031.00
130_K134_Q1.5541.00
119_I151_E1.5471.00
134_Q143_I1.5321.00
127_N130_K1.5271.00
80_I132_Y1.5001.00
104_T144_S1.5001.00
139_S142_Q1.4691.00
74_D77_K1.4511.00
111_E163_Y1.4211.00
157_G163_Y1.4071.00
80_I84_F1.3781.00
117_Y120_S1.3731.00
158_H162_A1.3651.00
130_K143_I1.3581.00
105_V130_K1.3571.00
104_T146_V1.3311.00
127_N145_I1.3171.00
82_S85_A1.3161.00
127_N131_M1.3141.00
85_A132_Y1.2701.00
134_Q140_A1.2551.00
92_A133_L1.2121.00
87_M90_A1.1501.00
138_V143_I1.1211.00
130_K140_A1.1131.00
102_K144_S1.1111.00
106_E146_V1.1091.00
93_N96_R1.0901.00
108_H153_P1.0871.00
103_V143_I1.0841.00
117_Y150_K1.0781.00
92_A136_K1.0641.00
106_E152_K1.0501.00
132_Y135_G1.0501.00
138_V142_Q1.0421.00
80_I128_A1.0401.00
159_D163_Y1.0351.00
156_L159_D1.0321.00
78_Y121_L1.0171.00
34_E38_G1.0171.00
123_E145_I1.0071.00
81_R84_F0.9951.00
75_L117_Y0.9881.00
108_H170_V0.9821.00
153_P166_N0.9761.00
34_E37_L0.9711.00
116_E120_S0.9711.00
31_D38_G0.9611.00
112_R160_E0.9561.00
72_Y84_F0.9431.00
98_N101_Y0.9421.00
94_F98_N0.9371.00
31_D34_E0.9251.00
131_M135_G0.9231.00
111_E157_G0.9211.00
22_C25_N0.9181.00
161_A165_K0.9161.00
86_Q90_A0.9151.00
14_L18_A0.9101.00
89_D93_N0.9001.00
31_D35_G0.9001.00
111_E158_H0.8981.00
75_L110_D0.8831.00
111_E150_K0.8781.00
85_A89_D0.8711.00
28_A33_S0.8631.00
27_N30_N0.8611.00
93_N97_S0.8561.00
154_A165_K0.8511.00
15_P18_A0.8481.00
92_A96_R0.8461.00
110_D118_N0.8441.00
105_V143_I0.8441.00
96_R138_V0.8441.00
16_V20_A0.8411.00
53_S56_E0.8391.00
35_G38_G0.8371.00
153_P163_Y0.8331.00
33_S37_L0.8231.00
28_A31_D0.8181.00
86_Q89_D0.8171.00
114_T117_Y0.8161.00
14_L17_M0.8131.00
129_V169_A0.8011.00
123_E147_S0.7991.00
162_A165_K0.7901.00
126_A147_S0.7831.00
12_I16_V0.7781.00
20_A23_S0.7721.00
113_G118_N0.7661.00
158_H163_Y0.7651.00
26_K29_S0.7631.00
95_L103_V0.7631.00
73_F169_A0.7631.00
78_Y128_A0.7601.00
105_V126_A0.7601.00
75_L113_G0.7561.00
23_S28_A0.7561.00
32_G35_G0.7511.00
29_S33_S0.7511.00
131_M134_Q0.7501.00
10_L13_A0.7501.00
59_R62_M0.7491.00
70_I170_V0.7431.00
91_H95_L0.7421.00
111_E166_N0.7391.00
160_E163_Y0.7391.00
90_A94_F0.7371.00
81_R164_S0.7311.00
117_Y124_R0.7281.00
54_S58_A0.7251.00
88_L129_V0.7221.00
26_K30_N0.7201.00
115_P119_I0.7201.00
108_H151_E0.7191.00
92_A138_V0.7141.00
80_I85_A0.7121.00
111_E162_A0.7081.00
106_E170_V0.7041.00
9_G13_A0.6921.00
29_S32_G0.6921.00
73_F129_V0.6811.00
108_H148_Y0.6801.00
21_A24_S0.6801.00
30_N37_L0.6791.00
58_A62_M0.6791.00
88_L133_L0.6761.00
57_Q66_Q0.6731.00
33_S36_M0.6681.00
68_N91_H0.6671.00
112_R117_Y0.6661.00
15_P19_I0.6631.00
115_P149_G0.6581.00
123_E146_V0.6531.00
112_R150_K0.6521.00
120_S123_E0.6491.00
61_Q65_L0.6481.00
30_N33_S0.6461.00
96_R139_S0.6461.00
90_A93_N0.6441.00
31_D37_L0.6411.00
153_P157_G0.6371.00
29_S35_G0.6351.00
66_Q170_V0.6281.00
84_F87_M0.6271.00
13_A17_M0.6261.00
17_M20_A0.6241.00
124_R127_N0.6221.00
109_A150_K0.6111.00
107_G169_A0.6001.00
128_A131_M0.6001.00
114_T150_K0.6001.00
25_N30_N0.5981.00
155_V159_D0.5961.00
111_E153_P0.5931.00
126_A145_I0.5921.00
19_I22_C0.5891.00
32_G36_M0.5891.00
56_E60_L0.5880.99
94_F101_Y0.5820.99
25_N28_A0.5800.99
30_N36_M0.5790.99
60_L63_Q0.5790.99
61_Q64_Q0.5770.99
159_D166_N0.5720.99
26_K34_E0.5720.99
78_Y120_S0.5710.99
155_V166_N0.5710.99
91_H171_L0.5650.99
13_A16_V0.5640.99
25_N31_D0.5630.99
63_Q67_Q0.5630.99
102_K142_Q0.5630.99
31_D36_M0.5620.99
72_Y154_A0.5570.99
18_A21_A0.5570.99
72_Y164_S0.5550.99
11_M20_A0.5530.99
29_S34_E0.5480.99
29_S37_L0.5480.99
55_E58_A0.5460.99
26_K32_G0.5420.99
60_L64_Q0.5410.99
67_Q72_Y0.5410.99
59_R63_Q0.5400.99
66_Q69_N0.5370.99
30_N34_E0.5340.99
118_N150_K0.5330.99
10_L14_L0.5310.99
115_P120_S0.5290.99
11_M14_L0.5250.99
69_N87_M0.5240.99
63_Q68_N0.5220.99
65_L69_N0.5180.99
24_S27_N0.5150.99
75_L118_N0.5150.99
19_I25_N0.5150.99
11_M15_P0.5140.99
28_A32_G0.5120.99
108_H168_R0.5020.98
57_Q60_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ldtA 2 0.8035 100 0.239 Contact Map
2k1sA 1 0.7977 100 0.268 Contact Map
2aizP 1 0.7746 100 0.28 Contact Map
2hqsH 1 0.6185 100 0.282 Contact Map
1r1mA 1 0.6705 100 0.286 Contact Map
2l26A 1 0.9884 100 0.291 Contact Map
2kgwA 1 0.7399 100 0.293 Contact Map
4b62A 1 0.7861 100 0.295 Contact Map
3td3A 2 0.6763 100 0.296 Contact Map
4b5cA 1 0.6879 100 0.299 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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