OMPA - ECOLI - GREMLIN Contacts

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OMPA - Outer membrane protein A

UniProt:	P0A910	Sequences: MKKTAIAIAVALAGFATVAQAAPKDNTWYTGAKLGWSQYHDTGFINNNGPTHENQLGAGAFGGYQVNPYVGFEMGYDWLGRMPYKGSVENGAYKAQGVQLTAKLGYPITDDLDIYTRLGGMVWRADTKSNVYGKNHDTGVSPVFAGGVEYAITPEIATRLEYQWTNNIGDAHTIGTRPDNGMLSLGVSYRFGQGEAAPVVAPAPAPAPEVQTKHFTLKSDVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQSVVDYLISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEVKGIKDVVTQPQA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10669
Length:	346 (300)
Sequences:	2799 (2341)
Seq/√Len:	135.1

ECOLI - OMPA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
226_N	269_Y	5.757	1.00
275_E	279_Q	4.886	1.00
272_G	276_R	4.272	1.00
271_Q	275_E	4.067	1.00
282_V	297_A	3.817	1.00
258_L	300_M	3.562	1.00
224_N	231_K	3.478	1.00
279_Q	283_D	3.468	1.00
260_Y	304_N	3.422	1.00
228_A	276_R	3.421	1.00
309_N	314_V	3.328	1.00
239_D	288_K	3.059	1.00
290_I	294_K	2.928	1.00
307_T	314_V	2.895	1.00
300_M	304_N	2.885	1.00
225_F	264_I	2.869	1.00
238_L	284_Y	2.860	1.00
239_D	284_Y	2.775	1.00
267_D	302_E	2.739	1.00
279_Q	282_V	2.657	1.00
279_Q	297_A	2.654	1.00
309_N	315_K	2.589	1.00
308_G	314_V	2.523	1.00
243_S	247_N	2.509	1.00
224_N	227_K	2.432	1.00
255_V	295_I	2.318	1.00
245_L	294_K	2.260	1.00
264_I	315_K	2.257	1.00
311_C	314_V	2.227	1.00
282_V	286_I	2.212	1.00
156_I	189_Y	2.184	1.00
307_T	317_R	2.174	1.00
274_S	299_G	2.148	1.00
267_D	303_S	2.140	1.00
152_I	158_T	2.119	1.00
282_V	292_A	2.097	1.00
271_Q	303_S	2.095	1.00
291_P	294_K	2.023	1.00
230_L	284_Y	2.014	1.00
283_D	287_S	1.965	1.00
33_K	59_G	1.964	1.00
237_A	240_Q	1.958	1.00
225_F	269_Y	1.945	1.00
231_K	316_Q	1.930	1.00
257_V	278_A	1.897	1.00
223_F	321_I	1.875	1.00
31_G	61_F	1.875	1.00
256_V	298_R	1.834	1.00
278_A	299_G	1.824	1.00
263_R	302_E	1.823	1.00
18_V	21_A	1.823	1.00
153_T	156_I	1.767	1.00
283_D	286_I	1.749	1.00
305_P	309_N	1.734	1.00
275_E	297_A	1.693	1.00
225_F	265_G	1.648	1.00
262_D	270_N	1.638	1.00
242_Y	285_L	1.625	1.00
230_L	280_S	1.605	1.00
105_G	108_I	1.601	1.00
111_D	150_Y	1.600	1.00
112_L	148_V	1.595	1.00
271_Q	299_G	1.565	1.00
256_V	296_S	1.554	1.00
129_S	133_G	1.534	1.00
230_L	235_Q	1.532	1.00
269_Y	273_L	1.497	1.00
269_Y	272_G	1.492	1.00
228_A	272_G	1.476	1.00
305_P	315_K	1.469	1.00
224_N	229_T	1.459	1.00
269_Y	276_R	1.458	1.00
276_R	279_Q	1.427	1.00
223_F	259_G	1.425	1.00
260_Y	303_S	1.422	1.00
257_V	321_I	1.403	1.00
100_L	105_G	1.399	1.00
230_L	234_G	1.378	1.00
258_L	304_N	1.374	1.00
239_D	243_S	1.364	1.00
284_Y	288_K	1.359	1.00
259_G	321_I	1.359	1.00
63_G	73_E	1.356	1.00
232_P	235_Q	1.354	1.00
310_T	314_V	1.347	1.00
234_G	237_A	1.342	1.00
263_R	309_N	1.335	1.00
104_L	107_P	1.324	1.00
256_V	300_M	1.322	1.00
254_S	296_S	1.311	1.00
225_F	262_D	1.307	1.00
242_Y	288_K	1.292	1.00
226_N	276_R	1.287	1.00
17_T	21_A	1.263	1.00
29_Y	63_G	1.263	1.00
97_G	108_I	1.259	1.00
275_E	298_R	1.257	1.00
223_F	281_V	1.251	1.00
258_L	298_R	1.250	1.00
238_L	244_Q	1.250	1.00
242_Y	290_I	1.228	1.00
19_A	22_A	1.226	1.00
162_Y	183_L	1.218	1.00
306_V	314_V	1.214	1.00
269_Y	302_E	1.201	1.00
159_R	186_G	1.192	1.00
282_V	295_I	1.189	0.99
191_F	195_E	1.167	0.99
286_I	292_A	1.167	0.99
263_R	315_K	1.164	0.99
268_A	272_G	1.162	0.99
115_Y	147_G	1.157	0.99
311_C	315_K	1.147	0.99
308_G	311_C	1.129	0.99
263_R	305_P	1.113	0.99
164_W	179_D	1.111	0.99
265_G	270_N	1.109	0.99
263_R	314_V	1.108	0.99
122_V	138_T	1.081	0.99
231_K	234_G	1.070	0.99
162_Y	181_G	1.065	0.99
260_Y	300_M	1.057	0.99
239_D	242_Y	1.056	0.99
17_T	20_Q	1.053	0.99
259_G	281_V	1.045	0.99
284_Y	287_S	1.033	0.99
245_L	250_P	1.033	0.99
250_P	294_K	1.033	0.99
222_L	316_Q	1.017	0.98
257_V	295_I	1.012	0.98
117_R	121_M	1.003	0.98
310_T	315_K	0.991	0.98
245_L	290_I	0.986	0.98
156_I	187_V	0.986	0.98
257_V	282_V	0.984	0.98
258_L	324_L	0.979	0.98
314_V	317_R	0.977	0.98
228_A	273_L	0.968	0.98
66_V	72_F	0.967	0.98
260_Y	318_A	0.964	0.98
217_L	220_D	0.961	0.98
258_L	322_D	0.951	0.98
234_G	323_C	0.940	0.97
199_V	209_E	0.933	0.97
263_R	311_C	0.931	0.97
305_P	318_A	0.929	0.97
95_A	105_G	0.928	0.97
246_S	290_I	0.925	0.97
307_T	315_K	0.922	0.97
242_Y	284_Y	0.919	0.97
149_E	157_A	0.909	0.97
96_Q	108_I	0.907	0.97
225_F	315_K	0.905	0.97
275_E	299_G	0.904	0.97
104_L	108_I	0.904	0.97
102_A	108_I	0.897	0.96
101_T	105_G	0.894	0.96
98_V	101_T	0.893	0.96
117_R	145_A	0.888	0.96
70_V	104_L	0.887	0.96
219_S	222_L	0.887	0.96
305_P	314_V	0.887	0.96
260_Y	305_P	0.885	0.96
210_V	213_K	0.881	0.96
238_L	288_K	0.879	0.96
235_Q	284_Y	0.878	0.96
63_G	71_G	0.875	0.96
286_I	295_I	0.864	0.96
253_G	325_A	0.862	0.96
160_L	185_L	0.861	0.96
101_T	104_L	0.859	0.96
244_Q	253_G	0.859	0.96
6_I	13_A	0.856	0.95
255_V	285_L	0.856	0.95
264_I	312_D	0.853	0.95
195_E	198_P	0.852	0.95
101_T	107_P	0.851	0.95
18_V	22_A	0.850	0.95
306_V	309_N	0.838	0.95
112_L	150_Y	0.838	0.95
99_Q	105_G	0.836	0.95
101_T	143_V	0.825	0.94
290_I	295_I	0.822	0.94
93_Y	100_L	0.816	0.94
115_Y	119_G	0.811	0.94
313_N	316_Q	0.809	0.94
99_Q	103_K	0.808	0.94
97_G	105_G	0.805	0.94
305_P	320_L	0.790	0.93
73_E	161_E	0.790	0.93
220_D	241_L	0.785	0.93
242_Y	246_S	0.773	0.92
308_G	315_K	0.773	0.92
256_V	324_L	0.770	0.92
97_G	100_L	0.767	0.92
12_L	16_A	0.761	0.92
271_Q	298_R	0.756	0.91
270_N	302_E	0.754	0.91
103_K	108_I	0.748	0.91
255_V	323_C	0.746	0.91
117_R	163_Q	0.741	0.91
29_Y	73_E	0.737	0.90
103_K	107_P	0.737	0.90
102_A	106_Y	0.736	0.90
246_S	289_G	0.735	0.90
30_T	34_L	0.735	0.90
245_L	253_G	0.733	0.90
59_G	77_D	0.733	0.90
59_G	75_G	0.731	0.90
3_K	6_I	0.731	0.90
157_A	190_R	0.728	0.90
97_G	104_L	0.726	0.90
19_A	24_K	0.724	0.90
309_N	313_N	0.723	0.89
176_T	179_D	0.722	0.89
236_A	239_D	0.722	0.89
312_D	315_K	0.721	0.89
66_V	69_Y	0.720	0.89
32_A	189_Y	0.718	0.89
263_R	307_T	0.716	0.89
102_A	105_G	0.714	0.89
141_S	149_E	0.714	0.89
296_S	323_C	0.711	0.89
272_G	275_E	0.707	0.88
13_A	22_A	0.707	0.88
137_D	140_V	0.707	0.88
6_I	11_A	0.704	0.88
99_Q	104_L	0.704	0.88
266_S	269_Y	0.703	0.88
309_N	316_Q	0.701	0.88
76_Y	96_Q	0.700	0.88
94_K	97_G	0.699	0.88
93_Y	107_P	0.697	0.88
264_I	269_Y	0.696	0.88
315_K	321_I	0.695	0.88
246_S	294_K	0.694	0.87
304_N	322_D	0.693	0.87
311_C	317_R	0.693	0.87
13_A	18_V	0.691	0.87
100_L	104_L	0.690	0.87
295_I	323_C	0.690	0.87
222_L	255_V	0.688	0.87
31_G	34_L	0.688	0.87
149_E	159_R	0.686	0.87
219_S	244_Q	0.686	0.87
4_T	16_A	0.683	0.87
107_P	110_D	0.682	0.87
257_V	281_V	0.681	0.87
67_N	70_V	0.680	0.86
223_F	257_V	0.677	0.86
264_I	314_V	0.676	0.86
93_Y	102_A	0.676	0.86
265_G	281_V	0.676	0.86
114_I	147_G	0.676	0.86
188_S	194_G	0.671	0.86
281_V	321_I	0.670	0.86
136_H	141_S	0.669	0.86
190_R	193_Q	0.669	0.86
185_L	190_R	0.667	0.85
11_A	15_F	0.663	0.85
95_A	106_Y	0.663	0.85
311_C	318_A	0.660	0.85
157_A	161_E	0.659	0.85
98_V	105_G	0.658	0.85
273_L	277_R	0.658	0.85
220_D	323_C	0.654	0.84
287_S	292_A	0.649	0.84
5_A	10_V	0.647	0.84
267_D	271_Q	0.645	0.83
259_G	309_N	0.644	0.83
133_G	138_T	0.643	0.83
191_F	194_G	0.641	0.83
11_A	14_G	0.641	0.83
143_V	165_T	0.641	0.83
65_Q	70_V	0.639	0.83
57_G	184_S	0.638	0.83
14_G	210_V	0.638	0.83
314_V	318_A	0.637	0.83
185_L	191_F	0.635	0.82
35_G	57_G	0.634	0.82
99_Q	102_A	0.633	0.82
145_A	161_E	0.633	0.82
253_G	323_C	0.632	0.82
278_A	297_A	0.631	0.82
225_F	266_S	0.631	0.82
275_E	282_V	0.627	0.82
241_L	245_L	0.627	0.82
155_E	191_F	0.627	0.82
285_L	289_G	0.624	0.81
228_A	280_S	0.624	0.81
13_A	17_T	0.624	0.81
28_W	64_Y	0.622	0.81
145_A	152_I	0.620	0.81
266_S	302_E	0.620	0.81
225_F	270_N	0.611	0.80
92_A	95_A	0.610	0.80
150_Y	160_L	0.608	0.80
188_S	191_F	0.606	0.79
254_S	293_D	0.606	0.79
93_Y	105_G	0.604	0.79
227_K	231_K	0.603	0.79
250_P	254_S	0.603	0.79
214_H	324_L	0.602	0.79
226_N	273_L	0.602	0.79
93_Y	104_L	0.601	0.79
297_A	300_M	0.599	0.79
222_L	306_V	0.599	0.79
235_Q	288_K	0.598	0.79
235_Q	239_D	0.597	0.78
99_Q	108_I	0.597	0.78
224_N	316_Q	0.596	0.78
34_L	56_L	0.596	0.78
96_Q	104_L	0.596	0.78
234_G	262_D	0.596	0.78
259_G	315_K	0.595	0.78
93_Y	97_G	0.594	0.78
97_G	107_P	0.594	0.78
150_Y	164_W	0.591	0.78
6_I	9_A	0.591	0.78
219_S	240_Q	0.589	0.78
182_M	191_F	0.589	0.78
73_E	159_R	0.589	0.78
227_K	280_S	0.587	0.77
220_D	234_G	0.587	0.77
96_Q	107_P	0.587	0.77
61_F	73_E	0.587	0.77
227_K	261_T	0.585	0.77
31_G	35_G	0.585	0.77
14_G	22_A	0.584	0.77
91_G	95_A	0.584	0.77
30_T	210_V	0.583	0.77
91_G	94_K	0.583	0.77
305_P	310_T	0.582	0.77
117_R	161_E	0.582	0.77
259_G	319_A	0.581	0.77
110_D	114_I	0.580	0.76
261_T	299_G	0.580	0.76
219_S	237_A	0.579	0.76
60_A	76_Y	0.577	0.76
223_F	273_L	0.577	0.76
237_A	241_L	0.576	0.76
229_T	280_S	0.574	0.76
51_T	54_N	0.572	0.75
93_Y	99_Q	0.570	0.75
254_S	294_K	0.568	0.75
100_L	103_K	0.567	0.75
246_S	291_P	0.567	0.75
92_A	102_A	0.566	0.75
222_L	234_G	0.566	0.75
179_D	189_Y	0.564	0.74
309_N	318_A	0.563	0.74
184_S	189_Y	0.562	0.74
50_P	54_N	0.561	0.74
253_G	294_K	0.558	0.74
151_A	156_I	0.557	0.74
50_P	53_E	0.555	0.73
264_I	309_N	0.555	0.73
61_F	80_G	0.554	0.73
73_E	79_L	0.554	0.73
14_G	21_A	0.553	0.73
313_N	317_R	0.553	0.73
224_N	233_E	0.552	0.73
225_F	302_E	0.552	0.73
189_Y	193_Q	0.552	0.73
126_D	129_S	0.552	0.73
133_G	140_V	0.551	0.73
262_D	309_N	0.550	0.73
257_V	299_G	0.550	0.73
5_A	12_L	0.550	0.73
77_D	80_G	0.550	0.73
235_Q	238_L	0.549	0.72
133_G	141_S	0.549	0.72
276_R	302_E	0.547	0.72
223_F	316_Q	0.547	0.72
308_G	312_D	0.546	0.72
271_Q	274_S	0.546	0.72
149_E	158_T	0.545	0.72
222_L	261_T	0.545	0.72
226_N	266_S	0.544	0.72
61_F	75_G	0.544	0.72
306_V	315_K	0.543	0.72
35_G	71_G	0.543	0.72
183_L	187_V	0.543	0.72
110_D	113_D	0.542	0.72
259_G	310_T	0.542	0.72
76_Y	79_L	0.541	0.71
221_V	237_A	0.541	0.71
36_W	40_H	0.541	0.71
220_D	316_Q	0.541	0.71
260_Y	320_L	0.541	0.71
142_P	168_I	0.540	0.71
98_V	102_A	0.539	0.71
5_A	14_G	0.539	0.71
19_A	23_P	0.538	0.71
73_E	80_G	0.538	0.71
115_Y	161_E	0.537	0.71
95_A	99_Q	0.536	0.71
93_Y	103_K	0.535	0.71
263_R	318_A	0.535	0.71
65_Q	68_P	0.533	0.70
219_S	238_L	0.533	0.70
184_S	190_R	0.532	0.70
11_A	21_A	0.531	0.70
217_L	230_L	0.529	0.70
91_G	97_G	0.528	0.70
5_A	19_A	0.527	0.69
264_I	302_E	0.525	0.69
118_L	144_F	0.525	0.69
161_E	184_S	0.525	0.69
58_A	78_W	0.524	0.69
241_L	285_L	0.523	0.69
36_W	54_N	0.523	0.69
13_A	21_A	0.523	0.69
264_I	310_T	0.522	0.69
153_T	164_W	0.522	0.69
226_N	261_T	0.521	0.69
138_T	141_S	0.519	0.68
221_V	292_A	0.519	0.68
97_G	101_T	0.519	0.68
26_N	42_T	0.516	0.68
246_S	288_K	0.516	0.68
97_G	103_K	0.516	0.68
187_V	192_G	0.516	0.68
119_G	147_G	0.515	0.68
164_W	181_G	0.515	0.68
73_E	163_Q	0.515	0.68
71_G	105_G	0.514	0.68
111_D	128_K	0.514	0.68
182_M	190_R	0.514	0.68
35_G	64_Y	0.513	0.67
16_A	21_A	0.513	0.67
115_Y	159_R	0.512	0.67
221_V	234_G	0.512	0.67
116_T	146_G	0.512	0.67
262_D	265_G	0.512	0.67
102_A	107_P	0.511	0.67
42_T	85_K	0.510	0.67
100_L	108_I	0.510	0.67
191_F	196_A	0.509	0.67
31_G	188_S	0.508	0.67
101_T	257_V	0.507	0.66
222_L	231_K	0.506	0.66
75_G	79_L	0.504	0.66
142_P	145_A	0.503	0.66
219_S	261_T	0.502	0.66
308_G	317_R	0.502	0.66
222_L	323_C	0.501	0.66
189_Y	192_G	0.501	0.66
136_H	154_P	0.501	0.66
103_K	163_Q	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3nb3A	2	0.396	100	0.257	Contact Map
4rhaA	2	0.3526	100	0.555	Contact Map
1r1mA	1	0.3468	100	0.558	Contact Map
4b5cA	1	0.3497	100	0.563	Contact Map
2kgwA	1	0.3642	100	0.569	Contact Map
2hqsH	1	0.3121	100	0.571	Contact Map
3td3A	2	0.3497	100	0.571	Contact Map
3ldtA	2	0.4162	100	0.574	Contact Map
2aizP	1	0.3671	100	0.578	Contact Map
3cypB	3	0.3613	100	0.578	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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