GREMLIN Database
OMPA - Outer membrane protein A
UniProt: P0A910 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10669
Length: 346 (300)
Sequences: 2799 (2341)
Seq/√Len: 135.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
226_N269_Y5.7571.00
275_E279_Q4.8861.00
272_G276_R4.2721.00
271_Q275_E4.0671.00
282_V297_A3.8171.00
258_L300_M3.5621.00
224_N231_K3.4781.00
279_Q283_D3.4681.00
260_Y304_N3.4221.00
228_A276_R3.4211.00
309_N314_V3.3281.00
239_D288_K3.0591.00
290_I294_K2.9281.00
307_T314_V2.8951.00
300_M304_N2.8851.00
225_F264_I2.8691.00
238_L284_Y2.8601.00
239_D284_Y2.7751.00
267_D302_E2.7391.00
279_Q282_V2.6571.00
279_Q297_A2.6541.00
309_N315_K2.5891.00
308_G314_V2.5231.00
243_S247_N2.5091.00
224_N227_K2.4321.00
255_V295_I2.3181.00
245_L294_K2.2601.00
264_I315_K2.2571.00
311_C314_V2.2271.00
282_V286_I2.2121.00
156_I189_Y2.1841.00
307_T317_R2.1741.00
274_S299_G2.1481.00
267_D303_S2.1401.00
152_I158_T2.1191.00
282_V292_A2.0971.00
271_Q303_S2.0951.00
291_P294_K2.0231.00
230_L284_Y2.0141.00
283_D287_S1.9651.00
33_K59_G1.9641.00
237_A240_Q1.9581.00
225_F269_Y1.9451.00
231_K316_Q1.9301.00
257_V278_A1.8971.00
223_F321_I1.8751.00
31_G61_F1.8751.00
256_V298_R1.8341.00
278_A299_G1.8241.00
263_R302_E1.8231.00
18_V21_A1.8231.00
153_T156_I1.7671.00
283_D286_I1.7491.00
305_P309_N1.7341.00
275_E297_A1.6931.00
225_F265_G1.6481.00
262_D270_N1.6381.00
242_Y285_L1.6251.00
230_L280_S1.6051.00
105_G108_I1.6011.00
111_D150_Y1.6001.00
112_L148_V1.5951.00
271_Q299_G1.5651.00
256_V296_S1.5541.00
129_S133_G1.5341.00
230_L235_Q1.5321.00
269_Y273_L1.4971.00
269_Y272_G1.4921.00
228_A272_G1.4761.00
305_P315_K1.4691.00
224_N229_T1.4591.00
269_Y276_R1.4581.00
276_R279_Q1.4271.00
223_F259_G1.4251.00
260_Y303_S1.4221.00
257_V321_I1.4031.00
100_L105_G1.3991.00
230_L234_G1.3781.00
258_L304_N1.3741.00
239_D243_S1.3641.00
284_Y288_K1.3591.00
259_G321_I1.3591.00
63_G73_E1.3561.00
232_P235_Q1.3541.00
310_T314_V1.3471.00
234_G237_A1.3421.00
263_R309_N1.3351.00
104_L107_P1.3241.00
256_V300_M1.3221.00
254_S296_S1.3111.00
225_F262_D1.3071.00
242_Y288_K1.2921.00
226_N276_R1.2871.00
17_T21_A1.2631.00
29_Y63_G1.2631.00
97_G108_I1.2591.00
275_E298_R1.2571.00
223_F281_V1.2511.00
258_L298_R1.2501.00
238_L244_Q1.2501.00
242_Y290_I1.2281.00
19_A22_A1.2261.00
162_Y183_L1.2181.00
306_V314_V1.2141.00
269_Y302_E1.2011.00
159_R186_G1.1921.00
282_V295_I1.1890.99
191_F195_E1.1670.99
286_I292_A1.1670.99
263_R315_K1.1640.99
268_A272_G1.1620.99
115_Y147_G1.1570.99
311_C315_K1.1470.99
308_G311_C1.1290.99
263_R305_P1.1130.99
164_W179_D1.1110.99
265_G270_N1.1090.99
263_R314_V1.1080.99
122_V138_T1.0810.99
231_K234_G1.0700.99
162_Y181_G1.0650.99
260_Y300_M1.0570.99
239_D242_Y1.0560.99
17_T20_Q1.0530.99
259_G281_V1.0450.99
284_Y287_S1.0330.99
245_L250_P1.0330.99
250_P294_K1.0330.99
222_L316_Q1.0170.98
257_V295_I1.0120.98
117_R121_M1.0030.98
310_T315_K0.9910.98
245_L290_I0.9860.98
156_I187_V0.9860.98
257_V282_V0.9840.98
258_L324_L0.9790.98
314_V317_R0.9770.98
228_A273_L0.9680.98
66_V72_F0.9670.98
260_Y318_A0.9640.98
217_L220_D0.9610.98
258_L322_D0.9510.98
234_G323_C0.9400.97
199_V209_E0.9330.97
263_R311_C0.9310.97
305_P318_A0.9290.97
95_A105_G0.9280.97
246_S290_I0.9250.97
307_T315_K0.9220.97
242_Y284_Y0.9190.97
149_E157_A0.9090.97
96_Q108_I0.9070.97
225_F315_K0.9050.97
275_E299_G0.9040.97
104_L108_I0.9040.97
102_A108_I0.8970.96
101_T105_G0.8940.96
98_V101_T0.8930.96
117_R145_A0.8880.96
70_V104_L0.8870.96
219_S222_L0.8870.96
305_P314_V0.8870.96
260_Y305_P0.8850.96
210_V213_K0.8810.96
238_L288_K0.8790.96
235_Q284_Y0.8780.96
63_G71_G0.8750.96
286_I295_I0.8640.96
253_G325_A0.8620.96
160_L185_L0.8610.96
101_T104_L0.8590.96
244_Q253_G0.8590.96
6_I13_A0.8560.95
255_V285_L0.8560.95
264_I312_D0.8530.95
195_E198_P0.8520.95
101_T107_P0.8510.95
18_V22_A0.8500.95
306_V309_N0.8380.95
112_L150_Y0.8380.95
99_Q105_G0.8360.95
101_T143_V0.8250.94
290_I295_I0.8220.94
93_Y100_L0.8160.94
115_Y119_G0.8110.94
313_N316_Q0.8090.94
99_Q103_K0.8080.94
97_G105_G0.8050.94
305_P320_L0.7900.93
73_E161_E0.7900.93
220_D241_L0.7850.93
242_Y246_S0.7730.92
308_G315_K0.7730.92
256_V324_L0.7700.92
97_G100_L0.7670.92
12_L16_A0.7610.92
271_Q298_R0.7560.91
270_N302_E0.7540.91
103_K108_I0.7480.91
255_V323_C0.7460.91
117_R163_Q0.7410.91
29_Y73_E0.7370.90
103_K107_P0.7370.90
102_A106_Y0.7360.90
246_S289_G0.7350.90
30_T34_L0.7350.90
245_L253_G0.7330.90
59_G77_D0.7330.90
59_G75_G0.7310.90
3_K6_I0.7310.90
157_A190_R0.7280.90
97_G104_L0.7260.90
19_A24_K0.7240.90
309_N313_N0.7230.89
176_T179_D0.7220.89
236_A239_D0.7220.89
312_D315_K0.7210.89
66_V69_Y0.7200.89
32_A189_Y0.7180.89
263_R307_T0.7160.89
102_A105_G0.7140.89
141_S149_E0.7140.89
296_S323_C0.7110.89
272_G275_E0.7070.88
13_A22_A0.7070.88
137_D140_V0.7070.88
6_I11_A0.7040.88
99_Q104_L0.7040.88
266_S269_Y0.7030.88
309_N316_Q0.7010.88
76_Y96_Q0.7000.88
94_K97_G0.6990.88
93_Y107_P0.6970.88
264_I269_Y0.6960.88
315_K321_I0.6950.88
246_S294_K0.6940.87
304_N322_D0.6930.87
311_C317_R0.6930.87
13_A18_V0.6910.87
100_L104_L0.6900.87
295_I323_C0.6900.87
222_L255_V0.6880.87
31_G34_L0.6880.87
149_E159_R0.6860.87
219_S244_Q0.6860.87
4_T16_A0.6830.87
107_P110_D0.6820.87
257_V281_V0.6810.87
67_N70_V0.6800.86
223_F257_V0.6770.86
264_I314_V0.6760.86
93_Y102_A0.6760.86
265_G281_V0.6760.86
114_I147_G0.6760.86
188_S194_G0.6710.86
281_V321_I0.6700.86
136_H141_S0.6690.86
190_R193_Q0.6690.86
185_L190_R0.6670.85
11_A15_F0.6630.85
95_A106_Y0.6630.85
311_C318_A0.6600.85
157_A161_E0.6590.85
98_V105_G0.6580.85
273_L277_R0.6580.85
220_D323_C0.6540.84
287_S292_A0.6490.84
5_A10_V0.6470.84
267_D271_Q0.6450.83
259_G309_N0.6440.83
133_G138_T0.6430.83
191_F194_G0.6410.83
11_A14_G0.6410.83
143_V165_T0.6410.83
65_Q70_V0.6390.83
57_G184_S0.6380.83
14_G210_V0.6380.83
314_V318_A0.6370.83
185_L191_F0.6350.82
35_G57_G0.6340.82
99_Q102_A0.6330.82
145_A161_E0.6330.82
253_G323_C0.6320.82
278_A297_A0.6310.82
225_F266_S0.6310.82
275_E282_V0.6270.82
241_L245_L0.6270.82
155_E191_F0.6270.82
285_L289_G0.6240.81
228_A280_S0.6240.81
13_A17_T0.6240.81
28_W64_Y0.6220.81
145_A152_I0.6200.81
266_S302_E0.6200.81
225_F270_N0.6110.80
92_A95_A0.6100.80
150_Y160_L0.6080.80
188_S191_F0.6060.79
254_S293_D0.6060.79
93_Y105_G0.6040.79
227_K231_K0.6030.79
250_P254_S0.6030.79
214_H324_L0.6020.79
226_N273_L0.6020.79
93_Y104_L0.6010.79
297_A300_M0.5990.79
222_L306_V0.5990.79
235_Q288_K0.5980.79
235_Q239_D0.5970.78
99_Q108_I0.5970.78
224_N316_Q0.5960.78
34_L56_L0.5960.78
96_Q104_L0.5960.78
234_G262_D0.5960.78
259_G315_K0.5950.78
93_Y97_G0.5940.78
97_G107_P0.5940.78
150_Y164_W0.5910.78
6_I9_A0.5910.78
219_S240_Q0.5890.78
182_M191_F0.5890.78
73_E159_R0.5890.78
227_K280_S0.5870.77
220_D234_G0.5870.77
96_Q107_P0.5870.77
61_F73_E0.5870.77
227_K261_T0.5850.77
31_G35_G0.5850.77
14_G22_A0.5840.77
91_G95_A0.5840.77
30_T210_V0.5830.77
91_G94_K0.5830.77
305_P310_T0.5820.77
117_R161_E0.5820.77
259_G319_A0.5810.77
110_D114_I0.5800.76
261_T299_G0.5800.76
219_S237_A0.5790.76
60_A76_Y0.5770.76
223_F273_L0.5770.76
237_A241_L0.5760.76
229_T280_S0.5740.76
51_T54_N0.5720.75
93_Y99_Q0.5700.75
254_S294_K0.5680.75
100_L103_K0.5670.75
246_S291_P0.5670.75
92_A102_A0.5660.75
222_L234_G0.5660.75
179_D189_Y0.5640.74
309_N318_A0.5630.74
184_S189_Y0.5620.74
50_P54_N0.5610.74
253_G294_K0.5580.74
151_A156_I0.5570.74
50_P53_E0.5550.73
264_I309_N0.5550.73
61_F80_G0.5540.73
73_E79_L0.5540.73
14_G21_A0.5530.73
313_N317_R0.5530.73
224_N233_E0.5520.73
225_F302_E0.5520.73
189_Y193_Q0.5520.73
126_D129_S0.5520.73
133_G140_V0.5510.73
262_D309_N0.5500.73
257_V299_G0.5500.73
5_A12_L0.5500.73
77_D80_G0.5500.73
235_Q238_L0.5490.72
133_G141_S0.5490.72
276_R302_E0.5470.72
223_F316_Q0.5470.72
308_G312_D0.5460.72
271_Q274_S0.5460.72
149_E158_T0.5450.72
222_L261_T0.5450.72
226_N266_S0.5440.72
61_F75_G0.5440.72
306_V315_K0.5430.72
35_G71_G0.5430.72
183_L187_V0.5430.72
110_D113_D0.5420.72
259_G310_T0.5420.72
76_Y79_L0.5410.71
221_V237_A0.5410.71
36_W40_H0.5410.71
220_D316_Q0.5410.71
260_Y320_L0.5410.71
142_P168_I0.5400.71
98_V102_A0.5390.71
5_A14_G0.5390.71
19_A23_P0.5380.71
73_E80_G0.5380.71
115_Y161_E0.5370.71
95_A99_Q0.5360.71
93_Y103_K0.5350.71
263_R318_A0.5350.71
65_Q68_P0.5330.70
219_S238_L0.5330.70
184_S190_R0.5320.70
11_A21_A0.5310.70
217_L230_L0.5290.70
91_G97_G0.5280.70
5_A19_A0.5270.69
264_I302_E0.5250.69
118_L144_F0.5250.69
161_E184_S0.5250.69
58_A78_W0.5240.69
241_L285_L0.5230.69
36_W54_N0.5230.69
13_A21_A0.5230.69
264_I310_T0.5220.69
153_T164_W0.5220.69
226_N261_T0.5210.69
138_T141_S0.5190.68
221_V292_A0.5190.68
97_G101_T0.5190.68
26_N42_T0.5160.68
246_S288_K0.5160.68
97_G103_K0.5160.68
187_V192_G0.5160.68
119_G147_G0.5150.68
164_W181_G0.5150.68
73_E163_Q0.5150.68
71_G105_G0.5140.68
111_D128_K0.5140.68
182_M190_R0.5140.68
35_G64_Y0.5130.67
16_A21_A0.5130.67
115_Y159_R0.5120.67
221_V234_G0.5120.67
116_T146_G0.5120.67
262_D265_G0.5120.67
102_A107_P0.5110.67
42_T85_K0.5100.67
100_L108_I0.5100.67
191_F196_A0.5090.67
31_G188_S0.5080.67
101_T257_V0.5070.66
222_L231_K0.5060.66
75_G79_L0.5040.66
142_P145_A0.5030.66
219_S261_T0.5020.66
308_G317_R0.5020.66
222_L323_C0.5010.66
189_Y192_G0.5010.66
136_H154_P0.5010.66
103_K163_Q0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nb3A 2 0.396 100 0.257 Contact Map
4rhaA 2 0.3526 100 0.555 Contact Map
1r1mA 1 0.3468 100 0.558 Contact Map
4b5cA 1 0.3497 100 0.563 Contact Map
2kgwA 1 0.3642 100 0.569 Contact Map
2hqsH 1 0.3121 100 0.571 Contact Map
3td3A 2 0.3497 100 0.571 Contact Map
3ldtA 2 0.4162 100 0.574 Contact Map
2aizP 1 0.3671 100 0.578 Contact Map
3cypB 3 0.3613 100 0.578 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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